CN105997967B - 用于治疗癌症的化合物和组合物 - Google Patents

用于治疗癌症的化合物和组合物 Download PDF

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CN105997967B
CN105997967B CN201610353298.3A CN201610353298A CN105997967B CN 105997967 B CN105997967 B CN 105997967B CN 201610353298 A CN201610353298 A CN 201610353298A CN 105997967 B CN105997967 B CN 105997967B
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cancer
compound
formula
mmol
compounds
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CN105997967A (zh
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L·加尼翁
B·格劳克斯
L·格尔茨
P·劳伦
C·彭尼
B·扎卡赖尔
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General Midike Pharmaceutical Co Ltd Smt
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    • C07—ORGANIC CHEMISTRY
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    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/32—Phenylacetic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
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    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
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    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201610353298.3A 2010-10-27 2011-10-26 用于治疗癌症的化合物和组合物 Expired - Fee Related CN105997967B (zh)

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US (2) US9114118B2 (OSRAM)
EP (2) EP2632452B1 (OSRAM)
JP (2) JP6007186B2 (OSRAM)
KR (2) KR101821646B1 (OSRAM)
CN (2) CN105997967B (OSRAM)
AU (2) AU2011356583C1 (OSRAM)
BR (1) BR112013010507A2 (OSRAM)
CA (1) CA2816093C (OSRAM)
CL (1) CL2013001152A1 (OSRAM)
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ES (2) ES2703257T3 (OSRAM)
IL (2) IL225599A (OSRAM)
MX (2) MX381345B (OSRAM)
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PH (2) PH12013500766B1 (OSRAM)
PL (2) PL2632452T3 (OSRAM)
PT (2) PT3443957T (OSRAM)
SG (2) SG189538A1 (OSRAM)
TR (1) TR201819987T4 (OSRAM)
TW (2) TWI578983B (OSRAM)
WO (1) WO2012097427A1 (OSRAM)
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TWI689489B (zh) * 2013-03-15 2020-04-01 英商邊緣生物科技有限公司 用於治療肺纖維化、肝纖維化、皮膚纖維化及心臟纖維化之經取代之芳族化合物
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CN106267213A (zh) * 2015-05-27 2017-01-04 聊城市奥润生物医药科技有限公司 环二核苷酸cGAMP在治疗肿瘤联合用药中的应用
BR112020000832A2 (pt) 2017-07-25 2020-07-21 Taris Biomedical Llc métodos para tratar metástase tumoral
IL274343B2 (en) 2017-11-08 2023-10-01 Taris Biomedical Llc Treatment methods and maintenance treatment for bladder cancer using gemcitabine
JP2022510436A (ja) * 2018-12-05 2022-01-26 リミナル・バイオサイエンシーズ・リミテッド アルストレーム症候群の治療における２－（３－ペンチルフェニル）酢酸ナトリウムの使用
US11246945B2 (en) 2019-06-07 2022-02-15 National Defense Medical Center Cisplatin-loaded microbubbles, pharmaceutical composition for treatment of cancer, method for preparing pharmaceutical compositions and method for treating cancer
MX2022000570A (es) 2019-07-26 2022-03-11 Espervita Therapeutics Inc Acidos mono- y dicarboxilicos hidrocarbonados de cadena larga funcionalizados y su uso para la prevencion o el tratamiento de enfermedad.
US20240043372A1 (en) * 2020-10-06 2024-02-08 Pharmaceutique Ingenew Inc. Substituted aromatic compounds and pharmaceutical compositions thereof
TW202237073A (zh) 2021-01-25 2022-10-01 美商艾斯佩維他治療學公司 官能化長鏈烴單羧酸及二羧酸及其衍生物以及其於預防或治療疾病之用途
CN114436822B (zh) * 2022-01-12 2024-04-16 厦门稀土材料研究所 一枝蒿酮酸和生物碱复盐及其制备方法和用途
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