CN105941419A - Fungicide composition containing spiroxamine and epoxiconazole - Google Patents

Fungicide composition containing spiroxamine and epoxiconazole Download PDF

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Publication number
CN105941419A
CN105941419A CN201610385210.6A CN201610385210A CN105941419A CN 105941419 A CN105941419 A CN 105941419A CN 201610385210 A CN201610385210 A CN 201610385210A CN 105941419 A CN105941419 A CN 105941419A
Authority
CN
China
Prior art keywords
epoxiconazole
bacterium amine
volution bacterium
compositions
spiroxamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610385210.6A
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Chinese (zh)
Inventor
任学祥
叶正和
苏贤岩
张勇
陈莉
陈超
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institute of Plant Protection and Agricultural Products Quality Safety of AAAS
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Institute of Plant Protection and Agricultural Products Quality Safety of AAAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute of Plant Protection and Agricultural Products Quality Safety of AAAS filed Critical Institute of Plant Protection and Agricultural Products Quality Safety of AAAS
Priority to CN201610385210.6A priority Critical patent/CN105941419A/en
Publication of CN105941419A publication Critical patent/CN105941419A/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/24—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms
    • A01N43/26—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms five-membered rings
    • A01N43/28—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms five-membered rings with two hetero atoms in positions 1,3
    • A01N43/30—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms five-membered rings with two hetero atoms in positions 1,3 with two oxygen atoms in positions 1,3, condensed with a carbocyclic ring

Abstract

The invention discloses a fungicide composition containing spiroxamine and epoxiconazole. The active components of the fungicide composition are spiroxamine and epoxiconazole, the mass ratio of spiroxamine to epoxiconazole is 1:20 to 20:1, and the mass percentages content of the active components in the composition is 1%-80%. The fungicide composition has the very good prevention effect on diseases such as wheat rust, delays generation and development of the fungicide resistance of pathogens, decreases the prevention and control dosage in actual production and is efficient, economical, safe and environmentally.

Description

A kind of containing volution bacterium amine and the microbicide compositions of epoxiconazole
Technical field
The present invention relates to disinfectant use in agriculture field, be specifically related to a kind of containing volution bacterium amine and the bactericidal composition of epoxiconazole.
Background technology
Wheat rust is commonly called as jaundice, yellow rust, is the great disease of Semen Tritici aestivi that China's occurring area is the widest, harm is the heaviest.Northwest, Southwest and Huang-Huai-Hai Mai Qu are rust Major Epidemic districts.Since the 1950's, being very popular of rust there occurs 9 in China Secondary, cause serious impact to Wheat Production.
Volution bacterium amine (Spiroxamine), another name spiral shell evil cyclopentadienyl amine, chemical name: the N-ethyl-N-propyl group-8-tert-butyl group-1, 4-dioxo spiro [4.5] certain herbaceous plants with big flowers alkane-2-methylamine.The mechanism of action is sterol synthetic inhibitor, main suppression C-14 demethylation enzyme Synthesis.Speed of action is fast and the lasting period is long, has protection therapeutical effect concurrently.
Epoxiconazole (Epoxiconazole), calls epoxy bacterium azoles, chemical name: (2RS, 3RS)-1-[3-(2 monochloro-benzenes Base)-2,3 one epoxy-2-(4 phenyl-monofluoride bases) propyl group] one 1 hydrogen one 1,2,4 one triazoles.Belong to interior absorption triazole bactericidal agent, press down The synthesis of pathogenic bacteria ergosterol processed, hinders the formation of pathogenic bacteria cell wall, and epoxiconazole can improve the chitinase activity of crop, cause The contraction of fungus haustorium, pathogenic bacteria invades in suppression.To a series of cereal diseases such as damping-off, powdery mildew, eyeprint disease etc. ten Multiple diseases has good preventive and therapeutic effect.
There is presently no both composite usages in the report preventing and treating wheat rust.
Summary of the invention
The invention provides a kind of containing volution bacterium amine and the bactericidal composition of epoxiconazole, there is bactericidal activity high, dosage Little, on plant growth without impact, economic, efficient, the feature of environmental protection, there is specially good effect to preventing and treating wheat rust.
It is combined that two classes are had the antibacterial of different mechanism of action, i.e. volution bacterium amine and epoxiconazole by the present invention, and processes Become and produce upper easy-to-use preparation, be used alone in two kinds of compositions and compare, there is biological activity high, total in unit are Dosage declines, and greatly reduces dispenser cost, delays pathogen Drug resistance to produce to a greater extent and development simultaneously, reduces Pathogenic fungi produces the risk of resistance to single antibacterial, extends the service life of each component in bactericidal composition, thus Realize economic, efficient, the goal of the invention of environmental protection.
The technical scheme is that
A kind of containing volution bacterium amine and the microbicide compositions of epoxiconazole, it is characterised in that active group of described microbicide compositions Being divided into volution bacterium amine and epoxiconazole, the mass ratio of volution bacterium amine and epoxiconazole is 1:20 to 20:1, active component matter in compositions Amount percentage composition is 1-80%.
It is described containing volution bacterium amine and the bactericidal composition of epoxiconazole, it is characterised in that: described active component volution bacterium The mass ratio of amine and epoxiconazole is 5:1 to 1:5.
It is described containing volution bacterium amine and the microbicide compositions of epoxiconazole, it is characterised in that: described microbicide compositions Dosage form is suspending agent, cream, water dispersible granules, wettable powder, seed coat agent or microcapsule suspending agent.
The described application of the microbicide compositions containing volution bacterium amine and epoxiconazole, it is characterised in that: this microbicide compositions Various crop disease there is good prevention effect.
Remarkable result and the advantage of the present invention be:
The present invention has higher prevention effect to wheat rust, there is notable synergistic effect between two components；Part can be replaced high Price pesticide species, and reduce dosage, effectively reduce ecological disruption and environmental pollution, and crop yield and quality can be improved； The pathogenic bacteria Drug resistance to single medicament can be delayed.
First volution bacterium amine and the EC of epoxiconazole two single compound (hereinafter referred to as medicament) are measured50(drug safety refers to Mark), according to the EC of two single medicaments50The portfolio ratio of two medicaments is set by the abundant method of Sun Yun, and according to co-toxicity coefficient CTC value, really Fixed suitable compositions ratio.
Test objective thing is wheat rust, but is not limited to this.Test uses mycelial growth rate method, makes by different disposal Pastille culture medium, 4 repetitions of each process, after connecing bacterium 3 days, investigate each process growth inhibitory effect to wheat rust pathogenic bacteria.Logical Cross the linear regression analysis between the probit value of preventive effect and the logarithm value of series drug concentration, obtain the EC of each medicament50, according to grandson The abundant method of rue calculates co-toxicity coefficient (CTC), and makes overall merit accordingly.CTC≤80 represent have antagonism, 80 ＜ CTC ＜ 120 represents have summation action, and CTC >=120 are potentiation.CTC value calculating method is as follows:
The EC of CTC=A50* the EC of B50* the EC50*(P of 100/(MA* the EC of B50+PB* the EC of A50))
Table 1 volution bacterium amine and epoxiconazole and the compounding indoor biometrics result to wheat rust thereof
Proportioning (A:B) Slope value (± SE) Correlation coefficient EC50(mg/L) CTC
Volution bacterium amine (A) 1.510±0.041 0.985 0.153 -
Epoxiconazole (B) 1.014±0.012 0.989 0.082 -
20:1 1.332±0.010 0.986 0.099 148.22
10:1 1.413±0.021 0.990 0.100 141.14
5:1 1.612±0.031 0.991 0.080 167.80
1:1 1.243±0.102 0.990 0.080 133.07
1:5 1.442±0.064 0.987 0.060 149.09
1:10 1.545±0.031 0.994 0.071 120.44
1:20 1.210±0.012 0.988 0.051 164.15
As can be seen from the above data, the volution bacterium amine of different proportion and the epoxiconazole composition antibacterial effect to wheat rust pathogenic bacteria The most different, on the whole, its ratio has potentiation in the range of 1:20 to 20:1, and wherein maximum enhancing proportions is 5:1, CTC value is 167.80.
Below in conjunction with embodiment, the invention will be further described, it is contemplated that the processing difficulty or ease journey of volution bacterium amine and epoxiconazole Degree and price factor, this experiment determines the proportioning using 1:5 as both mixtures, but is not limited to this.Involved by embodiment The content of effective ingredient be also not necessarily limited to this.
Detailed description of the invention
Embodiment 1 (30% volution bacterium amine epoxiconazole suspension concentrate)
Composition of raw materials: by mass percentage
Active component volution bacterium amine 5%
Active component epoxiconazole 25%
NNO 3%
BY110 2%
APE-1 2%
Xanthan gum 0.15%
Propylene glycol 1%
Capryl alcohol 0.05%
Water surplus.
Preparation method is as follows:
According to formula, component is weighed in proportion, add ball mill ball milling 30 minutes, filter, suction dispersion tank high speed shear 3 points Being fully ground through sand mill after clock, control solid constituent particle diameter, within 2 microns, grinds and stirs after terminating, to obtain final product Suspending agent product.
Embodiment 2 (60% volution bacterium amine epoxiconazole cream)
Composition of raw materials: by mass percentage
Active component volution bacterium amine 10%
Active component epoxiconazole 50%
Dimethylbenzene 20%
DMF 2%
Anhydrous calcium salt 5%
Tween 80 5%
Carbon tetrachloride surplus.
Preparation method: fully dissolved in dimethylbenzene reactor by active component epoxiconazole, makes A liquid；By active component Epoxiconazole fully dissolves in carbon tetrachloride and DMF reactor, makes B liquid；Under not stopping stirring, A liquid is mixed into B liquid, fills Divide and stir, add anhydrous calcium salt and Tween 80, then adjust content with solvent carbon tetrachloride.
Embodiment 3(30% volution bacterium amine epoxiconazole water dispersant)
Active component volution bacterium amine 5%
Active component epoxiconazole 25%
Methyl fatty amide benzenesulfonic acid calcium 4%
Sodium carbonate 3%
Sodium lignin sulfonate 4%
Attapulgite surplus.
Preparation method: volution bacterium amine, epoxiconazole, Methyl fatty amide benzenesulfonic acid calcium, sodium carbonate, attapulgite are mixed together After closing uniformly, be crushed to particle diameter 5 m through jet mill, obtain female powder, mother powder and sodium lignin sulfonate are sufficiently mixed rear pelletize, Dry, sieve, thus prepare water-dispersible granules.
Embodiment 4(60% volution bacterium amine epoxiconazole wettable powder)
Active component volution bacterium amine 10%
Active component epoxiconazole 50%
Wood sodium 3%
Amine carbonate 3%
White carbon 10%
Attapulgite surplus.
Preparation method: uniformly mixed by above-mentioned substance, mixture is pulverized through jet mill, prepares wettable powder.
Embodiment 5(12% volution bacterium amine epoxiconazole microcapsule suspending agent)
Active component volution bacterium amine 2%
Active component epoxiconazole 10%
Dimethylformamide 2%
Methyl diphenylene diisocyanate 3%
Fatty acid amide N methyl taurine sodium salt 2%
Hexamethylene diamine 0.5%
Radix Acaciae senegalis 2%
Polyvinyl alcohol 2%
Water polishing is to 100%
(1) volution bacterium amine and epoxiconazole are dissolved in solvent, add methyl diphenylene diisocyanate and be uniformly mixing to obtain oil Phase；(2) add emulsifying agent in water, adjuvant is uniformly mixing to obtain aqueous phase；(3) during aqueous phase joins oil phase, high speed homogenizing shape Become O/w emulsion；(4) under 450 revs/min of speed conditions, adding ethylenediamine and participate in interface polymerization reaction, reaction temperature rises to 55 DEG C, keep 3 hours solidification encystation；(5) add dispersant, thickening agent, stir and i.e. make microcapsule suspending agent.
Embodiment 6(24% volution bacterium amine epoxiconazole suspension seed-coating agent)
Active component volution bacterium amine 4%
Active component epoxiconazole 20%
NNO 3%
BY110 2%
APE-1 2%
Xanthan gum 0.15%
Propylene glycol 1%
Film former 3%
Dyestuff 4%
Water surplus.
According to formula, component (except dyestuff, film former) is weighed in proportion, adds ball mill ball milling 30 minutes, filter, Suction dispersion tank high speed shear was fully ground through sand mill after 3 minutes, and control solid constituent particle diameter, within 2 microns, grinds Mill stirs after terminating, and adds film former and dyestuff, obtains suspension seed-coating agent product.
Prevention effect is tested:
The field efficiency test of wheat rust is carried out in experimental plot, market town, hilllock, Changfeng County, and test area is 0.3hm2, often process weight Multiple three times, carry out spraying treatment or Cotton seeds at wheat rust their early stage, carry out preventive effect investigation in dispenser after 17 days, preventing and treating The results are shown in Table 2.Result shows, this bactericidal composition has good prevention effect to wheat rust, at same dose or relatively low Can reach higher prevention effect under using dosage, and each preventive effect that processes of this bactericidal composition is all higher than 85%, it is right to be significantly higher than According to medicament.
Table 2 volution bacterium amine epoxiconazole bactericidal composition prevents and treats the land for growing field crops drug effect of wheat rust
Finally, in addition it is also necessary to be only several specific embodiments of the present invention it is noted that listed above.Obviously, the present invention is not It is limited to above embodiment, it is also possible to have many variations.Those of ordinary skill in the art can be straight from present disclosure Connect all deformation derived or associate, be all considered the scope of protection of the invention.

Claims (3)

1. one kind contains volution bacterium amine and the microbicide compositions of epoxiconazole, it is characterised in that the activity of described microbicide compositions Component is volution bacterium amine and epoxiconazole, and kobam is 1:20 to 20:1 with the mass ratio of Tebuconazole, active component matter in compositions Amount percentage composition is 1-80%.
It is the most according to claim 1 containing volution bacterium amine and the microbicide compositions of epoxiconazole, it is characterised in that: described spiral shell The mass ratio of ring bacterium amine and epoxiconazole is 5:1 to 1:5.
It is the most according to claim 1 containing volution bacterium amine and the microbicide compositions of epoxiconazole, it is characterised in that: described sterilization The dosage form of agent compositions is suspending agent, cream, water dispersible granules, wettable powder, seed coat agent or microcapsule suspending agent.
CN201610385210.6A 2016-06-03 2016-06-03 Fungicide composition containing spiroxamine and epoxiconazole Pending CN105941419A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108684676A (en) * 2018-07-07 2018-10-23 安徽省农业科学院植物保护与农产品质量安全研究所 A kind of bactericidal composition containing volution bacterium amine and fludioxonil

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1099552A (en) * 1993-06-02 1995-03-08 拜尔公司 Fungicidal compositions
CN101160047A (en) * 2005-04-18 2008-04-09 巴斯福股份公司 Preparation containing at least one type of fungicidal conazole
CN105165834A (en) * 2015-08-14 2015-12-23 陕西上格之路生物科学有限公司 Sterilization composition containing spiroxamine and triazole bactericide

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1099552A (en) * 1993-06-02 1995-03-08 拜尔公司 Fungicidal compositions
CN101160047A (en) * 2005-04-18 2008-04-09 巴斯福股份公司 Preparation containing at least one type of fungicidal conazole
CN105165834A (en) * 2015-08-14 2015-12-23 陕西上格之路生物科学有限公司 Sterilization composition containing spiroxamine and triazole bactericide

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108684676A (en) * 2018-07-07 2018-10-23 安徽省农业科学院植物保护与农产品质量安全研究所 A kind of bactericidal composition containing volution bacterium amine and fludioxonil

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Application publication date: 20160921