CN106857590B - Bactericidal composition containing thiabendazole and benthiavalicarb isopropyl - Google Patents
Bactericidal composition containing thiabendazole and benthiavalicarb isopropyl Download PDFInfo
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- CN106857590B CN106857590B CN201710105262.8A CN201710105262A CN106857590B CN 106857590 B CN106857590 B CN 106857590B CN 201710105262 A CN201710105262 A CN 201710105262A CN 106857590 B CN106857590 B CN 106857590B
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- benthiavalicarb
- isopropyl
- probenazole
- bactericidal composition
- composition containing
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/12—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, neither directly attached to a ring nor the nitrogen atom being a member of a heterocyclic ring
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
- A01N43/78—1,3-Thiazoles; Hydrogenated 1,3-thiazoles
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a bactericidal composition containing probenazole and benthiavalicarb-isopropyl, which is prepared from effective components of probenazole and benthiavalicarb-isopropyl and a proper agricultural auxiliary agent into a common agricultural bactericide dosage form. The invention has obvious control effect on fungal diseases of crops such as potato late blight and the like, has obvious synergistic effect between the two medicaments, can reduce the dosage and delay the drug resistance of germs to a single medicament, and is economic, efficient and environment-friendly.
Description
Technical Field
The invention belongs to the field of agricultural bactericides and particularly relates to a bactericidal composition containing thiabendazole and benthiavalicarb isopropyl.
Background
Thiabendazole (Triabendazole, common English name) belongs to benzimidazole bactericide, has an action mechanism of inhibiting the formation of microscopic protein in the mitosis process of fungi, belongs to high-efficiency, broad-spectrum and systemic bactericide, has protection and treatment effects, and can prevent and treat various plant diseases.
Benthiavalicarb isopropyl (English common name: Benthiavalicarb) has good bactericidal activity on phytophthora root rot and has good inhibition effect on the formation of sporangia and the germination of the sporangia at low temperature. The medicament does not influence radon ization and synthesis of nucleic acid and protein, does not influence the function of a phytophthora pathogenic bacteria protoplasm membrane, has an action mechanism supposedly possibly serving as a cell wall synthesis inhibitor, and has good pesticide effects on late blight, downy mildew and the like of crops.
At present, no report exists that two medicaments are mixed and applied to control crop diseases and pests.
Disclosure of Invention
The invention provides a novel bactericide composition containing thiabendazole and benthiavalicarb-isopropyl, which is used for preventing and treating various crop diseases such as potato late blight, cucumber downy mildew and the like. The probenazole and the benthiavalicarb-isopropyl have different structural types and different action mechanisms, the probenazole and the benthiavalicarb-isopropyl are combined according to a certain proportion, the bactericidal activity is high in practical use, the selective pressure on pathogens caused by the single pesticide of the probenazole and the benthiavalicarb-isopropyl when the single pesticide is used independently can be avoided to a greater extent, the generation and the development of the drug resistance of the pathogens are delayed, the total pesticide dosage in unit area is reduced, and the probenazole and the benthiavalicarb-isopropyl are economical, efficient and environment-friendly.
The technical scheme of the invention is as follows
A sterilization composition containing probenazole and benthiavalicarb-isopropyl, wherein the mass ratio of probenazole to benthiavalicarb-isopropyl is 20: 1-1: 20.
the preferable mass ratio of the probenazole to the benthiavalicarb-isopropyl of the sterilizing composition is 10: 1-1: 1.
the dosage form of the bactericidal composition can be prepared into missible oil, suspending agent, wettable powder, water dispersible granules, microcapsules, seed coating agent and the like. The adopted agricultural bactericide auxiliary agents comprise various auxiliary agents such as wetting agents, dispersing agents, thickening agents, defoaming agents, fillers and the like, and the adopted wetting agents and dispersing agents can be one or more of alkyl naphthalene sulfonate formaldehyde condensate, sodium dibutyl naphthalene sulfonate (nekal), oleic acid methyl amino ethyl sodium sulfonate, sodium lignosulfonate, calcium lignosulfonate, alkylphenol polyoxyethylene ether, alkylphenol polyoxyethylene phosphate, castor oil polyoxyethylene ether and the like; the adopted thickening agent can be xanthan gum, polyvinyl alcohol and the like; the adopted defoaming agent can be one or more of phosphate defoaming agent and organic silicon defoaming agent; the adopted filler can be one or more of white carbon black, kaolin, attapulgite and the like;
the effective components of the sterilizing composition, preferably probenazole and benthiavalicarb-isopropyl, account for 10-60% of the total mass of the sterilizing composition.
The bactericidal composition is applied to preventing and treating crop fungal diseases such as potato late blight, cucumber downy mildew and the like.
By detailed analysis of the action mechanism and the bactericidal property of the probenazole and the benthiavalicarb-isopropyl, a Wadley method is used for experimental design and result processing. Firstly, determining EC of two single compounds (hereinafter referred to as medicament) of probenazole and benthiavalicarb50EC according to two single agents50The combination ratio of the two medicaments is set according to the Wadley method, and the CTC value of the medicaments is calculated according to the Sun-cloud-Peel method, so that the proper combination ratio is determined.
The test target is potato late blight. The colony diameter method is adopted in the test. Taking the mother liquor of probenazole and benthiavalicarb-isopropyl, preparing a liquid medicine-needed flat plate with about 14ml per dish, setting a medicine-free flat plate Control (CK), and repeating for 3 dishes per treatment, namely repeating for 3 times. Preparing 5 mm-diameter hypha blocks at the edge of the pre-cultured colony by using a sterilized hole puncher, respectively transferring the hypha blocks to different culture medium plates, culturing the hypha blocks at 28 ℃ for 2d, measuring the diameter (mm) of the colony, and calculating the growth inhibition rate by using the following formula:
converting the hypha growth inhibition rate into an inhibition probability value (Y), converting the medicament concentration into a concentration logarithm (X), taking the concentration logarithm as an abscissa and the concentration logarithm as an ordinate as a toxicity regression line, obtaining a toxicity regression equation of the probenazole, benthiavalicarb-isopropyl single agent and the mixed agent thereof on the potato late blight, and calculating EC50And the like.
CTC is less than or equal to 80, namely the antagonistic action is realized, CTC is more than 80 and less than 120, namely the additive action is realized, and the synergistic action is realized when CTC is more than or equal to 120. The CTC values were calculated as follows:
EC of CTC = a50EC of B50100/(M EC50 of M) (P)AEC of B50+PBEC of A50））
TABLE 1 toxicity test results of single preparation of thiabendazole and benthiavalicarb isopropyl and its mixture for potato late blight
From the data in table 1, probenazole and benthiavalicarb were analyzed at a ratio of 20: 1-1: when the components are mixed in a ratio of 20, the growth of potato late blight hyphae can be inhibited strongly, and synergistic effects are shown, wherein the effect of the probenazole and the benthiavalicarb isopropyl in inhibiting the potato late blight is the best in a ratio of 10: 1-1: 1, the synergistic effect is the most obvious, and the synergistic effect is the most obvious in a ratio of 5: 1.
The invention has better control effect on the fungal diseases of the crops such as potato late blight and the like, and the two medicaments have obvious synergistic effect, so that the dosage can be reduced, the ecological damage and the environmental pollution can be effectively reduced, and the yield and the quality of the crops can be improved; the probenazole and the benthiavalicarb isopropyl are safe to people, livestock and beneficial organisms; can delay the drug resistance of germs to a single medicament.
Detailed Description
The present invention will be further described with reference to the following examples, but the spirit of the present invention is not limited to the following examples.
Example 1 (30% probenazole Benthiavalicarb suspension concentrate)
The raw material formula is as follows: according to mass percent
5 percent of benthiavalicarb isopropyl as an active component
Active component thiabendazole 25%
NNO 3%
BY110 2%
APE-1 2%
Xanthan gum 0.15%
1 percent of propylene glycol
Octanol 0.05%
The balance of water.
The preparation method comprises the following steps:
according to the formula, the components are weighed in proportion, added into a ball mill for ball milling for 30 minutes, filtered, pumped into a dispersion tank for high-speed shearing for 3 minutes, fully ground by a sand mill, the particle diameter of the solid component is controlled within 2 microns, and uniformly stirred after the grinding is finished, so that the suspending agent product is obtained.
Example 2 (48% probenazole Benthiavalicarb isopropyl emulsion)
The raw material formula is as follows: according to mass percent
8 percent of benthiavalicarb isopropyl as an active component
Active component thiabendazole 40%
20 percent of dimethylbenzene
DMF 2%
Anhydrous calcium salt 5%
Tween 805%
The balance of carbon tetrachloride.
The preparation method comprises the following steps: fully dissolving active components of probenazole and benthiavalicarb-isopropyl in dimethylbenzene; mixing solution A with solution B under stirring, adding anhydrous calcium salt and Tween 80, adjusting content with solvent DMF, and adjusting the balance with carbon tetrachloride.
Example 3 (30% probenazole-benthiavalicarb water dispersible granule)
5 percent of benthiavalicarb isopropyl as an active component
Active component thiabendazole 25%
Methyl fatty amide calcium benzenesulfonate 4%
3 percent of sodium carbonate
Sodium lignosulfonate 4%
And the balance of attapulgite.
The preparation method comprises the following steps: the benthiavalicarb isopropyl, the probenazole, the methyl fatty amide calcium benzene sulfonate, the sodium carbonate and the attapulgite are uniformly mixed, crushed to a particle size of 5 mu m by a jet mill to obtain a mother powder, and the mother powder and the sodium lignosulfonate are fully mixed, granulated, dried and sieved to prepare the water dispersible granule.
Example 4 (60% probenazole-benthiavalicarb isopropyl wettable powder)
The active component benthiavalicarb isopropyl is 10%
50 percent of thiabendazole serving as an active component
3 percent of sodium lignosulphonate
3 percent of amine carbonate
White carbon black 10%
And the balance of attapulgite.
The preparation method comprises the following steps: the substances are uniformly mixed, and the mixture is crushed by a jet mill to prepare the wettable powder.
Example 5 (12% probenazole-benthiavalicarb microcapsule suspension)
2 percent of benthiavalicarb isopropyl as an active component
Active component thiabendazole 10%
Dimethylformamide 2%
3 percent of diphenylmethane diisocyanate
Fatty amide N-methyl taurinic acid sodium salt 2%
0.5 percent of ethylenediamine
Arabic gum 2%
Polyvinyl alcohol 2%
The water is supplemented to 100 percent
(1) Dissolving the medicament in a solvent, adding diphenylmethane diisocyanate, and uniformly stirring to obtain an oil phase; (2) adding an emulsifier and an auxiliary agent into water, and uniformly stirring to obtain a water phase; (3) adding the water phase into the oil phase, and homogenizing at high speed to form an oil-in-water emulsion; (4) adding ethylenediamine to take part in interfacial polymerization reaction at the rotation speed of 450 rpm, raising the reaction temperature to 55 ℃, keeping for 3 hours, and curing to form capsules; (5) adding dispersant and thickener, and stirring to obtain microcapsule suspension.
Example 6 (24% probenazole-benthiavalicarb suspension seed coating)
4 percent of benthiavalicarb isopropyl as an active component
20 percent of thiabendazole serving as an active component
NNO 3%
BY110 2%
APE-1 2%
Xanthan gum 0.15%
1 percent of propylene glycol
3 percent of film forming agent
Dye 4%
The balance of water.
According to the formula, the components (except the dye and the film forming agent) are weighed according to the proportion, added into a ball mill for ball milling for 30 minutes, filtered, pumped into a dispersion tank for high-speed shearing for 3 minutes, fully ground by a sand mill, the particle diameter of the solid component is controlled within 2 microns, stirred uniformly after grinding is finished, and the film forming agent and the dye are added to obtain the suspended seed coating agent product.
Finally, it is also noted that the above-mentioned lists merely illustrate a few specific embodiments of the invention. It is obvious that the invention is not limited to the above embodiments, but that many variations are possible. The formula can also be processed into a hot fogging concentrate for use in a hot fogging machine and an ultra-low volume spray for application in the fields of unmanned aerial vehicles, manned machines and the like. All modifications which can be derived or suggested by a person skilled in the art from the disclosure of the invention are considered to be within the scope of the invention.
Claims (4)
1. A sterilization composition containing thiabendazole and benthiavalicarb isopropyl is characterized in that: in the bactericidal composition, the mass ratio of the probenazole to the benthiavalicarb-isopropyl is 20: 1-1: 20.
2. the germicidal composition of claim 1, wherein: the mass ratio of the probenazole to the benthiavalicarb-isopropyl is 10: 1-1: 1.
3. the germicidal composition of claim 1, wherein: the dosage form of the bactericidal composition is missible oil, water suspending agent, wettable powder, water dispersible granules, microcapsule suspending agent and seed coating agent.
4. The germicidal composition of claim 1, wherein: the effective components of the probenazole and the benthiavalicarb-isopropyl account for 10-60% of the total mass of the bactericidal composition.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710105262.8A CN106857590B (en) | 2017-02-26 | 2017-02-26 | Bactericidal composition containing thiabendazole and benthiavalicarb isopropyl |
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| CN201710105262.8A CN106857590B (en) | 2017-02-26 | 2017-02-26 | Bactericidal composition containing thiabendazole and benthiavalicarb isopropyl |
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| CN107467048A (en) * | 2017-08-21 | 2017-12-15 | 京博农化科技股份有限公司 | Complex composition and its application containing benzene metsulfovax and systemic fungicide |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105010364A (en) * | 2015-07-07 | 2015-11-04 | 安徽省农业科学院植物保护与农产品质量安全研究所 | Bactericidal composition comprising probenazole and thifluzamide and application of bactericidal composition |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105010364A (en) * | 2015-07-07 | 2015-11-04 | 安徽省农业科学院植物保护与农产品质量安全研究所 | Bactericidal composition comprising probenazole and thifluzamide and application of bactericidal composition |
Non-Patent Citations (1)
| Title |
|---|
| 氟醚菌酰胺与烯酰吗啉混配对马铃薯晚疫病菌增效作用及田间药效;孟润杰等;《农药》;20170210;第56卷(第2期);第142-144页 * |
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