CN107467048A - Complex composition and its application containing benzene metsulfovax and systemic fungicide - Google Patents

Complex composition and its application containing benzene metsulfovax and systemic fungicide Download PDF

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Publication number
CN107467048A
CN107467048A CN201710719525.4A CN201710719525A CN107467048A CN 107467048 A CN107467048 A CN 107467048A CN 201710719525 A CN201710719525 A CN 201710719525A CN 107467048 A CN107467048 A CN 107467048A
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benzene metsulfovax
systemic fungicide
complex composition
containing benzene
agent
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Inventor
张建建
李士广
王兴胜
张元珍
王小涛
吴磊
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Jingbo Agrochemicals Technology Co Ltd
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Jingbo Agrochemicals Technology Co Ltd
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Priority to CN201710719525.4A priority Critical patent/CN107467048A/en
Publication of CN107467048A publication Critical patent/CN107467048A/en
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/12—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, neither directly attached to a ring nor the nitrogen atom being a member of a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/18—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, directly attached to a heterocyclic or cycloaliphatic ring
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/20—N-Aryl derivatives thereof

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  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention belongs to technical field of pesticide, and in particular to the complex composition containing benzene metsulfovax and systemic fungicide, and the application of said composition.Complex composition containing benzene metsulfovax and systemic fungicide, it is characterised in that the active ingredient of said composition is made up of benzene metsulfovax and systemic fungicide.The beneficial effects of the present invention are：（1）Compared with single dose, complex composition of the invention has obvious synergistic function, its drug effect height, lasting period length, the generation for having delayed disease drug resistance in certain proportion；Table of field test results in embodiment is bright, and in the case where the dosage of complex composition is less than single dose, the effect of complex composition of the invention is better than single dose；（2）Disease control spectrum is expanded, a medicine is controlled more, reduces dosage and times for spraying, reduce cost.

Description

Complex composition and its application containing benzene metsulfovax and systemic fungicide
Technical field
The invention belongs to technical field of pesticide, and in particular to the compounded combination containing benzene metsulfovax and systemic fungicide Thing, and the application of said composition.
Background technology
It is the maximally efficient means for preventing and treating fungal diseases of plants using chemical agent.But the administration of long-term continuous high dose Single chemical bactericide, easily cause residual, environmental pollution and the generation of resistance to resistance to the action of a drug fungi of medicament.
Peasant household's continuous several times or similar medicament is largely used, can make pathogen that these medicaments are produced with stronger anti-medicine Property, cause drug effect to reduce.Use, not only result in if peasant household's two or more optional medicaments in dispenser are arranged in pairs or groups with any dosage Dose is big, the waste of medicament, and the medicine arbitrarily arranged in pairs or groups does not have synergistic effect not only to disease, but also can play antagonism work With.Therefore, it is necessary to develop the composition of high-efficiency broad spectrum, it is set to be advantageous to agricultural production.
Therefore, rational chemical bactericide compounding or mixture, which have, expands fungicidal spectrum, improves prevention effect, extension dispenser is fitted Phase, dosage is reduced, poisoning is reduced, reduces residual, delays Antifungal resistance and drug-fast generation, bactericide compounded or mixture It is one of maximally efficient method for solving problem above.
Benzene metsulfovax have good bactericidal activity to phytophthora root rot, and the sprouting of the formation sporangium to its sporangium is low dense There is good inhibiting effect under degree, but release to zoospore and the movement of zoospore do not act on.To downy mildew of garpe Bacterium (PlasmoparaviticolaBerl) downy mildew of cucurbits bacterium (PseudoperonosporacubensisRostov.) and ten The field test results of Zi Hua sections Pseudoperonospora cubensis (PeronosporaparasiticaFr.) are similar.The biochemistry of benzene metsulfovax The mechanism of action just under study for action, benzene metsulfovax phytophthora infestans resistant to benzoyl amine functional group and to methoxy propyl The resistant downy mildew of cucurbits of olefin(e) acid ester functional group has bactericidal activity, thus it is speculated that benzene metsulfovax containing these functional groups with sterilizing The mechanism of action of agent is different.Moreover, benzene metsulfovax do not influence the oxidative synthesis of nucleic acid and protein, to phytophthora germ protoplasmic membrane Function does not influence.
Diethofencarb (diethofencarb), chemical name：3,4- diethoxy phenylcarbamic acid isopropyl esters, it is interior suction Property bactericide, suppress botrytis cinerea gemma spindle formed, it is simultaneous to control white powder for preventing and treating the bacterial strain of the anti-Bentazon such as grape, citrus Disease.
Benomyl (benomyl) is systemic fungicide, is that carbendazim and another kind have volatility in plant intracellular metabolite Butyl isocyanate, it is its major antibacterial material.Benomyl can be used for the multiple diseases of the crops such as preventing and treating vegetables, fruit tree, rice wheat, often As seed dressing, spraying and soil treatment, in addition to having protection and therapeutic action, also with acaricidal action.
The B of CN 102578124 disclose a kind of Bactericidal composition containing fluoxastrobin and diethofencarb, its effective active composition The weight of fluoxastrobin and diethofencarb ratio is 1：60~60：1.Its disease prevented and treated includes powdery mildew, droop, downy mildew, ash Mildew, epidemic disease, anthracnose, ring spot, banded sclerotial blight, spot defoliation.
CN101491252A discloses a kind of bactericidal composition containing 2-cyano-3-amino-3-phenylancryic acetate and carbendazim, wherein 2-cyano-3-amino-3-phenylancryic acetate with Carbendazim percentage by weight is 5-60：80-10.It is mainly used in preventing and treating wheat scab, bakanae disease of rice.
More than document in disclose benzene metsulfovax and bactericide compounded combined and diethofencarb is answered with ester pesticides with other Match somebody with somebody and apply, the compounding of 2-cyano-3-amino-3-phenylancryic acetate and carbendazim, its shortcoming be fluoxastrobin, 2-cyano-3-amino-3-phenylancryic acetate resistance produce speed compared with It hurry up, lasting effect is weak.
But the medicine for mutually compounding benzene metsulfovax with carbendazim with diethofencarb or benzene metsulfovax, but have no relevant report. Whether benzene metsulfovax have synergistic function after mutually being compounded with carbendazim with diethofencarb or benzene metsulfovax, also there are no document and drape over one's shoulders Dew.
The content of the invention
In order to solve above-mentioned technical problem, the invention provides one kind with benzene metsulfovax and systemic fungicide compounding association With the composition of synergy, the resistance generation speed of said composition is slow, and lasting effect is stronger.
Present invention also offers the application in above-mentioned built composition for preventing and controlling corps diseases.
The complex composition containing benzene metsulfovax and systemic fungicide of the present invention, the active ingredient of said composition is by benzene Metsulfovax and systemic fungicide composition, wherein, the mass ratio of benzene metsulfovax and systemic fungicide is 30:1~1:30.
Preferably, the mass ratio of benzene metsulfovax and systemic fungicide is 20:1~1:20.
Systemic fungicide is diethofencarb or benomyl.
Benzene metsulfovax and the quality sum of systemic fungicide account for the 5~80% of composition gross mass.
Preferably, benzene metsulfovax and the quality sum of systemic fungicide account for the 10~60% of composition gross mass.
Composition includes wetting agent, dispersant, sustained release agent, disintegrant, emulsifying agent, antifreezing agent, thickener, defoamer, viscous Tie at least one of agent or filler.
Emulsifying agent is selected from：Alkyl benzene calcium sulfonate (such as agriculture breast 500# of Nanjing Tai Hua Co., Ltds), OP series phosphate (nonyls Base phenol polyethenoxy ether phosphate), phenyl phenol polyoxyethanyl ether phosphate (the 600# phosphates of such as Nanjing Tai Hua Co., Ltds), Styrene polyoxyethylene ether ammonium sulfate salt, alkyl biphenyl ether disulfonic acid magnesium salts, triethanolamine salt, benzyl dimethyl phenol polyoxyethanyl Ether (such as agriculture breast 400# of Xingtai blue star auxiliary reagent factory), peaceful newborn 36# (phenethyl phenol formaldehyde resin polyoxyethyl ether), phenethyl phenol are gathered Oxygen ethyl polypropylene-base ether (such as agriculture breast 1600# of Handan City Xin Diya chemical industry Co., Ltd), oxirane-epoxy third Alkane block copolymer, NPE (the OP series of such as Hai'an petrochemical industry), castor oil polyoxyethylene ether (grand U.S. in such as Tianjin EL series), alkylaryl polyoxyethylene polyoxypropylene ether again (the agriculture breast 33# that such as Nanjing is changed very much), alkylaryl polyoxyethylene gather Oxypropylene ether (the agriculture breast 34# that such as Nanjing is changed very much), Span series (sorbitan monostearate), TWEEN Series (Sorbitan Polyol fatty acid ester APEO), one kind or more in the fat alcohol alcohol APEO AEO of such as Xingtai blue star auxiliary reagent factory (series) Kind.
Above-mentioned dispersant is selected from：Polycarboxylate (for example, TERSPERSE2500, Huntsman Corporation of the U.S. produces), lignin Sulfonate, APES formaldehyde condensation products sulfat, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, In APES, aliphatic amine polyoxyethylene ether, polyoxyethylene carboxylate, glycerine fatty acid ester APEO It is one or more.
Above-mentioned wetting agent is selected from：Alkylphenol-polyethenoxy base ether formaldehyde condensation products sulfate, alkylbenzene APEO phosphorus Acid esters, phenethyl phenol polyoxyethylene groups ether phosphate, alkyl sulfate, alkylsulfonate (such as TERSPERSE2425, the U.S. Huntsman Corporation produce), naphthalene sulfonate (such as NNO), lauryl sodium sulfate, Nekal BX, wetting and penetrating agent F, dodecane One or more in base benzene sulfonic acid.
Disintegrant is selected from：One kind in ammonium sulfate, bentonite, urea, succinic acid, sodium acid carbonate, aluminium chloride, citric acid or It is a variety of.
Antifreezing agent is selected from：One or more in ethylene glycol, propane diols, glycerine, glycerine, urea.
Thickener is selected from：Xanthans, hydroxymethyl cellulose, hydroxyethyl cellulose, methylcellulose, alumina silicate be beautiful, poly- second One or more in enol.
Defoamer is selected from：Silicone compound, silicone oil, C8-10 aliphatic alcohols compound, C10-20 saturated fat acids One or more in compound.
Binding agent is selected from：Polyvinyl alcohol, dextrin, hydroxymethyl cellulose, polyvinylpyrrolidone, sodium alginate, wooden sulphur Sour calcium etc..
Above-mentioned sustained release agent is selected from：Methylcellulose, hydroxymethyl cellulose, modified starch, Arabic gum, polyvinyl alcohol etc..
Filler is selected from：In kaolin, clay, diatomite, bentonite, white carbon, attapulgite, starch, precipitated calcium carbonate One or more.
The formulation of composition is any of wettable powder, water dispersible granules or suspending agent.
The present composition includes following component when benzene metsulfovax diethofencarb wettable powder is made：Benzene metsulfovax 1% ~50%, diethofencarb 1%~50%, wetting agent 1%~4%, dispersant 1%~10%, sustained release agent 1%~8%, disintegrant 1%~4%, filler surplus.
The present composition includes following component when benzene metsulfovax benomyl wettable powder is made：Benzene metsulfovax 1% ~50%, benomyl 1%~50%, wetting agent 1%~4%, dispersant 1%~10%, sustained release agent 1%~8%, disintegrant 1%~4%, filler surplus.
Bactericidal composition of the present invention is prepared into the method for wettable powder is：Formulation material is well mixed, used Micro jet crushes, and remixes, is then sampled analysis.
The present composition includes following component when benzene metsulfovax diethofencarb aqueous suspension agent is made：Benzene metsulfovax 1~ 50%th, diethofencarb 1~50%, emulsifying agent 1~4%, dispersant 2~6%, sustained release agent 0.1~3%, antifreezing agent 1~8%, thickening Agent 0.1~1%, defoamer 0.1~0.5%, water surplus.
The present composition includes following component when benzene metsulfovax benomyl aqueous suspension agent is made：Benzene metsulfovax 1~ 50%th, benomyl 1~50%, emulsifying agent 1~4%, dispersant 2~6%, sustained release agent 0.1~3%, antifreezing agent 1~8%, thickening Agent 0.1~1%, defoamer 0.1~0.5%, water surplus.
Bactericidal composition of the present invention is prepared into the method for suspending agent is：Active ingredient will be removed in above-mentioned formulation material Remaining outer component is well mixed through high speed shear, adds active ingredient, ball milling 2~3 hours, make particle diameter exist in ball mill Below 5um.
The present composition includes following component when benzene metsulfovax benomyl water dispersible granules are made：Benzene metsulfovax 1~ 50%th, benomyl 1~50%, wetting agent 1~4%, dispersant 1~10%, sustained release agent 1~8%, disintegrant 1~4%, bonding The filler surplus of agent 1~5%.
The present composition includes following component when benzene metsulfovax diethofencarb water dispersible granules are made：Benzene metsulfovax 1~ 50%th, diethofencarb 1~50%, wetting agent 1~4%, dispersant 1~10%, sustained release agent 1~8%, disintegrant 1~4%, bonding The filler surplus of agent 1~5%.
The present composition includes following component when benzene metsulfovax diethofencarb wettable powder is made：Benzene metsulfovax 1~ 50%th, diethofencarb 1~50%, wetting agent 1~4%, dispersant 1~10%, sustained release agent 1~8%, disintegrant 1~4%, filler Surplus.
The present composition includes following component when benzene metsulfovax benomyl wettable powder is made：Benzene metsulfovax 1~ 50%th, benomyl 1~50%, wetting agent 1~4%, dispersant 1~10%, sustained release agent 1~8%, disintegrant 1~4%, filler Surplus.
Bactericidal composition of the present invention is prepared into the method for wettable powder is：Formulation material is well mixed, used Micro jet crushes, and remixes, is then sampled analysis.
The present composition includes following component when benzene metsulfovax diethofencarb aqueous suspension agent is made：Benzene metsulfovax 1~ 50%th, diethofencarb 1~50%, emulsifying agent 1~4%, dispersant 2~6%, sustained release agent 0.1~3%, antifreezing agent 1~8%, thickening Agent 0.1~1%, defoamer 0.1~0.5%, water surplus.
The present composition includes following component when benzene metsulfovax benomyl aqueous suspension agent is made：Benzene metsulfovax 1~ 50%th, benomyl 1~50%, emulsifying agent 1~4%, dispersant 2~6%, sustained release agent 0.1~3%, antifreezing agent 1~8%, thickening Agent 0.1~1%, defoamer 0.1~0.5%, water surplus.
The present composition is prepared into the method for suspending agent is：By remaining group in above-mentioned formulation material in addition to active ingredient Lease making high speed shear is well mixed, and is added active ingredient, ball milling 2~3 hours in ball mill, is made particle diameter in below 5um.
The present composition includes following component when benzene metsulfovax benomyl water dispersible granules are made：Benzene metsulfovax 1~ 50%th, benomyl 1~50%, wetting agent 1~4%, dispersant 1~10%, sustained release agent 1~8%, disintegrant 1~4%, bonding The filler surplus of agent 1~5%.
The present composition includes following component when benzene metsulfovax diethofencarb water dispersible granules are made：Benzene metsulfovax 1~ 50%th, diethofencarb 1~50%, wetting agent 1~4%, dispersant 1~10%, sustained release agent 1~8%, disintegrant 1~4%, bonding The filler surplus of agent 1~5%.
Bactericidal composition of the present invention is prepared into the method for water dispersible granules is：Formulation material is well mixed, used Micro jet crush, through mediate, then add fluidized-bed granulation dryer in be granulated, dry, sieve after sample Analysis.
Bactericidal composition of the present invention is prepared into the method for water dispersible granules is：Formulation material is well mixed, used Micro jet crush, through mediate, then add fluidized-bed granulation dryer in be granulated, dry, sieve after sample Analysis.
The complex composition of the present invention is applied to preventing and treating crops and met with including cereal crop, fruit tree, vegetable crop etc. The disease received, as gray mold, sclerotiniose, powdery mildew, grape grey mould, rice blast, banded sclerotial blight, gray mold of cucumber, rot The diseases such as disease, downy mildew or late blight.
The beneficial effects of the present invention are：
(1) compared with single dose, there is complex composition of the invention obvious collaboration to increase in certain proportion Effect acts on, its drug effect height, lasting period length, the generation for having delayed disease drug resistance；Table of field test results in embodiment is bright, In the case that the dosage of complex composition is less than single dose, the effect of complex composition of the invention is better than single dose；
(2) disease control spectrum is expanded, a medicine is controlled more, reduces dosage and times for spraying, reduce cost.
Embodiment
The present invention is further described with reference to specific embodiment, so that those skilled in the art knows more about The present invention, but and it is not so limited the present invention.
For raw material channel used in the present invention as disclosed by the content of the invention, other do not disclose is purchased in market；
Embodiment 1
The preparation method of 80% benzene metsulfovax diethofencarb wettable powder is as follows：
Each raw material is taken by following percentage by weight：
Formulation material is well mixed, crushed with micro jet, remixes obtained 80% benzene metsulfovax diethofencarb Wettable powder.
The main function mechanism of benzene metsulfovax is to suppress sporogenesis and the sprouting of sporangium, focuses on the prevention of disease and controls Treat.Diethofencarb mainly suppresses gemma spindle and formed, and influences cell division, focuses on treatment.Benomyl is systemic fungicide, It is that carbendazim and another kind have volatility butyl isocyanate to play a role in plant intracellular metabolite, extremely strong absorbability, protectiveness By force.The either combination of the combination of benzene metsulfovax and diethofencarb or benzene metsulfovax and benomyl, be respectively provided with efficient protection and Double action is treated, Synergistic is obvious.
Embodiment 2
Each raw material is taken by following percentage by weight：
The preparation method of 60% benzene metsulfovax diethofencarb water dispersible granules is as follows：
Material in formula is well mixed, crushed with micro jet, through mediating, then adds fluidized bed prilling It is granulated in drying machine, dries obtained 60% benzene metsulfovax diethofencarb water dispersible granules.
Embodiment 3
Each raw material is taken by following percentage by weight：
The preparation method of 50% benzene metsulfovax diethofencarb aqueous suspension agent is as follows：
Remaining component in above-mentioned formula material in addition to active ingredient benzene metsulfovax and diethofencarb is mixed through high speed shear Uniformly, active ingredient benzene metsulfovax and diethofencarb are added, 50% benzene metsulfovax second is made in 2~3 hours in ball milling in ball mill Mould prestige aqueous suspension agent.
Embodiment 4
The preparation method of 60% benzene metsulfovax benomyl wettable powder is as follows：
Each raw material is taken by following percentage by weight：
Raw material in formula is well mixed, crushed with micro jet, remixes obtained 60% benzene metsulfovax Benomyl wettable powder.
Embodiment 5
The preparation method of 70% benzene metsulfovax benomyl water dispersible granules is as follows：
Each raw material is taken by following percentage by weight：
Formulation material is well mixed, crushed with micro jet, through mediating, then adds fluidized-bed granulation dryer In be granulated, dry obtained 70% benzene metsulfovax benomyl water dispersible granules.
Embodiment 6
The preparation method of 50% benzene metsulfovax benomyl aqueous suspension agent is as follows：
Each raw material is taken by following percentage by weight：
Remaining component in above-mentioned formulation material in addition to active ingredient is well mixed through high speed shear, adds active ingredient, 50% benzene metsulfovax benomyl aqueous suspension agent is made in 2~3 hours in ball milling in ball mill.
Embodiment 7
The present inventor is directed to the effect of the built composition for preventing and controlling corps diseases of the present invention, is compared with single dose, Field test has been done, has verified its synergistic results；The field test that the present inventor is carried out, it is specific as follows：
Field test：Gray mold of cucumber；
Each preparation in Example 1-3, is handled gray mold of cucumber
Test site：Shandong Province Accessories during Binzhou Boxing County
Subjects：Gray mold of cucumber；
Investigation method：Before medicine, 7 days and 14 days after medicine, each cell whole plant is investigated respectively, records total strain number and diseased plant Number；
Simultaneously using 15% single dose benzene metsulfovax and 50% diethofencarb, clear water as control, to gray mold Cucumber imposes the medicine of same dose, observes the disease before its medicine and refers to, and the disease after dispenser 7 days refers to, and calculates its preventive effect, its effect is such as Under：
Such as：The calculation formula of preventive effect is as follows：
Preventive effect %=(blank district diseased plant rate-treatment region diseased plant rate)/blank district diseased plant rate × 100%；
Disease index=∑ (the sick numbers of sheets at different levels × relative value of series)/(investigation total number of sheets × 9) × 100
Prevention effect (%)=(1- (disease index after disease index × treatment region medicine before blank district medicine)/(blank pair According to
Disease index before disease index × treatment region medicine after area's medicine)) × 100.
Prevention effect table of the table 1 to gray mold of cucumber
As shown in Table 1, benzene metsulfovax can be with effectively preventing gray mold of cucumber with diethofencarb mixture, and prevention effect is bright It is aobvious to be better than 15% benzene metsulfovax single dose and 50% diethofencarb single dose.
Embodiment 8
Field test in embodiment 8 is roughly the same with embodiment 7, and subjects are replaced with into balsam pear gray mold；Medicine Replace with each preparation in embodiment 4-6；
Each preparation in Example 4-6, to the prevention effect such as following table of balsam pear sclerotiniose：
Simultaneously using 15% single dose benzene metsulfovax and 50% diethofencarb, clear water as control, to gray mold Balsam pear imposes the medicine of same dose, observes the disease before its medicine and refers to, and the disease after dispenser 7 days refers to, and calculates its preventive effect, its effect is such as Under：
Prevention effect table of the table 2 to balsam pear sclerotiniose
As shown in Table 2, benzene metsulfovax are substantially better than the preventing and treating of two kinds of single doses with 5 days preventive effects after 1 dispenser of benomyl mixture Effect；10 days preventive effects are equally significantly better than 15% benzene metsulfovax single dose and 50% benomyl single dose after 2nd dispenser, illustrate suitable When proportioning under, the significant effect of Mixed Pharmacy is better than single dose, and in the range of test dose, plant growth is normal, does not go out Now to balsam pear poisoning phenomenon, it is safe to balsam pear to illustrate it.
Embodiment 9
Toxicity test of the benzene metsulfovax with diethofencarb mixture to gray mold of cucumber
Following indoor biometricses experiment calculates co-toxicity coefficient (CTC) to evaluate mixed effect using the abundant methods of Sun Yun.
Diethofencarb is denoted as B, and benzene metsulfovax are denoted as A；
Toxicity index TI (B)=(standard agent A EC50The EC of ÷ B agent50)×100
Actual toxicity index ATI (AB)=(A EC50÷ AB EC50)×100
Percentage+TI (B) × B percentages in mixture of theoretical toxicity index TTI (AB)=TI (the A) × A in mixture Number
Survey toxicity index (ATI)=(standard agent EC50÷ reagent agents EC50)×100
A percentage composition+B medicament toxicity index in theoretical toxicity index (TTI)=A medicament toxicity index × mixture × mixed B percentage composition in agent
Co-toxicity coefficient (CTC)=[mixture surveys toxicity index (ATI) ÷ mixtures theoretical toxicity index (TTI)] × 100
Evaluation criterion is：
Co-toxicity coefficient >=120 show as synergistic effect；
Co-toxicity coefficient≤80 show as antagonism；
80<Co-toxicity coefficient<120 show as summation action.
Subjects：
Gray mold of cucumber germ (picks up from field, and through isolating and purifying)
Test method：
Using gray mold of cucumber indoor pot determination method.Botrytis cinerea pers are cultivated in PDA culture medium, spore to be generated After son, with spore under sterile washing, and with 2 layers of filtered through gauze, the suspension of 1 × 10 spore/milliliter is made, it is standby.
On the basis of pilot study, the consistent melon seedling of 2 leaf periods, growing ways is selected, numbers, insert potted plant cucumber seedling basin It is interior, sequentially discharge.Using cauline leaf spray-on process, medicament is uniformly sprayed on melon seedling blade, material will be tried after spraying in greenhouse Zhong Yin It is dry, botrytis cinerea pers spore suspension is uniformly inoculated with crop spray tower after 24h, moisturizing culture 7d in greenhouse is then placed on and adjusts Prevention effect is looked into, calculates EC, co-toxicity coefficient.
Measurement result is following (table 3)：
The benzene metsulfovax of table 3 compound the Toxicity Determination result to gray mold of cucumber with diethofencarb
Processing EC(μg/ml) ATI TTI Co-toxicity coefficient CTC
Diethofencarb (B) 3.10 100.0 —— ——
Benzene metsulfovax (A) 0.42 738.0 —— ——
A:B=1:50 2.42 128.1 112.5 113.9
A:B=1:20 1.69 183.4 130.4 140.6
A:B=1:1 0.43 720.9 419.0 172.1
A:B=20:1 0.32 968.8 707.0 137.0
A:B=50:1 0.39 794.9 752.5 105.6
From table 3, benzene metsulfovax compound with diethofencarb, have good indoor virulence to botrytis cinerea pers, 5 are matched somebody with somebody The CTC values of ratio more than 100, show two it is bactericide compounded there is good synergistic function, while can be seen that benzene Metsulfovax is different from the synergistic effect that diethofencarb different proportion compounds, and compound proportion is 20:1~1:Synergy is the most between 20 Significantly.
Embodiment 10
Toxicity test of the benzene metsulfovax with benomyl mixture to balsam pear sclerotiniose
Benomyl is denoted as B, and benzene metsulfovax are denoted as A；
Subjects：
Balsam pear sclerotiniose germ (picks up from field, and through isolating and purifying)
Test method：
After balsam pear hyphal cluster germ is isolated and purified, preserved on PDA inclined-planes in 4 DEG C of refrigerator cultures, be for examination culture medium PDA.It is measured using growth rate method.Medicament is set into suitable concentration gradient, the medicament prepared is added into sterilizing culture In base, drug containing flat board is made.Using not drug containing as control, each in triplicate.Bacteria cake is inoculated with sterile working, as 25 DEG C of cultures It is incubated in case, colony diameter is measured with crossing method after a few days, calculates EC, co-toxicity coefficient.
Measurement result such as table 4：
The benzene metsulfovax of table 4 compound the Toxicity Determination result to balsam pear sclerotiniose with benomyl
Processing EC(μg/ml) ATI TTI Co-toxicity coefficient CTC
Benomyl (B) 0.98 100.0 —— ——
Benzene metsulfovax (A) 0.12 781.7 —— ——
A:B=1:50 0.74 132.4 113.4 116.8
A:B=1:20 0.51 192.2 132.5 145.1
A:B=1:1 0.14 700.0 440.9 158.8
A:B=20:1 0.09 1088.9 749.2 145.3
A:B=50:1 0.11 890.9 768.3 116.0
From table 4, benzene metsulfovax compound with benomyl, have good indoor virulence to balsam pear hyphal cluster germ, 5 are matched somebody with somebody The CTC values of ratio more than 100, show two it is bactericide compounded there is good synergistic function, and compound proportion exists 20:1~1:Synergy is the most notable between 20, and co-toxicity coefficient is all more than 145.
Embodiment 11
Field test prevents and treats late blight of potato experimental result
Field test prevents and treats the late blight of potato
1 test method
In Shandong Province Boxing County proving ground, experiment kind is Holland seven, often handles 4 repetitions for experiment, double per cell Diagonal investigates 5 points, five plants of whole blades during investigation, and a situation arises for statistics disease.
Occurring degree is recorded with staging, grade scale is as follows：
0 grade：It is disease-free；
1 grade：Scab heap area accounts for less than the 5% of whole leaf area；
3 grades：Scab heap area accounts for below the 6%-10% of whole leaf area；
5 grades：Scab heap area accounts for below the 11%-20% of whole leaf area；
7 grades：Scab heap area accounts for below the 21%-50% of whole leaf area；
9 grades：Scab heap area accounts for more than the 50% of whole leaf area
Experiment is investigated 4 times altogether, i.e., disease index is investigated before medicine, preventive effect investigation in 7 days after the 1st medicine, 15 days 7 days after 2 medicines Preventive effect is investigated.
2. drug effect computational methods
Sick leaf rate (the %)=sick number of sheets/investigation total number of sheets × 100%
Disease index=∑ (the sick numbers of sheets at different levels × relative value of series)/(investigation total number of sheets × 9) × 100
Prevention effect (%)=(1- (disease index after disease index × treatment region medicine before blank district medicine)/(blank pair According to disease index before disease index after area's medicine × treatment region medicine)) × 100.
3 control times and method
Whether continuous 7d range estimations medicament has poisoning to crop after dispenser.
4. result of the test and analysis
The benzene metsulfovax of table 5 compound the field experiment result to the late blight of potato with benomyl
50% benzene metsulfovax benomyl aqueous suspension agent ratio composite bactericide is for the late blight of potato as shown in Table 5 Positive effect is controlled higher than benzene metsulfovax and benomyl single dose, bactericidal effect is incremented by with the increase of dosage.Estimated according to field, In the range of test dose, plant growth is normal, and each treatment agent does not occur the poisoning phenomenon to rice, illustrates it to potato Be it is safe, for agricultural volume increase it is significant, be worthy to be popularized.

Claims (10)

1. the complex composition containing benzene metsulfovax and systemic fungicide, it is characterised in that the active ingredient of said composition by Benzene metsulfovax and systemic fungicide composition, wherein, the mass ratio of benzene metsulfovax and systemic fungicide is 30:1~1:30.
2. the complex composition containing benzene metsulfovax and systemic fungicide as claimed in claim 1, it is characterised in that
The mass ratio of benzene metsulfovax and systemic fungicide is 20:1~1:20.
3. the complex composition containing benzene metsulfovax and systemic fungicide as claimed in claim 1, it is characterised in that
Systemic fungicide is diethofencarb or benomyl.
4. the complex composition containing benzene metsulfovax and systemic fungicide as claimed in claim 1, it is characterised in that
Benzene metsulfovax and the quality sum of systemic fungicide account for the 5~80% of composition gross mass.
5. the complex composition containing benzene metsulfovax and systemic fungicide as claimed in claim 1, it is characterised in that
Benzene metsulfovax and the quality sum of systemic fungicide account for the 10~60% of composition gross mass.
6. the complex composition containing benzene metsulfovax and systemic fungicide as claimed in claim 1, it is characterised in that
Composition includes wetting agent, dispersant, sustained release agent, disintegrant, emulsifying agent, antifreezing agent, thickener, defoamer, binding agent Or at least one of filler.
7. the complex composition containing benzene metsulfovax and systemic fungicide as claimed in claim 1, it is characterised in that combination The formulation of thing is any of wettable powder, water dispersible granules or suspending agent.
8. the complex composition containing benzene metsulfovax and systemic fungicide as claimed in claim 1, in preventing and treating crop disease Application in evil.
9. the complex composition as claimed in claim 8 containing benzene metsulfovax and systemic fungicide is in preventing and treating corps diseases In application, it is characterised in that crops include cereal crop, fruit tree, vegetable crop.
10. the complex composition as claimed in claim 8 containing benzene metsulfovax and systemic fungicide is in preventing and treating crop disease Application in evil, it is characterised in that disease is that gray mold, sclerotiniose, powdery mildew, grape grey mould, rice blast, line are withered Any of disease, gray mold of cucumber, rot, downy mildew or late blight.
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CN106508936A (en) * 2015-09-15 2017-03-22 南京华洲药业有限公司 Bactericidal composition containing benthiavalicarb-isopropyl and carbendazim, and applications thereof
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