CN105900995A - Bactericide composition containing zoxamid and metconazole - Google Patents
Bactericide composition containing zoxamid and metconazole Download PDFInfo
- Publication number
- CN105900995A CN105900995A CN201610385258.7A CN201610385258A CN105900995A CN 105900995 A CN105900995 A CN 105900995A CN 201610385258 A CN201610385258 A CN 201610385258A CN 105900995 A CN105900995 A CN 105900995A
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- China
- Prior art keywords
- metconazole
- zoxamide
- composition
- zoxamid
- bactericide
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
- A01N37/20—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof containing the group, wherein Cn means a carbon skeleton not containing a ring; Thio analogues thereof
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a bactericide composition containing zoxamid and metconazole. Active components of the bactericide composition are zoxamid and metconazole, the mass ratio between zoxamid and metconazole is 1:20-20:1, and the mass percentage of the active components in the composition is 1-80%. The bactericide composition has good preventing effects for treating wheat rust and other diseases, and can delay generation and development of bactericide resistance of pathogens; dosage for control and prevention in real production is reduced, and the composition has the advantages of high efficiency, economy, safety, and environmental protection.
Description
Technical field
The present invention relates to disinfectant use in agriculture field, be specifically related to a kind of containing zoxamide with the antimicrobial combination of metconazole
Thing.
Background technology
Wheat rust is commonly called as jaundice, yellow rust, is the great disease of wheat that China's occurring area is the widest, harm is the heaviest.Northwest,
Southwest and Huang-Huai-Hai Mai Qu are rust Major Epidemic districts.Since the 1950's, being very popular of rust there occurs 9 in China
Secondary, cause serious impact to Wheat Production.
Zoxamide (Zoxamid), calls benzene cave azoles, chemical name: 3,5-bis-chloro-N-(3-chloro-1-ethyl-1-methyl-
2-oxopropyl)-4-methyl benzamide.The mechanism of action is unique, by combination and the microtubule cytoskeleton of tubulin subunit
Rupture and suppress sclerotium to divide.With conventional medicament no interactions resistance.
Metconazole (Metconazole), calls hydroxyl bacterium azoles, chemical name: 5-(4-chlorphenyl)-2,2-dimethyl-1-
(1H-1,2,4-triazol-1-yl methyl) cyclopentanol.It it is a kind of new, broad spectrum activity systemic fungicide.Suppression ergosterol is biological
C-14 demethylation enzyme in synthesis.It is mainly used in preventing and treating wheat septoria, fusarium disease, has excellent protection concurrently and treatment is made
With.
There is presently no both composite usages in the report preventing and treating wheat rust and other diseases.
Summary of the invention
The invention provides a kind of containing zoxamide with the bactericidal composition of metconazole, there is bactericidal activity high, dosage
Little, on plant growth without impact, economic, efficient, the feature of environmental protection, there is special efficacy to preventing and treating wheat rust.
It is combined that two classes are had the bactericide of different mechanism of action, i.e. zoxamide and metconazole by the present invention, and processes
Become and produce upper easy-to-use preparation, be used alone in two kinds of compositions and compare, there is biologically active high, total in unit are
Dosage declines, and greatly reduces dispenser cost, delays the pathogen resistance to the action of a drug to produce to a greater extent and development simultaneously, reduces
Disease fungus produces the risk of resistance to single bactericide, extends the service life of each component in bactericidal composition, thus
Realize economic, efficient, the goal of the invention of environmental protection.
The technical scheme is that
A kind of containing zoxamide with the microbicide compositions of metconazole, it is characterised in that active group of described microbicide compositions
The mass ratio being divided into zoxamide and metconazole, zoxamide and metconazole is 1:20 to 20:1, active component matter in composition
Amount percentage composition is 1-80%.
It is described containing zoxamide and the bactericidal composition of metconazole, it is characterised in that: described zoxamide and leaf bacterium
The mass ratio of azoles is 5:1 to 1:5.
It is described containing zoxamide and the microbicide compositions of metconazole, it is characterised in that: described microbicide compositions
Formulation is suspending agent, missible oil, water dispersible granules, wettable powder, seed coat agent or microcapsule suspending agent.
The described application of the microbicide compositions containing zoxamide and metconazole, it is characterised in that: this microbicide compositions
The various crop disease such as wheat, paddy rice there is good prevention effect.
Remarkable result and the advantage of the present invention be:
The present invention has higher prevention effect to wheat rust, there is notable synergistic effect between two components；Part can be replaced high
Price pesticide species, and reduce dosage, effectively reduce ecological disruption and environmental pollution, and crop yield and quality can be improved；
The germ resistance to the action of a drug to single medicament can be delayed.
First zoxamide and the EC of metconazole two single compound (hereinafter referred to as medicament) are measured50(drug safety refers to
Mark), according to the EC of two single medicaments50The portfolio ratio of two medicaments is set by the abundant method of Sun Yun, and according to co-toxicity coefficient CTC value, really
Fixed suitable composition ratio.
Test objective thing is wheat rust, but is not limited to this.Test uses mycelial growth rate method, makes by different disposal
Pastille culture medium, 4 repetitions of each process, after connecing bacterium 3 days, investigate each process growth inhibitory effect to wheat rust germ.Logical
Cross the linear regression analysis between the probit value of preventive effect and the logarithm value of series drug concentration, obtain the EC of each medicament50, according to grandson
The abundant method of rue calculates co-toxicity coefficient (CTC), and makes overall merit accordingly.CTC≤80 represent have antagonism, 80 ＜ CTC
＜ 120 represents have summation action, and CTC >=120 are synergistic effect.CTC value calculating method is as follows:
The EC of CTC=A50* the EC of B50* the EC50*(P of 100/(MA* the EC of B50+PB* the EC of A50))
Table 1 zoxamide and metconazole and the compounding indoor biometrics result to wheat rust thereof
| Proportioning (A:B) | Slope value (± SE) | Coefficient correlation | EC50(mg/L) | CTC |
| Zoxamide (A) | 1.324±0.011 | 0.987 | 0.102 | - |
| Metconazole (B) | 1.133±0.006 | 0.989 | 0.243 | - |
| 20:1 | 1.241±0.013 | 0.986 | 0.087 | 120.57 |
| 10:1 | 1.641±0.031 | 0.996 | 0.088 | 122.36 |
| 5:1 | 1.352±0.016 | 0.991 | 0.094 | 120.13 |
| 1:1 | 1.141±0.014 | 0.983 | 0.110 | 130.62 |
| 1:5 | 1.313±0.022 | 0.987 | 0.114 | 173.24 |
| 1:10 | 1.410±0.010 | 0.987 | 0.142 | 152.02 |
| 1:20 | 1.314±0.004 | 0.990 | 0.174 | 131.03 |
As can be seen from the above data, the zoxamide of different proportion and the metconazole composition antibacterial effect to wheat rust germ
The most different, on the whole, its ratio has synergistic effect in the range of 1:20 to 20:1, and wherein maximum enhancing proportions is
1:5, CTC value is 167.80.
Below in conjunction with embodiment, the invention will be further described, it is contemplated that the processing difficulty or ease journey of zoxamide and metconazole
Degree and price factor, this experiment determines the proportioning using 1:5 as both mixtures, but is not limited to this.Involved by embodiment
The content of active ingredient be also not necessarily limited to this.
Detailed description of the invention
Embodiment 1 (30% zoxamide metconazole suspending agent)
Composition of raw materials: by mass percentage
Active component zoxamide 5%
Active component metconazole 25%
NNO 3%
BY110 2%
APE-1 2%
Xanthans 0.15%
Propane diols 1%
Octanol 0.05%
Water surplus.
Preparation method is as follows:
According to formula, component is weighed in proportion, add ball mill ball milling 30 minutes, filter, suction dispersion tank high speed shear 3 points
Being fully ground through sand mill after clock, control solid constituent particle diameter, within 2 microns, grinds and stirs after terminating, to obtain final product
Suspending agent product.
Embodiment 2 (60% zoxamide metconazole missible oil)
Composition of raw materials: by mass percentage
Active component zoxamide 10%
Active component metconazole 50%
Dimethylbenzene 20%
DMF 2%
Anhydrous calcium salt 5%
Tween 80 5%
Carbon tetrachloride surplus.
Preparation method: fully dissolved in dimethylbenzene reactor by active component zoxamide, makes A liquid；By activity group
Divide metconazole fully to dissolve in carbon tetrachloride and DMF reactor, make B liquid；Under not stopping stirring, A liquid is mixed into B liquid,
Stir, add anhydrous calcium salt and Tween 80, then adjust content with solvent carbon tetrachloride.
Embodiment 3(30% zoxamide metconazole water dispersible granules)
Active component zoxamide 5%
Active component metconazole 25%
Methyl fatty acid amides benzene sulfonic acid calcium 4%
Sodium carbonate 3%
Sodium lignin sulfonate 4%
Attapulgite surplus.
Preparation method: zoxamide, metconazole, Methyl fatty acid amides benzene sulfonic acid calcium, sodium carbonate, attapulgite are mixed together
After closing uniformly, be crushed to particle diameter 5 m through airslide disintegrating mill, obtain female powder, mother powder and sodium lignin sulfonate are sufficiently mixed rear granulation,
Dry, sieve, thus prepare water-dispersible granules.
Embodiment 4(60% zoxamide metconazole wettable powder)
Active component zoxamide 10%
Active component metconazole 50%
Wood sodium 3%
Amine carbonate 3%
White carbon 10%
Attapulgite surplus.
Preparation method: uniformly mixed by above-mentioned substance, mixture is pulverized through airslide disintegrating mill, prepares wettable powder.
Embodiment 5(12% zoxamide metconazole microcapsule suspending agent)
Active component zoxamide 2%
Active component metconazole 10%
Dimethylformamide 2%
Methyl diphenylene diisocyanate 3%
Fatty acid amide N methyl taurine sodium salt 2%
Hexamethylene diamine 0.5%
Gum arabic 2%
Polyvinyl alcohol 2%
Water polishing is to 100%
(1) zoxamide and metconazole are dissolved in solvent, add methyl diphenylene diisocyanate and be uniformly mixing to obtain oil
Phase；(2) add emulsifying agent in water, adjuvant is uniformly mixing to obtain aqueous phase；(3) during aqueous phase joins oil phase, high speed homogenizing shape
Become O/w emulsion；(4) under 450 revs/min of speed conditions, adding ethylenediamine and participate in interface polymerization reaction, reaction temperature rises to
55 DEG C, keep 3 hours solidification encystation；(5) add dispersant, thickener, stir and i.e. make microcapsule suspending agent.
Embodiment 6(24% zoxamide metconazole suspension seed-coating agent)
Active component zoxamide 4%
Active component metconazole 20%
NNO 3%
BY110 2%
APE-1 2%
Xanthans 0.15%
Propane diols 1%
Film forming agent 3%
Dyestuff 4%
Water surplus.
According to formula, component (except dyestuff, film forming agent) is weighed in proportion, adds ball mill ball milling 30 minutes, filter,
Suction dispersion tank high speed shear was fully ground through sand mill after 3 minutes, and control solid constituent particle diameter, within 2 microns, grinds
Mill stirs after terminating, and adds film forming agent and dyestuff, obtains suspension seed-coating agent product.
Prevention effect is tested:
The field efficiency test of wheat rust is carried out in experimental plot, market town, hilllock, Changfeng County, and test area is 0.3hm2, often process weight
Multiple three times, carry out spraying treatment or Cotton seeds at wheat rust early stage, carry out preventive effect investigation in dispenser after 17 days, preventing and treating
The results are shown in Table 2.Result shows, this bactericidal composition has good prevention effect to wheat rust, at same dose or relatively low
Can reach higher prevention effect under dosage, and each preventive effect that processes of this bactericidal composition is all higher than 89%, it is right to be significantly higher than
According to medicament.
Table 2 zoxamide metconazole bactericidal composition prevents and treats the land for growing field crops drug effect of wheat rust
Finally, in addition it is also necessary to be only several specific embodiments of the present invention it is noted that listed above.Obviously, the present invention is not
It is limited to above embodiment, it is also possible to have many variations.Those of ordinary skill in the art can be straight from present disclosure
Connect all deformation derived or associate, be all considered the scope of protection of the invention.
Claims (3)
1. one kind contains zoxamide and the microbicide compositions of metconazole, it is characterised in that the activity of described microbicide compositions
Component be the mass ratio of zoxamide and metconazole, zoxamide and metconazole be 1:20 to 20:1, active component in composition
Weight/mass percentage composition is 1-80%.
It is the most according to claim 1 containing zoxamide with the microbicide compositions of metconazole, it is characterised in that: described benzene
The mass ratio of acyl bacterium amine and metconazole is 5:1 to 1:5.
It is the most according to claim 1 containing zoxamide with the microbicide compositions of metconazole, it is characterised in that: described sterilization
The formulation of agent composition is suspending agent, missible oil, water dispersible granules, wettable powder, seed coat agent or microcapsule suspending agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610385258.7A CN105900995A (en) | 2016-06-03 | 2016-06-03 | Bactericide composition containing zoxamid and metconazole |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610385258.7A CN105900995A (en) | 2016-06-03 | 2016-06-03 | Bactericide composition containing zoxamid and metconazole |
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| Publication Number | Publication Date |
|---|---|
| CN105900995A true CN105900995A (en) | 2016-08-31 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610385258.7A Pending CN105900995A (en) | 2016-06-03 | 2016-06-03 | Bactericide composition containing zoxamid and metconazole |
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| Country | Link |
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| CN (1) | CN105900995A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101642120A (en) * | 2009-07-09 | 2010-02-10 | 深圳诺普信农化股份有限公司 | Pesticide composition containing dyson fungicides |
| CN101647433A (en) * | 2009-07-21 | 2010-02-17 | 深圳诺普信农化股份有限公司 | Sterilization composition based on zoxamide |
| EP2826367A1 (en) * | 2013-07-18 | 2015-01-21 | Basf Se | Fungicidal mixtures comprising boscalid and zoxamide |
| CN104412989A (en) * | 2013-09-06 | 2015-03-18 | 陕西韦尔奇作物保护有限公司 | Pesticide composition containing nitro zoxamide and triazole |
-
2016
- 2016-06-03 CN CN201610385258.7A patent/CN105900995A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101642120A (en) * | 2009-07-09 | 2010-02-10 | 深圳诺普信农化股份有限公司 | Pesticide composition containing dyson fungicides |
| CN101647433A (en) * | 2009-07-21 | 2010-02-17 | 深圳诺普信农化股份有限公司 | Sterilization composition based on zoxamide |
| EP2826367A1 (en) * | 2013-07-18 | 2015-01-21 | Basf Se | Fungicidal mixtures comprising boscalid and zoxamide |
| CN104412989A (en) * | 2013-09-06 | 2015-03-18 | 陕西韦尔奇作物保护有限公司 | Pesticide composition containing nitro zoxamide and triazole |
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Application publication date: 20160831 |
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