CN105924392A - 一种孟鲁司特钠制备方法 - Google Patents
一种孟鲁司特钠制备方法 Download PDFInfo
- Publication number
- CN105924392A CN105924392A CN201610112379.4A CN201610112379A CN105924392A CN 105924392 A CN105924392 A CN 105924392A CN 201610112379 A CN201610112379 A CN 201610112379A CN 105924392 A CN105924392 A CN 105924392A
- Authority
- CN
- China
- Prior art keywords
- preparation
- amino
- acid
- montelukast
- menglusitena
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
Abstract
Description
Claims (14)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610112379.4A CN105924392B (zh) | 2016-02-29 | 2016-02-29 | 一种孟鲁司特钠制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610112379.4A CN105924392B (zh) | 2016-02-29 | 2016-02-29 | 一种孟鲁司特钠制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN105924392A true CN105924392A (zh) | 2016-09-07 |
CN105924392B CN105924392B (zh) | 2018-03-02 |
Family
ID=56840097
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610112379.4A Active CN105924392B (zh) | 2016-02-29 | 2016-02-29 | 一种孟鲁司特钠制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN105924392B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106928138A (zh) * | 2017-05-04 | 2017-07-07 | 威海迪素制药有限公司 | 一种孟鲁司特钠杂质d的制备方法 |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004108679A1 (en) * | 2003-06-06 | 2004-12-16 | Morepen Laboratories Limited | An improved method for the preparation of montelukast acid and sodium salt thereof in amorphous form |
WO2006043846A1 (en) * | 2004-10-22 | 2006-04-27 | Instytut Farmaceutyczny | Salt of montelukast with tert.-butylamine |
CN101213177A (zh) * | 2005-07-05 | 2008-07-02 | 特瓦制药工业有限公司 | 孟鲁司特的纯化 |
WO2009006861A2 (en) * | 2007-07-09 | 2009-01-15 | Zentiva, A.S. | A method for isolation and purification of montelukast |
CN101432267A (zh) * | 2006-03-17 | 2009-05-13 | 斯索恩有限公司 | 孟鲁司特金刚烷胺盐 |
CN101501000A (zh) * | 2006-08-09 | 2009-08-05 | 埃斯特维化学股份有限公司 | 孟鲁司特和其胺盐的纯化方法 |
WO2009111998A2 (en) * | 2008-03-14 | 2009-09-17 | Zentiva, K.S. | Specific impurities of montelukast |
WO2011076237A1 (en) * | 2009-12-23 | 2011-06-30 | Pharmathen S.A. | Improved process for the preparation of montelukast and salts thereof |
WO2014118796A1 (en) * | 2013-01-31 | 2014-08-07 | Melody Healthcare Pvt. Ltd. | An in-situ process for the preparation of highly pure montelukast sodium |
CN104119270A (zh) * | 2014-08-12 | 2014-10-29 | 牡丹江恒远药业有限公司 | 一种孟鲁司特钠的制备方法 |
-
2016
- 2016-02-29 CN CN201610112379.4A patent/CN105924392B/zh active Active
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004108679A1 (en) * | 2003-06-06 | 2004-12-16 | Morepen Laboratories Limited | An improved method for the preparation of montelukast acid and sodium salt thereof in amorphous form |
WO2006043846A1 (en) * | 2004-10-22 | 2006-04-27 | Instytut Farmaceutyczny | Salt of montelukast with tert.-butylamine |
CN101213177A (zh) * | 2005-07-05 | 2008-07-02 | 特瓦制药工业有限公司 | 孟鲁司特的纯化 |
CN101432267A (zh) * | 2006-03-17 | 2009-05-13 | 斯索恩有限公司 | 孟鲁司特金刚烷胺盐 |
CN101501000A (zh) * | 2006-08-09 | 2009-08-05 | 埃斯特维化学股份有限公司 | 孟鲁司特和其胺盐的纯化方法 |
WO2009006861A2 (en) * | 2007-07-09 | 2009-01-15 | Zentiva, A.S. | A method for isolation and purification of montelukast |
WO2009111998A2 (en) * | 2008-03-14 | 2009-09-17 | Zentiva, K.S. | Specific impurities of montelukast |
WO2011076237A1 (en) * | 2009-12-23 | 2011-06-30 | Pharmathen S.A. | Improved process for the preparation of montelukast and salts thereof |
WO2014118796A1 (en) * | 2013-01-31 | 2014-08-07 | Melody Healthcare Pvt. Ltd. | An in-situ process for the preparation of highly pure montelukast sodium |
CN104119270A (zh) * | 2014-08-12 | 2014-10-29 | 牡丹江恒远药业有限公司 | 一种孟鲁司特钠的制备方法 |
Non-Patent Citations (1)
Title |
---|
骆红英等: "孟鲁司特的合成研究", 《浙江大学硕士学位论文》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106928138A (zh) * | 2017-05-04 | 2017-07-07 | 威海迪素制药有限公司 | 一种孟鲁司特钠杂质d的制备方法 |
CN106928138B (zh) * | 2017-05-04 | 2019-08-16 | 威海迪素制药有限公司 | 一种孟鲁司特钠杂质d的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN105924392B (zh) | 2018-03-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN106083691B (zh) | 一种盐酸阿比朵尔一水合物的制备方法 | |
CN1817862A (zh) | 一种抗纤维化药物吡非尼酮的制备方法 | |
CN108047077B (zh) | 一种奥司他韦手性杂质的制备方法 | |
CN106256824B (zh) | 一种高纯度德拉沙星葡甲胺盐的制备方法 | |
CN105541819A (zh) | 一种依匹唑派的制备方法及其中间体和中间体的制备方法 | |
CN102395591B (zh) | 一种合成普拉格雷的方法 | |
CN102351778A (zh) | 一种盐酸阿比朵尔的制备方法 | |
CN105924392A (zh) | 一种孟鲁司特钠制备方法 | |
CN103145636B (zh) | 一种1,4-二酰基-3,6-二苯基-1,4-二氢均四嗪类化合物及其制备方法和应用 | |
CN110862372B (zh) | 氯吡格雷中间体(s)-2-(2-噻吩乙胺基)-(2-氯苯基)-乙酸甲酯的合成 | |
CN105622444B (zh) | 1-苄基-3-哌啶酮盐酸盐的制备方法 | |
CN104478871A (zh) | 一种胆碱m受体拮抗剂阿地溴铵及其制备方法 | |
CN106831756A (zh) | 一种高纯度高收率适合工业化生产的阿地溴铵制备方法 | |
CN106916151A (zh) | 一种盐酸鲁拉西酮的制备方法 | |
CN103373956B (zh) | 一种制备丁酸氯维地平的方法 | |
CN111635358B (zh) | 一种羟氯喹的制备方法 | |
WO2018210354A1 (zh) | 一种抗痛风药Lesinurad的新型制备方法及其关键中间体 | |
WO2018121051A1 (zh) | 一种3-氰基-4-异丙氧基苯甲酸甲酯的制备方法 | |
CN105348279B (zh) | 一种r‑2,2‑二(2‑噻吩基)‑2‑羟基乙酸奎宁‑3‑基酯及其制备和应用 | |
CN104447355A (zh) | 一种制备盐酸溴己新的新方法 | |
CN104327098B (zh) | 一种头孢他美酸二异丙胺盐 | |
CN1865227A (zh) | 合成抗疟疾药物的改进方法 | |
CN104761599B (zh) | 一种5,4’‑二羟基黄酮‑7‑o‑d‑葡萄糖醛酸的制备方法 | |
CN105585524B (zh) | 一种由孟鲁司特酸制备孟鲁司特钠的方法 | |
CN108586450B (zh) | 一种胆碱m受体抗结剂的重结晶纯化方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A preparation method of montelukast sodium Effective date of registration: 20211224 Granted publication date: 20180302 Pledgee: Industrial and Commercial Bank of China Limited Feixian sub branch Pledgor: SHANDONG NEW TIME PHARMACEUTICAL Co.,Ltd. Registration number: Y2021980016193 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20221028 Granted publication date: 20180302 Pledgee: Industrial and Commercial Bank of China Limited Feixian sub branch Pledgor: SHANDONG NEW TIME PHARMACEUTICAL Co.,Ltd. Registration number: Y2021980016193 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A preparation method of montelukast sodium Effective date of registration: 20221103 Granted publication date: 20180302 Pledgee: Industrial and Commercial Bank of China Limited Feixian sub branch Pledgor: SHANDONG NEW TIME PHARMACEUTICAL Co.,Ltd. Registration number: Y2022980020531 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right |