CN105920068A - Preparation method of Blumeae preparatum Tabellae - Google Patents
Preparation method of Blumeae preparatum Tabellae Download PDFInfo
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- CN105920068A CN105920068A CN201610426708.2A CN201610426708A CN105920068A CN 105920068 A CN105920068 A CN 105920068A CN 201610426708 A CN201610426708 A CN 201610426708A CN 105920068 A CN105920068 A CN 105920068A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/02—Recovery or refining of essential oils from raw materials
- C11B9/027—Recovery of volatiles by distillation or stripping
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention discloses a preparation method of Blumeae preparatum Tabellae. The preparation method comprises the following steps: distilling and condensing fresh leaves of Herba Blumeae Balsamiferae with water vapor and collecting Herba Blumeae Balsamiferae powder; dissolving the Herba Blumeae Balsamiferae powder in water and filtering to obtain filtrate; squeezing the filtrate, and separating to obtain solid pressed powder and mixed liquor; leaving the mixed liquor standstill and separating, wherein an upper-layer oily substance is Herba Blumeae Balsamiferae volatile oil, and a lower-layer aqueous solution is Herba Blumeae Balsamiferae liquid; and sublimating and crystallizing the solid pressed powder, wherein collected crystals are Blumeae preparatum Tabellae. A high-temperature and high-pressure water vapor extracting technology is adopted, by two-time condensation and a three-level sublimation technology, the extraction rate of the Blumeae preparatum Tabellae is increased, the Blumeae preparatum Tabellae is purified, and industrial production is facilitated. By a pure physical hot and cold extraction technology, the excellent quality of the Blumeae preparatum Tabellae is guaranteed. In addition, the Herba Blumeae Balsamiferae volatile oil collected in the process is refined to obtain Herba Blumeae Balsamiferae oil as a by-product, and the Herba Blumeae Balsamiferae oil has unique curative effect on burn and scald below a second degree; and the Herba Blumeae Balsamiferae liquid collected in the process has effects of diminishing inflammation, stopping pain and sterilizing, and can be used for preparing skin care products for infants.
Description
Technical field
The invention belongs to plant extract processing technique field, be specifically related to the preparation method of a kind of L-Borneol.
Background technology
Blumea balsamifera is that composite family Blumea balsamifera belongs to, and another name Balsamiferou Blumea Herb, the ears of an ox or cow Chinese mugwort, big blade, purple maple again (" the sward property of medicine standby want "), again wind Chinese mugwort (" south of the Five Ridges gather medicinal herbs record "), great Ai, big maple grass (" Chinese tree taxology "), Ramulus Et Folium Adhatodae Vasicae (" Nanning City's medicine will "), Radix Et Rhizoma Rhei (" Chinese medicinal herbal "), Herba Blumeae Balsamiferae (" medicine investigation is planted in Guizhou "), borneol end (Guangzhou army " commonly using Chinese herbal medicine handbook ").Medicinal for branches and leaves, spray root, can adopt the whole year, but preferable with the quality adopted autumn.There is logical all keys and dissipate the effect such as stagnated fire, swelling and pain relieving.It is treatment cold-damp diarrhea dysentery, stomachache borborygmus, swelling, arthralgia and myalgia, traumatic injury, the herbal medicine of tinea sore.
Blumea balsamifera originates in Yunnan, Guizhou, Guangxi, Guangdong, Fujian and Taiwan.It is born on border, sylvan life, valley floor, riverbed or meadow, height above sea level 600-1000 rice.Also there are distribution in India, Pakistan, Burma, Thailand, South East Asia Mainland, Malaysia, Indonesia and Philippine.
Herba Blumeae Balsamiferae extract is injected in animal can cause drop in blood pressure, blood vessel dilatation, suppression stomodaeal nervous system, can be used for excitement, insomnia or hyperpietic.
L-Borneol, for the extracted crystallization being processed into of fresh leaf of feverfew Blumea balsamifera, is mainly composed of L-Borneol.There is inducing resuscitation of having one's ideas straightened out, effect of clearing away heat to and alleviating pain.Be usually used in pyreticosis coma, apoplexy coma due to blocking of the respiratory system, the obstruction of the circulation of vital energy are fainted cruelly, middle dislike stupor, hot eyes, aphtha, abscess of throat, duct is suppurated, and is Chinese medicine material medicine and the spices dispensing of ophthalmology, the department of stomatology and cardiology department's medication.
Owing to L-Borneol is in the extensive application of the industries such as medicine, chemical industry, food, demand is considerably beyond quantity delivered, therefore, it is achieved the industrialized efficient production of L-Borneol has great importance.Traditional L-Borneol preparation technology energy consumption is high, and recovery rate is low.For overcoming the defect of traditional handicraft, the present invention uses high-temperature high-pressure steam extractive technique, by twice condensation and three grades of distillation crystallization processes, improves recovery rate and the purity of product, is conducive to industrializing large-scale production.During the Blumea balsamifera volatile oil collected, make blumea oil through technique refinings such as sterilization, purifications, the burn and scalds of less than two degree had unique curative effect, can be with anti-inflammatory, analgesia, and preventing from scar；The Ai Shui collected during it addition, containing L-Borneol and ten multiple proteins and Flavonoid substances, has miliaria of dispelling, antipruritic, mosquito proof, anti-inflammatory, pain relieving, effect of sterilization, can be used for making the special skin-protection product of infant.
Summary of the invention
It is an object of the invention to provide the preparation method of a kind of L-Borneol, to solve the problem that conventional preparation techniques energy consumption is high, recovery rate is low.Meanwhile, during the Blumea balsamifera volatile oil collected, make blumea oil through technique refinings such as sterilization, purifications, the burn and scalds of less than two degree had unique curative effect；The Ai Shui collected during it addition, containing L-Borneol and ten multiple proteins and Flavonoid substances, has miliaria of dispelling, antipruritic, mosquito proof, anti-inflammatory, pain relieving, effect of sterilization, can be used for making the special skin-protection product of infant.
For solving above-mentioned technical problem, the present invention by the following technical solutions:
A kind of preparation method of L-Borneol, employing following steps: crystallization of distilling, condense, filter, squeeze and distil.
Described still-process is: distill with steam leaf fresh to Blumea balsamifera, in still-process pressure be 0.4～0.7MPa, temperature be 150～201 DEG C, the time be 90 minutes, collect Blumea balsamifera volatile ingredient.
Described condensation process is: condensed by the Blumea balsamifera volatile ingredient collected, through 90 minutes, in condensation process, Blumea balsamifera volatile ingredient temperature is reduced to 80～100 DEG C, close still-process and the interface channel of condensation process, continue the gas of non-total condensation in cooling condensation process, condensation time is 15～25 minutes, and the solid collected is Chinese mugwort powder.After closing the interface channel of still-process and condensation process, continue the gas of non-total condensation in cooling condensation process, it is possible to ensure the steam condensation containing Blumea balsamifera volatile ingredient fully, improve the content of L-Borneol in Chinese mugwort powder.
Described filter process is: the Chinese mugwort powder collected in condensation process is dissolved in the water and is filtered, takes filtrate.
Described expressing process is: the filtrate collected squeezed, the isolated solid muffin containing main component L-Borneol and the mixed aqueous solution containing Blumea balsamifera volatile oil.
Described distillation crystallization process is: solid muffin carries out one-level distillation Crystallization Procedure, sublimation process temperature is 120～210 DEG C, pressure is 0.4～0.6MPa, the time is 12～16 hours, after sublimation process completes, close sublimation process and the interface channel of crystallization process, the steam not being fully crystallized is continued crystallisation by cooling 15～25 minutes, collects crystal.After closing the interface channel of sublimation process and crystallization process, continue the steam that cooling is not fully crystallized, it is possible to increase the recovery rate of L-Borneol.
Further, the crystal that the Crystallization Procedure that one-level distilled is collected carries out two grades of distillation Crystallization Procedure, two grades of distillation Crystallization Procedure collect crystal after completing, two grades of distillation crystal of collecting of Crystallization Procedure carry out three grades of distillation Crystallization Procedure again, and the crystal that three grades of distillation Crystallization Procedure are collected is L-Borneol.Multistage distillation Crystallization Procedure, it is possible to the L-Borneol crystal that purifying, collecting arrives, L-Borneol outward appearance Bai Jieru sugar, it is ensured that the fine quality of L-Borneol.
Further, the described squeezing time is 20 minutes, the mixed aqueous solution standing separation that will obtain after squeezing, takes upper strata grease and is Blumea balsamifera volatile oil, and lower aqueous solution is Ai Shui.Blumea balsamifera volatile oil makes blumea oil through technique refinings such as sterilization, purifications, has the curative effect of uniqueness to the burn and scalds of less than two degree.Ai Shui, containing L-Borneol and ten multiple proteins and Flavonoid substances, has miliaria of dispelling, antipruritic, mosquito proof, anti-inflammatory, pain relieving, effect of sterilization, can be used for making the special skin-protection product of infant.
Compared with prior art, the invention has the beneficial effects as follows:
The present invention uses high-temperature high-pressure steam extractive technique, the Blumea balsamifera volatile ingredient collected passes through twice condensation and three grades of distillation Crystallization Procedure, improves the recovery rate of L-Borneol, and purified by L-Borneol, beneficially industrialized production.Simple physical thermal cold extraction method, it is ensured that the fine quality of L-Borneol, quality meets " Chinese Pharmacopoeia 2010 " requirement, whole during L-Borneol recovery rate be up to more than 91%.During the Blumea balsamifera volatile oil collected, make blumea oil through method refinings such as sterilization, purifications, the burn and scalds of less than two degree had unique curative effect, can be with anti-inflammatory, analgesia, and preventing from scar；During the Ai Shui that collects, containing L-Borneol and ten multiple proteins and Flavonoid substances, there is miliaria of dispelling, antipruritic, mosquito proof, anti-inflammatory, pain relieving, effect of sterilization, can be used for making the special skin-protection product of infant.
Detailed description of the invention
In order to make the purpose of the present invention, technical scheme and advantage clearer, below in conjunction with embodiment, the present invention is further elaborated.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not intended to limit the present invention.
Embodiment 1:
The invention provides the preparation method of a kind of L-Borneol, employing following steps:
Distillation: heated horizontal type steam boiler equipment, the steam produced in horizontal steam boiler equipment imports leaf 850kg fresh to Blumea balsamifera in distillation equipment distill, distillation equipment inwall material is stainless steel, control pressure in distillation equipment be 0.4MPa, temperature be 150 DEG C, distillation time be 90 minutes, collect Blumea balsamifera volatile ingredient.
Condensation: the Blumea balsamifera volatile ingredient collected is condensed, condensing plant inwall material is stainless steel, through 90 minutes, in condensation process, Blumea balsamifera volatile ingredient temperature is reduced to 80 DEG C, closes still-process and the interface channel of condensation process, continues the gas of non-total condensation in cooling condensation process, condensation time is 15 minutes, after having condensed, the powder of scraping condensing plant inwall, obtain the powder 7.5kg that ends.
Filter, squeeze: the Chinese mugwort powder collected in condensation process is dissolved in the water and filters, take filtrate, the filtrate collected is inserted in squeezer and is squeezed, and the squeezing time is 20 minutes, the isolated solid muffin containing main component L-Borneol and the mixed aqueous solution containing Blumea balsamifera volatile oil.By mixed aqueous solution standing separation, upper strata grease is Blumea balsamifera volatile oil, and lower aqueous solution is Ai Shui.
Distillation crystallization: solid muffin is inserted and carries out one-level distillation Crystallization Procedure in distillation crystallizer, heating sublimation device temperature to 120 DEG C, pressure is 0.4MPa in equipment, after 12h distillation crystallization process, close the interface channel in sublimation apparatus and crystallizer, stop heating sublimation equipment, continue cooling crystallizing equipment 15 minutes, crystallizer is collected crystal.The crystal that the Crystallization Procedure that one-level distilled is collected carries out two grades of distillation Crystallization Procedure, two grades of distillation Crystallization Procedure collect crystal after completing, two grades of distillation crystal of collecting of Crystallization Procedure carry out three grades of distillation Crystallization Procedure again, and the crystal that three grades of distillation Crystallization Procedure are collected is L-Borneol.
GC detection confirms that the L-Borneol crystal mass collected in crystallizer meets " Chinese Pharmacopoeia 2010 " requirement, extraction rate reached to 91.2%.
Embodiment 2:
The invention provides the preparation method of a kind of L-Borneol, employing following steps:
Distillation: heated horizontal type steam boiler equipment, the steam produced in horizontal steam boiler equipment imports leaf 900kg fresh to Blumea balsamifera in distillation equipment distill, distillation equipment inwall material is stainless steel, control pressure in distillation equipment be 0.5MPa, temperature be 180 DEG C, distillation time be 90 minutes, collect Blumea balsamifera volatile ingredient.
Condensation: the Blumea balsamifera volatile ingredient collected is condensed, condensing plant inwall material is stainless steel, through 90 minutes, in condensation process, Blumea balsamifera volatile ingredient temperature is reduced to 90 DEG C, closes still-process and the interface channel of condensation process, continues the gas of non-total condensation in cooling condensation process, condensation time is 20 minutes, after having condensed, the powder of scraping condensing plant inwall, obtain the powder 7.9kg that ends.
Filter, squeeze: the Chinese mugwort powder collected in condensation process is dissolved in the water and filters, take filtrate, the filtrate collected is inserted in squeezer and is squeezed, and the squeezing time is 20 minutes, the isolated solid muffin containing main component L-Borneol and the mixed aqueous solution containing Blumea balsamifera volatile oil.By mixed aqueous solution standing separation, upper strata grease is Blumea balsamifera volatile oil, and lower aqueous solution is Ai Shui.
Distillation crystallization: solid muffin is inserted and carries out one-level distillation Crystallization Procedure in distillation crystallizer, heating sublimation device temperature to 180 DEG C, pressure is 0.5MPa in equipment, after 14h distillation crystallization process, close the interface channel in sublimation apparatus and crystallizer, stop heating sublimation equipment, continue cooling crystallizing equipment 20 minutes, crystallizer is collected crystal.The crystal that the Crystallization Procedure that one-level distilled is collected carries out two grades of distillation Crystallization Procedure, two grades of distillation Crystallization Procedure collect crystal after completing, two grades of distillation crystal of collecting of Crystallization Procedure carry out three grades of distillation Crystallization Procedure again, and the crystal that three grades of distillation Crystallization Procedure are collected is L-Borneol.
GC detection confirms that the L-Borneol crystal mass collected in crystallizer meets " Chinese Pharmacopoeia 2010 " requirement, extraction rate reached to 91.3%.
Embodiment 3:
The invention provides the preparation method of a kind of L-Borneol, employing following steps:
Distillation: heated horizontal type steam boiler equipment, the steam produced in horizontal steam boiler equipment imports leaf 950kg fresh to Blumea balsamifera in distillation equipment distill, distillation equipment inwall material is stainless steel, control pressure in distillation equipment be 0.7MPa, temperature be 201 DEG C, distillation time be 90 minutes, collect Blumea balsamifera volatile ingredient.
Condensation: the Blumea balsamifera volatile ingredient collected is condensed, condensing plant inwall material is stainless steel, through 90 minutes, in condensation process, Blumea balsamifera volatile ingredient temperature is reduced to 100 DEG C, closes still-process and the interface channel of condensation process, continues the gas of non-total condensation in cooling condensation process, condensation time is 25 minutes, after having condensed, the powder of scraping condensing plant inwall, obtain the powder 8.4kg that ends.
Filter, squeeze: the Chinese mugwort powder collected in condensation process is dissolved in the water and filters, take filtrate, the filtrate collected is inserted in squeezer and is squeezed, and the squeezing time is 20 minutes, the isolated solid muffin containing main component L-Borneol and the mixed aqueous solution containing Blumea balsamifera volatile oil.By mixed aqueous solution standing separation, upper strata grease is Blumea balsamifera volatile oil, and lower aqueous solution is Ai Shui.
Distillation crystallization: solid muffin is inserted and carries out one-level distillation Crystallization Procedure in distillation crystallizer, heating sublimation device temperature to 210 DEG C, pressure is 0.6MPa in equipment, after 16h distillation crystallization process, close the interface channel in sublimation apparatus and crystallizer, stop heating sublimation equipment, continue cooling crystallizing equipment 25 minutes, crystallizer is collected crystal.The crystal that the Crystallization Procedure that one-level distilled is collected carries out two grades of distillation Crystallization Procedure, two grades of distillation Crystallization Procedure collect crystal after completing, two grades of distillation crystal of collecting of Crystallization Procedure carry out three grades of distillation Crystallization Procedure again, and the crystal that three grades of distillation Crystallization Procedure are collected is L-Borneol.
GC detection confirms that the L-Borneol crystal mass collected in crystallizer meets " Chinese Pharmacopoeia 2010 " requirement, extraction rate reached to 91.5%.
Although reference be made herein to invention has been described for the multiple explanatory embodiment of the present invention, but, it should be understood that those skilled in the art can be designed that a lot of other amendments and embodiment, these amendments and embodiment will fall within spirit disclosed in the present application and spirit.More specifically, in the range of disclosure and claim, the building block of theme composite configuration and/or layout can be carried out multiple modification and improvement.In addition to the deformation carrying out building block and/or layout and improving, to those skilled in the art, other purposes also will be apparent from.
Claims (8)
1. a preparation method for L-Borneol, it is characterized in that use following steps: crystallization of distilling, condense, filter, squeeze and distil.
The preparation method of a kind of L-Borneol the most according to claim 1, it is characterized in that: described still-process is, distill with steam leaf fresh to Blumea balsamifera, in still-process pressure be 0.4～0.7MPa, temperature be 150～201 DEG C, the time be 90 minutes, collect Blumea balsamifera volatile ingredient.
The preparation method of a kind of L-Borneol the most according to claim 1, it is characterized in that: described condensation process is, the Blumea balsamifera volatile ingredient collected is condensed, through 90 minutes, in condensation process, Blumea balsamifera volatile ingredient temperature is reduced to 80～100 DEG C, closes still-process and the interface channel of condensation process, continues the gas of non-total condensation in cooling condensation process, condensation time is 15～25 minutes, and the solid collected is Chinese mugwort powder.
The preparation method of a kind of L-Borneol the most according to claim 1, it is characterised in that: described filter process is, the Chinese mugwort powder collected is dissolved in the water and is filtered, take filtrate in condensation process.
The preparation method of a kind of L-Borneol the most according to claim 1, it is characterised in that: described expressing process is, the filtrate collected is squeezed, the isolated solid muffin containing main component L-Borneol and the mixed aqueous solution containing Blumea balsamifera volatile oil.
The preparation method of a kind of L-Borneol the most according to claim 1, it is characterized in that: described distillation crystallization process is, solid muffin is carried out one-level distillation Crystallization Procedure, sublimation process temperature is 120～210 DEG C, pressure is 0.4～0.6MPa, the time is 12～16 hours, after sublimation process completes, close sublimation process and the interface channel of crystallization process, the steam not being fully crystallized is continued crystallisation by cooling 15～25 minutes, collects crystal.
The preparation method of a kind of L-Borneol the most according to claim 6, it is characterized in that: the crystal that the Crystallization Procedure that one-level distilled is collected carries out two grades of distillation Crystallization Procedure, two grades of distillation Crystallization Procedure collect crystal after completing, two grades of distillation crystal of collecting of Crystallization Procedure carry out three grades of distillation Crystallization Procedure again, and the crystal that three grades of distillation Crystallization Procedure are collected is L-Borneol.
The preparation method of a kind of L-Borneol the most as claimed in any of claims 1 to 7, it is characterized in that: the described squeezing time is 20 minutes, the mixed aqueous solution standing separation that will obtain after squeezing, upper strata grease is Blumea balsamifera volatile oil, and lower aqueous solution is Ai Shui.
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Cited By (5)
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| CN109134193A (en) * | 2017-06-27 | 2019-01-04 | 贵州艾源生态药业开发有限公司 | A kind of method that Blumea balsamifera extracts borneol |
| CN109212043A (en) * | 2017-07-01 | 2019-01-15 | 贵州艾源生态药业开发有限公司 | The measuring method of content of bornyl alcohol in a kind of Blumea balsamifera |
| CN110075149A (en) * | 2019-06-10 | 2019-08-02 | 贵州艾力康中草药开发有限公司 | Herba Blumeae Balsamiferae extract and preparation method thereof |
| CN110101730A (en) * | 2019-06-10 | 2019-08-09 | 贵州艾力康中草药开发有限公司 | Processing method for preventing Blumea balsamifera active constituent from reducing |
| CN115708786A (en) * | 2022-11-19 | 2023-02-24 | 贵州省罗甸县全兴药业开发有限责任公司 | Preparation method and application of blumea balsamifera and borneol water and bacteriostatic agent |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109134193A (en) * | 2017-06-27 | 2019-01-04 | 贵州艾源生态药业开发有限公司 | A kind of method that Blumea balsamifera extracts borneol |
| CN109212043A (en) * | 2017-07-01 | 2019-01-15 | 贵州艾源生态药业开发有限公司 | The measuring method of content of bornyl alcohol in a kind of Blumea balsamifera |
| CN110075149A (en) * | 2019-06-10 | 2019-08-02 | 贵州艾力康中草药开发有限公司 | Herba Blumeae Balsamiferae extract and preparation method thereof |
| CN110101730A (en) * | 2019-06-10 | 2019-08-09 | 贵州艾力康中草药开发有限公司 | Processing method for preventing Blumea balsamifera active constituent from reducing |
| CN110101730B (en) * | 2019-06-10 | 2021-07-23 | 贵州艾力康中草药开发有限公司 | Processing method for preventing reduction of active ingredients of blumea balsamifera |
| CN110075149B (en) * | 2019-06-10 | 2021-07-23 | 贵州艾力康中草药开发有限公司 | Blumea balsamifera extract and preparation method thereof |
| CN115708786A (en) * | 2022-11-19 | 2023-02-24 | 贵州省罗甸县全兴药业开发有限责任公司 | Preparation method and application of blumea balsamifera and borneol water and bacteriostatic agent |
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Application publication date: 20160907 |