CN1686186A - Eight-Gem capsule and its preparation method - Google Patents

Abstract

A Chinese medicine 'Bazheng softcapsule' for treating the infectious diseases in urinary and reproductive systems is prepared from 9 Chinese-medicinal materials including plantain seed, rhubarb, talc, liquorice root, etc. Its preparing process is also disclosed.

Description

Eight-Gem capsule and preparation method thereof

Technical field

The present invention relates to medicament preparation, specifically, relate to the pharmaceutical product of natural drug effective ingredient, particularly the soft capsule of treatment infectious diseases of urogenital system.

Background technology

In medical practice, various infectious diseases of urogenital system are treated quite thorny because of its cause of disease complexity, relapse rate height.Motherland's medical science is many to belong to it " damp invasion of lower energizer, malicious stasis of blood knot gather ", belongs to " five types of stranguria " category." General Treatise on the Cause and Symptoms of Diseases " book is called it " so bladder is warm also by suffering from a deficiency of the kidney for all patients ".The traditional Chinese medical science is thought: bladder is the water mansion, and its water liquid effluxes and relies bladder steamization, if wetly tie up the visitor and stay bladder, water, heat, wetly deposits the state all, disturbance in functioning of QI; All canal is difficult to using pungent drugs for dispersion and bitter drugs for purgation, and water channel is unfavorable for it, the Gui stranguria.Show as puckery pain when urinating, it is not smooth to drench drop, cramp and pain in the lower abdomen, urine short number or scorching hot twinge, or the attached pain of waist sacrum.The suitable suitable clearly pain of controlling is got rid of evils and is frustrated heat, when holding the treating stranguria method of clearing away heat-damp and promoting diuresis.Having put down in writing " BAZHENG SAN " be made up of 8 flavor Chinese medicines such as Herba Polygoni Avicularis, Herba Dianthi, Semen Plantaginis, Radix Et Rhizoma Rhei, Caulis Akebiae, Talcum, Fructus Gardeniae, Radix Glycyrrhizae in Song dynasty's " formulary of peaceful benevolent dispensary ", is exactly the conventional medicament that ancients are used for treating infectious diseases of urogenital system.The descendant processes BAZHENG HEJI on this basis.It is a method that this mixture clearing up internal heat by using drugs of bitter in taste and cold in nature detoxifcation is melted with sweet light eliminating dampness by diuresis diuresis, cold through winning heat, hardship can be fallen and be let out, and bitter cold is let out damp and hot clearly, the evil malicious influence and power of pause and transition in rhythm or melody, make the damp-heat in the urinary bladder must be through disheartened clearly, sweet light eliminating dampness by diuresis diuresis makes damp and hot heresy efflux from urethra to dredge all water in a canal roads, makes damp and hot through disheartened, functioning of bladder is normal, and water goes out nature.Semen Plantaginis, Herba Dianthi, Caulis Akebiae, Pulvis Talci are the product of relieving stranguria by diuresis in the side, eliminating damp-heat.5 and SHANZHIZI, it is damp and hot to rush down three warmers clearly, the Radix Et Rhizoma Rhei pathogenic fire reducing that expels the heat-evil; Wick heat conduction is descending, the Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.Modern study shows, BAZHENG HEJI have antiinflammatory preferably, antibiotic, ease pain and improve the effect of local blood.

Yet at present the general dosage form of BAZHENG HEJI is an oral liquid, and the easy aerogenesis of this oral liquid produces acid, so that medicine becomes sour and goes mouldy; The vial of powder charge is heavy in addition, and is broken easily again; Simultaneously contain more volatile oil composition in the eight positive sides, all there are certain problem in its clarity and stability.In a word, original BAZHENG HEJI exists the shortcoming that inconvenience is carried, stored and transports.Recently the someone is made into " nanometer 'Bazheng ' " (No. 01100781.8, Chinese patent application part), but this technology has been used high-tech such as microwave extracting, supersonic jet, and its cost is inevitable very high, for common drug, does not also have this necessity.Therefore, utilize prior art the BAZHENG HEJI prescription to be made cost is low, the measured patent medicine of matter is necessary.Yet up to now, Shang Weiyou makes the BAZHENG HEJI prescription report of soft capsule.

Summary of the invention

Purpose of the present invention just provides the eight-Gem capsule that a kind of people of being convenient to carry and use.

Another purpose of the present invention provides the preparation method of eight-Gem capsule.

The eight-Gem capsule that the inventor provides is the prescription according to BAZHENG HEJI, adds adjuvant by preparation BAZHENG HEJI extractum, reinstalls the prepared soft capsule of soft capsule shell.

The mass parts of Chinese medicine of respectively distinguishing the flavor of in the prescription of above-mentioned BAZHENG HEJI is:

Herba Dianthi 2 Semen Plantaginiss 2 Herba Polygoni Avicularis 2 Radix Et Rhizoma Rhei 2 Pulvis Talci 2

Caulis Clematidis Armandii 2 Fructus Gardeniaes 2 Radix Glycyrrhizaes 2 Medulla Juncies 1.

The quality component of drug extract and adjuvant is:

Drug extract 5%～40%, adjuvant 95%～60%

As adjuvant be that in edible vegetable oil such as Oleum Glycines, Polyethylene Glycol, glycerol, the dimethicone one or more mix, wherein used Polyethylene Glycol is one or more in Macrogol 200, Liquid Macrogol, PEG400, the Macrogol 600.Adjuvant can play correctives.

The manufacture method of the eight-Gem capsule that the inventor provides comprises:

(1) get the Semen Plantaginis of parch in advance in proportion, use 25% alcohol dipping, collect impregnation liquid, standby;

(2) get Radix Et Rhizoma Rhei in proportion, carry out percolation according to the percolation in " pharmacy of Chinese materia medica " after 24 hours, collect percolate with 50% alcohol dipping, standby behind the decompression recycling ethanol;

(3) get Herba Polygoni Avicularis, Herba Dianthi, Caulis Akebiae, Talcum, Fructus Gardeniae, Radix Glycyrrhizae and Medulla Junci in proportion, decoct with water 3 times, filter, merging filtrate, filtrate is concentrated into into extractum, and is standby;

(4) above-mentioned impregnation liquid, percolate and extractum are merged, concentrate, add adjuvant after the drying and crushing in proportion, make suspension, it is the soft capsule of capsule material that last machine is made with the glycerin gelatine;

(5) bottle or be pressed into plastic-aluminum bubble according to plate, packing, being up to the standards promptly obtains eight-Gem capsule.

With the eight-Gem capsule that said method makes, if bottling, specification is 50 every bottle, 100 or 200; If be pressed into aluminum-plastic bubble-cap palte, 12,16 or 20 of every plates.Its quality standard should meet the regulation of Chinese Pharmacopoeia to capsule product.

The usage of eight-Gem capsule of the present invention is oral, every day 3～4 times, and each 2～4, or follow the doctor's advice.This product should be preserved under shading, airtight, cryogenic conditions.

Eight-Gem capsule of the present invention has avoided original BAZHENG HEJI aerogenesis to produce sour problem, has hidden bad smell; Without glass bottle packaging, in light weight, the patient is easy to carry, takes; Safe in utilization, stable, have no side effect, can be used for the treatment of infectious diseases of urogenital system.

The specific embodiment

Embodiment: at first, get the Semen Plantaginis 118g of parch in advance,, collect impregnation liquid with 25% ethanol 1000ml dipping, standby behind the decompression recycling ethanol; Then, get Radix Et Rhizoma Rhei 118g, carry out percolation according to the percolation under fluid extract and the extractum item in " pharmacy of Chinese materia medica " after 24 hours, collect percolate with 50% ethanol 1000ml dipping, standby behind the decompression recycling ethanol; Get Herba Polygoni Avicularis 118g, Herba Dianthi 118g, Caulis Akebiae 118g, Talcum 118g, Fructus Gardeniae 118g, Radix Glycyrrhizae 118g and Medulla Junci 59g again, decoct with water 3 times.The 1st time amount of water is 8L, decocts 60 minutes; The 2nd time amount of water is 5L, decocts 120 minutes; The 3rd time amount of water is 4L, decocts 180 minutes.Filter, merging filtrate, filtrate is condensed into extractum, and extractum density is about 1.3kg/L, and is standby.Above-mentioned impregnation liquid, percolate and extractum are merged, and drying and crushing obtains the about 60g of spice, add 60g adjuvant Polyethylene Glycol-400 at last, grind to form suspension, it is the soft capsule of capsule shells that last machine is made with the glycerin gelatine, every the 0.5g that packs into can be made into about 240 of soft capsules; Be pressed into aluminum-plastic bubble-cap palte, packing, being up to the standards promptly obtains eight-Gem capsule.

Claims (4)

1 eight-Gem capsule is characterized in that it is a prescription according to BAZHENG HEJI, adds adjuvant by preparation BAZHENG HEJI dry extract and makes suspension and go up the soft capsule that machine is made again, and the mass parts of the Chinese medicine of respectively distinguishing the flavor of in the prescription is:

Herba Dianthi 2 Semen Plantaginiss 2 Herba Polygoni Avicularis 2 Radix Et Rhizoma Rhei 2 Pulvis Talci 2

Caulis Clematidis Armandii 2 Fructus Gardeniaes 2 Radix Glycyrrhizaes 2 Medulla Juncies 1;

The quality component of drug extract and adjuvant is:

Drug extract 5%～40%, adjuvant 95%～60%.

2 eight-Gem capsules as claimed in claim 1 is characterized in that used adjuvant is one or more mixing in edible vegetable oil such as Oleum Glycines, Polyethylene Glycol, glycerol, the dimethicone.

3 eight-Gem capsules as claimed in claim 2 is characterized in that used Polyethylene Glycol is one or more in Macrogol 200, Liquid Macrogol, PEG400, the Macrogol 600.

The preparation method of 4 eight-Gem capsules as claimed in claim 1, its feature comprises: (1) gets the Semen Plantaginis of parch in advance in proportion, uses 25% alcohol dipping, collects impregnation liquid, and is standby; (2) get Radix Et Rhizoma Rhei in proportion, carry out percolation with percolation after 24 hours, collect percolate with 50% alcohol dipping, standby behind the decompression recycling ethanol; (3) get Herba Polygoni Avicularis, Herba Dianthi, Caulis Akebiae, Talcum, Fructus Gardeniae, Radix Glycyrrhizae and Medulla Junci in proportion, decoct with water 3 times, filter, merging filtrate, filtrate is concentrated into into extractum, and is standby; (4) above-mentioned impregnation liquid, percolate and extractum are merged, concentrate, add adjuvant after the drying and crushing in proportion, make suspension, it is the soft capsule of capsule material that last machine is made with the glycerin gelatine; (5) bottle or be pressed into aluminum-plastic bubble-cap palte, sterilization, packing, being up to the standards promptly obtains eight-Gem capsule.