CN1650957A - Eight corrections effervescent granules and its preparation method - Google Patents
Eight corrections effervescent granules and its preparation method Download PDFInfo
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- CN1650957A CN1650957A CN 200410081322 CN200410081322A CN1650957A CN 1650957 A CN1650957 A CN 1650957A CN 200410081322 CN200410081322 CN 200410081322 CN 200410081322 A CN200410081322 A CN 200410081322A CN 1650957 A CN1650957 A CN 1650957A
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Abstract
A Chinese medicine 'Bazheng effervescent particles' for treating the infectious diseases in urinary system and reproductive system is prepared from 9 Chinese-medicinal materials including rhubarb, plantain seed, talc, liquorice root, etc. Its preparing process process is also disclosed.
Description
Technical field
The present invention relates to medicament preparation, specifically, relate to the pharmaceutical product of natural drug effective ingredient, particularly the effervescent granule of treatment infectious diseases of urogenital system.
Background technology
In medical practice, various infectious diseases of urogenital system are treated quite thorny because of its cause of disease complexity, relapse rate height.Motherland's medical science is many to belong to it " damp invasion of lower energizer, malicious stasis of blood knot gather ", belongs to " five types of stranguria " category." General Treatise on the Cause and Symptoms of Diseases " book is called it " so bladder is warm also by suffering from a deficiency of the kidney for all patients ".The traditional Chinese medical science is thought: bladder is the water mansion, and its water liquid effluxes and relies bladder steamization, if wetly tie up the visitor and stay bladder, water, heat, wetly deposits the state all, disturbance in functioning of QI; All canal is difficult to using pungent drugs for dispersion and bitter drugs for purgation, and water channel is unfavorable for it, the Gui stranguria.Show as puckery pain when urinating, it is not smooth to drench drop, cramp and pain in the lower abdomen, urine short number or scorching hot twinge, or the attached pain of waist sacrum.The suitable suitable clearly pain of controlling is got rid of evils and is frustrated heat, when holding the treating stranguria method of clearing away heat-damp and promoting diuresis.Having put down in writing " BAZHENG SAN " be made up of 8 flavor Chinese medicines such as Herba Polygoni Avicularis, Herba Dianthi, Semen Plantaginis, Radix Et Rhizoma Rhei, Caulis Akebiae, Talcum, Fructus Gardeniae, Radix Glycyrrhizae in Song dynasty's " formulary of peaceful benevolent dispensary ", is exactly the conventional medicament that ancients are used for treating infectious diseases of urogenital system.The descendant processes BAZHENG HEJI on this basis.It is a method that this mixture clearing up internal heat by using drugs of bitter in taste and cold in nature detoxifcation is melted with sweet light eliminating dampness by diuresis diuresis, cold through winning heat, hardship can be fallen and be let out, and bitter cold is let out damp and hot clearly, the evil malicious influence and power of pause and transition in rhythm or melody, make the damp-heat in the urinary bladder must be through disheartened clearly, sweet light eliminating dampness by diuresis diuresis makes damp and hot heresy efflux from urethra to dredge all water in a canal roads, makes damp and hot through disheartened, functioning of bladder is normal, and water goes out nature.Semen Plantaginis, Herba Dianthi, Caulis Akebiae, Pulvis Talci are the product of relieving stranguria by diuresis in the side, eliminating damp-heat.5 and SHANZHIZI, it is damp and hot to rush down three warmers clearly, the Radix Et Rhizoma Rhei pathogenic fire reducing that expels the heat-evil; Wick heat conduction is descending, the Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.Modern study shows, BAZHENG HEJI have antiinflammatory preferably, antibiotic, ease pain and improve the effect of local blood.
Yet at present the general dosage form of BAZHENG HEJI is an oral liquid, and the easy aerogenesis of this oral liquid produces acid, so that medicine becomes sour and goes mouldy; The vial of powder charge is heavy in addition, and is broken easily again; Simultaneously contain more volatile oil composition in the eight positive sides, all there are certain problem in its clarity and stability.In a word, original BAZHENG HEJI exists the shortcoming that inconvenience is carried, stored and transports.Recently the someone is made into " nanometer 'Bazheng ' " (No. 01100781.8, Chinese patent application part), but this technology has been used high-tech such as microwave extracting, supersonic jet, and its cost is inevitable very high, for common drug, does not also have this necessity.Therefore, utilize prior art the BAZHENG HEJI prescription to be made cost is low, the measured patent medicine of matter is necessary.Yet up to now, Shang Weiyou makes the BAZHENG HEJI prescription report of effervescent granule.
Summary of the invention
Purpose of the present invention just provides the eight corrections effervescent granules that a kind of people of being convenient to carry and use.
Another purpose of the present invention provides the preparation method of eight corrections effervescent granules.
The eight corrections effervescent granules that the inventor provides is according to the BAZHENG HEJI prescription, and by spice preparation and add the adjuvant made effervescent granule of drying of granulating again, wherein the component of crude drug and consumption thereof (consumption is a weight portion) are as follows:
Herba Dianthi 2 Semen Plantaginiss 2 Herba Polygoni Avicularis 2 Radix Et Rhizoma Rhei 2 Pulvis Talci 2
Caulis Clematidis Armandii 2 Fructus Gardeniaes 2 Radix Glycyrrhizaes 2 Medulla Juncies 1
The quality component of spice and adjuvant is
Spice 5%～40%, adjuvant 95%～60%.
Adjuvant wherein comprises acidic excipient, for example citric acid, tartaric acid, sodium dihydrogen phosphate, Sodium Acid Pyrophosphate, sodium sulfite etc.; Also comprise basic auxiliary, for example sodium bicarbonate, sodium carbonate, potassium bicarbonate, sodium glycine carbonate, sodium sesquicarbonate etc.; Also comprise other additives, for example cane sugar powder, lactose, dextrin, soluble starch etc.
The quality proportioning of used acidic excipient and basic auxiliary is:
Acidic excipient 40%～50%, basic auxiliary 50%～60%.
Adjuvant can play correctives.
Eight corrections effervescent granules of the present invention belongs to the granule in the pharmacy of Chinese materia medica.
The manufacture method of the eight corrections effervescent granules that the inventor provides comprises:
(1) get the Semen Plantaginis of parch in advance in proportion, use 25% alcohol dipping, collect impregnation liquid, standby;
(2) get Radix Et Rhizoma Rhei in proportion, carry out percolation according to the percolation under fluid extract and the extractum item in " pharmacy of Chinese materia medica " after 24 hours, collect percolate with 50% alcohol dipping, standby behind the decompression recycling ethanol;
(3) get Herba Polygoni Avicularis, Herba Dianthi, Caulis Akebiae, Talcum, Fructus Gardeniae, Radix Glycyrrhizae and Medulla Junci in proportion, decoct with water 3 times, filter, merging filtrate, filtrate is concentrated into into extractum, and is standby;
(4) above-mentioned impregnation liquid, percolate and extractum are merged, obtain spice after stirring, be divided into two parts, portion adds acidic excipient and other additives in proportion, and another part adds basic auxiliary and other additives in proportion, fully mixing, granulate with conventional method then, dry respectively back merges mixing, and packing makes eight corrections effervescent granules after the assay was approved.
Eight corrections effervescent granules usage of the present invention is for oral administration, and the patient obeys 3 every day, each 10g, or follow the doctor's advice; Take with the eliminating cold for resuscitation water dissolution.This product should be preserved under shading, airtight, cryogenic conditions.
Eight corrections effervescent of the present invention has avoided original BAZHENG HEJI aerogenesis to produce sour problem, and mouthfeel is better, and the local flavor of soda pop is arranged when taking; Without glass bottle packaging, in light weight, the patient is easy to carry, takes; Safe in utilization, stable, have no side effect, can be used for the treatment of infectious diseases of urogenital system.
The specific embodiment
Embodiment: at first, get the Semen Plantaginis 118g of parch in advance,, collect impregnation liquid with 25% ethanol 1000ml dipping, standby behind the decompression recycling ethanol; Then, get Radix Et Rhizoma Rhei 118g, carry out percolation according to the percolation under fluid extract and the extractum item in " pharmacy of Chinese materia medica " after 24 hours, collect percolate with 50% ethanol 1000ml dipping, standby behind the decompression recycling ethanol; Get Herba Polygoni Avicularis 118g, Herba Dianthi 118g, Caulis Akebiae 118g, Talcum 118g, Fructus Gardeniae 118g, Radix Glycyrrhizae 118g and Medulla Junci 59g again, decoct with water 3 times.The 1st time amount of water is 8L, decocts 60 minutes; The 2nd time amount of water is 5L, decocts 120 minutes; The 3rd time amount of water is 4L, decocts 180 minutes.Filter, merging filtrate, filtrate is concentrated into into extractum, and extractum density is about 1.3kg/L, and is standby; Above-mentioned impregnation liquid, percolate and extractum merging are obtained the about 300g of spice, be divided into two parts, portion adds acidic excipient tartaric acid 800g and starch 150g in proportion, another part adds basic auxiliary sodium bicarbonate 900g and sucrose 150g in proportion, fully stirring and evenly mixing is even once more, granulates according to a conventional method, after using 70 ℃ of hot air dryings respectively, merge mixing.Packing makes about 2200g eight corrections effervescent granules after the assay was approved.This product is developed by Gaoxin Ruide Tech Development Co., Ltde., Guiyang.
Claims (3)
1 eight corrections effervescent granules is characterized in that it is made by crude drug and adjuvant, and wherein the component of crude drug and consumption thereof (consumption is a weight portion) are as follows:
Herba Dianthi 2 Semen Plantaginiss 2 Herba Polygoni Avicularis 2 Radix Et Rhizoma Rhei 2 Pulvis Talci 2
Caulis Clematidis Armandii 2 Fructus Gardeniaes 2 Radix Glycyrrhizaes 2 Medulla Juncies 1;
The quality component of drug extract and adjuvant is:
Drug extract 5%～40%, adjuvant 95%～60%.
2 eight corrections effervescent granules as claimed in claim 1 is characterized in that used adjuvant comprises acidic excipient, for example citric acid, tartaric acid, sodium dihydrogen phosphate, Sodium Acid Pyrophosphate, sodium sulfite; Also comprise basic auxiliary, for example sodium bicarbonate, sodium carbonate, potassium bicarbonate, sodium glycine carbonate, sodium sesquicarbonate; Also comprise additive, for example cane sugar powder, lactose, dextrin, soluble starch.
The preparation method of 3 eight corrections effervescent granules as claimed in claim 1, its feature comprises: (1) gets the Semen Plantaginis of parch in advance in proportion, uses 25% alcohol dipping, collects impregnation liquid, and is standby behind the decompression recycling ethanol; (2) get Radix Et Rhizoma Rhei in proportion, carry out percolation according to the percolation under fluid extract and the extractum item in " pharmacy of Chinese materia medica " after 24 hours, collect percolate with 50% alcohol dipping, standby behind the decompression recycling ethanol; (3) get Herba Polygoni Avicularis, Herba Dianthi, Caulis Akebiae, Talcum, Fructus Gardeniae, Radix Glycyrrhizae and Medulla Junci in proportion, decoct with water 3 times, filter, merging filtrate, filtrate is concentrated into into extractum, and is standby; (4) above-mentioned impregnation liquid, percolate and extractum are merged, obtain spice after stirring, be divided into two parts, portion adds acidic excipient and additive in proportion, and another part adds basic auxiliary and additive in proportion, fully mixing, granulate with conventional method then, dry respectively back merges mixing, and packing makes eight corrections effervescent granules after the assay was approved.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410081322 CN1650957A (en) | 2004-11-20 | 2004-11-20 | Eight corrections effervescent granules and its preparation method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200410081322 CN1650957A (en) | 2004-11-20 | 2004-11-20 | Eight corrections effervescent granules and its preparation method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102293873A (en) * | 2011-08-26 | 2011-12-28 | 太极集团重庆涪陵制药厂有限公司 | Preparation method of Bazheng mixture |
| CN104107284A (en) * | 2013-06-06 | 2014-10-22 | 成都绿迪科技有限公司 | Traditional Chinese medicine preparation for treating pyelonephritis |
| CN104107281A (en) * | 2013-06-06 | 2014-10-22 | 成都绿迪科技有限公司 | Traditional Chinese medicine for treating pyelonephritis |
| CN110625133A (en) * | 2019-09-11 | 2019-12-31 | 陕西中医药大学 | Method for preparing silver nanoparticles from traditional Chinese medicine residues and application thereof |
-
2004
- 2004-11-20 CN CN 200410081322 patent/CN1650957A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102293873A (en) * | 2011-08-26 | 2011-12-28 | 太极集团重庆涪陵制药厂有限公司 | Preparation method of Bazheng mixture |
| CN104107284A (en) * | 2013-06-06 | 2014-10-22 | 成都绿迪科技有限公司 | Traditional Chinese medicine preparation for treating pyelonephritis |
| CN104107281A (en) * | 2013-06-06 | 2014-10-22 | 成都绿迪科技有限公司 | Traditional Chinese medicine for treating pyelonephritis |
| CN110625133A (en) * | 2019-09-11 | 2019-12-31 | 陕西中医药大学 | Method for preparing silver nanoparticles from traditional Chinese medicine residues and application thereof |
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