CN106075380B - Externally-applied compound health-care product containing gingerol and preparation method thereof - Google Patents
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Abstract
The invention relates to an external compound health product containing gingerol and a preparation method thereof, which is characterized in that gingerol, ginger oil, ginger essential oil and folium artemisiae argyi essential oil are mixed according to a proper weight ratio, so that the content of gingerol in the external compound health product is not less than 15 wt%, the content of α -zingiberene is not less than 5 wt%, the content of α -curcumene is not less than 2 wt%, and the content of folium artemisiae argyi essential oil is not less than 10 wt%.
Description
Technical Field
The invention belongs to the technical field of gingerol application, and particularly relates to an external compound health-care product containing gingerol and a preparation method thereof.
Background
Besides being an indispensable condiment and vegetable, ginger is one of important Chinese medicinal materials in medicine, and is one of the first medical and edible resources published by the Ministry of health. Since ancient times, medical scientists regard ginger as a medicinal and edible traditional Chinese medicinal material, the medical sciences have recorded the treatment of diseases with ginger in the early Han dynasty, and books on herbal medicines in later generations have recorded a large amount of medicinal functions and related preparations of ginger. Li Shizhen recorded in Ben Cao gang mu of Li Shizhen has pungent and warm taste, has effects of warming spleen and stomach, warming spleen, dispelling cold, restoring yang, dredging collaterals, warming lung, softening, bathing dampness and eliminating phlegm, and can be used for treating nausea, abdominal pain and diarrhea due to deficiency-cold of spleen and stomach. Of 112 prescriptions in Shang Zhong Jing (treatise on miscellaneous diseases with typhoid fever), 59 are combined with Sheng Jiang.
Folium Artemisiae Argyi is the dried leaf of Artemisia argyi of Compositae, and is generally the dried or shade-dried leaf of Artemisia argyi, folium Artemisiae Argyi, sweet folium Artemisiae Argyi, and herba Medicaginis, which are picked up in spring and summer when flower is not opened and leaf is full. In long-term practice, the traditional Chinese medicine concludes that the folium artemisiae argyi has bitter, warm and pungent taste, has the functions of expelling cold and dampness, warming channels, regulating qi and blood, stopping bleeding, preventing miscarriage and the like, and is mainly applied to various diseases of killing parasites, relieving itching, bleeding, internal medicine, gynecology and the like in clinic.
The ginger essential oil mainly comprises α -zingiberene and α -curcumene, and has the main characteristic components of antivirus, bacteriostasis, anti-inflammation, endocrine regulation and the like, the gingerol substance can stimulate gastric mucosa, promote blood circulation, stimulate stomach function, achieve the effects of invigorating stomach, relieving pain, sweating and relieving fever, has the effects of resisting oxidation and removing free radicals, stimulates heart and cardiovascular system, accelerates blood flow, promotes perspiration, inhibits scalp itching, strengthens hairy roots and the like, in addition, the gingerol has obvious functions of diminishing inflammation and resisting rheumatism, has obvious curative effect on motion sickness, and simultaneously, the gingerol also has the effects of diuresis, resisting tumor, resisting platelet aggregation and the like.
The main effective component of folium Artemisiae Argyi is volatile oil substance, which has effects of inhibiting growth of pathogenic bacteria such as Bacillus typhi and Bacillus dysenteriae, softening blood vessel, relieving trigeminal neuralgia, treating respiratory system diseases such as bronchial asthma and chronic bronchitis, and treating arthritis, allergic dermatosis, chronic hepatitis, etc.
However, no product prepared by compounding the effective components in the ginger and the effective components in the folium artemisiae argyi is available at present.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides an external compound health care product containing gingerol, which has better efficacies of generating heat and promoting blood circulation and has the effects of resisting virus, inhibiting bacteria, diminishing inflammation, resisting rheumatism, resisting tumors, resisting platelet aggregation and the like, and a preparation method thereof.
The technical scheme adopted by the invention is as follows:
a topical compound health product containing gingerol comprises the following components:
30-60 parts of gingerol;
17-67 parts by weight of raw ginger oil;
10-50 parts of ginger essential oil;
10-25 parts of folium artemisiae argyi essential oil.
The content of α -zingiberene in the raw ginger oil is 28.7-31.2 wt%.
The content of α -curcumene in the ginger essential oil is 19.6-22.3 wt%.
The gingerol, the ginger oil and the ginger essential oil are extracted from ginger, and the specific process comprises the following steps:
(S1) drying and crushing the ginger in sequence to obtain ginger powder;
(S2) supercritical CO at a pressure of 24-25MPa and a temperature of 42-45 deg.C2Fluid is used for carrying out primary extraction on the ginger powder to prepare primary supercritical CO2Extracting liquid;
(S3) subjecting the first supercritical CO of step (S2)2Introducing the extractive solution into a first separation device, and separating under 12-14MPa and 50-55 deg.C to obtain gingerol and supercritical CO2A fluid;
(S4) subjecting the supercritical CO of step (S3)2Introducing the fluid into a second separation device, and separating under the conditions of 5-7MPa and 35-40 deg.C to obtain ginger essential oil crude product and CO2A gas;
(S5) supercritical CO at a pressure of 12-14MPa and a temperature of 42-45 deg.C2Performing secondary extraction on the ginger essential oil crude product by using a fluid to obtain secondary supercritical CO containing the original ginger essential oil2Extracting the liquid, and separating to obtain ginger essential oil;
(S6) subjecting the second supercritical CO of step (S5)2Introducing the extract into a third separation device, under the conditions of 5-7MPa of pressure and 45-50 ℃ of temperature,separating to obtain ginger oil and CO2A gas.
In the step (S1), the particle size of the ginger powder is 15-25 mesh.
In the step (S2), the time for the first extraction is 3-6 h;
in the step (S5), the time of the second extraction is 3-6 h.
The folium artemisiae argyi essential oil is extracted from folium artemisiae argyi, and the specific process comprises the following steps:
(SS1) drying and crushing the folium artemisiae argyi in sequence to obtain folium artemisiae argyi powder;
(SS2) by using supercritical CO at a pressure of 10-12MPa and a temperature of 42-45 DEG C2Extracting folium Artemisiae Argyi powder with fluid to obtain supercritical CO2Extracting liquid;
(SS3) subjecting the supercritical CO obtained in the step (SS2)2Introducing the extractive solution into a fourth separation device, and separating under 5-7MPa and 35-40 deg.C to obtain folium Artemisiae Argyi essential oil and CO2A gas.
In the step (SS1), the folium Artemisiae Argyi powder has a particle size of 5-15 mesh.
In the step (SS2), the extraction time is 2-5 h.
The preparation method of the external compound health-care product containing the gingerol comprises the following steps:
weighing the components according to the weight parts respectively, and fully mixing to obtain the externally-applied compound health-care product containing gingerol.
The invention has the beneficial effects that:
the gingerol-containing external compound health-care product disclosed by the invention is prepared by mixing gingerol, raw ginger oil, ginger essential oil and folium artemisiae argyi essential oil according to a proper weight ratio, so that the content of gingerol in the external compound health-care product is not lower than 15 wt%, the content of α -zingiberene is not lower than 5 wt%, the content of α -curcumene is not lower than 2 wt%, and the content of folium artemisiae argyi essential oil is not lower than 10 wt%.
Detailed Description
The present invention will be described in detail with reference to specific examples.
In the following examples, 1 part by weight represents 1 g.
Example 1
A topical compound health product containing gingerol comprises the following components:
30 parts of gingerol;
17 parts of raw ginger oil;
10 parts of ginger essential oil;
10 parts of argy wormwood leaf essential oil.
Wherein α -zingiberene content in the raw ginger oil is 28.7 wt%, α -curcumene content in the ginger essential oil is 19.6 wt%, and the gingerol, the raw ginger oil and the ginger essential oil are extracted from ginger, and the specific process comprises the following steps:
(S1) drying and crushing the ginger in sequence to obtain ginger powder with the particle size of 15 meshes;
(S2) supercritical CO at a pressure of 24MPa and a temperature of 42℃ is used2Extracting rhizoma Zingiberis recens powder with fluid for 3 hr to obtain first supercritical CO2Extracting liquid;
(S3) subjecting the first supercritical CO of step (S2)2Introducing the extractive solution into a first separation device, and separating under 12MPa and 50 deg.C to obtain gingerol and supercritical CO2A fluid;
(S4) subjecting the supercritical CO of step (S3)2Introducing the fluid into a second separation device, and separating under the conditions of 5MPa of pressure and 35 ℃ to obtain ginger essential oil crude product and CO2A gas;
(S5) supercritical CO at a pressure of 12MPa and a temperature of 42℃ is used2Performing secondary extraction on the ginger essential oil crude product for 3h by using fluid to obtain secondary supercritical CO containing the original ginger essential oil2Extracting the liquid, and separating to obtain ginger essential oil;
(S6) subjecting the second supercritical CO of step (S5)2Introducing the extractive solution into a third separation device, and separating under 5MPa and 45 deg.C to obtain ginger oil and CO2A gas.
The folium artemisiae argyi essential oil is extracted from folium artemisiae argyi, and the specific process comprises the following steps:
(SS1) drying and crushing the folium artemisiae argyi in sequence to obtain folium artemisiae argyi powder with the particle size of 5 meshes;
(SS2) by using supercritical CO at a pressure of 10MPa and a temperature of 42 DEG C2Extracting folium Artemisiae Argyi powder with fluid for 2 hr to obtain supercritical CO2Extracting liquid;
(SS3) subjecting the supercritical CO obtained in the step (SS2)2Introducing the extractive solution into a fourth separation device, and separating under the conditions of 5MPa and 35 deg.C to obtain folium Artemisiae Argyi essential oil and CO2A gas.
Further, the preparation method of the external compound health product containing gingerol in the embodiment comprises the following steps:
the components are weighed according to the weight and fully mixed to obtain the externally applied compound health care product containing the gingerol, and the externally applied compound health care product is detected to contain 15 wt% of the gingerol, 5 wt% of α -zingiberene, 2 wt% of α -curcumene and 10 wt% of folium artemisiae argyi essential oil.
Example 2
A topical compound health product containing gingerol comprises the following components:
60 parts of gingerol;
67 parts by weight of raw ginger oil;
50 parts of ginger essential oil;
25 parts of argy wormwood leaf essential oil.
Wherein α -zingiberene content in the raw ginger oil is 31.2 wt%, α -curcumene content in the ginger essential oil is 22.3 wt%, and the gingerol, the raw ginger oil and the ginger essential oil are extracted from ginger, and the specific process comprises the following steps:
(S1) drying and crushing the ginger in sequence to obtain ginger powder with the particle size of 25 meshes;
(S2) by using supercritical CO at a pressure of 25MPa and a temperature of 45 DEG C2Extracting rhizoma Zingiberis recens powder with fluid for 6 hr to obtain first supercritical CO2Extracting liquid;
(S3) subjecting the first supercritical CO of step (S2)2Introducing the extractive solution into a first separation device, and separating under the conditions of pressure of 14MPa and temperature of 55 deg.C to obtain gingerol and supercritical CO2A fluid;
(S4) subjecting the supercritical CO of step (S3)2Introducing the fluid into a second separation device, and separating under the conditions of pressure of 7MPa and temperature of 40 deg.C to obtain ginger essential oil crude product and CO2A gas;
(S5) supercritical CO at a pressure of 14MPa and a temperature of 45 DEG C2Performing secondary extraction on the ginger essential oil crude product for 6h by using fluid to obtain secondary supercritical CO containing the original ginger essential oil2Extracting the liquid, and separating to obtain ginger essential oil;
(S6) subjecting the second supercritical CO of step (S5)2Introducing the extractive solution into a third separation device, and separating under the conditions of pressure of 7MPa and temperature of 50 deg.C to obtain ginger oil and CO2A gas.
The folium artemisiae argyi essential oil is extracted from folium artemisiae argyi, and the specific process comprises the following steps:
(SS1) drying and crushing the folium artemisiae argyi in sequence to obtain folium artemisiae argyi powder with the particle size of 15 meshes;
(SS2) Using supercritical CO at a pressure of 12MPa and a temperature of 45 ℃2Extracting folium Artemisiae Argyi powder with fluid for 5 hr to obtain supercritical CO2Extracting liquid;
(SS3) subjecting the supercritical CO obtained in the step (SS2)2Introducing the extractive solution into a fourth separation device, and separating under the conditions of pressure of 7MPa and temperature of 40 deg.C to obtain folium Artemisiae Argyi essential oil and CO2A gas.
Further, the preparation method of the external compound health product containing gingerol in the embodiment comprises the following steps:
the components are weighed according to the weight and fully mixed to obtain the externally applied compound health care product containing the gingerol, and the externally applied compound health care product is detected to contain 26 wt% of the gingerol, α -11 wt% of the zingiberene, α -4 wt% of the curcumene and 18 wt% of the argy wormwood leaf essential oil.
Example 3
A topical compound health product containing gingerol comprises the following components:
38.2 parts by weight of gingerol;
34.8 parts of raw ginger oil;
10.2 parts by weight of ginger essential oil;
17.8 parts of argy wormwood leaf essential oil.
Wherein α -zingiberene content in the raw ginger oil is 28.7 wt%, α -curcumene content in the ginger essential oil is 19.6 wt%, and the gingerol, the raw ginger oil and the ginger essential oil are extracted from ginger, and the specific process comprises the following steps:
(S1) drying and crushing the ginger in sequence to obtain ginger powder with the particle size of 20 meshes;
(S2) by using supercritical CO at a pressure of 25MPa and a temperature of 43 DEG C2Extracting rhizoma Zingiberis recens powder with fluid for 4.5 hr to obtain first supercritical CO2Extracting liquid;
(S3) subjecting the first supercritical CO of step (S2)2Introducing the extractive solution into a first separation device, and separating under 13MPa and 52 deg.C to obtain gingerol and supercritical CO2A fluid;
(S4) subjecting the supercritical CO of step (S3)2Introducing the fluid into a second separation device, and separating under 6MPa and 38 deg.C to obtain ginger essential oil crude product and CO2A gas;
(S5) by using supercritical CO at a pressure of 13MPa and a temperature of 43 DEG C2Performing secondary extraction on the ginger essential oil crude product for 4.5h by using fluid to obtain secondary supercritical CO containing the original ginger essential oil2Extracting the liquid, and separating to obtain ginger essential oil;
(S6) subjecting the second supercritical CO of step (S5)2Introducing the extractive solution into a third separation device, and separating under 6MPa and 48 deg.C to obtain ginger oil and CO2A gas.
The folium artemisiae argyi essential oil is extracted from folium artemisiae argyi, and the specific process comprises the following steps:
(SS1) drying and crushing the folium artemisiae argyi in sequence to obtain folium artemisiae argyi powder with the particle size of 10 meshes;
(SS2) Using supercritical CO at a pressure of 11MPa and a temperature of 43 ℃2Extracting folium Artemisiae Argyi powder with fluid for 4.5 hr to obtain supercritical CO2Extracting liquid;
(SS3) subjecting the supercritical CO obtained in the step (SS2)2Introducing the extractive solution into a fourth separation device, and separating under 6MPa and 38 deg.C to obtain folium Artemisiae Argyi essential oil and CO2A gas.
Further, the preparation method of the external compound health product containing gingerol in the embodiment comprises the following steps:
the components are weighed according to the weight and fully mixed to obtain the externally applied compound health care product containing the gingerol, and the externally applied compound health care product is detected to contain 20% of the gingerol, 10% of α -zingiberene, 2% of α -curcumene and 17.8% of folium artemisiae argyi essential oil.
Example 4
A topical compound health product containing gingerol comprises the following components:
359.6 parts by weight of gingerol;
197.1 parts by weight of raw ginger oil;
104 parts of ginger essential oil;
109.3 parts of argyi leaf essential oil.
Wherein α -zingiberene content in the raw ginger oil is 31.2 wt%, α -curcumene content in the ginger essential oil is 22.3 wt%, and the gingerol, the raw ginger oil and the ginger essential oil are extracted from ginger, and the specific process comprises the following steps:
(S1) drying and crushing the ginger in sequence to obtain ginger powder with the particle size of 20 meshes;
(S2) supercritical CO at a pressure of 24MPa and a temperature of 43℃ is used2Extracting rhizoma Zingiberis recens powder with fluid for 4.5 hr to obtain first supercritical CO2Extracting liquid;
(S3) subjecting the first supercritical CO of step (S2)2Introducing the extractive solution into a first separation device, and separating under 13MPa and 52 deg.C to obtain gingerol and supercritical CO2A fluid;
(S4) subjecting the supercritical CO of step (S3)2Introducing the fluid into a second separation device, and separating under 6MPa and 38 deg.C to obtain ginger essential oil crude product and CO2A gas;
(S5) by using supercritical CO at a pressure of 13MPa and a temperature of 43 DEG C2Performing secondary extraction on the ginger essential oil crude product for 4.5h by using fluid to obtain secondary supercritical CO containing the original ginger essential oil2Extracting the liquid, and separating to obtain ginger essential oil;
(S6) subjecting the second supercritical CO of step (S5)2Introducing the extractive solution into a third separation device, and separating under 6MPa and 48 deg.C to obtain ginger oil and CO2A gas.
The folium artemisiae argyi essential oil is extracted from folium artemisiae argyi, and the specific process comprises the following steps:
(SS1) drying and crushing the folium artemisiae argyi in sequence to obtain folium artemisiae argyi powder with the particle size of 10 meshes;
(SS2) Using supercritical CO at a pressure of 11MPa and a temperature of 43 ℃2Extracting folium Artemisiae Argyi powder with fluid for 4 hr to obtain supercritical CO2Extracting liquid;
(SS3) subjecting the supercritical CO obtained in the step (SS2)2Introducing the extractive solution into a fourth separation device, and separating under 6MPa and 38 deg.C to obtain folium Artemisiae Argyi essential oil and CO2A gas.
Further, the preparation method of the external compound health product containing gingerol in the embodiment comprises the following steps:
the components are weighed according to the weight and fully mixed to obtain the externally applied compound health care product containing the gingerol, and the externally applied compound health care product contains 25% of the gingerol, 8% of α -zingiberene, 3% of α -curcumene and 14.2% of folium artemisiae argyi essential oil through detection.
The present invention is not limited to the above-mentioned preferred embodiments, and any other products in various forms can be obtained by anyone in the light of the present invention, but any changes in the shape or structure thereof, which have the same or similar technical solutions as those of the present application, fall within the protection scope of the present invention.
Claims (4)
1. The preparation method of the externally applied compound health care product containing the gingerol is characterized in that the externally applied compound health care product containing the gingerol comprises the following raw material components:
30-60 parts of gingerol;
17-67 parts by weight of raw ginger oil;
10-50 parts of ginger essential oil;
10-25 parts of folium artemisiae argyi essential oil;
the content of α -zingiberene in the raw ginger oil is 28.7-31.2 wt%;
the content of α -curcumene in the ginger essential oil is 19.6-22.3 wt%;
the gingerol, the ginger oil and the ginger essential oil are extracted from ginger, and the specific process comprises the following steps:
(S1) drying and crushing the ginger in sequence to obtain ginger powder with the grain diameter of 15-25 meshes;
(S2) supercritical CO at a pressure of 24-25MPa and a temperature of 42-45 deg.C2Extracting rhizoma Zingiberis recens powder with fluid for 3-6 hr to obtain first supercritical CO2Extracting liquid;
(S3) subjecting the first supercritical CO of step (S2)2Introducing the extractive solution into a first separation device, and separating under 12-14MPa and 50-55 deg.C to obtain gingerol and supercritical CO2A fluid;
(S4) subjecting the supercritical CO of step (S3)2Introducing the fluid into a second separation device, and separating under the conditions of 5-7MPa and 35-40 deg.C to obtain ginger essential oil crude product and CO2A gas;
(S5) supercritical CO at a pressure of 12-14MPa and a temperature of 42-45 deg.C2The fluid carries out secondary extraction on the ginger essential oil crude product for 3-6 hours,obtaining second supercritical CO containing the ginger oil2Extracting the liquid, and separating to obtain ginger essential oil;
(S6) subjecting the second supercritical CO of step (S5)2Introducing the extractive solution into a third separation device, and separating under 5-7MPa and 45-50 deg.C to obtain ginger oil and CO2A gas;
the folium artemisiae argyi essential oil is extracted from folium artemisiae argyi, and the specific process comprises the following steps:
(SS1) drying and crushing the folium artemisiae argyi in sequence to obtain folium artemisiae argyi powder;
(SS2) by using supercritical CO at a pressure of 10-12MPa and a temperature of 42-45 DEG C2Extracting folium Artemisiae Argyi powder with fluid to obtain supercritical CO2Extracting liquid;
(SS3) subjecting the supercritical CO obtained in the step (SS2)2Introducing the extractive solution into a fourth separation device, and separating under 5-7MPa and 35-40 deg.C to obtain folium Artemisiae Argyi essential oil and CO2A gas.
2. The preparation method of the externally-applied compound health product containing gingerol according to claim 1, characterized in that in the step (SS1), the particle size of the folium artemisiae argyi powder is 5-15 meshes.
3. The preparation method of the compound health product containing gingerol for external use according to claim 1, characterized in that in step (SS2), the extraction time is 2-5 h.
4. The preparation method of the externally-applied compound health-care product containing gingerol according to any one of claims 1 to 3, characterized by comprising the following specific preparation steps:
weighing the components according to the weight parts respectively, and fully mixing to obtain the externally-applied compound health-care product containing gingerol.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1251367A (en) * | 1999-08-20 | 2000-04-26 | 广州市轻工研究所 | Process for supercritical carbon dioxide extracting and separating effective components of ginger |
| CN1857701A (en) * | 2006-03-07 | 2006-11-08 | 苏州大学 | Ginger extract and its preparing method and application |
| CN102813956A (en) * | 2012-08-17 | 2012-12-12 | 天津市中科健新材料技术有限公司 | Thermal skin warming agent composition for disposable hygienic product and preparation method of thermal skin warming agent |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1251367A (en) * | 1999-08-20 | 2000-04-26 | 广州市轻工研究所 | Process for supercritical carbon dioxide extracting and separating effective components of ginger |
| CN1857701A (en) * | 2006-03-07 | 2006-11-08 | 苏州大学 | Ginger extract and its preparing method and application |
| CN102813956A (en) * | 2012-08-17 | 2012-12-12 | 天津市中科健新材料技术有限公司 | Thermal skin warming agent composition for disposable hygienic product and preparation method of thermal skin warming agent |
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Denomination of invention: The invention relates to an external compound health product containing gingerol and a preparation method thereof Effective date of registration: 20211025 Granted publication date: 20200710 Pledgee: Qingdao high technology financing Company limited by guarantee Pledgor: Lihe flavor (Qingdao) Food Industry Co., Ltd Registration number: Y2021370010105 |
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