CN105899538A - 靶向her2阳性肿瘤的化合物和组合物 - Google Patents
靶向her2阳性肿瘤的化合物和组合物 Download PDFInfo
- Publication number
- CN105899538A CN105899538A CN201580004171.4A CN201580004171A CN105899538A CN 105899538 A CN105899538 A CN 105899538A CN 201580004171 A CN201580004171 A CN 201580004171A CN 105899538 A CN105899538 A CN 105899538A
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- China
- Prior art keywords
- alkyl
- imidazo
- amino
- quinolin
- ethoxymethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- XLDWGZOVRLEDHM-UHFFFAOYSA-N CC(C)C(C(NC(CCCNC(N)=O)C(Nc1ccc(COC(C)=O)cc1)=O)=O)NC Chemical compound CC(C)C(C(NC(CCCNC(N)=O)C(Nc1ccc(COC(C)=O)cc1)=O)=O)NC XLDWGZOVRLEDHM-UHFFFAOYSA-N 0.000 description 1
- 0 CC(C)C(C*(CCCCC*(C(CC1C)=O)C1=O)=C)[N+](C=CCC(CCC[C@](C)ON)[N+](*(c1ccc(CO[N+](C)[O-])cc1)=C)[O-])[O-] Chemical compound CC(C)C(C*(CCCCC*(C(CC1C)=O)C1=O)=C)[N+](C=CCC(CCC[C@](C)ON)[N+](*(c1ccc(CO[N+](C)[O-])cc1)=C)[O-])[O-] 0.000 description 1
- NGWSAUQBWVWFCU-UHFFFAOYSA-N CCNC(C)(C)C(C)C Chemical compound CCNC(C)(C)C(C)C NGWSAUQBWVWFCU-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- A—HUMAN NECESSITIES
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210258366.3A CN114671954A (zh) | 2014-01-10 | 2015-01-08 | 靶向her2阳性肿瘤的化合物和组合物 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2014100112628 | 2014-01-10 | ||
| CN201410011324.5A CN104861067A (zh) | 2014-01-10 | 2014-01-10 | 用于免疫疗法的化合物和组合物 |
| CN201410011362.0A CN104861064A (zh) | 2014-01-10 | 2014-01-10 | 靶向表达egfr的肿瘤的化合物和组合物 |
| CN201410011262.8A CN104861063A (zh) | 2014-01-10 | 2014-01-10 | 靶向her2阳性肿瘤的化合物和组合物 |
| CN2014100113245 | 2014-01-10 | ||
| CN2014100113620 | 2014-01-10 | ||
| PCT/CN2015/070377 WO2015103987A1 (en) | 2014-01-10 | 2015-01-08 | Compounds and compositions for treating her2 positive tumors |
Related Child Applications (1)
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| CN114671954A (zh) * | 2014-01-10 | 2022-06-28 | 博笛生物科技有限公司 | 靶向her2阳性肿瘤的化合物和组合物 |
| CN112955434A (zh) * | 2018-09-17 | 2021-06-11 | 国家科学研究中心 | 包含喹啉衍生物的药物偶联物 |
| CN112955434B (zh) * | 2018-09-17 | 2023-12-08 | 国家科学研究中心 | 包含喹啉衍生物的药物偶联物 |
| US12172965B2 (en) | 2018-09-17 | 2024-12-24 | Universite Paris-Saclay | Drug conjugate comprising quinoline derivatives |
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