CN105891401B - 金钱胆通颗粒质量控制方法 - Google Patents
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- CN105891401B CN105891401B CN201610387095.6A CN201610387095A CN105891401B CN 105891401 B CN105891401 B CN 105891401B CN 201610387095 A CN201610387095 A CN 201610387095A CN 105891401 B CN105891401 B CN 105891401B
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Abstract
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6428826B1 (en) * | 1999-10-07 | 2002-08-06 | Bioactiva Microtechne | Chilco product and method of making and using same |
CN1907340A (zh) * | 2005-08-04 | 2007-02-07 | 四川旭华制药有限公司 | 一种肾石通制剂的质量检测控制方法 |
CN101757099A (zh) * | 2009-11-23 | 2010-06-30 | 重庆赛诺生物药业股份有限公司 | 金茵利胆药物及其制备方法和质量控制方法 |
CN101856449A (zh) * | 2009-04-10 | 2010-10-13 | 北京亚东生物制药有限公司 | 一种清热利湿,活血通淋中药组合物及制备方法和质量检测方法 |
CN102133335A (zh) * | 2011-03-22 | 2011-07-27 | 唐秋海 | 一种尿路康颗粒质量检测方法 |
KR20140065674A (ko) * | 2012-11-20 | 2014-05-30 | 재단법인 전남생물산업진흥원 | 양파 부산물로부터 퀘르세틴을 대량으로 분리, 정제하는 방법 |
-
2016
- 2016-06-03 CN CN201610387095.6A patent/CN105891401B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6428826B1 (en) * | 1999-10-07 | 2002-08-06 | Bioactiva Microtechne | Chilco product and method of making and using same |
CN1907340A (zh) * | 2005-08-04 | 2007-02-07 | 四川旭华制药有限公司 | 一种肾石通制剂的质量检测控制方法 |
CN101856449A (zh) * | 2009-04-10 | 2010-10-13 | 北京亚东生物制药有限公司 | 一种清热利湿,活血通淋中药组合物及制备方法和质量检测方法 |
CN101757099A (zh) * | 2009-11-23 | 2010-06-30 | 重庆赛诺生物药业股份有限公司 | 金茵利胆药物及其制备方法和质量控制方法 |
CN102133335A (zh) * | 2011-03-22 | 2011-07-27 | 唐秋海 | 一种尿路康颗粒质量检测方法 |
KR20140065674A (ko) * | 2012-11-20 | 2014-05-30 | 재단법인 전남생물산업진흥원 | 양파 부산물로부터 퀘르세틴을 대량으로 분리, 정제하는 방법 |
Non-Patent Citations (1)
Title |
---|
正交设计优选金钱胆通颗粒的最佳提取工艺;林妮等;《辽宁中医杂志》;20081231;第35卷(第7期);1074-7075 * |
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