CN105849111B - 吡喃并秋葵纤维异甲酚衍生物以及代谢综合征或炎症疾病治疗用药学组成物 - Google Patents
吡喃并秋葵纤维异甲酚衍生物以及代谢综合征或炎症疾病治疗用药学组成物 Download PDFInfo
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- CN105849111B CN105849111B CN201480070935.5A CN201480070935A CN105849111B CN 105849111 B CN105849111 B CN 105849111B CN 201480070935 A CN201480070935 A CN 201480070935A CN 105849111 B CN105849111 B CN 105849111B
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- branched
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- benzyloxy
- dimethyl
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- 0 C*(C)(C)c1cc(O)c(C2COc3c(CCC(C)(C)O4)c4ccc3C2)cc1 Chemical compound C*(C)(C)c1cc(O)c(C2COc3c(CCC(C)(C)O4)c4ccc3C2)cc1 0.000 description 1
- YRTQOUWVTAUXOF-UHFFFAOYSA-N CC(C)(CC1)Oc2c1c(OCC(C1)c3ccc(C)cc3O)c1cc2 Chemical compound CC(C)(CC1)Oc2c1c(OCC(C1)c3ccc(C)cc3O)c1cc2 YRTQOUWVTAUXOF-UHFFFAOYSA-N 0.000 description 1
- HYFGBBSJYOWLTC-UHFFFAOYSA-N CC1(C)Oc2ccc(CC(CO3)C(C(O)=C4)=CCC4c4ccccc4)c3c2CC1 Chemical compound CC1(C)Oc2ccc(CC(CO3)C(C(O)=C4)=CCC4c4ccccc4)c3c2CC1 HYFGBBSJYOWLTC-UHFFFAOYSA-N 0.000 description 1
- RDLLHEWNPCCPDX-UHFFFAOYSA-N CC1(C)Oc2ccc(CC(CO3)c(c(O)c4)ccc4-c4ccccc4)c3c2CC1 Chemical compound CC1(C)Oc2ccc(CC(CO3)c(c(O)c4)ccc4-c4ccccc4)c3c2CC1 RDLLHEWNPCCPDX-UHFFFAOYSA-N 0.000 description 1
- PMPYOYXFIHXBJI-UHFFFAOYSA-N CC1(C)Oc2ccc(CC(CO3)c(c(O)c4)ccc4O)c3c2CC1 Chemical compound CC1(C)Oc2ccc(CC(CO3)c(c(O)c4)ccc4O)c3c2CC1 PMPYOYXFIHXBJI-UHFFFAOYSA-N 0.000 description 1
- CZRMWARCFBCTDN-UHFFFAOYSA-N CC1(C)Oc2ccc(CC(CO3)c4ccc(CCOC)cc4O)c3c2CC1 Chemical compound CC1(C)Oc2ccc(CC(CO3)c4ccc(CCOC)cc4O)c3c2CC1 CZRMWARCFBCTDN-UHFFFAOYSA-N 0.000 description 1
- KVZVLKOCCCLONS-UHFFFAOYSA-N CC1(C)Oc2ccc(CC(CO3)c4ccccc4O)c3c2CC1 Chemical compound CC1(C)Oc2ccc(CC(CO3)c4ccccc4O)c3c2CC1 KVZVLKOCCCLONS-UHFFFAOYSA-N 0.000 description 1
- IKJXIGCXRAYEMN-UHFFFAOYSA-N CCCCc1ccc(C2COc3c(CCC(C)(C)O4)c4ccc3C2)c(O)c1 Chemical compound CCCCc1ccc(C2COc3c(CCC(C)(C)O4)c4ccc3C2)c(O)c1 IKJXIGCXRAYEMN-UHFFFAOYSA-N 0.000 description 1
- XZGZJDJZYPSQJJ-UHFFFAOYSA-N CCc1ccc(C2COc3c(CCC(C)(C)O4)c4ccc3C2)c(O)c1 Chemical compound CCc1ccc(C2COc3c(CCC(C)(C)O4)c4ccc3C2)c(O)c1 XZGZJDJZYPSQJJ-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20130162909 | 2013-12-24 | ||
| KR10-2013-0162909 | 2013-12-24 | ||
| KR10-2014-0181951 | 2014-12-17 | ||
| KR1020140181951A KR102344479B1 (ko) | 2013-12-24 | 2014-12-17 | 피라노크로메닐페놀 유도체, 및 대사증후군 또는 염증 질환 치료용 약학 조성물 |
| PCT/KR2014/012688 WO2015099392A1 (ko) | 2013-12-24 | 2014-12-23 | 피라노크로메닐페놀 유도체, 및 대사증후군 또는 염증 질환 치료용 약학 조성물 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105849111A CN105849111A (zh) | 2016-08-10 |
| CN105849111B true CN105849111B (zh) | 2018-05-04 |
Family
ID=53788040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480070935.5A Active CN105849111B (zh) | 2013-12-24 | 2014-12-23 | 吡喃并秋葵纤维异甲酚衍生物以及代谢综合征或炎症疾病治疗用药学组成物 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9783551B2 (enExample) |
| EP (1) | EP3098224B1 (enExample) |
| JP (2) | JP6620096B2 (enExample) |
| KR (1) | KR102344479B1 (enExample) |
| CN (1) | CN105849111B (enExample) |
| AU (1) | AU2014370697B2 (enExample) |
| BR (1) | BR112016011281B1 (enExample) |
| CA (1) | CA2929001C (enExample) |
| CY (1) | CY1121554T1 (enExample) |
| DK (1) | DK3098224T3 (enExample) |
| ES (1) | ES2718878T3 (enExample) |
| HR (1) | HRP20190573T1 (enExample) |
| HU (1) | HUE043902T2 (enExample) |
| IL (1) | IL245908B (enExample) |
| MX (1) | MX374944B (enExample) |
| NZ (1) | NZ720328A (enExample) |
| PL (1) | PL3098224T3 (enExample) |
| PT (1) | PT3098224T (enExample) |
| SG (1) | SG11201604371PA (enExample) |
| TW (1) | TWI585093B (enExample) |
| WO (1) | WO2015099392A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102344479B1 (ko) * | 2013-12-24 | 2021-12-29 | 주식회사 글라세움 | 피라노크로메닐페놀 유도체, 및 대사증후군 또는 염증 질환 치료용 약학 조성물 |
| ES2964146T3 (es) * | 2016-06-29 | 2024-04-04 | Glaceum Inc | Derivado de piranocromenilfenol ópticamente activo y composición farmacéutica que lo comprende |
| EP3524609B1 (en) | 2016-10-04 | 2021-05-26 | Glaceum, Inc. | Process for the preparation of 3-phenyl-2,3,4,8,9,10-hexahydropyrano[2,3-f]chromene derivatives, optical isomers thereof, and intermediates of the process |
| TWI804600B (zh) * | 2018-04-03 | 2023-06-11 | 南韓商格雷森伍股份有限公司 | 3-苯基-2,8-二氫吡喃[2,3-ƒ]苯并哌喃衍生物的合成方法 |
| KR20190116099A (ko) | 2018-04-03 | 2019-10-14 | 주식회사 글라세움 | 3-페닐-2,8-디히드로피라노[2,3-f]크로멘 유도체 및 이를 포함하는 약학적 조성물 |
| KR20200105198A (ko) * | 2019-02-28 | 2020-09-07 | 주식회사 글라세움 | 신경계 질환의 예방 또는 치료용 약학적 조성물 |
| KR102692932B1 (ko) | 2019-07-30 | 2024-08-07 | 주식회사 글라세움 | 2-((6-(히드록시메틸)크로멘-5-일)옥시)-1-페닐에타논 유도체의 합성 방법 |
| EP4353226A4 (en) | 2021-06-08 | 2024-10-16 | Glaceum, Inc. | PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF DEGENERATIVE EYE DISEASES |
| CN113616548B (zh) * | 2021-09-02 | 2023-04-28 | 河南科技大学 | 一种水溶性光甘草定包合物及其制备方法 |
| EP4509510A4 (en) * | 2022-04-12 | 2025-10-15 | Glaceum Inc | Process for the preparation of 3-PHENYL-2,3,4,9,10-HEXAHYDROPYRANO[2,3-F]CHROMENE derivatives |
| CN114903879B (zh) * | 2022-06-23 | 2023-10-31 | 东北大学 | 3-烃基苯酚衍生物在制备预防或治疗高脂血症及相关代谢性疾病产品中的用途 |
| WO2024151017A1 (ko) | 2023-01-12 | 2024-07-18 | 주식회사 글라세움 | 퇴행성 골관절염의 예방 또는 치료용 약학적 조성물 |
| KR20250081177A (ko) | 2023-11-29 | 2025-06-05 | 한국화학연구원 | Hsg4112 r형을 유효성분으로 포함하는 반려동물의 비만 예방, 개선 또는 치료용 조성물 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007058480A1 (en) * | 2005-11-16 | 2007-05-24 | Md Bioalpha Co., Ltd. | Composition having effect on treatment and prevention of diseases syndrome treatment with glabridin |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1599602A (zh) | 2001-10-11 | 2005-03-23 | 钟渊化学工业株式会社 | 过氧化物酶体增殖剂应答性受体配体剂及其制备方法 |
| KR100565423B1 (ko) * | 2003-10-20 | 2006-03-30 | 빅 바이오 주식회사 | 이소플라반 유도체 또는 이소플라벤 유도체의 제조방법 |
| JP2006008604A (ja) | 2004-06-25 | 2006-01-12 | Kuraray Co Ltd | イソフラバン誘導体の製造方法 |
| KR102344479B1 (ko) * | 2013-12-24 | 2021-12-29 | 주식회사 글라세움 | 피라노크로메닐페놀 유도체, 및 대사증후군 또는 염증 질환 치료용 약학 조성물 |
-
2014
- 2014-12-17 KR KR1020140181951A patent/KR102344479B1/ko active Active
- 2014-12-23 PT PT14873860T patent/PT3098224T/pt unknown
- 2014-12-23 US US15/037,230 patent/US9783551B2/en active Active
- 2014-12-23 DK DK14873860.2T patent/DK3098224T3/da active
- 2014-12-23 EP EP14873860.2A patent/EP3098224B1/en active Active
- 2014-12-23 HU HUE14873860 patent/HUE043902T2/hu unknown
- 2014-12-23 JP JP2016540481A patent/JP6620096B2/ja active Active
- 2014-12-23 MX MX2016008429A patent/MX374944B/es active IP Right Grant
- 2014-12-23 ES ES14873860T patent/ES2718878T3/es active Active
- 2014-12-23 CA CA2929001A patent/CA2929001C/en active Active
- 2014-12-23 PL PL14873860T patent/PL3098224T3/pl unknown
- 2014-12-23 CN CN201480070935.5A patent/CN105849111B/zh active Active
- 2014-12-23 BR BR112016011281-4A patent/BR112016011281B1/pt active IP Right Grant
- 2014-12-23 WO PCT/KR2014/012688 patent/WO2015099392A1/ko not_active Ceased
- 2014-12-23 AU AU2014370697A patent/AU2014370697B2/en active Active
- 2014-12-23 HR HRP20190573TT patent/HRP20190573T1/hr unknown
- 2014-12-23 SG SG11201604371PA patent/SG11201604371PA/en unknown
- 2014-12-23 NZ NZ720328A patent/NZ720328A/en unknown
- 2014-12-24 TW TW103145316A patent/TWI585093B/zh active
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2016
- 2016-05-29 IL IL245908A patent/IL245908B/en active IP Right Grant
-
2018
- 2018-03-23 JP JP2018056783A patent/JP2018135343A/ja active Pending
-
2019
- 2019-04-16 CY CY20191100423T patent/CY1121554T1/el unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007058480A1 (en) * | 2005-11-16 | 2007-05-24 | Md Bioalpha Co., Ltd. | Composition having effect on treatment and prevention of diseases syndrome treatment with glabridin |
Non-Patent Citations (4)
| Title |
|---|
| Glabrene and Isoliquiritigenin as Tyrosinase Inhibitors from Licorice Roots;OHAD NERYA et al.;《J. Agric. Food Chem.》;20030201;第51卷(第5期);第1201-1207页，abstract，introduction，figure 1 * |
| Hypoglycemic effects of glabridin, a polyphenolic flavonoid from licorice, in an animal model of diabetes mellitus;FEIHUA WU et al.;《MOLECULAR MEDICINE REPORTS》;20130219;第7卷(第4期);第1278-1282页，abstract，introduction，figure 1-6 * |
| Structure and Synthesis of Some Complex Pyranoisoflavonoids from the Bark of Dalbergia nitidula Welw. ex Bak.;Fanie R. van Heerden et al.;《J.C.S. Perkin I》;19780101;第137-145页，第138页右栏化合物6 * |
| Synthesis of Glabridin Derivatives as Tyrosinase Inhibitors;Warunee Jirawattanapong et al.;《Arch Pharm Res》;20090527;第32卷(第5期);第647-654页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| SG11201604371PA (en) | 2016-07-28 |
| US9783551B2 (en) | 2017-10-10 |
| JP2017501163A (ja) | 2017-01-12 |
| ES2718878T3 (es) | 2019-07-05 |
| AU2014370697B2 (en) | 2017-01-19 |
| KR20150075030A (ko) | 2015-07-02 |
| HRP20190573T1 (hr) | 2019-05-17 |
| DK3098224T3 (da) | 2019-05-13 |
| IL245908B (en) | 2020-08-31 |
| CA2929001C (en) | 2018-02-20 |
| CY1121554T1 (el) | 2020-05-29 |
| TWI585093B (zh) | 2017-06-01 |
| US20160272650A1 (en) | 2016-09-22 |
| NZ720328A (en) | 2018-02-23 |
| TW201607949A (zh) | 2016-03-01 |
| CN105849111A (zh) | 2016-08-10 |
| KR102344479B1 (ko) | 2021-12-29 |
| IL245908A0 (en) | 2016-08-02 |
| PT3098224T (pt) | 2019-04-26 |
| CA2929001A1 (en) | 2015-07-02 |
| EP3098224A4 (en) | 2017-07-05 |
| WO2015099392A1 (ko) | 2015-07-02 |
| JP6620096B2 (ja) | 2019-12-11 |
| EP3098224B1 (en) | 2019-01-30 |
| AU2014370697A1 (en) | 2016-06-16 |
| BR112016011281B1 (pt) | 2021-11-16 |
| BR112016011281A2 (enExample) | 2017-08-08 |
| JP2018135343A (ja) | 2018-08-30 |
| PL3098224T3 (pl) | 2019-07-31 |
| HUE043902T2 (hu) | 2019-10-28 |
| MX2016008429A (es) | 2017-02-23 |
| MX374944B (es) | 2025-03-06 |
| EP3098224A1 (en) | 2016-11-30 |
Similar Documents
| Publication | Publication Date | Title |
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