CN105793276A - 针对肺炎链球菌进行保护的富含脯氨酸的肽 - Google Patents

针对肺炎链球菌进行保护的富含脯氨酸的肽 Download PDF

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Publication number
CN105793276A
CN105793276A CN201480066380.7A CN201480066380A CN105793276A CN 105793276 A CN105793276 A CN 105793276A CN 201480066380 A CN201480066380 A CN 201480066380A CN 105793276 A CN105793276 A CN 105793276A
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CN
China
Prior art keywords
peptide
lipopeptid
proline
amino acid
construction unit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201480066380.7A
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English (en)
Chinese (zh)
Inventor
A·加斯帕里安
A·祖尼加
N·盖伯
M·坦博里尼
M·尤德
G·普卢施克
A·马雷罗诺达尔斯
J·A·鲁滨逊
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
VIROMETIX AG
Universitaet Basel
Zurich Universitaet Institut fuer Medizinische Virologie
Swiss Tropical and Public Health Inst
Original Assignee
VIROMETIX AG
Universitaet Basel
Zurich Universitaet Institut fuer Medizinische Virologie
Swiss Tropical and Public Health Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by VIROMETIX AG, Universitaet Basel, Zurich Universitaet Institut fuer Medizinische Virologie, Swiss Tropical and Public Health Inst filed Critical VIROMETIX AG
Publication of CN105793276A publication Critical patent/CN105793276A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6018—Lipids, e.g. in lipopeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16023—Virus like particles [VLP]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201480066380.7A 2013-12-03 2014-12-02 针对肺炎链球菌进行保护的富含脯氨酸的肽 Pending CN105793276A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13195402 2013-12-03
EP13195402.6 2013-12-03
PCT/EP2014/076313 WO2015082501A1 (en) 2013-12-03 2014-12-02 Proline-rich peptides protective against s. pneumoniae

Publications (1)

Publication Number Publication Date
CN105793276A true CN105793276A (zh) 2016-07-20

Family

ID=49765797

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480066380.7A Pending CN105793276A (zh) 2013-12-03 2014-12-02 针对肺炎链球菌进行保护的富含脯氨酸的肽

Country Status (12)

Country Link
US (2) US9943583B2 (enExample)
EP (1) EP3077410B1 (enExample)
JP (2) JP2017501990A (enExample)
KR (1) KR20160088323A (enExample)
CN (1) CN105793276A (enExample)
AU (1) AU2014359292B2 (enExample)
BR (1) BR112016012306A2 (enExample)
CA (1) CA2931570A1 (enExample)
HK (1) HK1225739A1 (enExample)
RU (1) RU2737638C2 (enExample)
WO (1) WO2015082501A1 (enExample)
ZA (1) ZA201603962B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113260377A (zh) * 2018-12-20 2021-08-13 维罗米蒂克斯股份公司 脂肽构建块和合成病毒样颗粒

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI769150B (zh) * 2016-03-08 2022-07-01 碁米庫斯生物科技股份有限公司 糖尿病之治療、類鐸受體第四型調節劑及其使用方法
EP3548076A2 (en) * 2016-12-03 2019-10-09 The UAB Research Foundation Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein a
EP4295866A3 (en) 2017-06-14 2024-03-20 Virometix AG Cyclic peptides for protection against respiratory syncytial virus
CN108559784B (zh) * 2018-07-06 2021-08-20 陕西省动物研究所 一种同时检测三种病原菌的三重pcr检测用引物、探针、试剂盒及检测方法
JP7395200B2 (ja) * 2019-03-25 2023-12-11 イミュンワーク インク． 金属結合モチーフを有する複合ポリペプチド及びそれを備える分子構築物
WO2021260176A1 (en) 2020-06-25 2021-12-30 Virometix Ag Synthetic epitopes of betacoronaviruses
EP4216992A1 (en) 2020-09-28 2023-08-02 DBV Technologies Particle comprising an rsv-f protein for use in rsv vaccination
WO2025012364A1 (en) 2023-07-12 2025-01-16 Virometix Ag Compositions of pneumococcal antigens
WO2025242657A1 (en) 2024-05-21 2025-11-27 Shape Biopharmaceuticals Ag Lipopeptide building blocks and aggregates

Citations (2)

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WO1996040290A1 (en) * 1995-06-07 1996-12-19 Connaught Laboratories, Inc. Immunological combination compositions and methods
WO2008068017A1 (en) * 2006-12-09 2008-06-12 Universität Zürich Prorektorat Forschung Coiled-coil lipopeptide helical bundles and synthetic virus-like particles

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US5391712A (en) 1991-08-30 1995-02-21 Beckman Instruments, Inc. Non-hemolytic streptolysin O variants
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113260377A (zh) * 2018-12-20 2021-08-13 维罗米蒂克斯股份公司 脂肽构建块和合成病毒样颗粒

Also Published As

Publication number Publication date
JP2017501990A (ja) 2017-01-19
WO2015082501A1 (en) 2015-06-11
AU2014359292B2 (en) 2019-02-28
EP3077410B1 (en) 2021-02-03
US20180256698A1 (en) 2018-09-13
ZA201603962B (en) 2020-02-26
RU2737638C2 (ru) 2020-12-01
EP3077410A1 (en) 2016-10-12
AU2014359292A1 (en) 2016-06-23
CA2931570A1 (en) 2015-06-11
BR112016012306A2 (pt) 2017-09-26
US20160324947A1 (en) 2016-11-10
HK1225739A1 (zh) 2017-09-15
US9943583B2 (en) 2018-04-17
KR20160088323A (ko) 2016-07-25
JP2020073487A (ja) 2020-05-14

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