RU2737638C2 - ПРОЛИН-БОГАТЫЕ ПЕПТИДЫ, ЗАЩИЩАЮЩИЕ ОТ S.pneumoniae - Google Patents

ПРОЛИН-БОГАТЫЕ ПЕПТИДЫ, ЗАЩИЩАЮЩИЕ ОТ S.pneumoniae Download PDF

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Publication number
RU2737638C2
RU2737638C2 RU2016126433A RU2016126433A RU2737638C2 RU 2737638 C2 RU2737638 C2 RU 2737638C2 RU 2016126433 A RU2016126433 A RU 2016126433A RU 2016126433 A RU2016126433 A RU 2016126433A RU 2737638 C2 RU2737638 C2 RU 2737638C2
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Russia
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peptide
lipopeptide
proline
long hydrocarbon
antigen
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RU2016126433A
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English (en)
Russian (ru)
Inventor
Арин ГАСПАРЯН
Армандо ЗУНИГА
Нина ГАЙБ
Марко ТАМБОРИНИ
Майя ДЖУД
Герд ПЛУШКЕ
НОДАРСЕ Анибрис МАРРЕРО
Джон Энтони Робинсон
Original Assignee
Вирометикс Аг
Свисс Тропикал Энд Паблик Хелт Инститьют
Универзитет Базель
Универзитет Цюрих
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/09Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092Streptococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5258Virus-like particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55516Proteins; Peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6018Lipids, e.g. in lipopeptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16023Virus like particles [VLP]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
RU2016126433A 2013-12-03 2014-12-02 ПРОЛИН-БОГАТЫЕ ПЕПТИДЫ, ЗАЩИЩАЮЩИЕ ОТ S.pneumoniae RU2737638C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13195402.6 2013-12-03
EP13195402 2013-12-03
PCT/EP2014/076313 WO2015082501A1 (en) 2013-12-03 2014-12-02 Proline-rich peptides protective against s. pneumoniae

Publications (1)

Publication Number Publication Date
RU2737638C2 true RU2737638C2 (ru) 2020-12-01

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RU2016126433A RU2737638C2 (ru) 2013-12-03 2014-12-02 ПРОЛИН-БОГАТЫЕ ПЕПТИДЫ, ЗАЩИЩАЮЩИЕ ОТ S.pneumoniae

Country Status (12)

Country Link
US (2) US9943583B2 (enExample)
EP (1) EP3077410B1 (enExample)
JP (2) JP2017501990A (enExample)
KR (1) KR20160088323A (enExample)
CN (1) CN105793276A (enExample)
AU (1) AU2014359292B2 (enExample)
BR (1) BR112016012306A2 (enExample)
CA (1) CA2931570A1 (enExample)
HK (1) HK1225739A1 (enExample)
RU (1) RU2737638C2 (enExample)
WO (1) WO2015082501A1 (enExample)
ZA (1) ZA201603962B (enExample)

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TWI769150B (zh) * 2016-03-08 2022-07-01 碁米庫斯生物科技股份有限公司 糖尿病之治療、類鐸受體第四型調節劑及其使用方法
AU2017366726B2 (en) * 2016-12-03 2021-12-09 The Uab Research Foundation Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein A
MX2019014719A (es) 2017-06-14 2020-08-03 Virometix Ag Peptidos ciclicos para proteccion contra el virus sincitial respiratorio.
CN108559784B (zh) * 2018-07-06 2021-08-20 陕西省动物研究所 一种同时检测三种病原菌的三重pcr检测用引物、探针、试剂盒及检测方法
CN113260377B (zh) * 2018-12-20 2025-08-22 维罗米蒂克斯股份公司 脂肽构建块和合成病毒样颗粒
US11203614B2 (en) * 2019-03-25 2021-12-21 Immunwork Inc. Composite polypeptide having a metal binding motif and molecular construct comprising the same
WO2021260176A1 (en) 2020-06-25 2021-12-30 Virometix Ag Synthetic epitopes of betacoronaviruses
EP4216992A1 (en) 2020-09-28 2023-08-02 DBV Technologies Particle comprising an rsv-f protein for use in rsv vaccination
WO2025012364A1 (en) 2023-07-12 2025-01-16 Virometix Ag Compositions of pneumococcal antigens
WO2025242657A1 (en) 2024-05-21 2025-11-27 Shape Biopharmaceuticals Ag Lipopeptide building blocks and aggregates

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RU2141527C1 (ru) * 1992-02-03 1999-11-20 Коннот Лабораториз Лимитед Синтетический пептид, синтетический липопептид, иммуногенный конъюгат (варианты), способ получения олигомера, защищенный твердым монометиловым эфиром полиэтиленгликоля полисахарид
WO2008068017A1 (en) * 2006-12-09 2008-06-12 Universität Zürich Prorektorat Forschung Coiled-coil lipopeptide helical bundles and synthetic virus-like particles
WO2012100233A1 (en) * 2011-01-20 2012-07-26 Genocea Biosciences, Inc. Vaccines and compositions against streptococcus pneumoniae

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Publication number Publication date
ZA201603962B (en) 2020-02-26
EP3077410A1 (en) 2016-10-12
BR112016012306A2 (pt) 2017-09-26
KR20160088323A (ko) 2016-07-25
US20160324947A1 (en) 2016-11-10
AU2014359292B2 (en) 2019-02-28
HK1225739A1 (zh) 2017-09-15
CA2931570A1 (en) 2015-06-11
EP3077410B1 (en) 2021-02-03
WO2015082501A1 (en) 2015-06-11
JP2020073487A (ja) 2020-05-14
CN105793276A (zh) 2016-07-20
JP2017501990A (ja) 2017-01-19
AU2014359292A1 (en) 2016-06-23
US9943583B2 (en) 2018-04-17
US20180256698A1 (en) 2018-09-13

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