RU2737638C2 - ПРОЛИН-БОГАТЫЕ ПЕПТИДЫ, ЗАЩИЩАЮЩИЕ ОТ S.pneumoniae - Google Patents

ПРОЛИН-БОГАТЫЕ ПЕПТИДЫ, ЗАЩИЩАЮЩИЕ ОТ S.pneumoniae Download PDF

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Publication number
RU2737638C2
RU2737638C2 RU2016126433A RU2016126433A RU2737638C2 RU 2737638 C2 RU2737638 C2 RU 2737638C2 RU 2016126433 A RU2016126433 A RU 2016126433A RU 2016126433 A RU2016126433 A RU 2016126433A RU 2737638 C2 RU2737638 C2 RU 2737638C2
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RU
Russia
Prior art keywords
peptide
lipopeptide
proline
long hydrocarbon
structural element
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RU2016126433A
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English (en)
Russian (ru)
Inventor
Арин ГАСПАРЯН
Армандо ЗУНИГА
Нина ГАЙБ
Марко ТАМБОРИНИ
Майя ДЖУД
Герд ПЛУШКЕ
НОДАРСЕ Анибрис МАРРЕРО
Джон Энтони Робинсон
Original Assignee
Вирометикс Аг
Свисс Тропикал Энд Паблик Хелт Инститьют
Универзитет Базель
Универзитет Цюрих
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6018—Lipids, e.g. in lipopeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16023—Virus like particles [VLP]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2016126433A 2013-12-03 2014-12-02 ПРОЛИН-БОГАТЫЕ ПЕПТИДЫ, ЗАЩИЩАЮЩИЕ ОТ S.pneumoniae RU2737638C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13195402.6 2013-12-03
EP13195402 2013-12-03
PCT/EP2014/076313 WO2015082501A1 (en) 2013-12-03 2014-12-02 Proline-rich peptides protective against s. pneumoniae

Publications (1)

Publication Number Publication Date
RU2737638C2 true RU2737638C2 (ru) 2020-12-01

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RU2016126433A RU2737638C2 (ru) 2013-12-03 2014-12-02 ПРОЛИН-БОГАТЫЕ ПЕПТИДЫ, ЗАЩИЩАЮЩИЕ ОТ S.pneumoniae

Country Status (12)

Country Link
US (2) US9943583B2 (enExample)
EP (1) EP3077410B1 (enExample)
JP (2) JP2017501990A (enExample)
KR (1) KR20160088323A (enExample)
CN (1) CN105793276A (enExample)
AU (1) AU2014359292B2 (enExample)
BR (1) BR112016012306A2 (enExample)
CA (1) CA2931570A1 (enExample)
HK (1) HK1225739A1 (enExample)
RU (1) RU2737638C2 (enExample)
WO (1) WO2015082501A1 (enExample)
ZA (1) ZA201603962B (enExample)

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CA3016815A1 (en) 2016-03-08 2017-09-14 KeMyth Biotech Co., Ltd. Use of pneumolysin peptides as antagonists against toll-like receptor 4 and methods of treating toll-like receptor 4 related diseases
CN110381992A (zh) * 2016-12-03 2019-10-25 Uab研究基金会 组合了肺炎球菌表面蛋白A的选择的α螺旋结构域和脯氨酸富集结构域的肺炎球菌疫苗
JP7356911B2 (ja) 2017-06-14 2023-10-05 ヴァイロメティックス アーゲー 呼吸器合胞体ウイルスに対する予防のための環状ペプチド
CN108559784B (zh) * 2018-07-06 2021-08-20 陕西省动物研究所 一种同时检测三种病原菌的三重pcr检测用引物、探针、试剂盒及检测方法
CA3121724A1 (en) 2018-12-20 2020-06-25 Virometix Ag Lipopeptide building blocks and synthetic virus-like particles
TWI739358B (zh) * 2019-03-25 2021-09-11 免疫功坊股份有限公司 帶有金屬結合區的複合多肽及其分子構建體
CA3130470A1 (en) * 2019-03-29 2020-10-08 Yoshikazu Yuki Pneumococcal surface proteins
WO2021260176A1 (en) 2020-06-25 2021-12-30 Virometix Ag Synthetic epitopes of betacoronaviruses
US20230355737A1 (en) 2020-09-28 2023-11-09 Dbv Technologies Particle comprising an rsv-f protein for use in rsv vaccination
CN121693342A (zh) 2023-07-12 2026-03-17 维罗迈科斯股份公司 肺炎球菌抗原的组合物
WO2025242657A1 (en) 2024-05-21 2025-11-27 Shape Biopharmaceuticals Ag Lipopeptide building blocks and aggregates

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WO2008068017A1 (en) * 2006-12-09 2008-06-12 Universität Zürich Prorektorat Forschung Coiled-coil lipopeptide helical bundles and synthetic virus-like particles
WO2012100233A1 (en) * 2011-01-20 2012-07-26 Genocea Biosciences, Inc. Vaccines and compositions against streptococcus pneumoniae

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Publication number Publication date
US9943583B2 (en) 2018-04-17
HK1225739A1 (zh) 2017-09-15
CN105793276A (zh) 2016-07-20
WO2015082501A1 (en) 2015-06-11
AU2014359292A1 (en) 2016-06-23
KR20160088323A (ko) 2016-07-25
CA2931570A1 (en) 2015-06-11
US20180256698A1 (en) 2018-09-13
US20160324947A1 (en) 2016-11-10
EP3077410A1 (en) 2016-10-12
EP3077410B1 (en) 2021-02-03
JP2017501990A (ja) 2017-01-19
BR112016012306A2 (pt) 2017-09-26
AU2014359292B2 (en) 2019-02-28
JP2020073487A (ja) 2020-05-14
ZA201603962B (en) 2020-02-26

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