CN105770256A - Haemorrhoids paste - Google Patents

Haemorrhoids paste Download PDF

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Publication number
CN105770256A
CN105770256A CN201610351334.2A CN201610351334A CN105770256A CN 105770256 A CN105770256 A CN 105770256A CN 201610351334 A CN201610351334 A CN 201610351334A CN 105770256 A CN105770256 A CN 105770256A
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CN
China
Prior art keywords
parts
rhizoma
haemorrhoids
radix
paste
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Pending
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CN201610351334.2A
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Chinese (zh)
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李玉兰
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Individual
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Priority to CN201610351334.2A priority Critical patent/CN105770256A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/237—Notopterygium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238—Saposhnikovia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8884—Arisaema, e.g. Jack in the pulpit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

Abstract

The invention discloses haemorrhoids paste.The haemorrhoids paste is prepared from, by weight, 1-5 parts of herba hypericum patulum thunb, 1-5 parts of notopterygium root, 1-5 parts of radix saposhnikoviae, 1-5 parts of pedate pinalliajackinthepulpit rhizome, 1-5 parts of radix angelicae and 10-15 parts of rhizoma typhonii.The haemorrhoids paste is formed by compounding six medicine materials having good synergistic effect in haemorrhoids treatment, the haemorrhoids paste can enhance blood vessel resistance, reduce permeability and brittleness, diminish inflammation, disperse swelling, stop bleeding and promote wound repairing and healing, and has good treatment effect on inflammation, swelling, bleeding and other symptoms of haemorrhoids.

Description

ZHICHUANG GAO
Technical field
The present invention relates to a kind of Chinese medicine plaster, be specifically related to a kind of ZHICHUANG GAO.
Background technology
The soft vein group occurring expansion and flexing to be formed under human rectum's end mucosa with anal canal skin venous plexus, becomes hemorrhoid.Medical science indication hemorrhoid include internal hemorrhoid, external hemorrhoid, mixed hemorrhoid, are bottom hepatic portal rectum and a kind of chronic disease of the vein group of the venous plexus generation varicose of anal mucosa and one or more softnesses of being formed.At present, the sickness rate in China's recial disease is 59.1%, and hemorrhoid account for the 87.25% of all anal and intestinal diseases.Reason very common in the pathogeny of hemorrhoid is exactly local vascular because inflammation or thrombosis etc. cause that its permeability increases, and in blood, composition oozes out blood vessel in a large number, causes edema and pain in hepatic portal local, and adds the symptom of hyperphlogosis.Therefore, treatment hemorrhoid are exactly antiinflammatory, and detumescence reduces vascular permeability and controls hemorrhage.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of ZHICHUANG GAO.
Technical scheme provided by the invention is a kind of ZHICHUANG GAO, is made up of the raw material of following weight portion: Herba Hyperici Patuli 1～5 part, Rhizoma Et Radix Notopterygii 1～5 part, Radix Saposhnikoviae 1～5 part, Rhizoma Arisaematis 1～5 part, the Radix Angelicae Dahuricae 1～5 part, Rhizoma Typhonii 10～15 parts.
As preferably, the weight portion of each raw material is: Herba Hyperici Patuli 1 part, Rhizoma Et Radix Notopterygii 1 part, Radix Saposhnikoviae 1 part, Rhizoma Arisaematis 1 part, the Radix Angelicae Dahuricae 1 part, Rhizoma Typhonii 10 parts.
The preparation method of above-mentioned ointment for injuries is: by the Herba Hyperici Patuli of formula ratio, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae, Rhizoma Arisaematis, the Radix Angelicae Dahuricae and Rhizoma Typhonii co-grinding, adds unguentum customary adjuvant, to obtain final product.
Above-mentioned raw materials is crushed to 100～200 orders.
Above-mentioned adjuvant is one or more in paraffin, lanoline and vaseline.
In the formula of the present invention:
Herba Hyperici Patuli (Classification system: HypericumpatulumThunb.exMurray) is Guttiferae Hypericum, and half is evergreen or the root of evergreen dwarf shrub, can relaxing muscles and tendons to promote blood circulation, lactogenic, diuresis.
Rhizoma Et Radix Notopterygii (Notopterygiumincisum.) is Umbelliferae, the dry root of Notopterygium plant, for affection of exogenous wind-cold, have a headache lossless, cold-damp numbness, upper limb rheumatalgia.
Radix Saposhnikoviae is the dry root of umbelliferae Saposhnikovia divaricata.There are expelling pathogenic wind from the body surface, removing dampness to relieve pain, effect of relieving convulsion.
Rhizoma Arisaematis takes from the rhizome of Rhizoma Arisaematis (aroid Rhizoma Arisaematis Arisaemaerubescens (Wall.) Schott., Arisaema heterophyllum B1. ArisaemaheterophyllumBlume or arisaema amurense Maxim ArisaemaamurenseMaxim.).There is drying dampness to eliminate phlegm, expelling wind and relieving convulsion, effect of mass dissipating and swelling eliminating.
The Radix Angelicae Dahuricae (Latin literary fame: Angelicadahurica (Fisch.exHoffm.) Benth.etHook.f.exFranch.etSav), for the dry root of the Radix Angelicae Dahuricae, have dispel the wind, dampness, detumescence, pain relieving effect.
Rhizoma Typhonii is the dry tuber of aroid Herba Typhonii gigantei TyphoniumgiganteumEngl., have the expectorant that dispels the wind, arresting convulsion jerk, detoxicating and resolving stagnation of pathogens, pain relieving effect.
Compared with prior art, the method have the advantages that
1) ZHICHUANG GAO of the present invention is formed by 6 kinds of medical materials are composite, hemorrhoid treating has good synergism, VAR can be increased, reduce its permeability, reduce fragility, antiinflammatory can also go to swell, stop blooding, promote that wound repair acts on healing etc. that the inflammation of hemorrhoid, swelling and the symptom such as hemorrhage are all had good therapeutic effect simultaneously.
2) owing to the present invention adopts Chinese herbal medicine to be raw material, action temperature and, have no side effect.
Detailed description of the invention
The present invention is further elaborated for specific examples below, but not as a limitation of the invention.
Embodiment 1
Formula: Herba Hyperici Patuli 5 parts, Rhizoma Et Radix Notopterygii 5 parts, Radix Saposhnikoviae 5 parts, Rhizoma Arisaematis 5 parts, the Radix Angelicae Dahuricae 5 parts, Rhizoma Typhonii 15 parts.
Preparation method:
1) by the Herba Hyperici Patuli of formula ratio, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae, Rhizoma Arisaematis, the Radix Angelicae Dahuricae and Rhizoma Typhonii co-grinding to 200 orders；
2) take mixed-powder 1g, add paraffin 1g, lanoline 1g and vaseline 8g, mixing, obtain ointment for injuries.
Embodiment 2
Formula: Herba Hyperici Patuli 2 parts, Rhizoma Et Radix Notopterygii 3 parts, Radix Saposhnikoviae 4 parts, Rhizoma Arisaematis 2 parts, the Radix Angelicae Dahuricae 3 parts, Rhizoma Typhonii 12 parts.
Preparation method:
1) by the Herba Hyperici Patuli of formula ratio, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae, Rhizoma Arisaematis, the Radix Angelicae Dahuricae and Rhizoma Typhonii co-grinding to 150 orders；
2) take mixed-powder 1g, add paraffin 1g, lanoline 1g and vaseline 8g, mixing, obtain ointment for injuries.
Embodiment 3
Formula: Herba Hyperici Patuli 1 part, Rhizoma Et Radix Notopterygii 1 part, Radix Saposhnikoviae 1 part, Rhizoma Arisaematis 1 part, the Radix Angelicae Dahuricae 1 part, Rhizoma Typhonii 10 parts.
Preparation method:
1) by the Herba Hyperici Patuli of formula ratio, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae, Rhizoma Arisaematis, the Radix Angelicae Dahuricae and Rhizoma Typhonii co-grinding to 100～200 orders；
2) take mixed-powder 1g, add paraffin 1g, lanoline 1g and vaseline 8g, mixing, obtain ointment for injuries.
Embodiment 4
Formula: Herba Hyperici Patuli 1 part, Rhizoma Et Radix Notopterygii 5 parts, Radix Saposhnikoviae 1 part, Rhizoma Arisaematis 5 parts, the Radix Angelicae Dahuricae 1 part, Rhizoma Typhonii 15 parts.
Preparation method:
1) by the Herba Hyperici Patuli of formula ratio, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae, Rhizoma Arisaematis, the Radix Angelicae Dahuricae and Rhizoma Typhonii co-grinding to 200 orders；
2) take mixed-powder 1g, add paraffin 1g, lanoline 1g and vaseline 8g, mixing, obtain ointment for injuries.
Experimental example
1, the ZHICHUANG GAO impact on SD rat paw edema model
1.1 reagents
MAYINGLONG MUSK HEMORRHOID UNGUENTUM (Wuhan the 3rd pharmaceutical factory)；
Carrageenin (specification is 25g/ bottle for Sigma company, lot number 127H227)；
Dimethylbenzene (lot number is 040301-2 for analytical pure, Guangzhou Chemical Reagent Factory)；
Medical proof fabric (vapor-permeable type) (Jinhua Heng Di medical supplies company limited, lot number 20110402).
1.2 experimental techniques
Choose the SD rat some that quarantine is qualified, first press capillary tube measurement by magnification method and measure volume based on the right metapedes volume of all animals, eliminate the rat that basis volume is too big or too little simultaneously.After the volume packet of basis, except naive animals, behind all the other animals all right sides, whole sole of the foot position subcutaneous injection 1% carrageenin 0.1ml/ is only, blank group injects isometric normal saline, again with volume whole behind the right side of the capillary tube measurement by magnification method all rats of measurement after about 2h after injection, and calculate its swelling, eliminate the rat of swelling < 0.3ml, satisfactory for swelling rat is divided into 7 groups according to paw swelling Stochastic Equilibrium, often group 10, respectively experimental group 1～4, model group, positive group (MAYINGLONG MUSK HEMORRHOID UNGUENTUM) and blank group.Require to smear medicine in rat swelling place according to packet after packet, model group wrapping paper adhesive plaster.Measure after administration about 1 respectively, 2,4, whole volume behind the right side of 6h so that scorching forward and backward sufficient volume difference is swelling, administration group compares with matched group, carries out statistical procedures.Dosage: in this experiment, the rat consumption of experimental group 1～4 smears the plaster of experimental example 1～4 respectively, dosage is 1.76g/kg.It is 1.76g/kg that positive controls smears the dosage of MAYINGLONG MUSK HEMORRHOID UNGUENTUM, and model group smears the distilled water of equivalent every day.
1.3 experimental results
Table 1 ZHICHUANG GAO on Carrageenan of the present invention cause rat paw edema impact (N=10)
Compare with model control group, * P < 0.05, * * P < 0.01.
As shown in Table 1, the ZHICHUANG GAO single abdominal part of the present invention is applied ointment or plaster and can substantially be reduced carrageenin and cause the paw swelling of SD rat after administration, and instant effect, drug effect peak time is 1h after administration, well below the drug effect peak time (after administration 4h) of positive controls.
2, the ZHICHUANG GAO impact on mice ear model
2.1 experimental techniques
Choose the ICR mice 60 that quarantine is qualified, male, it is randomly divided into 6 groups by body weight.Respectively model group, positive controls and experimental group 1～4, often group 10.Each group of mice being administered respectively, 1 time/d, continuous 5d, positive controls only last is administered 1 time, and model group smears the distilled water of equivalent every day.After last administration, the auris dextra profile of about 2h every mice of experimental group is coated with dimethylbenzene (0.04ml/ is only) and causes auricle edema, and left ear compares.After 120min, de-cervical vertebra puts to death mice, is cut with position homalographic by ears with the card punch of diameter 8mm, weighs by precision electronic balance, and the difference of left and right auricle weight is swelling.Medication is ibid.
2.2 experimental results
Table 2 ZHICHUANG GAO xylol of the present invention cause mice ear impact (N=10)
Group Left ear weight/mg Auris dextra weight/mg Auris dextra swelling/mg
Model group 11.2±0.6 23.5±1.7 12.3±1.7
Positive controls 11.4±0.8 15.9±1.9* 4.6±1.6*
Experimental group 1 10.5±0.7 12.6±2.0* 2.1±2.2**
Experimental group 2 11.3±1.2 13.2±2.5** 1.9±2.3**
Experimental group 3 10.9±0.8 12.2±1.8* 1.3±1.6*
Experimental group 4 11.0±0.9 12.8±2.1** 1.8±1.8*
Compare with model control group, * P < 0.05, * * P < 0.01.
As shown in Table 2, the continuous abdominal part of ZHICHUANG GAO of the present invention is applied ointment or plaster after being administered 5d can substantially reduce the mouse ear profile swelling that dimethylbenzene causes, and antiinflammatory action is substantially better than positive controls, it was shown that ZHICHUANG GAO has obvious antiinflammatory action.
3, mice Intradermal pigment oozes out method
Kunming mouse 60, body weight is 20～22g, male and female half and half, is randomly divided into 6 groups, experimental group 1～4, positive controls and model control group.Experimental group 1～4 smears the ZHICHUANG GAO that embodiment 1～4 prepares respectively；Positive controls smears MAYINGLONG MUSK HEMORRHOID UNGUENTUM；Model group smears distilled water.24h abdominal part depilation before experiment.Only medicaments uniformity is applied in abdominal part by 1g/, gauze wraps, residual drug is removed after 30min, only intradermal injection 0.5% histamine phosphate 0.03ml/ is hit exactly in abdominal part, and tail vein injection 0.5% Azo-Blue 0.1ml/10g immediately, after 20min, mice cervical dislocation is put to death, peel off skin of abdomen, overturn, carefully take off Evans Blue dye skin, shred and be placed in 10ml acetone-0.5% sodium sulfate (7:3) solution and soak 24h, filter, take filtrate to survey absorbance (OD) in 590nm place and OD value directly taken statistics process, experimental result is in Table 3.
Table 3 ZHICHUANG GAO histamine is caused effect that capillary permeability strengthens (N=10)
Group Number of animals OD
Model control group 10 0.114±0.022
Positive controls 10 0.075±0.012*
Experimental group 1 10 0.043±0.017**
Experimental group 2 10 0.045±0.021*
Experimental group 3 10 0.038±0.019*
Experimental group 4 10 0.046±0.020**
Compare with model control group, * P < 0.05, * * P < 0.01.
As shown in Table 3, the ZHICHUANG GAO of the present invention can cause mice capillary permeability to increase by antagonizing histamine, and effect is substantially better than MAYINGLONG MUSK HEMORRHOID UNGUENTUM.
4, mice docking bleeding time
Kunming mouse 60, body weight is 20～22g, male and female half and half, and medicine, with 3, by 0.5g/ only, is applied in mouse tail by packet.After 30min, mice is placed in special solids container, wipes residual drug, then cut off rat-tail point 0.5cm, treat that blood overflows voluntarily, suck drop of blood every 30s filter paper, during suction, firmly do not extrude section, being the bleeding time from being artificially formed wound surface to stopped bleeding institute elapsed time, result is in Table 4.
Table 4 ZHICHUANG GAO on mice dock the bleeding time impact (N=10)
Compare with model control group, * P < 0.05, * * P < 0.01.
As shown in Table 4, the ZHICHUANG GAO of the present invention has good anastalsis, and effect is substantially better than positive controls.

Claims (5)

1. ZHICHUANG GAO, it is characterised in that: the raw material including following weight portion is made: Herba Hyperici Patuli 1～5 part, Rhizoma Et Radix Notopterygii 1～5 part, Radix Saposhnikoviae 1～5 part, Rhizoma Arisaematis 1～5 part, the Radix Angelicae Dahuricae 1～5 part, Rhizoma Typhonii 10～15 parts.
2. ZHICHUANG GAO according to claim 1, it is characterised in that: the weight portion of each raw material is: Herba Hyperici Patuli 1 part, Rhizoma Et Radix Notopterygii 1 part, Radix Saposhnikoviae 1 part, Rhizoma Arisaematis 1 part, the Radix Angelicae Dahuricae 1 part, Rhizoma Typhonii 10 parts.
3. the ZHICHUANG GAO according to claim, it is characterised in that: its preparation method is by the Herba Hyperici Patuli of formula ratio, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae, Rhizoma Arisaematis, the Radix Angelicae Dahuricae and Rhizoma Typhonii co-grinding, adds unguentum customary adjuvant, to obtain final product.
4. ZHICHUANG GAO according to claim 3, it is characterised in that: it is crushed to 100～200 orders.
5. ZHICHUANG GAO according to claim 3, it is characterised in that: described adjuvant is one or more in paraffin, lanoline and vaseline.
CN201610351334.2A 2016-05-24 2016-05-24 Haemorrhoids paste Pending CN105770256A (en)

Priority Applications (1)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107468844A (en) * 2017-08-22 2017-12-15 王守峰 One kind fires anxious acne cream

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1724028A (en) * 2005-07-06 2006-01-25 郭萍 Traditional Chinese medicine for treating bed sore, and its prepn. method

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1724028A (en) * 2005-07-06 2006-01-25 郭萍 Traditional Chinese medicine for treating bed sore, and its prepn. method

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107468844A (en) * 2017-08-22 2017-12-15 王守峰 One kind fires anxious acne cream

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