CN107468844A - One kind fires anxious acne cream - Google Patents

One kind fires anxious acne cream Download PDF

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Publication number
CN107468844A
CN107468844A CN201710721265.4A CN201710721265A CN107468844A CN 107468844 A CN107468844 A CN 107468844A CN 201710721265 A CN201710721265 A CN 201710721265A CN 107468844 A CN107468844 A CN 107468844A
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parts
mentioned metering
chinese
extraction
anxious
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王守峰
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/614—Cnidaria, e.g. sea anemones, corals, coral animals or jellyfish
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/28—Mercury; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/237—Notopterygium
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238—Saposhnikovia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/38—Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/41—Crassulaceae (Stonecrop family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/739—Sanguisorba (burnet)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/86—Violaceae (Violet family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8884—Arisaema, e.g. Jack in the pulpit
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
    • A—HUMAN NECESSITIES
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    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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Abstract

It is specifically a kind of to fire anxious acne cream the present invention relates to field of medicaments.Raw material including following parts by weight is made：80 100 parts of 40 70 parts of yellow sea anemone, 30 40 parts of Herba Hyperici Patuli, windproof 30 60 parts, 10 30 parts of garden burnet, 30 60 parts of Chinese gall, 20 40 parts of castor bean, 20 40 parts of Chinese violet, 20 40 parts of arisacma consanguineum schott, 20 40 parts of notopterygium root, 20 40 parts of calamine, 20 40 parts of Orostachys fimbriatus, 20 40 parts of calomel mercurous chloride, 20 40 parts of catechu and vaseline；The medicinal material compounding of the present invention forms, there is good synergy in hemorrhoid treating, vascular resistance can be increased, reduce its permeability, reduce fragility, simultaneously can also anti-inflammatory go to swell, stop blooding, promoting wound repair and healing etc. to act on, have preferable therapeutic effect to symptoms such as the inflammation of hemorrhoid, swelling and bleedings.

Description

One kind fires anxious acne cream
Technical field
It is specifically a kind of to fire anxious acne cream the present invention relates to field of medicaments.
Background technology
" hemorrhoid of ten people nine ", the incidence of disease of hemorrhoid is high, accounts for the 87.25% of all anorectal diseases, and male's incidence of disease is 53.9%, The women incidence of disease is 67%.In terms of age of onset, the patient of 20-40 year is more, and aggravates with advancing age and gradually.
Clinical treatment method is a lot, is broadly divided into Nei Zhi and controls outside.Internal therapy from organic conception, evidence-based ask because, It is dialectical to treat, with oral drug therapy disease；External therapy is to use medicine, operation and other means, directly act on focus and Body surface corresponding site, to reach a kind for the treatment of method of therapeutic purposes.The more slowly effects of existing externally applied drug, curative effect is not good enough.
The reason for very common in the pathogenesis of hemorrhoid is exactly local vascular because inflammation or thrombus etc. cause its permeability to increase Add, composition largely oozes out blood vessel in blood, locally causes oedema and pain in hepatic portal, and aggravate the symptom of inflammation.Therefore, treat Hemorrhoid are exactly anti-inflammatory, detumescence, reduce vasopermeability and control bleeding.
The content of the invention
In view of the above-mentioned problems, in order to solve the deficiencies in the prior art, the present invention provides a kind of anxious acne cream of combustion.
Technical solution of the present invention is as follows：
One kind fires anxious acne cream, it is characterised in that：Raw material including following parts by weight is made：Yellow sea anemone 40-70 parts, spun gold Plum 30-40 parts, windproof 30-60 parts, garden burnet 10-30 parts, Chinese gall 30-60 parts, castor bean 20-40 parts, Chinese violet 20-40 Part, arisacma consanguineum schott 20-40 parts, notopterygium root 20-40 parts, calamine 20-40 parts, Orostachys fimbriatus 20-40 parts, calomel mercurous chloride 20-40 parts, catechu 20-40 Part and vaseline 80-100 parts；
Yellow sea anemone, calamine, Orostachys fimbriatus, calomel mercurous chloride press the direct grinds of above-mentioned metering；
Herba Hyperici Patuli crushed 40 mesh sieves by above-mentioned metering, load extractor, using carbon dioxide supercritical extraction, extraction pressure Power is 35~40MPa, and extraction temperature is 38~42 DEG C, and extraction time is 100~105min, 20~30kg/h of CO2 flows；It must extract Take rear pulvis；
After windproof, Chinese violet, notopterygium root and catechu decoct 6-8 hours by above-mentioned metering, heating evaporation is condensed into powder；
After garden burnet crushes, add the deionized water of 6-10 times of weight, soak 1-3 hours, ultrasonic wave extraction 10-15 minutes, mistake Filter, centrifugation, discard precipitation supernatant concentration, obtained Radix Sangusorbae extract, control Radix Sangusorbae extract density is left in 1.05g/cm3 It is right；
Chinese gall selection grown up to and the aphid of the inside not yet through goitre wall when, by above-mentioned metering pluck after use boiling water in time Scalding, when Chinese gall surface switchs to grey by yellowish-brown, pull out immediately and dry or dry, ground into end；
After castor bean is by above-mentioned metering peeling, fries to outer layer is golden yellow and be milled into powder, arisacma consanguineum schott is kept away after being plucked by above-mentioned metering Exempt from Exposure to Sunlight, with cold water leaching drift to when playing foam, water is changed, repeatedly until immersion 3-5 days；Taking-up is dried, ground into end；
Directly mixing is well mixed with being heated to 50-80 DEG C of vaseline and ointment is made after above-mentioned raw materials processing.
Compared with other common organic fertilizers, main advantages of the present invention are：
The medicinal material compounding of the present invention forms, and has good synergy in hemorrhoid treating, can increase vascular resistance, drops Its low permeability, reduces fragility, at the same can also anti-inflammatory go to swell, stop blooding, promoting wound repair and healing etc. to act on, to the inflammation of hemorrhoid The symptoms such as disease, swelling and bleeding have preferable therapeutic effect.
Due to the present invention use Chinese herbal medicine as raw material, action temperature with, have no toxic side effect.
Embodiment
The present invention is described in detail below by embodiment.
Embodiment 1 (in terms of ratio of weight and number, similarly hereinafter)
Raw material including following parts by weight is made：50 parts of yellow sea anemone, 35 parts of Herba Hyperici Patuli, windproof 35 parts, 20 parts, five times of garden burnet 40 parts of son, 25 parts of castor bean, 25 parts of Chinese violet, 25 parts of arisacma consanguineum schott, 35 parts of notopterygium root, 35 parts of calamine, 30 parts of Orostachys fimbriatus, calomel mercurous chloride 25 100 parts of part, 25 parts of catechu and vaseline；
Yellow sea anemone, calamine, Orostachys fimbriatus, calomel mercurous chloride press the direct grinds of above-mentioned metering；
Herba Hyperici Patuli crushed 40 mesh sieves by above-mentioned metering, load extractor, using carbon dioxide supercritical extraction, extraction pressure Power is 35~40MPa, and extraction temperature is 38~42 DEG C, and extraction time is 100~105min, 20~30kg/h of CO2 flows；It must extract Take rear pulvis；
After windproof, Chinese violet, notopterygium root and catechu decoct 6-8 hours by above-mentioned metering, heating evaporation is condensed into powder；
After garden burnet crushes, add the deionized water of 6-10 times of weight, soak 1-3 hours, ultrasonic wave extraction 10-15 minutes, mistake Filter, centrifugation, discard precipitation supernatant concentration, obtained Radix Sangusorbae extract, control Radix Sangusorbae extract density is left in 1.05g/cm3 It is right；
Chinese gall selection grown up to and the aphid of the inside not yet through goitre wall when, by above-mentioned metering pluck after use boiling water in time Scalding, when Chinese gall surface switchs to grey by yellowish-brown, pull out immediately and dry or dry, ground into end；
After castor bean is by above-mentioned metering peeling, fries to outer layer is golden yellow and be milled into powder, ripe shared state is given birth in forming component,
Arisacma consanguineum schott by above-mentioned metering pluck after avoid Exposure to Sunlight, with cold water leaching drift to rise foam when, change water, repeatedly until Immersion 3-5 days；Taking-up is dried, ground into end；
Directly mixing is well mixed with being heated to 50-80 DEG C of vaseline and ointment is made after above-mentioned raw materials processing.
Application effect
Clinical case is as follows：
Cai：Man, 30 years old, crissum swelling and pain, per anum inspection was diagnosed as that thrombotic is external, and crissum hemotoncus is obvious.Use this hemorrhoid 3 days after cream, hemotoncus is obviously reduced, and hemotoncus is completely eliminated after 7 days.
Zhao：Female, 21 years old, perianal abscess, after this acne cream 3 days, abscess ulceration, wound healing after 10 days.
Huang：Man, 36 years old, 3 months or so wounds of anal fistula Post operation failed to heal, and using this acne cream 15 days, wound was complete Heal in portion.
Zheng：Man, 65 years old, mixed hemorrhoid operating rear wound infection pain, concurrent unboiled water swelled, using after this acne cream, pain It is clearly better with oedema, wound healing after 10 days.
Mr. Wang, male 55 years old, hemorrhoid cutting operation postoperative infection, using acne cream of the present invention, fully recover within 7 days.
150 hemorrhoid patients are chosen,
Mainly to have blood in stool, secretion is more, itch based on patients with mild cure whole positive effects in 7 days, thoroughly controlled after 15 days More, without recurrence after 1 year；
Have blood in stool, hemorrhoid prolapse with defecation, but voluntarily can also receive moderate patient and cure 7 days, and more than 90% positive effect is a small number of People feel unobvious, after 15 days, only 1 people to no effect, without recurrence after 1 year；
Interior prolapse of hemorrhoid is in outside anal orifice, or every time outside defecation abjection anal orifice, it is impossible to voluntarily also receives, it is necessary to returned with hand rest Severe patient cure 7 days, more than 70% positive effect, a few peoples feel unobvious, after 15 days, only 2 people to no effect, after 1 year 1 people is recurred.

Claims (1)

1. one kind fires anxious acne cream, it is characterised in that：Raw material including following parts by weight is made：Yellow sea anemone 40-70 parts, Herba Hyperici Patuli 30-40 parts, windproof 30-60 parts, garden burnet 10-30 parts, Chinese gall 30-60 parts, castor bean 20-40 parts, Chinese violet 20-40 parts, Arisacma consanguineum schott 20-40 parts, notopterygium root 20-40 parts, calamine 20-40 parts, Orostachys fimbriatus 20-40 parts, calomel mercurous chloride 20-40 parts, catechu 20-40 parts and Vaseline 80-100 parts；
Yellow sea anemone, calamine, Orostachys fimbriatus, calomel mercurous chloride press the direct grinds of above-mentioned metering；
Herba Hyperici Patuli crushed 40 mesh sieves by above-mentioned metering, load extractor, using carbon dioxide supercritical extraction, extracting pressure is 35~40MPa, extraction temperature are 38~42 DEG C, and extraction time is 100~105min, 20~30kg/h of CO2 flows；After must extracting Pulvis；
After windproof, Chinese violet, notopterygium root and catechu decoct 6-8 hours by above-mentioned metering, heating evaporation is condensed into powder；
After garden burnet crushes, add the deionized water of 6-10 times of weight, soak 1-3 hours, ultrasonic wave extraction 10-15 minutes, filtering, from The heart, discard and precipitate supernatant concentration, Radix Sangusorbae extract is made, control Radix Sangusorbae extract density is in 1.05g/cm3 or so；
Chinese gall selection grown up to and the aphid of the inside not yet through goitre wall when, by above-mentioned metering pluck after soaked in time with boiling water Scald, when Chinese gall surface switchs to grey by yellowish-brown, pull out immediately and dry or dry, ground into end；
After castor bean is by above-mentioned metering peeling, fries to outer layer is golden yellow and be milled into powder, arisacma consanguineum schott avoids day after being plucked by above-mentioned metering Shine, with cold water leaching drift to when playing foam, water is changed, repeatedly until immersion 3-5 days；Taking-up is dried, ground into end；
Directly mixing is well mixed with being heated to 50-80 DEG C of vaseline and ointment is made after above-mentioned raw materials processing.
CN201710721265.4A 2017-08-22 2017-08-22 One kind fires anxious acne cream Pending CN107468844A (en)

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Application Number Priority Date Filing Date Title
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3935310A (en) * 1974-03-07 1976-01-27 Homan John D Remedy for treatment of hemorrhoids
CN101045104A (en) * 2007-04-24 2007-10-03 张秀丽 External use suppository for treating hemorrhoids
CN105770256A (en) * 2016-05-24 2016-07-20 李玉兰 Haemorrhoids paste

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3935310A (en) * 1974-03-07 1976-01-27 Homan John D Remedy for treatment of hemorrhoids
CN101045104A (en) * 2007-04-24 2007-10-03 张秀丽 External use suppository for treating hemorrhoids
CN105770256A (en) * 2016-05-24 2016-07-20 李玉兰 Haemorrhoids paste

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