CN102671091B - Medicine composition for preventing surgical postoperative uroschesis - Google Patents
Medicine composition for preventing surgical postoperative uroschesis Download PDFInfo
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- CN102671091B CN102671091B CN2012101698539A CN201210169853A CN102671091B CN 102671091 B CN102671091 B CN 102671091B CN 2012101698539 A CN2012101698539 A CN 2012101698539A CN 201210169853 A CN201210169853 A CN 201210169853A CN 102671091 B CN102671091 B CN 102671091B
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Abstract
The invention discloses a medicine composition for preventing surgical postoperative uroschesis. The medicine composition is characterized in that raw material medicine consists of aralis tengyuch euonymus bark, cowherb seed, resurrection lily rhizome, saponin, fistular onion stalk, almond, mother chrysanthemum, elecampane, borneol and peach gum. Clinical study results show that the medicine composition can reduce the occurrence rate of the surgical postoperative uroschesis, the urination condition of patients is effectively relieved, the safety performance is good, the operation is simple and convenient, the painlessness is realized, and the medicine composition can be easily accepted by patients.
Description
[technical field]
The present invention relates to the field of Chinese medicines, be specifically related to treat a kind of pharmaceutical composition for the prevention of surgical postoperative urine retention.
[background technology]
The surgical postoperative urine retention is the modal complication of abdominal surgery, polyphyly anesthesia reaction inhibition micturition reflex or abdominal muscular relaxation, bladder muscle Tension Difference, the pressure that inside is increased is insensitive, the incision pain reflexive causes the sphincter of urethra spasm and uncomfortablely urinates in bed, due to the reasons such as tearing wound of being afraid of firmly to urinate.Especially for Elderly male patient, may cause that the incidence rate of urine retention is more higher than general patient because of recessive or dominant prostate hyperplasia.Once urine retention fails to get rid of in time, expansion of the bladder is excessively of a specified duration, and muscle loses contractility, is difficult in a short time recovering, and to the patient, brings adverse consequences.The normal employing of the method for traditional treatment urine retention listened a singing of the stream, hot compress, massage hypogastric region induced uresis, also adopts intramuscular injection neostigmine method, invalid after, finally need urethral catheterization.And indwelling catheter can cause suffering and inconvenience to the patient, also can increase the chance of urinary tract infection.
[summary of the invention]
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly, can be for the pharmaceutical composition of prevention of surgical postoperative urine retention.
The technical scheme that the present invention solves its technical problem is: a kind of pharmaceutical composition for the prevention of surgical postoperative urine retention, it is characterized in that making 14 ~ 20 parts of: Cortex araliae chinensis by the crude drug of following weight proportion, 10 ~ 16 parts of Semen Vaccariae, 10 ~ 16 parts of Rhizoma Kaempferiae, 10 ~ 16 parts of Fructus Gleditsia, 10 ~ 16 parts of Bulbus Allii Fistulosi, 6 ~ 10 parts, Semen Armeniacae Amarum, 14 ~ 20 parts of Flos Chrysanthemi Indicis, 14 ~ 20 parts of Radix Inulaes, 1 ~ 2 part of Borneolum Syntheticum, 3 ~ 5 parts of gumshiraz.
It optimizes weight proportion is 16 parts of: Cortex araliae chinensis, 12 parts of Semen Vaccariae, 12 parts of Rhizoma Kaempferiae, 12 parts of Fructus Gleditsia, 12 parts of Bulbus Allii Fistulosi, 8 parts, Semen Armeniacae Amarum, 16 parts of Flos Chrysanthemi Indicis, 16 parts of Radix Inulaes, 1 part of Borneolum Syntheticum, 4 parts of gumshiraz.
Wherein said:
Cortex araliae chinensis, for Wu adds the phloem of the Zhi Wu of section Cortex araliae chinensis.Warm in nature, distinguish the flavor of micro-salty.Enter liver, the heart, kidney three warps.Stomach invigorating is arranged, convergence, diuresis and sugaring effect.
Semen Vaccariae is the seed of pinkwort Vaccaria segetalis.Hardship, flat.Return liver, stomach warp.Promoting blood circulation to restore menstrual flow, the stimulating milk secretion detumescence.
Rhizoma Kaempferiae is the dry rhizome of zingiberaceous plant Rhizoma Kaempferiae.The nature and flavor suffering, temperature.Return the stomach warp.In the feasible temperature of merit, help digestion, pain relieving.
Fructus Gleditsia is the dry Fructus Gleditsia of leguminous plant.The nature and flavor suffering, temperature.Return liver, stomach warp.The merit poison holding of can subsiding a swelling, evacuation of pus, parasite killing.
Bulbus Allii Fistulosi, be the cauloid of Liliaceae allium Herba Alii fistulosi, and merit can be delivered and activate yang, the removing toxic substances parasite killing.
Semen Armeniacae Amarum, be the seed of rosaceous plant Fructus Pruni, wild apricot, Prunus armeniaca L.var.ansu Maxim., prunus mandshuricaKoehne, but the merit lung qi dispersing, loosening bowel to relieve constipation.
Flos Chrysanthemi Indici, be the head inflorescence of Compositae herbaceos perennial Herba Dendranthematis indici, but the merit heat-clearing and toxic substances removing, detumescence.
Radix Inulae is the dry root of feverfew Radix Inulae or Radix Inulae.Nature and flavor are hot, bitter, temperature.Return liver, spleen channel.But the merit invigorating the spleen and regulating the stomach, promoting the flow of QI for relieving the stagnancy, pain relieving is antiabortive.
Borneolum Syntheticum, be the processed goods of Spore density Borneolum Syntheticum resin, or be Camphora, Lignum Pini Nodi wet goods the be processed into product synthetic by chemical method.Nature and flavor are hot, bitter, are slightly cold.GUIXIN, spleen, lung meridian.The merit refreshment of can having one's ideas straightened out, clearing away heat to alleviate pain.
Gumshiraz is the dry upper resin flowed out of rosaceous plant peach tree, is water-soluble gum.But the merit removing heat from blood and promoting blood circulation, benefiting qi for promoting granulation.
Composition principle: the surgical postoperative urine retention refers to that the surgical postoperative intravesical is full of urine and can not discharges, and primary disease belongs to the traditional Chinese medical science " difficulty in urination ", " stranguria with turbid discharge " category.Its major lesions, at bladder, is controlled and should be adjusted smooth three warmers mechanism of qi, tonneau bladder.Cortex araliae chinensis can play diuresis; The Semen Vaccariae promoting blood circulation to restore menstrual flow, Rhizoma Kaempferiae circulation of qi promoting warming middle-JIAO, control from vim and vigour respectively; Fructus Gleditsia detumescence poison holding, Bulbus Allii Fistulosi is activated yang, and Semen Armeniacae Amarum a surname send out, the unobstructed yang-energy of this three; The Flos Chrysanthemi Indici heat-clearing and toxic substances removing; The Radix Inulae promoting the flow of QI for relieving the stagnancy; Borneolum Syntheticum increases transdermal absorption factor; Gumshiraz removing heat from blood and promoting blood circulation and can increase local adhesive ability.
In sum, this product compound basis Chinese herb decoction opinion is administered opinion and is obtained in conjunction with the modern medicine and pharmacology result of study coordinates, play altogether logical urinary bladder channel yang-energy, the heat clearing away of invigorating blood circulation, the effect of diuresis resolving depression, thereby can reduce the incidence rate of surgical postoperative urine retention, effectively improve patient's the situation of urinating, safety is good, easy and simple to handle, painless, the patient is easy to accept.
[specific embodiment]
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1,14 parts of crude drug weight proportion: Cortex araliae chinensis, 10 parts of Semen Vaccariae, 10 parts of Rhizoma Kaempferiae, 10 parts of Fructus Gleditsia, 10 parts of Bulbus Allii Fistulosi, 6 parts, Semen Armeniacae Amarum, 14 parts of Flos Chrysanthemi Indicis, 14 parts of Radix Inulaes, 1 part of Borneolum Syntheticum, 3 parts of gumshiraz.
Preparation method is as follows: get broken mistake 100 mesh sieves of above-mentioned raw materials medicated powder, mix homogeneously, during use, add 60 ℃ of hot water, stirs to obtain thick paste shape product.
Embodiment 2,20 parts of crude drug weight proportion: Cortex araliae chinensis, 16 parts of Semen Vaccariae, 16 parts of Rhizoma Kaempferiae, 16 parts of Fructus Gleditsia, 16 parts of Bulbus Allii Fistulosi, 10 parts, Semen Armeniacae Amarum, 20 parts of Flos Chrysanthemi Indicis, 20 parts of Radix Inulaes, 2 parts of Borneolum Syntheticums, 5 parts of gumshiraz.
The following: Qu of preparation method Cortex araliae chinensis, Semen Vaccariae, Rhizoma Kaempferiae, Fructus Gleditsia, Bulbus Allii Fistulosi, Semen Armeniacae Amarum, Flos Chrysanthemi Indici, Radix Inulae decoct twice, each 0.5 hour, boiling liquid filters, boil in liquid the gumshiraz coarse powder added after pulverizing, heat 80 ℃ and melt fully to gumshiraz, be concentrated into relative density 1.20 ~ 1.25, temperature adds the Borneolum Syntheticum after pulverizing while being down to 40 ℃, and stir, obtain thick paste shape product.
Embodiment 3,16 parts of crude drug weight proportion: Cortex araliae chinensis, 12 parts of Semen Vaccariae, 12 parts of Rhizoma Kaempferiae, 12 parts of Fructus Gleditsia, 12 parts of Bulbus Allii Fistulosi, 8 parts, Semen Armeniacae Amarum, 16 parts of Flos Chrysanthemi Indicis, 16 parts of Radix Inulaes, 1 part of Borneolum Syntheticum, 4 parts of gumshiraz.Preparation method is as embodiment 1.
Embodiment 4,16 parts of crude drug weight proportion: Cortex araliae chinensis, 12 parts of Semen Vaccariae, 12 parts of Rhizoma Kaempferiae, 12 parts of Fructus Gleditsia, 12 parts of Bulbus Allii Fistulosi, 8 parts, Semen Armeniacae Amarum, 16 parts of Flos Chrysanthemi Indicis, 16 parts of Radix Inulaes, 1 part of Borneolum Syntheticum, 4 parts of gumshiraz.Preparation method is as embodiment 2.
The using method of embodiment 1 ~ 4 is: get 30 ~ 40 gram gained thick pastes, fill up umbilical opening and around, gauze is soaked and wrings out in hot water, spread on umbilical part, the insulation of upper cover hot water bag, each 1 hour, 2 times on the one after folding.
The present invention can effectively reach and improve surgical postoperative urine retention symptom, and side effect is less.The above results is the clinical data sufficient proof, and interrelated data is as follows, and wherein the drugs use is the crude drug weight proportion in embodiment 4.
1 object and method
1.1 object: be in January, 2010 ~ 2010 year December inpatient 120 examples in my institute's anorectal disease postoperative urine retention, be divided at random two groups, treatment group 60 examples, male 44 examples, female's 16 examples, 34～62 years old age, average (43.6 ± 6.7) year.Matched group 60 examples, male 46 examples, female's 14 examples, 33～63 years old age, average (45.6 ± 7.4) year.Two groups of ages, sex, mixed hemorrhoid are by stages, consuming time, the operative incision number of performing the operation etc. learns by statistics and process, and difference there are no significant meaning (P > 0.05), there is comparability.
1.2 method:
1.2.1 research method: treatment group Application Example 4 gained pharmaceutical compositions, using method is for getting 30 ~ 40 gram gained thick pastes, fill up umbilical opening and around, gauze is soaked and wrings out in hot water, after folding, spread on umbilical part, the insulation of upper cover hot water bag, each 1 hour, 2 times on the one.The conventional intramuscular injection neostigmine of matched group medicinal liquid 2ml.
The number of cases that (being urine retention) occurs 1.2.2 do not urinate yet in voluntary micturition patient's urination time first in observation index record 10 hours, postoperative voided volume first, postoperative 10 hours total volume of urine, postoperative >=10 hour.
1.2.3 statistical analysis adopts the SPSS16.0 building database to go forward side by side line number according to one's analysis.Measurement data adopts the t check; Enumeration data adopts X 2 test.P<0.05 means to have significant.
2 results
2.1 a situation arises for two groups of urine retention in postoperative 10 hours relatively: after two groups of operation in patients in 10 hours urine retention incidence rate treatment group be 10.0%, matched group be 28.3%, two group of urine retention incidence rate relatively, difference has significant (P<0.05).
2.2 urination time is relatively first for two groups of postoperative voluntary micturition patients: two groups of postoperative voluntary micturition patient numbers and first the urination time treatment group be 54 examples, (6.34 ± 0.17) hour, matched group is 43 examples, (9.56 ± 0.36) hour, two groups relatively, and difference is very significant (P<0.01).
2.3 two groups of postoperative voluntary micturition patient voided volume, total volume of urine comparisons in postoperative 10 hours first: see the following form.Relatively, difference is very significant (P<0.01) to two groups of postoperative voided volume first; Relatively, difference is very significant (P<0.01) to two groups of postoperative 10 hours total volume of urine.
The postoperative voluntary micturition patient of table two group voided volume, postoperative 10 hours total volume of urine first compares (ml)
| n | Voided volume first | Postoperative 10 hours total volume of urine | |
| Treatment group | 54 | 130.00±25.22 | 977.89±104.12 |
| Matched group | 43 | 56.14±14.36 | 746.48±83.69 |
2.4 untoward reaction patient's vital sign (blood pressure, heart rate, body temperature, breathing), physical examination, blood biochemical analysis, electrocardiogram and routine urinalysis Non Apparent Abnormality during treating.
3. conclusion: the prompting of this result of study, the present invention is not only playing a role aspect the generation of prevention of postoperative urine retention, and is promoting postoperative patient to urinate and have certain effect as early as possible, and the untoward reaction occurred is few.
Claims (2)
1. the pharmaceutical composition for the prevention of surgical postoperative urine retention, it is characterized in that making 14～20 parts of: Cortex araliae chinensis by the crude drug of following weight proportion, 10～16 parts of Semen Vaccariae, 10～16 parts of Rhizoma Kaempferiae, 10～16 parts of Fructus Gleditsia, 10～16 parts of Bulbus Allii Fistulosi, 6～10 parts, Semen Armeniacae Amarum, 14～20 parts of Flos Chrysanthemi Indicis, 14～20 parts of Radix Inulaes, 1～2 part of Borneolum Syntheticum, 3～5 parts of gumshiraz; While treating, adopt umbilical dressing method.
2. a kind of pharmaceutical composition for the prevention of surgical postoperative urine retention according to claim 1, it is characterized in that making 16 parts of: Cortex araliae chinensis by the crude drug of following weight proportion, 12 parts of Semen Vaccariae, 12 parts of Rhizoma Kaempferiae, 12 parts of Fructus Gleditsia, 12 parts of Bulbus Allii Fistulosi, 8 parts, Semen Armeniacae Amarum, 16 parts of Flos Chrysanthemi Indicis, 16 parts of Radix Inulaes, 1 part of Borneolum Syntheticum, 4 parts of gumshiraz.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101698539A CN102671091B (en) | 2012-05-28 | 2012-05-28 | Medicine composition for preventing surgical postoperative uroschesis |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012101698539A CN102671091B (en) | 2012-05-28 | 2012-05-28 | Medicine composition for preventing surgical postoperative uroschesis |
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| CN102671091A CN102671091A (en) | 2012-09-19 |
| CN102671091B true CN102671091B (en) | 2013-12-04 |
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| CN103341108B (en) * | 2013-07-01 | 2015-05-20 | 黑龙江中医药大学 | Pharmaceutical composite for treating stress urinary incontinence after prostatectomy |
| CN104547594B (en) * | 2015-01-29 | 2015-09-16 | 陈柍汛 | A kind of Chinese medicine for the treatment of Qi-stagnation type abdominal postoperative urine retention |
| CN105288179A (en) * | 2015-10-13 | 2016-02-03 | 陈希云 | Traditional Chinese medicine hot-compress agent for treating postoperative urinary retention of mixed hemorrhoid and nursing method |
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| CN102228603B (en) * | 2011-06-16 | 2012-08-29 | 莫忆鸣 | Chinese medicine for treating retention of urine |
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Granted publication date: 20131204 Termination date: 20140528 |