CN102847058B

CN102847058B - Pharmaceutical composition for treating urinary retention after caesarean section

Info

Publication number: CN102847058B
Application number: CN 201210101948
Authority: CN
Inventors: 于泳; 李冬侠; 李月兰
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-04-10
Filing date: 2012-04-10
Publication date: 2013-10-16
Anticipated expiration: 2032-04-10
Also published as: CN102847058A

Abstract

The invention discloses a pharmaceutical composition for treating urinary retention after caesarean section. The pharmaceutical composition comprises cape jasmine, radix curcumae, fried white peony root, rhizoma alismatis, epimeddium, herba taxilli, mulberry, capillary wormwood, diplazium subsinuatum, and squill. Clinical research results show that the pharmaceutical composition disclosed herein can reduce the occurrence of urinary retention after caesarean section, effectively improve urination of patients, and has the advantages of good safety, simple operation, and no pain, and is easily accepted by patients.

Description

A kind of pharmaceutical composition for urine retention behind the cesarean section

Technical field

The present invention relates to the field of Chinese medicines, be specifically related to treat a kind of pharmaceutical composition for urine retention behind the cesarean section.

Background technology

Urine retention polyphyly anesthesia reaction inhibition micturition reflex or abdominal muscular relaxation, bladder muscle Tension Difference behind the cesarean section, insensitive to the pressure that inside increases, the incision pain reflexive causes the sphincter of urethra spasm and uncomfortablely urinates in bed, and the puerpera is afraid of firmly to urinate due to the reasons such as tearing wound.Urine retention also often affects uterine contraction in case generation not only can cause cystitis, causes the vaginal hemorrhage amount to increase, and increases incision pain, not only increases misery to the puerpera, also is the key factor that causes the urinary system infection in puerperal.The normal employing of the method for traditional treatment urine retention listened a singing of the stream, hot compress, massage hypogastric region induced uresis, also adopts intramuscular injection neostigmine method, invalid after, finally need urethral catheterization.And indwelling catheter can cause suffering and inconvenience to the patient, also can increase the chance of urinary tract infection.

Summary of the invention

Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly, can be for the pharmaceutical composition of urine retention behind the cesarean section.

The technical scheme that the present invention solves its technical problem is: a kind of pharmaceutical composition for urine retention behind the cesarean section, it is characterized in that being made by the crude drug of following weight proportion: 14 ~ 20 parts of Fructus Gardeniaes, 10 ~ 16 parts of Radix Curcumaes, 10 ~ 16 parts of Radix Paeoniae Alba (parched)s, 10 ~ 16 parts of RHIZOMA ALISMATISs, 10 ~ 16 parts of Herba Epimedii, 6 ~ 10 parts of Herba Taxillis, 14 ~ 20 parts of Fructus Mori, 14 ~ 20 parts of capillary wormwoods, 10 ~ 15 parts of Diplazium lanceum (Thunb)s, 3 ~ 5 parts of Bulbus scillae scilloidiss.

It optimizes weight proportion: 16 parts of Fructus Gardeniaes, 12 parts of Radix Curcumaes, 12 parts of Radix Paeoniae Alba (parched)s, 12 parts of RHIZOMA ALISMATISs, 12 parts of Herba Epimedii, 8 parts of Herba Taxillis, 16 parts of Fructus Mori, 16 parts of capillary wormwoods, 12 parts of Diplazium lanceum (Thunb)s, 4 parts of Bulbus scillae scilloidiss.

Wherein said:

Fructus Gardeniae is the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae Gardenia jasminoides Ellis.Nature and flavor are bitter, and are cold.GUIXIN, lung, tri-jiao channel.But merit pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.

Radix Curcumae is the dried root of zingiberaceous plant RADIX CURCUMAE Curcuma wenyujin Y. H. Chen et C. Ling, Rhizoma Curcumae Longae Curcuma longa L., Guangxi zedoary Curcuma kwangsiensis S. G. Lee et C. F. Liang or Rhizoma Curcumae Curcuma phaeocaulis Val..Nature and flavor are hot, bitter, and are cold.Return liver, the heart, lung meridian.But the merit regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.

Radix Paeoniae Alba (parched) is that the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall. is fried to little yellow.Nature and flavor are bitter, sour, are slightly cold.Return liver, spleen channel.But the pain relieving of merit suppressing the hyperactive liver, nourishing blood for regulating menstruation, astringing YIN to stop sweating.

RHIZOMA ALISMATIS is the dry tuber of Notes On Alism At Aceae Rhizoma Alismatis Alisma orientalis (Sam.) Juzep..Nature and flavor are sweet, and are cold.Return kidney, urinary bladder channel.But the merit diuresis, clearing away damp-heat.

Herba Epimedii is the dry aerial parts of Berberidaceae plant Herba Epimedii Epimedium brevicornum Maxim., arrow leaf Herba Epimedii Epimedium sagittatum (Sieb.et Zucc.) Maxim., pubescence Herba Epimedii Epimedium pubescens Maxim., Epimedium wushanense Epimedium wushanense T.S.Ying or Herba Epimedii Epimedium koreanum Nakai.Nature and flavor are hot, sweet, temperature.Return liver, kidney channel.But the merit kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.

Herba Taxilli is the dry stem and branch with leaf of Loranthaceae plant Herba Taxilli Taxillus chinensis (DC.) Danser.Nature and flavor are bitter, sweet, and are flat.Return liver, kidney channel.But the merit invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit.

Fructus Mori is the dry fruit ear of moraceae plants Mulberry Morus alba L..Nature and flavor are sweet, sour, and are cold.GUIXIN, liver, kidney channel.The merit YIN nourishing of can enriching blood is promoted the production of body fluid and is moisturized.

Capillary wormwood is the dry aerial parts of feverfew Artemisia scoparia Waldst. et Kit. Artemisia scoparia Waldst. et Kit. or Herba Artemisiae Scopariae Artemisia capillaris Thunb..Nature and flavor are bitter, hot, are slightly cold.Return spleen, stomach, liver, gallbladder meridian.But the merit clearing away damp-heat, the jaundice eliminating subcutaneous ulcer.

Diplazium lanceum (Thunb) is herb, the root stock of fern Athyriaceae lance leaf female dragon Diplazium lanceum (Thunb.) Presl.Sweet, hot, little hardship, cold.Clearing away heat and cooling blood, diuresis.

Bulbus scillae scilloidis is bulb or the whole herb with root of Liliaceae Scilla plant Bulbus scillae scilloidis Scilla scilloides (Lindl.) Druce [Scilla sinensis (Lour.) Merr.].Sweet, bitter, cold.The heart tonifying diuresis, reducing swelling and alleviating pain, detoxifcation.

Composition principle: urine retention refers to behind the cesarean section that intravesical is full of urine and can not discharges behind the cesarean section, and primary disease belongs to the traditional Chinese medical science " difficulty in urination ", " stranguria with turbid discharge " category.The normal discharge of urine is the functioning of bladder adjusting, open the normal of entire function and the gasification of bladder depends on kidney, therefore primary disease and kidney are in close relations, puerperal deficiency of kidney-QI, disturbance in functioning of QI and to cause damp and hot Yun Ji be the basic of primary disease, controlling should kidney-replenishing blood-nourishing, activating QI tonneau, clearing heat and expelling damp.In the prescription of the present invention: the Fructus Gardeniae clearing away heat and promoting diuresis, the Radix Curcumae regulating qi to disperse stagnation, Radix Paeoniae Alba (parched), the Fructus Mori YIN nourishing of enriching blood, RHIZOMA ALISMATIS, capillary wormwood diuresis clearing away damp-heat, Herba Epimedii, Herba Taxilli kidney-replenishing, the diuresis of Diplazium lanceum (Thunb) clearing away heat and cooling blood, Bulbus scillae scilloidis heart tonifying inducing diuresis to remove edema, modern pharmacological research shows, Diplazium lanceum (Thunb), Bulbus scillae scilloidis all can excited smooth muscle of bladder.

For safety, remove puerpera's misery fast and effectively, best applications of the present invention is the water decoction coloclysis, can stimulate enterokinesia after the coloclysis, nerve sacral nerves especially at the bottom of the reflex excitation basin, thereby detrusor of bladder is shunk, and bladder pressure increases, and impels and urinates.

In sum, this product compound basis Chinese herb decoction opinion is administered opinion and is got in conjunction with the modern medicine and pharmacology result of study cooperates, and all medicines share, and arrogant in then, air water is capable, rises clearly turbid falling, and urine is got profit.Add nursing staff's assistance and the nervous fear that the puerpera is in time eliminated in psychological counseling, obtain preferably cooperation, the very fast empty bladder of puerpera also recovers normal voiding, the urinary tract infection of having avoided urethral catheterization to cause.

The specific embodiment

Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.

Embodiment 1, the crude drug weight proportion: 14 parts of Fructus Gardeniaes, 10 parts of Radix Curcumaes, 10 parts of Radix Paeoniae Alba (parched)s, 10 parts of RHIZOMA ALISMATISs, 10 parts of Herba Epimedii, 6 parts of Herba Taxillis, 14 parts of Fructus Mori, 14 parts of capillary wormwoods, 10 parts of Diplazium lanceum (Thunb)s, 3 parts of Bulbus scillae scilloidiss.

Embodiment 2, the crude drug weight proportion: 20 parts of Fructus Gardeniaes, 16 parts of Radix Curcumaes, 16 parts of Radix Paeoniae Alba (parched)s, 16 parts of RHIZOMA ALISMATISs, 16 parts of Herba Epimedii, 10 parts of Herba Taxillis, 20 parts of Fructus Mori, 20 parts of capillary wormwoods, 15 parts of Diplazium lanceum (Thunb)s, 5 parts of Bulbus scillae scilloidiss.

Embodiment 3, the crude drug weight proportion: 16 parts of Fructus Gardeniaes, 12 parts of Radix Curcumaes, 12 parts of Radix Paeoniae Alba (parched)s, 12 parts of RHIZOMA ALISMATISs, 12 parts of Herba Epimedii, 8 parts of Herba Taxillis, 16 parts of Fructus Mori, 16 parts of capillary wormwoods, 12 parts of Diplazium lanceum (Thunb)s, 4 parts of Bulbus scillae scilloidiss.

The preparation method of embodiment 1 ~ 3 is as follows: get the water that all medicines add 3 times of volumes, decoct twice, each 0.5 hour, boil liquid and filter rear the merging.

The using method of embodiment 1 ~ 3 is: get the above-mentioned liquid 150ml that boils and filter in the disposable enemas bag, advise puerpera's left lateral position, the both legs flexing, insert gently anus 15 ~ 20cm after anal canal is lubricated, slowly inject medicinal liquid, pressure low (liquid level is no more than 30cm apart from anus) with buttocks bed hedgehopping 10cm, keeps 30min after the injection as far as possible.

The present invention can effectively reach and improve urine retention symptom behind the cesarean section, and side effect is less.The above results is the clinical data sufficient proof, and interrelated data is as follows, and wherein drugs uses and is the crude drug weight proportion among the embodiment 3.

1 object and method

1.1 object: be to add epidural at lumbar anesthesia in March, 2010 ~ 2011 year October to anaesthetize descending cesarean section childbirth, 24h pulls out urinary retention puerpera 80 examples behind the urinary catheter.At 20 ~ 38 years old age, be divided at random two groups and observe contrast.Two groups of ages, cesarean section indication and filling of bladder degree are Epidemiological Analysis by statistics, and difference there are no significant meaning (P〉0.05), have comparability.

1.2 method:

1.2.1 research method: treatment group Application Example 3 gained pharmaceutical compositions, using method is filtered in the disposable enemas bag for boiling liquid 150ml, advise puerpera's left lateral position, the both legs flexing, insert gently anus 15 ~ 20cm after anal canal is lubricated, slowly inject medicinal liquid, pressure low (liquid level is no more than 30cm apart from anus), with buttocks bed hedgehopping 10cm, keep 30min after the injection as far as possible.The conventional intramuscular injection neostigmine of matched group medicinal liquid 2ml.

1.2.2 observation index: patient's first voluntary micturition time after the record treatment.Voluntary micturition is successfully in the treatment group 1h, and the person that do not urinate yet behind the 1h is unsuccessfully.Voluntary micturition is successfully in the matched group 4h, and the 4h person of not urinating is unsuccessfully.

1.2.3 statistical analysis: adopt the SPSS16.0 building database to go forward side by side line number according to one's analysis.Measurement data adopts the t check; Enumeration data adopts X 2 test.P＜0.05 expression has significant.

2 results

2.1 two groups of urine retention Comparison of therapeutic: treatment group 38 examples are urinated successfully, 2 example failures, the success rate 95% of urinating; Matched group 32 examples are urinated successfully, failure 8 examples, success rate 80%.Two groups of comparing differences have significance (P＜0.05).

2.2 two groups of first urination time comparisons of patient: it is (30.12 ± 16.33) min that treatment group begins to discharge average time to urine from coloclysis, and matched group is (59.56 ± 30.36) min, and two groups relatively, and difference is very significant (P＜0.01).

2.3 untoward reaction record: patient's vital sign (blood pressure, heart rate, body temperature, breathing), physical examination, blood biochemical analysis, electrocardiogram and routine urinalysis Non Apparent Abnormality during treating.

3. conclusion: the prompting of this result of study, the present invention can effectively improve urine retention problem behind the cesarean section, can promote postoperative patient to urinate as early as possible, and without obvious adverse reaction.

Claims

1. pharmaceutical composition that is used for urine retention behind the cesarean section, it is characterized in that being made by the crude drug of following weight proportion: 14～20 parts of Fructus Gardeniaes, 10～16 parts of Radix Curcumaes, 10～16 parts of Radix Paeoniae Alba (parched)s, 10～16 parts of Rhizoma Alismatis, 10～16 parts of Herba Epimedii, 6～10 parts of Herba Taxillis, 14～20 parts of Fructus Mori, 14～20 parts of Herba Artemisiae Scopariaes, 10～15 parts of Diplazium lanceum (Thunb)s, 3～5 parts of Bulbus scillae scilloidiss.

2. a kind of pharmaceutical composition for urine retention behind the cesarean section according to claim 1, it is characterized in that being made by the crude drug of following weight proportion: 16 parts of Fructus Gardeniaes, 12 parts of Radix Curcumaes, 12 parts of Radix Paeoniae Alba (parched)s, 12 parts of Rhizoma Alismatis, 12 parts of Herba Epimedii, 8 parts of Herba Taxillis, 16 parts of Fructus Mori, 16 parts of Herba Artemisiae Scopariaes, 12 parts of Diplazium lanceum (Thunb)s, 4 parts of Bulbus scillae scilloidiss.