CN101732660B - Chinese medicinal preparation for treating prostate disease and preparation method thereof - Google Patents
Chinese medicinal preparation for treating prostate disease and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a Chinese medicinal preparation for treating a prostate disease, which is a medicament prepared from 70 raw material medicaments such as ginseng, deerhorn glue, medicinal indianmulberry root, common curculigo rhizome and the like. The medicament can be prepared into oral liquid, granules, powder, capsules, electuary, tablets or pills. A preparation method of the medicament comprises the following steps of: (1) preparing water extracting solution by the raw material medicaments; (2) preparing oral liquid by the water extracting solution; (3) drying, crushing and sieving the water extracting solution, and taking screening as medicinal extracting powder; and (4) preparing tablets, granules, pills or capsules from the medicinal extracting powder. The preparation method also can comprise the following steps of: (1) crushing and sieving the raw material medicaments, and taking the screening as medicinal powder; (2) disinfecting and sterilizing the medicinal powder to obtain raw powder; and (3) preparing tablets, granules, pills, electuary or capsules from raw powder. The adopted raw material medicaments are common Chinese medicaments, so the Chinese medicinal preparation has the advantages of low manufacturing cost, and nearly no toxic or side effects. The medicament has good curative effects on prostatitis, prostatic hypertrophy and prostatomegaly, and has obvious effect on prostate cancers.
Description
Technical field
The present invention relates to a kind of medicine with Chinese medicine preparation and preparation method thereof, concrete is a kind of Chinese medicine preparation for the treatment of prostatosis and preparation method thereof.
Background technology
Prostate is a male internal genital organs accessory gland soma.Prostatosis comprises prostatitis, prostatic hyperplasia, prostate hyperplasia and urinary tract infection.These diseases are person in middle and old age's commonly encountered diseases and frequently-occurring disease.Sickness rate increases with the age and increases gradually, and prostatosis mainly shows as: dysuria, frequent micturition, urinary incontinence, urine are unable etc., need urethral catheterization or operative treatment when serious, make the patient very painful, have a strong impact on patient's body and mind Jiankang and quality of life.The cause of disease of this class disease, pathology complexity, course of disease delay, obstinate and be difficult to cure.Though modern medicine Therapeutic Method in the practice of treatment prostatosis is many, curative effect is unsatisfactory.
Summary of the invention:
The objective of the invention is to propose a kind of new Chinese medicine preparation that can effectively treat prostatosis, concrete is the technical scheme of a kind of Chinese medicine preparation for the treatment of prostatosis and preparation method thereof.
Technical scheme of the present invention is: a kind of Chinese medicine preparation for the treatment of prostatosis is characterized in that it is the medicament of being made by following weight parts proportion raw material medical material:
Described medicament is oral liquid, granule, capsule, electuary, tablet or pill.
A kind of preparation method for the treatment of the Chinese medicine preparation of prostatosis is characterized in that being made up of following steps:
(1) crude drug of claim 1 being made as according to a conventional method water content is 10% aqueous extract,
(2) aqueous extract of using step (1) to make according to a conventional method is made as oral liquid,
(3) the aqueous extract drying that step (1) is obtained, pulverizing, mistake at least 200 mesh sieves, extracting screen underflow is extract drugs powder,
(4) the extract drugs powder of using step (3) to make according to a conventional method is made as tablet, granule, pill, electuary or capsule.
A kind of preparation method for the treatment of the Chinese medicine preparation of prostatosis is characterized in that, is made by following steps:
(1) the described crude drug of claim 1 is pulverized, and crosses at least 200 mesh sieves, and extracting screen underflow is a powder,
(2) according to a conventional method to the medicated powder sterilization, the pulvis of making a living,
(3) the fecula powder of using step (2) to make according to a conventional method is made as tablet, granule, pill, electuary or capsule.
The traditional Chinese medical science claims that prostatosis is " stranguria ", " turbid urine ", " difficulty in urination ".The traditional Chinese medical science is thought, diseases such as " stranguria ", " turbid urine ", " difficulty in urination ", how because of the pungent delicious food savoury of surfeit, or be addicted to drink too, or cloudy down unclean, foul heresy is invaded, make to give birth to damp and hot, damp and hot not understanding and in accumulate, make a bet in bladder, damp and hot fumigation, disturbance in functioning of QI, or because of heat accumulate in lung, lung qi can not respectfully fall, the defeated cloth of body fluid is not normal, water channel logical transfer unfavorable, can not descend defeated bladder, or because of feelings will is hindered, depression of liver-QI, catharsis are unfavorable, or because of stagnated QI transforming into fire, all can influence the operation gasification function of three warmers water liquid, cause the logical accent of water channel to be obstructed; Or with age, eipathia asthenia and overwork, intemperate sexual intercourse, insufficiency of kidney-YANG, QI failing to transform into body fluid, depletion of YANG being difficult of the moon then, or because of the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels is not healed long-pending summerday for a long time, body fluid consume so that kidney yin loss, the exhaustion of water mansion; Or because of overstrain impairing the spleen, eating and drinking without temperance, or eipathia asthenia, cause insufficiency of the spleen and clear QI failing to ascend, turbid YIN failing to descend; Or cause forming because of life, the resistance of the urinary tract stasis of blood etc. in obstinate disease, the blood stasis.
The present invention identifies and corrects according to Chinese medicine and executes the principle of controlling, the tame chief of the many doctors of collection, extensively adopt the strange medicine wonderful recipe in the rich Yunnan various nationalities of receipts area, based on pathogenetic understanding and the Therapeutic Principle of Chinese medicine to prostatosis, reference is the pharmacological research achievement at all times, and the natural Chinese medicine of screening kidney invigorating and YANG supporting, supplementing QI to induce diuresis, dissipating blood stasis for subsidence of swelling, heat-clearing and toxic substances removing is by the theory of Chinese medical science prescription, skim the cream off milk, and form through the clinical practice summary of long-term diagnosis and treatment case.Prove through clinical trial: it is not scorching that the present invention has kidney invigorating and YANG supporting, heat clearing away is imapirment of the spleen and stomach not, diuretic is impairment of body fluid not, and blood circulation promoting and blood stasis dispelling, hard masses softening and resolving are beneficial to regulates the flow of vital energy, and removing heat from blood is beneficial to Bao Yin, silk silk incision pathogenesis, the present invention presses the principle organic assembling of monarch, synergism, treating both the principal and secondary aspects of a disease, follow through send out disease all, all can be corresponding and heal.
Dialectical guide: kidney invigorating and YANG supporting, supplementing QI to induce diuresis, dissipating blood stasis for subsidence of swelling.
Prescription analysis of the present invention: Radix Ginseng, Cornu Cervi Pantotrichum, Radix Morindae Officinalis, Herba Epimedii, Cordyceps, Gecko, Actinolitum, Aspongopus, Bombycis mori, Radix Et Caulis Acanthopanacis Senticosi, the Radix Astragali, Folium Allii tuberosi seed, Cortex Cinnamomi, Fructus Cnidii kidney invigorating and YANG supporting in the side are monarch drug.Radix Rehmanniae Preparata, Herba Epimedii, Semen Cuscutae, Fructus Corni, Rhizoma Dioscoreae, Semen Juglandis, Radix Polygoni Multiflori, Radix Angelicae Sinensis, Formica fusca, Fructus Lycii enrich and benefit essence and blood are minister; Radix Salviae Miltiorrhizae, Cortex Moutan, Olibanum, Myrrha, SHANLING, Rhizoma Curcumae, Squama Manis, Carapax Trionycis, Eupolyphaga Seu Steleophaga, Radix Clematidis, Spina Gleditsiae, Semen Persicae, Flos Carthami, Radix Scrophulariae, Spica Prunellae, Fructus Aurantii, Herba Hedyotidis Diffusae, Herba Patriniae, Herba Taraxaci, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, detumescence are assistant; Semen Plantaginis, Pheretima, Rhizoma Alismatis, Poria, Rhizoma Smilacis Glabrae, Medulla Tetrapanacis, Fructus Liquidambaris, Semen Vaccariae, Polyporus, Herba Leonuri, Semen Benincasae, Lignum Aquilariae Resinatum, Radix Achyranthis Bidentatae, tonneau are urinated for making.Wherein Herba Epimedii, Semen Cuscutae, Fructus Corni, the kidney invigorating and tonifying both YIN and YANG, Cornu Cervi Pantotrichum, Carapax Trionycis, negative and positive are mended altogether, Lignum Aquilariae Resinatum, Cortex Cinnamomi guiding fire to origin, the Radix Achyranthis Bidentatae priming is descending, and the Fructus Aurantii circulation of qi promoting disappears stagnant, and Radix Ginseng, Radix Astragali strongly invigorating primordial QI are with the big spleen reinforcing kidney yang of all yang-tonifying drugs gas; Radix Polygoni Multiflori, Radix Angelicae Sinensis, Fructus Lycii, Radix Rehmanniae Preparata benefiting essence-blood, promptly so-called " YIN can't be produced without YANG, YANG can't be formed without YIN." gas of three warmers, form a connecting link, being so incensed that of the part of the body cavity above the diaphragm housing the heart and lungs, lung qi must be declared, and the bladder water channel is defeated logical; In burnt spleen soil must be good for, play the duty of the lucid yang sending up the turbid descending; Vigorous, cloudy smart abundant, the positive gasified water of part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels kidney yang, damp and hot heresy of coagulating are dispeled, and the swelling of stasis of blood knot is dissipated, thus the temper liter, the kidney yang fire from the gater of life is multiple, state gasification all, and grand disease of closing is more.
Pharmacological action of the present invention: Cornu Cervi Pantotrichum, Radix Ginseng, Radix Rehmanniae Preparata, Rhizoma Curculiginis, Radix Morindae Officinalis in the side, the kidney invigorating warming YANG has excitement and regulating action to hypophysis, adrenal cortex function.Radix Ginseng, Radix Astragali QI invigorating, and can improve body's immunological function, Semen Persicae, Flos Carthami, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Squama Manis, Spina Gleditsiae, Olibanum, Myrrha, SHANLING, Rhizoma Curcumae, blood circulation promoting and blood stasis dispelling, expansible blood vessel, anticoagulant, microcirculation improvement suppress connective tissue proliferation, promote fibrous tissue to absorb.Rhizoma Alismatis, Semen Plantaginis, Pheretima, Herba Leonuri, Polyporus, Semen Benincasae, Radix Achyranthis Bidentatae, the diuresis relieving distension of being open to the custom.Full side has blood circulation promoting and blood stasis dispelling Qu Disorder, the warming YANG activating QI disappears infirmity, its role is to promote recover dynamic equilibrium after kidney and the bladder, significantly improve dysuric function, can dwindle the body of gland of hypertrophy again, thereby remove urethral obstruction, loose, outgrowth body of gland is eliminated, smart road urinary tract is unblocked, and kidney yang is recovered, and called forth one's youthful vigor old age.Medicine of the present invention is pressed the principle organic assembling of monarch, synergism.The crude drug that the present invention adopts is common Chinese commonly used, and cost of manufacture is low, has no side effect substantially.Medicine of the present invention has curative effect preferably to prostatitis, prostatic hyperplasia, hypertrophy, and is obvious to the carcinoma of prostate effect.
Usage and dosage: the each 5-100ml of oral liquid of the present invention, day obeys oral 3 times, or chip select agent, granule, pill, powder, capsule, electuary etc. are wherein a kind of, each 3-10 gram, day obeys 3 times, various dosage forms can be used alternatingly, and extract powder and with each dosage form medicine and fecula powder and identical with each dosage form survival dose of its preparation of its preparation.Treating 20 days is a course of treatment, light disease 1-3 course of treatment, serious symptom 4-5 the course of treatment.Better with Western medicine therapeutic alliance effect.Must under instructing, the doctor use.
Untoward reaction: clothes are easily given birth to skin infection, increased blood pressure for a long time.Diabetes patient, deficiency of lung-YIN, hemoptysis of pulmonary tuberculosis person are unsuitable.
Taboo: patients such as the hepatic and renal YIN deficiency, excessive rising of liver-YANG, hypertension, apoplexy, hyperactivity of fire caused by deficiency of YIN, anemia of pregnant woman, flu, heat syndrome forbid to take.Must under instructing, the doctor use.
Clinical examination of the present invention
1, acute prostatitis disease
Adopt the present invention to follow the tracks of the anxious prostatitis of treatment totally 100 examples, age 40-80 year, morbidity back 1-7 days.Patient's cardinal symptom is, perineal position distending pain discomfort, and lower abdomen dull pain is more obvious, and pain is to lumbosacral region, penis portion and thigh root radiation.Symptoms such as frequent micturition, urgent micturition, dysurea appear in the patient with urinary system infection, and small number of patients has hematuria.It is more anxious to fall ill, and part patient is with heating, shiver with cold, anorexia and General Symptoms such as weak, and most of patients is with sexual dysfunction.The inspection leukocyte increases, visible a large amount of leukocytes in the urine.Rectal touch, but mould has tangible tenderness to the prostate of enlargement, and fluctuation is arranged when forming abscess.Patient's red tongue, tongue is white, and the tongue root is yellow greasy, and arteries and veins is seen stringy and thready pulse or heavy string, is deficiency of kidney-QI, the disease of dampness and heat stasis.Therapeutic Method: the each 10-20ml of oral liquid, day clothes 3 times, each 3-10 gram such as granule, powder, capsule, electuary, pill, day clothes 3 times.10 days one courses of treatment.Common 1-2 course of treatment, serious symptom 3-5 the course of treatment.
Take medicine 1-3 the course of treatment, the produce effects patient that clinical symptoms disappears substantially is 41 people, total obvious effective rate 41%, and produce effects patient fully recovers after after treatment.Effective patient that clinical symptoms partly disappears is 52 people, total effective rate 52%.Clinical symptoms does not have 7 people of improvement, total inefficiency 7%.Follow up a case by regular visits to the recovery from illness patient and do not see recurrence in 2 years.In therapeutic process, do not see obvious adverse effect and toxic and side effects, do not have to find to have the phenomenon of liver, kidney, lung, spleen, stomach upset.
2, chronic prostatitis syndrome
Adopt the present invention to follow the tracks of treatment chronic prostatitis syndrome totally 100 examples, age 40-80 year, morbidity back 1-5.Patient's cardinal symptom is, frequent micturition, urine retention sense or urine retention arranged, urethra scorching hot and itching.Perineal position distending pain and take out pain, to the radiation of penis portion and thigh root, on the pubis and the lumbosacral region discomfort, the little distention and fullness in the abdomen of urine retention patient is poverty-stricken, contracture pain.The patient has prostatorrhoea more, and when urinate terminal or stool exerted oneself, urethral orifice flowed out white secretions.Most of patients is with sexual dysfunction, and part patient has symptoms such as dizziness, weak, dreaminess and insomnia.The course of disease is long, often outbreak, and sx after medication during outbreak, but can not cure.Rectal touch, prostate soft or hard inequality has mild tenderness.The inspection leukocyte increases, visible a large amount of leukocytes in the urine.Patient's dimly pale tongue, tongue is white, and the tongue root is yellow greasy, and tongue with ecchymosis, arteries and veins are seen stringy and thready pulse or heavy string, are deficiency of kidney-QI, the disease of dampness and heat stasis.
Therapeutic Method: the each 10-20ml of oral liquid, day clothes 3 times, each 3-10 gram such as granule, powder, capsule, electuary, pill, day clothes 3 times.10 days one courses of treatment.Common 1-3 course of treatment, serious symptom 4-5 the course of treatment.
Take medicine 1-2 the course of treatment, the produce effects patient that clinical symptoms disappears substantially is 34 people, total obvious effective rate 34%, and produce effects patient fully recovers after after treatment.Effective patient that clinical symptoms partly disappears is 57 people, total effective rate 57%.Clinical symptoms does not have 9 people of improvement, total inefficiency 9%.Follow up a case by regular visits to the recovery from illness patient and do not see recurrence in 2 years.In therapeutic process, do not see obvious adverse effect and toxic and side effects, do not have to find to have the phenomenon of liver, kidney, lung, spleen, stomach upset.
3, prostatic hyperplasia
Adopt the present invention to follow the tracks of treatment prostatic hyperplasia totally 100 examples, age 40-90 year, morbidity back 1-20, wherein the person in middle and old age more than 50 years old account for the overwhelming majority.Patient's cardinal symptom is, frequent micturition, urgent micturition, nocturia increase and irritation sign of bladder and acraturesis such as urge incontinence, the urine line attenuates and dribbling, hematuria, urine retention etc. are urinated blocks symptom.Wherein, I degree hypertrophy 51 examples, II degree hypertrophy 38 examples, III degree hypertrophy 6 examples, 13 routine patients are with urinary tract infection, and 7 examples are with hydronephrosis, and 4 examples are with uremia, and 5 examples are diagnosed as carcinoma of prostate through prostate biopsy.Through examination of prostatic fluid, the NIP cell, prostatic fluid is cultivated does not also have bacterial growth, and blood plasma zinc content obviously increases, and detects through Abdominal B type ultrasonography, and prostate increases, and residual urine volume increases.Rectal touch: prostate increases, and quality is harder, smooth surface, disappearence of central groove.
Therapeutic Method: the each 10-20ml of oral liquid, day clothes 3 times, each 3-10 gram such as granule, powder, capsule, electuary, pill, day clothes 3 times.10 days one courses of treatment.Common 1-3 course of treatment, serious symptom 4-6 the course of treatment.
Take medicine 1-3 the course of treatment, clinical symptoms disappears substantially, and the produce effects patient that body of gland obviously dwindles is 31 people, total obvious effective rate 31%.Clinical symptoms partly disappears, and effective patient that body of gland dwindles is 53 people, total effective rate 53%.Clinical symptoms does not have 16 people of improvement, total inefficiency 16%.Wherein patients with prostate cancer is taken medicine has 3 people's sxs 4-6 the course of treatment, and body of gland dwindles.In therapeutic process, do not see obvious adverse effect and toxic and side effects, do not have to find to have the phenomenon of liver, kidney, lung, spleen, stomach upset.
The specific embodiment
Table 1
1, a kind of preparation method for the treatment of the Chinese medicine preparation of prostatosis is pressed table 1 and is equipped with crude drug, and all medicine is a dry product, and following steps are made:
(1) crude drug of table 1 being made as according to a conventional method water content is 10% aqueous extract,
(2) aqueous extract of using step (1) to make according to a conventional method is made as oral liquid,
(3) the aqueous extract drying that step (1) is obtained, pulverizing, mistake at least 200 mesh sieves, extracting screen underflow is extract drugs powder,
(4) the extract drugs powder of using step (3) to make according to a conventional method is made as tablet, granule, pill, electuary or the capsule in the oral agents.Granule, pill, electuary, every bag contains drug powder 3-5 gram; Tablet, every contains drug powder 0.2-0.5 gram; Capsule, every drug powder 0.2-0.5 gram; Powder, every bag of 3-5 gram.
2, a kind of preparation method for the treatment of the Chinese medicine preparation of prostatosis is pressed table 1 and is equipped with crude drug, and all medicine is a dry product, is made by following steps:
(1) crude drug sieve dedust soil is pulverized, and temperature is lower than 60 ℃ during pulverizing, crosses at least 200 mesh sieves, and extracting screen underflow is a medicated powder,
(2) according to a conventional method to the medicated powder sterilization, the pulvis of making a living,
(3) the fecula powder of using step (2) to make according to a conventional method is made as tablet, granule, pill, electuary or capsule.Granule, pill, electuary, every bag contains drug powder 3-5 gram; Tablet, every contains drug powder 0.2-0.5 gram; Capsule, every drug powder 0.2-0.5 gram; Powder, every bag of 3-5 gram.
Claims (2)
2. a kind of Chinese medicine preparation for the treatment of prostatosis according to claim 1 is characterized in that described medicament is oral liquid, powder, capsule, electuary, tablet or pill.
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