CN103071015B - Compound Cistanche deserticola tablet - Google Patents
Compound Cistanche deserticola tablet Download PDFInfo
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- CN103071015B CN103071015B CN201210531644.4A CN201210531644A CN103071015B CN 103071015 B CN103071015 B CN 103071015B CN 201210531644 A CN201210531644 A CN 201210531644A CN 103071015 B CN103071015 B CN 103071015B
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Abstract
The invention relates to a compound Cistanche deserticola tablet. Prostatic hyperplasia is a common disease in elderly men, and is mainly caused by yang acupoint mediation helplessness because of the internal organ deficiency, and no yin transformation and disordered opening and closing because of the kidney deficiency. Symptoms of the prostatic hyperplasia comprise difficult urination, urine discharge failure, penis ache, and urine retention caused by urethra obturation, urine retention in the bladder and underbelly distending pain when the prostatic hyperplasia is severe. The prostatic hyperplasia is treated through turbid yin descending by utilizing qi tonifying, lucidity ascending, qi transformation helping and downward obturation unblocking in the invention. The compound Cistanche deserticola tablet mainly comprises 35% of Cistanche deserticola, 15% of Rhodiola rosea, 10% of Oil Palm Fruit, 7% of root of Urtica dioica L., 5% of Rhizoma Alismatis, 5% of Dioscorea tokoro Makino, 10% of Pygeum Africanum, 2% of Cordyceps sinensis, 2% of lycopene, 2% of Radix Astragali saponin, 5% of Semen Plantaginis, and 2% of total glycoside of ginseng. A case that the prostatic hyperplasia is mainly caused by yang acupoint mediation helplessness because of the internal organ deficiency, and no yin transformation and disordered opening and closing because of the kidney deficiency is considered in the traditional Chinese medicinal science, so the turbid yin descending by utilizing qi tonifying, lucidity ascending, qi transformation helping and downward obturation unblocking is a primary treatment principle in the invention. The above twelve medicines are mixed according to corresponding proportions, undergo ultrafine crushing, and are uniformly stirred to prepare the tablet or a capsule. 1.5-2g of the tablet or the capsule is orally taken each time, and is continuously taken three times a day after each meal by warm water for 6-8 weeks.
Description
One, technical field
The invention belongs to medical technical field, relate to a kind of Chinese medicine compound tablet, refer to more specifically a kind of compound Chinese medicinal preparation of preventing and treating prostatic hyperplasia.
Two, background technology
Prostatic hyperplasia is male's common chronic disease in old age, and commercially available relevant medicine is all difficult to fundamentally prevent and treat prostatic hyperplasia at present, and the present invention adopts traditional Chinese medical science monarch, the mutually auxiliary theoretical control prostatic hyperplasia of negative and positive.
Three, summary of the invention
Prostatic hyperplasia is the old a kind of commonly encountered diseases of male, how to be declined by internal organs void, is difficult invigorating YANG and dredging the orifices, deficiency of kidney-QI, and being difficult of the moon, due to folding is lacked of proper care.This disease shows as dysuria, and drown and do not draw, penile pain, when serious, urethra obturation is obstructed, causes the retention of bladder urine, the swollen full distending pain of lower abdomen, the traditional Chinese medical science is called the difficulty in urination.To the treatment of primary disease, still lack at present effective method.The present invention uses QI invigorating the lucid yang sending up, helps its gasification, lower logical obturation, and the method for the turbid descending the moon is treated this disease, main component of the present invention and proportioning are as follows:
Herba Cistanches: another name Herba Cistanches, the fleshy stem of Orobanchaceae plant; Herba Cistanches is containing number of chemical composition, be mainly phenethyl alcohol glycosides, polysaccharide, iridoids, PEARLITOL 25C, cupreol, hydro carbons, flavonoid, alkaloid, aminoacid and inorganic microelement etc., there is the kidney invigorating, benefit essence, the organs such as kidney to male, testis, penis, spongy body have great tonification effect, cure mainly kidney yang deficiency, the frequent micturition heeltap.This medicine is monarch drug of the present invention.
Radix Rhodiolae: have another name called Rhodiola sachalinensis, for Crassulaceae Rhodida plant, Radix Rhodiolae is mainly containing phenyl propyl and flavonoid class, its unique activity chemical composition is phenyl propyl, rosavin (activity is the strongest), rosin, rosarin, rhodiolin, rhodioloside and its glycoside unit, to butyl alcohol.Rhodosin can promote the synthetic of protein, reduce phosphatase activity, improve superoxide dismutase (SOD) activity and glutathion (GSH) content, suppress the formation of peroxide lipid peroxide (LPO), suppress the formation of cell lipofuscin and active oxygen, the degeneration of inhibitory cell, organ changes, and therefore Radix Rhodiolae is a kind of stronger antioxidant, affects lipid metabolism and the effect of antagonism free-radical oxidation; Strengthen the metabolism of cell with synthetic, improve the vigor of cell.Have QI invigorating, invigorate blood circulation, change effect of silt, because of its magical effect that has strengthening healthy qi, benefiting qi and nourishing blood, YIN nourishing lung benefiting, successive dynasties Tibetan medicine is regarded as " lucky three essentials-essence ".
Palm fruit: palm fruit is Serenoa repens Serenoa repens (bartram) small mellow fruit, is rich in various fatty acids and volatile oil, mainly contains oleic acid, lauric acid, myristic acid, Palmic acid, linoleic acid, stearic acid, linolenic acid etc.Sabal, formal name used at school is " sabal ", belongs to Palmae shrub plant, is conventionally grown in the area of South and North America's hot climate, its ripe dry fruit can hyoscine.Palm fruit is in Europe also referred to as sabal, and the effect of its extract has: prevention of prostatic hyperplasia: palm fruit extract can suppress to stimulate the dihydro androgenic gland element secretion of prostate hyperplasia, fundamentally solves the problem of prostatic hyperplasia; Promotion is urinated: it is unblocked that palm fruit extract can keep prostate normal volume and function thereof to urinate, thereby alleviates the problems such as nocturia, frequent micturition, urgent micturition; Prevention aseptic prostatitis: palm fruit extract can suppress the activity of Cycloxygenase and lipoxidase, reduces the generation of the inflammatory mediators such as leukotriene, prostaglandin, thus play antiinflammatory, edema effect, prevention aseptic prostatitis; Prevent and treat urinary tract infection: palm fruit extract can promote urinary tract mucosa to produce 1gA, lgG, tri-kinds of immunoglobulins of lgC, strengthens the resistance of urethra, effectively prevents and treats urinary tract infection.
Palm fruit disturbs the diagnosis of early prostate cancer unlike the medicine of other treatment prostate hyperplasia, also can as some medicine, not have the side effect that causes sexual impotence, alopecia
Urtica dioica root: be the root of Urticaceae Urtica plant Urtica dioica, strain Herba Urticae Cannabinae (Urticadioica L.subsp.dioica) is a kind of herbaceos perennial, is extensively studied and applies in developed countries such as America and Europes.As a kind of medical herbs, be used for the treatment of prostatic hyperplasia; There is in addition the effect such as antiviral, enhancing immunity.Its active component mainly contains flavonoid, organic acid, phenols, Phenylpropanoid Glycosides class, sterol, protein, polysaccharide etc.Above three taste medicines are ministerial drug of the present invention.
Rhizoma Alismatis: belong to Alismataceae, tuber is containing rushing down alcohol (alisol) A, B, C, Alisol A monoacetate (alisol A monoacetate), Alisol B 23-monoacetate (alisol B monoacetate), the mono-acetic acid vinegar of alisol C (alisol C monoacetate) table alisol (epialisol) A, Rhizoma Alismatis azulene alcohol (alismol), Rhizoma Alismatis azulene alcohol oxide (alismoxide), 16 'beta '-methoxy Alisol B 23-monoacetates (16 β-methocyal-isol B monoacetate), 16 beta-hydroxy Alisol B 23-monoacetates (16 β-hydroxyal-isol B monoacetate), sitosterol-3-O-stearyl-β-D-glucopyanoside (sitosterol-3-O-steroyl-β-D-glucopyranoside).Also contain the elements such as choline (cho-line), sugar and potassium, calcium, magnesium.Be longer than promoting diuresis to eliminate damp pathogen, expel the heat-evil, for dysuria, edema distension, the puckery pain of stranguria with turbid discharge, seminal emission, foot knee joint flaccidity is soft.
Rhizoma Dioscoreae Septemlobae: Dioscoreaceae, Wild yam, Rhizoma Dioscoreae Septemlobae rhizome is mainly containing dioscin (Dioscin), still containing gracillin (Gracillin), dioscoreassapotoxin A, B (DioscoreasapotoxinA, B), Shan Rhizoma Dioscoreae Septemlobae Saponin (Tokoronin), yononin (Yononin), the Saponins such as holder gram ruscogenin-1-glycoside. dioscorea sapotoxin is the insecticidal constituent in the Rhizoma Dioscoreae Septemlobae of mountain. from rhizome, separating the glycoside unit obtaining has: diosgenin (Diosgenin), holder gram ruscogenin (Tokorogenin), Yamogenin (Yamoogenin), yonogenin (Yonogenin), kogagenin (Kogagenin), igagenin (Igagenin) etc. there is expelling wind and removing dampness, treating stranguria, diuretic, antiinflammatory, removing toxic substances, can treat stranguria with turbid discharge and urinary system infection.
Prunus africana: belong to Rosaceae Li Yake wild arbor trees, the extract of bark and fruit can be restrained human body fibroblastic growth, and can slow down epidermal growth factor generation, prostatosis is had to obvious curative effects.In the extract of prunus africana, contain---sterol, terpenoid, can reduce excessive prostaglandin in patient body, reduce the cholesterol depositing in prostate, improve the fragility of vein and blood capillary, also have diuresis and anthydropic effect simultaneously, can greatly improve developing of male prostate and sexual organ disease.Growth factor receptor inhibitors has the double effects that simultaneously acts on prostate and bladder, can effectively suppress the fibroblastic hypertrophy being caused by basic fibroblast growth factor, thereby can effectively suppress the hypertrophy of fibrous tissue in prostate, thereby suppress the hypertrophy of prostata tissue.The optimistic wall of urinary bladder fibrosis that suppresses, improves wall of urinary bladder elasticity simultaneously, and bladder function is had to protective effect, in addition, also has antiinflammatory and anthydropic activity.
Prunus africana is a kind of traditional prostatitic medical herbs that is used for the treatment of.Contained plant component, can diminish inflammation, and alleviates prostate because of the occurred swelling that is upset.Can reduce nocturia and urinate the situation of interrupting.Basic fibroblast growth factor (bFGF), is intraprostatic main somatomedin, and bFGF increases the hypertrophy that can cause prostatic cell.Prunus africana extract, the Secondary cases bFGF secretion that can effectively suppress wall of urinary bladder increases the compensatory causing and thickens, and the progression of fibrosis of wall of urinary bladder is slowed down, and can reduce the sensitivity of detrusor of bladder, and have antiinflammatory action.Above three taste medicines are adjuvant drug of the present invention.
Cordycepin: the neplanocin extracting from Cordyceps militaris (L.) Link., molecular formula C
10h
13n
5o
3, have obvious immunoregulation effect, antibacterial, antiinflammatory, antivirus action.
Lycopene (lycopene) is the main pigment of mature tomato, is a kind of oxygen-free carotenoid.Within 1873, Hartsen isolates this red crystals first from berry Rhizoma Dioscoreae TamuscommunisL..Schunk in 1913 find the difference of this material and carotene, by its called after lycopene first, use so far.Its molecular formula is C40H56, and molecular weight is 536.85, and sterling is needle-like peony crystal, on molecular structure by 11 conjugated double bonds and 2 straight chain type Hydrocarbon that unconjugated double bond forms.In carotenoid, it has the strongest antioxidant activity.Lycopene is removed effect of free radical and is outclassed other carotenoid and vitamin E, and the speed constant of its singlet-oxygen quenching is 100 times of vitamin E, is one of found powerful antioxidant of occurring in nature up to now.There is the effect of slow down prostatic hyperplasia and antioxidation, slow down aging.
Radix Astragali saponin: leguminous plant, the extract of the root of the Radix Astragali, containing flavones ingredient, calycosin, 3-hydroxy-9,10-dimethoxy pterocarpane, Radix Astragali saponin I, V, III, energy tonifying Qi and lifting yang, benefit is defended consolidating superficial resistance, regulates human body metabolism, and enhancing immunity improves antioxidant ability of organism.
Semen Plantaginis: Plantaginaceae, the seed of Herba Plantaginis, Herba Plantaginis seed is containing a month aucubin (aucubin), Herba Plantaginis mucopolysaccharide (plantago-mulilage), racemization-plantagoside (plantago-side), all square rafter glycoside acid (geniposidic acid), plantenolic acid (plantenolic acid), succinic acid (succinic acid), adenine (adenine), choline (choline) and 10.43% fatty oil, cupreol (β-sitosterol), cupreol-3-O-β-D-glucopyanoside (β-sitosteryl-3-O-β-D-glucopyranoside).Clearing away heat and promoting diuresis; Cure mainly: main dysuria, stranguria with turbid discharge leukorrhagia; Car owner's stranguria due to disorder of QI, pain relieving, dredging water passages.Radix Astragali saponin is with Semen Plantaginis two medicine one rise and one drop, and Radix Astragali yang invigorating activating QI, walks bladder with row water under Semen Plantaginis;
Radix Ginseng total glycosides: Araliaceae, the extract of Radix Ginseng, be rich in 18 kinds of Saponins, can obviously suppress cylinder super-oxidation lipid and form, increase the content of Superoxide dismutase and peroxidase simultaneously, there is antioxidation, reduce interior free yl content, be added to somatic cell vigor, suppress old and feeble, reduce blood glucose.Above five kinds of Chinese medicine is the medicine that makes of the present invention.
The traditional Chinese medical science think prostatic hyperplasia be mainly deficiency of kidney-QI, internal organs void declines, being difficult of the moon, due to folding imbalance.Therefore QI invigorating the lucid yang sending up, helps its gasification, lower logical obturation, and the turbid descending the moon is the main rule for the treatment of, adopts the formula of this 12 taste medical material, meets traditional Chinese medical science monarch, the mutually auxiliary theory of negative and positive.
Above-mentioned 12 herbal medicines, by proportioning superfine grinding, uniform stirring is made tablet or capsule.Each oral 1.5-2 gram, every day three times, swallows by warm water after meal, serve on six to eight weeks.
Four, detailed description of the invention
The present invention uses more than 20 routine patients with benign prostate hyperplasias, each oral 1.5-2 gram, every day three times, swallow by warm water after meal, serve on six to eight weeks, except 2 people are not effective, all the other are all effective, the phenomenons such as urgent micturition, frequent micturition, pouring drop and urine retention are taken an evident turn for the better, and most patient's nocturia are below 2 times, and what have does not even get up in the night to urinate.Effectively improve quality of life.
Claims (1)
1. be used for the treatment of a Chinese medicine compound tablet for prostatic hyperplasia, the one-tenth that it is characterized in that it be grouped into and proportioning as follows:
Above-mentioned 12 herbal medicines, by proportioning superfine grinding, uniform stirring is made tablet, and each oral 1.5-2 gram, swallows by warm water after meal at every day three times.
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| CN103599138B (en) * | 2013-11-22 | 2015-12-09 | 宁波广发文博生物科技有限公司 | Cordyceps militaris (L.) Link. extract lozenge |
Citations (2)
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| CN1753682A (en) * | 2003-01-16 | 2006-03-29 | 利盛私人有限公司 | The herbal-composition that is used for prostatosis |
| CN101732660A (en) * | 2009-12-25 | 2010-06-16 | 卢速江 | Chinese medicinal preparation for treating prostate disease and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1753682A (en) * | 2003-01-16 | 2006-03-29 | 利盛私人有限公司 | The herbal-composition that is used for prostatosis |
| CN101732660A (en) * | 2009-12-25 | 2010-06-16 | 卢速江 | Chinese medicinal preparation for treating prostate disease and preparation method thereof |
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| 邱云桥等.益肾通对前列腺增生症膀胧逼尿肌收缩力影响的临床研究.《新中医》.2004,第36卷(第9期),20-21. |
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Effective date of registration: 20160308 Address after: 010080 the Inner Mongolia Autonomous Region Hohhot Jinchuan Development Zone, Jin Er Lu Patentee after: Inner Mongolia Lantai Pharmaceutical Co., Ltd. Address before: 201200 Shanghai city Pudong New Area Chuansha 54 paper Stone Road Lane 4, Room 502 Patentee before: Shanghai Pudong Gaoxing Biotechnology Research Institute |