CN103071015A - Compound Cistanche deserticola tablet - Google Patents

Abstract

The invention relates to a compound Cistanche deserticola tablet. Prostatic hyperplasia is a common disease in elderly men, and is mainly caused by yang acupoint mediation helplessness because of the internal organ deficiency, and no yin transformation and disordered opening and closing because of the kidney deficiency. Symptoms of the prostatic hyperplasia comprise difficult urination, urine discharge failure, penis ache, and urine retention caused by urethra obturation, urine retention in the bladder and underbelly distending pain when the prostatic hyperplasia is severe. The prostatic hyperplasia is treated through turbid yin descending by utilizing qi tonifying, lucidity ascending, qi transformation helping and downward obturation unblocking in the invention. The compound Cistanche deserticola tablet mainly comprises 35% of Cistanche deserticola, 15% of Rhodiola rosea, 10% of Oil Palm Fruit, 7% of root of Urtica dioica L., 5% of Rhizoma Alismatis, 5% of Dioscorea tokoro Makino, 10% of Pygeum Africanum, 2% of Cordyceps sinensis, 2% of lycopene, 2% of Radix Astragali saponin, 5% of Semen Plantaginis, and 2% of total glycoside of ginseng. A case that the prostatic hyperplasia is mainly caused by yang acupoint mediation helplessness because of the internal organ deficiency, and no yin transformation and disordered opening and closing because of the kidney deficiency is considered in the traditional Chinese medicinal science, so the turbid yin descending by utilizing qi tonifying, lucidity ascending, qi transformation helping and downward obturation unblocking is a primary treatment principle in the invention. The above twelve medicines are mixed according to corresponding proportions, undergo ultrafine crushing, and are uniformly stirred to prepare the tablet or a capsule. 1.5-2g of the tablet or the capsule is orally taken each time, and is continuously taken three times a day after each meal by warm water for 6-8 weeks.

Description

Compound recipe Herba Cistanches sheet

One, technical field

The invention belongs to medical technical field, relate to a kind of Chinese medicine compound tablet, refer to more specifically a kind of compound Chinese medicinal preparation of preventing and treating prostatic hyperplasia.

Two, background technology

Prostatic hyperplasia is male's common chronic disease in old age, and commercially available relevant medicine all is difficult to fundamentally prevent and treat prostatic hyperplasia at present, and the present invention adopts traditional Chinese medical science monarch, the mutually auxiliary theoretical control prostatic hyperplasia of negative and positive.

Three, summary of the invention

Prostatic hyperplasia is the old a kind of commonly encountered diseases of male, how to be declined by internal organs void, is difficult invigorating YANG and dredging the orifices, deficiency of kidney-QI, and being difficult of the moon is due to folding is lacked of proper care.This disease shows as dysuria, drowns not draw, and penile pain, the urethra obturation is obstructed when serious, causes the retention of bladder urine, the swollen full distending pain of lower abdomen, the traditional Chinese medical science is called the difficulty in urination.To the treatment of primary disease, still lack at present effective method.The present invention uses the QI invigorating the lucid yang sending up, helps its gasification, lower logical obturation, and the method for the turbid descending the moon is treated this disease, main component of the present invention and proportioning are as follows:

Herba Cistanches: another name Herba Cistanches, the fleshy stem of Orobanchaceae plant; Herba Cistanches contains the number of chemical composition, be mainly phenethyl alcohol glycosides, polysaccharide, iridoids, PEARLITOL 25C, cupreol, hydro carbons, flavonoid, alkaloid, aminoacid and inorganic microelement etc., the kidney invigorating is arranged, the benefit essence, the organs such as male's kidney, testis, penis, spongy body there is great tonification effect, cure mainly kidney yang deficiency, the frequent micturition heeltap.This medicine is monarch drug of the present invention.

Radix Rhodiolae: have another name called Rhodiola sachalinensis, be the Crassulaceae Rhodida plant, Radix Rhodiolae mainly contains phenyl propyl and flavonoid class, its unique activity chemical composition is phenyl propyl, rosavin (activity is the strongest), rosin, rosarin, rhodiolin, rhodioloside and its glycoside unit are namely to butyl alcohol.Rhodosin can promote the synthetic of protein, reduce phosphatase activity, improve superoxide dismutase (SOD) activity and glutathion (GSH) content, suppress the formation of peroxide lipid peroxide (LPO), suppress the formation of cell lipofuscin and active oxygen, the degeneration of inhibitory cell, organ changes, so Radix Rhodiolae is a kind of stronger antioxidant, affect lipid metabolism and resists the free-radical oxidation effect; Strengthen the metabolism of cell with synthetic, improve the vigor of cell.Have QI invigorating, invigorate blood circulation, change the effect of silt, because it has the magical effect of strengthening healthy qi, benefiting qi and nourishing blood, YIN nourishing lung benefiting, the successive dynasties Tibetan medicine is considered as it " lucky three essentials-essence ".

Palm fruit: palm fruit is Serenoa repens Serenoa repens (bartram) small mellow fruit, is rich in various fatty acids and volatile oil, mainly contains oleic acid, lauric acid, myristic acid, Palmic acid, linoleic acid, stearic acid, linolenic acid etc.Sabal, formal name used at school is " sabal ", belongs to the Palmae shrub plant, usually is grown in the area of South and North America's hot climate, but its ripe dry fruit hyoscine.Palm fruit is also referred to as sabal in Europe, and the effect of its extract has: prevention of prostatic hyperplasia: the palm fruit extract can suppress to stimulate the dihydro androgenic gland element secretion of prostate hyperplasia, fundamentally solves the problem of prostatic hyperplasia; Promotion is urinated: it is unblocked that the palm fruit extract can keep prostate normal volume and function thereof to urinate, thereby alleviate the problems such as nocturia, frequent micturition, urgent micturition; Prevention aseptic prostatitis: the palm fruit extract can suppress the activity of Cycloxygenase and lipoxidase, reduces the generation of the inflammatory mediators such as leukotriene, prostaglandin, thereby plays antiinflammatory, edema effect, prevention aseptic prostatitis; Prevent and treat urinary tract infection: the palm fruit extract can promote urinary tract mucosa to produce 1gA, lgG, three kinds of immunoglobulins of lgC, strengthens the resistance of urethra, effectively prevents and treats urinary tract infection.

Palm fruit disturbs the diagnosis of early prostate cancer unlike the medicine of other treatment prostate hyperplasia, also the side effect that causes sexual impotence, alopecia can not arranged as some medicine

The Urtica dioica root: be the root of Urticaceae Urtica plant Urtica dioica, strain Herba Urticae Cannabinae (Urticadioica L.subsp.dioica) is a kind of herbaceos perennial, is extensively studied and uses in developed countries such as America and Europes.As a kind of medical herbs, be used for the treatment of prostatic hyperplasia; Have in addition the effects such as antiviral, enhancing immunity.Its active component mainly contains flavonoid, organic acid, phenols, Phenylpropanoid Glycosides class, sterol, protein, polysaccharide etc.Above three flavor medicines are ministerial drug of the present invention.

Rhizoma Alismatis: belong to Alismataceae; tuber contains and rushes down alcohol (alisol) A; B; C; Alisol A monoacetate (alisol A monoacetate); Alisol B 23-monoacetate (alisol B monoacetate); the single acetic acid vinegar of alisol C (alisol C monoacetate) table alisol (epialisol) A; Rhizoma Alismatis azulene alcohol (alismol); Rhizoma Alismatis azulene alcohol oxide (alismoxide); 16 'beta '-methoxy Alisol B 23-monoacetates (16 β-methocyal-isol B monoacetate); 16 beta-hydroxy Alisol B 23-monoacetates (16 β-hydroxyal-isol B monoacetate), and sitosterol-3-O-stearyl-β-D-glucopyanoside (sitosterol-3-O-steroyl-β-D-glucopyranoside).Also contain choline (cho-line), the elements such as sugar and potassium, calcium, magnesium.Be longer than promoting diuresis to eliminate damp pathogen, expel the heat-evil, be used for dysuria, the edema distension, the puckery pain of stranguria with turbid discharge, seminal emission, foot knee joint flaccidity is soft.

Rhizoma Dioscoreae Septemlobae: Dioscoreaceae, Wild yam; The Rhizoma Dioscoreae Septemlobae rhizome mainly contains dioscin (Dioscin), still contain gracillin (Gracillin), dioscoreassapotoxin A, B (DioscoreasapotoxinA, B) Shan Rhizoma Dioscoreae Septemlobae Saponin (Tokoronin), yononin (Yononin), holder gram ruscogenin-Saponins such as 1-glycoside. dioscorea sapotoxin is the insecticidal constituent in the Rhizoma Dioscoreae Septemlobae of mountain. separating the glycoside unit that obtains from rhizome has: diosgenin (Diosgenin), holder gram ruscogenin (Tokorogenin), Yamogenin (Yamoogenin), yonogenin (Yonogenin), kogagenin (Kogagenin), igagenin (Igagenin) etc. have expelling wind and removing dampness, treating stranguria, diuretic, antiinflammatory, detoxifcation can be treated stranguria with turbid discharge and urinary system infection.

Prunus africana: belong to Rosaceae Li Yake wild arbor trees, the extract of bark and fruit can be restrained the human body fibroblastic growth, and can slow down the epidermal growth factor generation, and prostatosis is had obvious curative effects.Contain in the extract of prunus africana---sterol, terpenoid, can reduce excessive prostaglandin in the patient body, reduce the cholesterol that deposits in the prostate, improve the fragility of vein and blood capillary, also have simultaneously diuresis and anthydropic effect, can greatly improve male prostate and sexual organ disease's genesis.Growth factor receptor inhibitors has the double effects that acts on simultaneously prostate and bladder, can effectively suppress fibroblastic hypertrophy of being caused by basic fibroblast growth factor, thereby can establishment the hypertrophy of fibrous tissue in the prostate, thereby suppress the hypertrophy of prostata tissue.The optimistic wall of urinary bladder fibrosis that suppresses is improved wall of urinary bladder elasticity simultaneously, and bladder function is had protective effect, in addition, also has antiinflammatory and anthydropic activity.

Prunus africana is a kind of traditional prostatitic medical herbs that is used for the treatment of.Contained plant component can diminish inflammation, and alleviates the swelling that prostate occurs because being upset.The situation that can reduce nocturia and urinate and interrupt.Basic fibroblast growth factor (bFGF) is intraprostatic main somatomedin, and bFGF increases the hypertrophy that can cause prostatic cell.The prunus africana extract, the Secondary cases bFGF secretion of energy establishment wall of urinary bladder increases the compensatory that causes and thickens, and the progression of fibrosis of wall of urinary bladder is slowed down, and can reduce the sensitivity of detrusor of bladder, and have antiinflammatory action.Above three flavor medicines are adjuvant drug of the present invention.

Cordycepin: the neplanocin that from Cordyceps militaris (L.) Link., extracts, molecular formula C ₁₀H ₁₃N ₅O ₃, obvious immunoregulation effect is arranged, antibiotic, antiinflammatory, antivirus action.

Lycopene (lycopene) is the main pigment of mature tomato, is a kind of oxygen-free carotenoid.Hartsen isolated this red crystals first from berry Rhizoma Dioscoreae TamuscommunisL. in 1873.Schunk found the different of this material and carotene in 1913, with its called after lycopene first, used so far.Its molecular formula is C40H56, and molecular weight is 536.85, and sterling is needle-like peony crystal, on molecular structure by 11 conjugated double bonds and 2 straight chain type Hydrocarbon that unconjugated double bond forms.In carotenoid, it has the strongest antioxidant activity.The effect that lycopene is removed free radical outclass other carotenoid and vitamin E, and the speed constant of its singlet-oxygen quenching is 100 times of vitamin E, is one of found powerful antioxidant of occurring in nature up to now.Effect with slow down prostatic hyperplasia and antioxidation, slow down aging.

Radix Astragali saponin: leguminous plant, the extract of the root of the Radix Astragali contains flavones ingredient, calycosin, 3-hydroxy-9,10-dimethoxy pterocarpane, Radix Astragali saponin I, V, III, energy tonifying Qi and lifting yang, benefit is defended consolidating superficial resistance, the balance the body metabolism, and enhancing immunity improves antioxidant ability of organism.

Semen Plantaginis: Plantaginaceae, the seed of Herba Plantaginis, the Herba Plantaginis seed contains a moon aucubin (aucubin), Herba Plantaginis mucopolysaccharide (plantago-mulilage), racemization-plantagoside (plantago-side), all square rafter glycoside acid (geniposidic acid), plantenolic acid (plantenolic acid), succinic acid (succinic acid), adenine (adenine), choline (choline) and 10.43% fatty oil, and cupreol (β-sitosterol), cupreol-3-O-β-D-glucopyanoside (β-sitosteryl-3-O-β-D-glucopyranoside).Clearing away heat and promoting diuresis; Cure mainly: main dysuria, stranguria with turbid discharge leukorrhagia; Car owner's stranguria due to disorder of QI, pain relieving, dredging water passages.Radix Astragali saponin is with Semen Plantaginis two medicine one rise and one drop, and Radix Astragali yang invigorating activating QI is walked bladder to go water under the Semen Plantaginis;

Radix Ginseng total glycosides: Araliaceae, the extract of Radix Ginseng, be rich in 18 kinds of Saponins, can obviously suppress cylinder super-oxidation lipid and form, increase simultaneously the content of Superoxide dismutase and peroxidase, have antioxidation, reduce interior free yl content, be added to the somatic cell vigor, suppress old and feeble, blood sugar lowering.Above five kinds of Chinese medicine is the medicine that makes of the present invention.

The traditional Chinese medical science think prostatic hyperplasia be mainly deficiency of kidney-QI, internal organs void declines, being difficult of the moon is due to the folding imbalance.Therefore the QI invigorating the lucid yang sending up helps its gasification, lower logical obturation, and the turbid descending the moon is the main rule for the treatment of, adopts the prescription of this 12 flavor medical material, meets traditional Chinese medical science monarch, the mutually auxiliary theory of negative and positive.

By the proportioning superfine grinding, uniform stirring is made tablet or capsule above-mentioned 12 herbal medicines.Each oral 1.5-2 gram is swallowed with warm water every day three times after meal, serve on for six to eight weeks.

Four, the specific embodiment

The present invention uses more than 20 routine patients with benign prostate hyperplasias, each oral 1.5-2 gram, every day three times, swallow with warm water after meal, serve on for six to eight weeks, except 2 people not the produce effects, all the other are produce effects all, the phenomenons such as urgent micturition, frequent micturition, pouring drop and urine retention are taken an evident turn for the better, and most patient's nocturia are below 2 times, and what have does not even get up in the night to urinate.Effectively improved quality of life.

Claims (1)

1. the present invention relates to a kind of herbal mixture oral tablet, the one-tenth that it is characterized in that it be grouped into and proportioning as follows:

By the proportioning superfine grinding, uniform stirring is made tablet or capsule above-mentioned 12 herbal medicines.Each oral 1.5-2 gram is swallowed with warm water every day three times after meal, serve on for six to eight weeks.