CN105434922A - Preparation for treating facial paralysis and preparation method thereof - Google Patents

Abstract

The invention discloses a preparation for treating facial paralysis. The preparation is prepared from, by weight, 9-15 parts of corn stigmas, 7-13 parts of radix puerariae, 4-10 parts of rungia chinensis benth, 6-12 parts of caulis bambusae in Taeniis, 8-13 parts of humifuse euphorbia herb, 6-11 parts of sweet tea roots, 2-5 parts of earthworms, 7-12 parts of Chinese alpine rush, 9-13 parts of roots of oriental paperbush, 5-11 parts of tribulus terrestris, 8-12 parts of largeleaf dogwood bark, 3-6 parts of paris rhizomes, 7-14 parts of roots of arachnoid cyanotis and 6-10 parts of Debregeasia orientalis C. J. Chen. The preparation for treating facial paralysis is prepared from various Chinese herbal medicine in a dialectical compatibility mode, the preparation has the functions of dispelling wind and removing obstruction in the meridians, dispelling wind and clearing away heat, relieving exterior by pungent-cold drugs, promoting blood circulation and removing obstruction in channels and tonifying blood and nourishing blood, the curative effect is exact, and the preparation has no side effects and is suitable for clinical use.

Description

The preparation of facial paralysis and method for making

Technical field

The present invention relates to traditional Chinese medicine field, particularly relate to a kind of preparation and method for making of facial paralysis.

Background technology

Facial paralysis and facial paralysis, also known as wapperijaw bar, wapperijaw etc., are a kind of commonly encountered diseases, frequently-occurring disease, it is the maxillofacial disease of more complicated, be a kind of commonly encountered diseases that is principal character with facial expression muscle group dyskinesia, not by age limit, general symptom is facial hemiparalysis.Patient facial region is often the most basic to lift the actions such as eyebrow, eye closing, drum mouth and all cannot complete.

Most patient often in early morning wash one's face, gargle time catch sight of that side buccal action is ineffective, face is crooked.The complete paralytic of sick side surface part histrionic muscles, forehead line disappears, palpebral fissure expands, nasolabial fold is smooth, ptosis of labial angle, and time grinningly, bicker is askew to strong lateral deviation.The actions such as sick side can not make wrinkle volume, frown, close order, air-blowing and be in a pout.The drum cheek, with when whistling, leaks gas because Ipsilateral lip can not close.During feed, food debris is often stranded in the tooth buccal space of disease side, and often has saliva to drop down from this side.Because lacrimal point is with lower eyelid entropion, make tear can not be excessive by normal drainage.Be divided into peripheral and central two kinds clinically.Wherein peripheral facial paralysis sickness rate is very high, and the most common person is facial neuritis or Bell's palsy.The facial paralysis that usual people often say refers to facial neuritis more.Because facial paralysis can cause very strange face, so be often called " disease of disfeaturing " by people.

Cause the cause of disease of facial paralysis (facial paralysis) to have multiple, commonly encountered diseases because: 1. infection, many being activated by the varicella zoster virus of resting state in nervus facialis sensory ganglion of hiding of infection causes; 2. ear source property disease, 3. autoimmune response; 4. tumor; 5. neurogenic; 6. traumatic; 7. poisoning, as alcoholism, Long Term Contact Toxic; 8. dysbolismus, as diabetes, vitamin deficiency; 9. vascular function is incomplete; 10. congenital nuclear agenesis.

The method of existing Chinese traditional treatment facial paralysis is more, publication number CN104758506A(application number 201510179322.1) the Chinese medicine that patent document discloses a kind of facial paralysis, be made up of the crude drug of following weight portion: Semen Impatientis 15-20, Fructus Liquidambaris 10-15, Rhizoma Homalomenae 8-12, Semen Strychni 10-12, Ramulus Uncariae Cum Uncis 10-15, Rhizoma Atractylodis Macrocephalae 6-10, Radix aconiti sinomontani 20-25, geranium 6-8, Spica Prunellae 10-12, Herba Taxilli 12-15, Herba Agrimoniae 15-20, Herba Pileae Scriptae 8-10, Folium Perillae 12-16, Radix Angelicae Pubescentis 6-10, Rhizoma Osmundae 15-20, Herba Moslae 16-18, Radix Rhodiolae 12-16, Radix Gentianae Macrophyllae 3-5, Herba Siegesbeckiae 3-5, above-mentioned 19 taste crude drug are soaked in water, to remove slag after decocting to obtain filtrate.The Chinese medicine that patent document discloses a kind of facial paralysis of publication number CN104721401A (application number 201510180336.5), is prepared from by the medical material of following weight proportion: Zaocys 5 parts, Fructus Liquidambaris 8 parts, Caulis Lonicerae 10 parts, Caulis Trachelospermi 5 parts, Lignum Pini Nodi 2 parts, Herba Sarcandrae 8 parts, Cortex erythrinae 6 parts, Radix Rhapontici 5 parts, Radix Ilicis Pubescentis 3 parts, Semen Cassiae 10 parts, Caulis Sargentodoxae 4 parts, Radix seu Caulis Parthenocissi tricuspidatae 7 parts, Radix Cudraniae 2 parts, Herba Bidentis Bipinnatae 5 parts.Publication number CN103520411A (application number 201310471493.2) patent document discloses a kind of medicine being used for the treatment of facial paralysis, and the crude drug of described Chinese medicine composition comprises Arisaema Cum Bile, Radix Isatidis, Ramulus Uncariae Cum Uncis, Radix Platycodonis, Fructus Liquidambaris, Herba Centipedae, Bombyx Batryticatus, Radix Gentianae, Herba Ecliptae, the Radix Astragali, Semen Cuscutae, Radix Bupleuri, Rhizoma Chuanxiong, Stigma Croci, Rhizoma Et Radix Notopterygii, Radix Gentianae Macrophyllae, Herba Hyperici Sampsonii, Herba Aristolochiae, Herba Fici Simplicissimae, Caulis et folium cryptotaeniae japonicae and Radix Glycyrrhizae.

The method of existing facial paralysis treatment mainly contains Drug therapy and surgical operation therapy, and mostly doctor trained in Western medicine is to take some hormones, easily produces a lot of side effect and retroaction, makes patient's immunity degradation, recovers slowly.Surgical operation therapy risk more greatly and costly.Traditional Chinese medical science aspect is mainly by acupuncture and moxibustion therapy, and healing time is longer, and the Chinese Herbs of current most facial paralysis is imprecise.

Summary of the invention

For the deficiency of prior art facial paralysis, an object of the present invention is the preparation providing facial paralysis, select multiple Chinese herbal medicine, dialectical compatibility, there is effect of dispelling wind and removing obstruction in the collateral, wind and heat dispersing, relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, promoting blood circulation to remove obstruction in the collateral, benefiting qi and nourishing blood, determined curative effect, to have no side effect, be applicable to Clinical practice.Another object is just to provide the preparation method of the preparation of above-mentioned facial paralysis.

Above-mentioned purpose of the present invention is achieved through the following technical solutions:

The preparation of facial paralysis, takes off the primary raw material stating weight proportion and is prepared from: Stigma Maydis 9-15 part; Radix Puerariae 7-13 part; Bright calyx grass 4-10 part; Caulis Bambusae In Taenia 6-12 part; Herba Euphorbiae Humifusae 8-13 part; Radix Hydrangeae Strigosae 6-11 part; Scolopendra 2-5 part; Chinese alpine rush 7-12 part; Radix edgeworthiae 9-13 part; Fructus Tribuli 5-11 part; Cortex Corni macrophyllae 8-12 part; Rhizoma Paridis 3-6 part; Radix Cyanotis arachnoideae 7-14 part; Ramulus et Folium Debregeasiae Edulis 6-10 part.

The preparation of facial paralysis, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Stigma Maydis 11-13 part; Radix Puerariae 9-11 part; Bright calyx grass 6-8 part; Caulis Bambusae In Taenia 8-10 part; Herba Euphorbiae Humifusae 10-12 part; Radix Hydrangeae Strigosae 8-10 part; Scolopendra 3-4 part; Chinese alpine rush 9-11 part; Radix edgeworthiae 10-12 part; Fructus Tribuli 7-9 part; Cortex Corni macrophyllae 9-11 part; Rhizoma Paridis 4-5 part; Radix Cyanotis arachnoideae 10-12 part; Ramulus et Folium Debregeasiae Edulis 7-9 part.

The preparation of facial paralysis, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from: Stigma Maydis 12 parts; Radix Puerariae 10 parts; Bright calyx grass 7 parts; Caulis Bambusae In Taenia 9 parts; Herba Euphorbiae Humifusae 11 parts; Radix Hydrangeae Strigosae 9 parts; Scolopendra 3.5 parts; Chinese alpine rush 10 parts; Radix edgeworthiae 11 parts; Fructus Tribuli 8 parts; Cortex Corni macrophyllae 10 parts; Rhizoma Paridis 4.5 parts; Radix Cyanotis arachnoideae 11 parts; Ramulus et Folium Debregeasiae Edulis 8 parts.

Present invention also offers the preparation method preparation of above-mentioned facial paralysis being made pharmaceutically acceptable decoction, tablet, capsule, granule and pill.

The preparation method of the preparation decoction of described facial paralysis, step is as follows:

(1) be placed in frying pan by Fructus Tribuli and Rhizoma Paridis, moderate heat stir-fries 20-30 minute, cools, pulverizes together with Scolopendra, crosses 140-180 mesh sieve (preferred cross 150-170 mesh sieve, be more preferably 160 mesh sieves);

(2) by Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae section, be placed in glass container, add yellow wine, moistening 3-5 hour;

(3) Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae are placed in container, (consumption of preferred alcohol is 3-5 times of Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae quality to add ethanol, the consumption being more preferably ethanol is Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae quality 4 times), reflux, extract, 2-3 hour, filter, reclaim ethanol, obtain extracting solution;

(4) after bright calyx grass, Caulis Bambusae In Taenia, Herba Euphorbiae Humifusae, Chinese alpine rush and Ramulus et Folium Debregeasiae Edulis being fully uniformly mixed, be placed in non iron container, add with 6-10 times amount water soaking 2-4 hour, pour in marmite, add step (2) gains, decoct twice, each decoction 30-40 minute, filters, merging filtrate;

(5) by step (3) gained extracting solution and step (4) gained filtrate mix homogeneously, add step (1) gained medicated powder, stir 5-7 minute clockwise, leave standstill 3-5 hour, filter, sterile packaged.

According to preparation method recited above, preferred scheme is: the consumption of the preferred yellow wine of step (2) is the 30%-40% of Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae quality, and the consumption being more preferably yellow wine is 35% of Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae quality.

Instructions of taking: each 200-300ml, every day 3 times, 5 days courses for the treatment of.

The preparation method of the formulation tablet of described facial paralysis, step is as follows:

(1) be placed in frying pan by Fructus Tribuli and Rhizoma Paridis, moderate heat stir-fries 20-30 minute, cools, pulverizes together with Scolopendra, crosses 140-180 mesh sieve (preferred cross 150-170 mesh sieve, be more preferably 160 mesh sieves);

(2) by Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae section, be placed in glass container, (consumption of preferred yellow wine is the 30%-40% of Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae quality to add yellow wine, the consumption being more preferably yellow wine is 35% of Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae quality), moistening 3-5 hour;

(3) Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae are placed in container, (consumption of preferred alcohol is 3-5 times of Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae quality to add ethanol, the consumption being more preferably ethanol is Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae quality 4 times), reflux, extract, 2-3 hour, filter, reclaim ethanol, obtain extracting solution;

(4) after bright calyx grass, Caulis Bambusae In Taenia, Herba Euphorbiae Humifusae, Chinese alpine rush and Ramulus et Folium Debregeasiae Edulis being fully uniformly mixed, be placed in non iron container, add with 6-10 times amount water soaking 2-4 hour, pour in marmite, add step (2) gains, decoct twice, each decoction 30-40 minute, filters, merging filtrate;

(5) by step (3) gained extracting solution and step (4) gained filtrate mix homogeneously, add step (1) gained medicated powder, stir 5-7 minute clockwise, leave standstill 3-5 hour, filter, being condensed into relative density is 1.20-1.40(45 DEG C) thick paste (be preferably condensed into the thick paste that relative density is 1.25-1.35, be more preferably and be condensed into the thick paste that relative density is 1.30), make the namely loose soft material that hands pinches agglomerating pressure, make uniform granule, drying, is pressed into lamellar, sugar coating.

Instructions of taking: each 2-3 sheet, every day 3 times, 5 days courses for the treatment of.

The preparation method of the preparation capsule of described facial paralysis, step is as follows:

(1) be placed in frying pan by Fructus Tribuli and Rhizoma Paridis, moderate heat stir-fries 20-30 minute, cools, pulverizes together with Scolopendra, crosses 140-180 mesh sieve (preferred cross 150-170 mesh sieve, be more preferably 160 mesh sieves);

(2) by Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae section, be placed in glass container, (consumption of preferred yellow wine is the 30%-40% of Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae quality to add yellow wine, the consumption being more preferably yellow wine is 35% of Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae quality), moistening 3-5 hour;

(3) Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae are placed in container, (consumption of preferred alcohol is 3-5 times of Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae quality to add ethanol, the consumption being more preferably ethanol is Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae quality 4 times), reflux, extract, 2-3 hour, filter, reclaim ethanol, obtain extracting solution;

(4) after bright calyx grass, Caulis Bambusae In Taenia, Herba Euphorbiae Humifusae, Chinese alpine rush and Ramulus et Folium Debregeasiae Edulis being fully uniformly mixed, be placed in non iron container, add with 6-10 times amount water soaking 2-4 hour, pour in marmite, add step (2) gains, decoct twice, each decoction 30-40 minute, filters, merging filtrate;

(5) by step (3) gained extracting solution and step (4) gained filtrate mix homogeneously, add step (1) gained medicated powder, stir 5-7 minute clockwise, leave standstill 3-5 hour, filter, being condensed into relative density is 1.20-1.40(45 DEG C) thick paste, dry, pulverize, obtain medicated powder;

(6) step (5) gained medicated powder is measured according to 0.4-0.6g/ grain (preferred 0.45-0.55g/ grain, is more preferably 0.5g/ grain), be processed into capsule according to the preparation for processing of capsule.

Instructions of taking: each 2-3 grain, every day 3 times, 5 days courses for the treatment of.

The preparation method of the preparation granules agent of described facial paralysis, step is as follows:

(1) be placed in frying pan by Fructus Tribuli and Rhizoma Paridis, moderate heat stir-fries 20-30 minute, cools, pulverizes together with Scolopendra, crosses 140-180 mesh sieve (preferred cross 150-170 mesh sieve, be more preferably 160 mesh sieves);

(2) by Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae section, be placed in glass container, (consumption of preferred yellow wine is the 30%-40% of Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae quality to add yellow wine, the consumption being more preferably yellow wine is 35% of Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae quality), moistening 3-5 hour;

(3) Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae are placed in container, (consumption of preferred alcohol is 3-5 times of Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae quality to add ethanol, the consumption being more preferably ethanol is Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae quality 4 times), reflux, extract, 2-3 hour, filter, reclaim ethanol, obtain extracting solution;

(4) after bright calyx grass, Caulis Bambusae In Taenia, Herba Euphorbiae Humifusae, Chinese alpine rush and Ramulus et Folium Debregeasiae Edulis being fully uniformly mixed, be placed in non iron container, add with 6-10 times amount water soaking 2-4 hour, pour in marmite, add step (2) gains, decoct twice, each decoction 30-40 minute, filters, merging filtrate;

(5) by step (3) gained extracting solution and step (4) gained filtrate mix homogeneously, add step (1) gained medicated powder, clockwise stirring 5-7 minute, leave standstill 3-5 hour, filter, being condensed into relative density is 1.20-1.40(45 DEG C) thick paste, make uniform fine particle, carry out sterile packaged with the specification of often wrapping 10g.

Instructions of taking: each 1 bag, every day 3 times, 5 days courses for the treatment of.

The preparation method of the preparation taste pill of described facial paralysis, step is as follows:

(1) be placed in frying pan by Fructus Tribuli and Rhizoma Paridis, moderate heat stir-fries 20-30 minute, cools, pulverizes together with Scolopendra, crosses 140-180 mesh sieve (preferred cross 150-170 mesh sieve, be more preferably 160 mesh sieves);

(2) by Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae section, be placed in glass container, (consumption of preferred yellow wine is the 30%-40% of Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae quality to add yellow wine, the consumption being more preferably yellow wine is 35% of Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae quality), moistening 3-5 hour;

(3) Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae are placed in container, (consumption of preferred alcohol is 3-5 times of Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae quality to add ethanol, the consumption being more preferably ethanol is Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae quality 4 times), reflux, extract, 2-3 hour, filter, reclaim ethanol, obtain extracting solution;

(4) after bright calyx grass, Caulis Bambusae In Taenia, Herba Euphorbiae Humifusae, Chinese alpine rush and Ramulus et Folium Debregeasiae Edulis being fully uniformly mixed, be placed in non iron container, add with 6-10 times amount water soaking 2-4 hour, pour in marmite, add step (2) gains, decoct twice, each decoction 30-40 minute, filters, merging filtrate;

(5) by step (3) gained extracting solution and step (4) gained filtrate mix homogeneously, add step (1) gained medicated powder, clockwise stirring 5-7 minute, leave standstill 3-5 hour, filter, being condensed into relative density is 1.20-1.40(45 DEG C) thick paste (be preferably condensed into the thick paste that relative density is 1.25-1.35, be more preferably and be condensed into the thick paste that relative density is 1.30), dry, pulverize, obtain medicated powder;

(6) Mel is placed in pot, slow fire is tempered to thick, add the medicated powder of step (5) gained, fully mix into ointment thoroughly, make the elementary finished product ball of the consistent size of color and luster even (preferred diameter is 3-5mm, and being more preferably diameter is 4mm), be placed in baking oven and slowly dry, take out, In Shadely naturally to dry in the shade, pack by pharmaceutically acceptable carrier.

According to preparation method recited above, preferred scheme is: the consumption of the preferred Mel of step (6) is the 10%-20% of medicated powder quality, and the consumption being more preferably Mel is 15% of medicated powder quality.

Using method: each 5-8 ball, every day 3 times, 5 days courses for the treatment of.

Beneficial effect of the present invention is mainly reflected in:

1, multiple Chinese herbal medicine selected by the preparation of facial paralysis of the present invention, dialectical compatibility, and have effect of dispelling wind and removing obstruction in the collateral, wind and heat dispersing, relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, promoting blood circulation to remove obstruction in the collateral, benefiting qi and nourishing blood, determined curative effect, cure rate is high, and short treating period is soon effective.

2, the preparation preparation of facial paralysis of the present invention is simple, and raw material is easy to get, Be very effective, has good application prospect.

3, the preparation of facial paralysis of the present invention adopts Common Chinese Herbs exquisiteness to form, and medicine source is extensive, and cost is low, has no side effect, and is applicable to Clinical practice.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.

The preparation of embodiment 1 facial paralysis, takes off and states primary raw material and be prepared from (getting 40g for every part): Stigma Maydis 9 parts; Radix Puerariae 7 parts; Bright calyx grass 4 parts; Caulis Bambusae In Taenia 6 parts; Herba Euphorbiae Humifusae 8 parts; Radix Hydrangeae Strigosae 6 parts; Scolopendra 2 parts; Chinese alpine rush 7 parts; Radix edgeworthiae 9 parts; Fructus Tribuli 5 parts; Cortex Corni macrophyllae 8 parts; Rhizoma Paridis 3 parts; Radix Cyanotis arachnoideae 7 parts; Ramulus et Folium Debregeasiae Edulis 6 parts.

The preparation method of the preparation decoction of above-mentioned facial paralysis, step is as follows:

(1) be placed in frying pan by Fructus Tribuli and Rhizoma Paridis, moderate heat stir-fries 25 minutes, cools, pulverizes together with Scolopendra, crosses 160 mesh sieves;

(2) by Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae section, be placed in glass container, add yellow wine (consumption is 35% of Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae quality), moistening 4 hours;

(3) Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae are placed in container, add ethanol (consumption is 4 times of Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae quality), reflux, extract, 2.5 hours, filter, reclaim ethanol, obtain extracting solution;

(4) after bright calyx grass, Caulis Bambusae In Taenia, Herba Euphorbiae Humifusae, Chinese alpine rush and Ramulus et Folium Debregeasiae Edulis being fully uniformly mixed, be placed in non iron container, add with 8 times amount water soaking 3 hours, pour in marmite, add step (2) gains, decoct twice, each decoction 35 minutes, filters, merging filtrate;

(5) by step (3) gained extracting solution and step (4) gained filtrate mix homogeneously, add step (1) gained medicated powder, stir 6 minutes clockwise, leave standstill 4 hours, filter, sterile packaged.

Instructions of taking: each 200-300ml, every day 3 times, 5 days courses for the treatment of.

The preparation of embodiment 2 facial paralysis, takes off and states primary raw material and be prepared from (getting 50g for every part): Stigma Maydis 15 parts; Radix Puerariae 13 parts; Bright calyx grass 10 parts; Caulis Bambusae In Taenia 12 parts; Herba Euphorbiae Humifusae 13 parts; Radix Hydrangeae Strigosae 11 parts; Scolopendra 5 parts; Chinese alpine rush 12 parts; Radix edgeworthiae 13 parts; Fructus Tribuli 11 parts; Cortex Corni macrophyllae 12 parts; Rhizoma Paridis 6 parts; Radix Cyanotis arachnoideae 14 parts; Ramulus et Folium Debregeasiae Edulis 10 parts.

The preparation method of the formulation tablet of above-mentioned facial paralysis, step is as follows:

(1) be placed in frying pan by Fructus Tribuli and Rhizoma Paridis, moderate heat stir-fries 25 minutes, cools, pulverizes together with Scolopendra, crosses 160 mesh sieves;

(2) by Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae section, be placed in glass container, add yellow wine (consumption is 35% of Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae quality), moistening 4 hours;

(3) Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae are placed in container, add ethanol (consumption is 4 times of Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae quality), reflux, extract, 3 hours, filter, reclaim ethanol, obtain extracting solution;

(4) after bright calyx grass, Caulis Bambusae In Taenia, Herba Euphorbiae Humifusae, Chinese alpine rush and Ramulus et Folium Debregeasiae Edulis being fully uniformly mixed, be placed in non iron container, add with 8 times amount water soaking 3 hours, pour in marmite, add step (2) gains, decoct twice, each decoction 35 minutes, filters, merging filtrate;

(5) by step (3) gained extracting solution and step (4) gained filtrate mix homogeneously, add step (1) gained medicated powder, clockwise stirring 6 minutes, leaves standstill 4 hours, filters, being condensed into relative density is 1.25(45 DEG C) thick paste, make the namely loose soft material that hands pinches agglomerating pressure, make uniform granule, dry, be pressed into lamellar, sugar coating.

Instructions of taking: each 2-3 sheet, every day 3 times, 5 days courses for the treatment of.

Model case one: Yao XX, female, 43 years old, people from From Shijiazhuang City of Hebei Province.Play discovery left side hypophasis lower morning without obvious inducement, bicker is to the right askew, and in people, crooked left eye can not be completely closed, and volume stricture of vagina disappears, and lifts eyebrow, and grinningly, the drum cheek has obvious obstacle.So remove examination in hospital: left side hypophasis, when quite opening order 1/3, the left side wing of nose can not be instigated, and bicker is to the right askew, the gas leakage of the drum cheek.Be diagnosed as facial paralysis (infranuclear facial palsy), treat DeGrain after two weeks.

After taking 2 courses for the treatment of of formulation tablet (embodiment 2) of facial paralysis of the present invention, left side volume stricture of vagina exists, and eyelid can close, and bicker is inclined, and the drum cheek is air tight.After continuing to take 2 courses for the treatment of, all malaise symptoms disappear, without uncomfortable reaction during medication.Visiting of later stage is learnt, has recovered normal.

The preparation of embodiment 3 facial paralysis, takes off and states primary raw material and be prepared from (getting 20g for every part): Stigma Maydis 11 parts; Radix Puerariae 9 parts; Bright calyx grass 6 parts; Caulis Bambusae In Taenia 8 parts; Herba Euphorbiae Humifusae 10 parts; Radix Hydrangeae Strigosae 8 parts; Scolopendra 3 parts; Chinese alpine rush 9 parts; Radix edgeworthiae 10 parts; Fructus Tribuli 7 parts; Cortex Corni macrophyllae 9 parts; Rhizoma Paridis 4 parts; Radix Cyanotis arachnoideae 10 parts; Ramulus et Folium Debregeasiae Edulis 7 parts.

The preparation method of the preparation capsule of above-mentioned facial paralysis, step is as follows:

(1) be placed in frying pan by Fructus Tribuli and Rhizoma Paridis, moderate heat stir-fries 25 minutes, cools, pulverizes together with Scolopendra, crosses 160 mesh sieves;

(2) by Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae section, be placed in glass container, add yellow wine (consumption is 35% of Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae quality), moistening 4 hours;

(3) Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae are placed in container, add ethanol (consumption is 4 times of Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae quality), reflux, extract, 3 hours, filter, reclaim ethanol, obtain extracting solution;

(4) after bright calyx grass, Caulis Bambusae In Taenia, Herba Euphorbiae Humifusae, Chinese alpine rush and Ramulus et Folium Debregeasiae Edulis being fully uniformly mixed, be placed in non iron container, add with 8 times amount water soaking 3 hours, pour in marmite, add step (2) gains, decoct twice, each decoction 35 minutes, filters, merging filtrate;

(5) by step (3) gained extracting solution and step (4) gained filtrate mix homogeneously, add step (1) gained medicated powder, stir 6 minutes clockwise, leave standstill 4 hours, filter, being condensed into relative density is 1.25(45 DEG C) thick paste, dry, pulverize, obtain medicated powder;

(6) step (5) gained medicated powder is measured according to 0.5g/ grain, be processed into capsule according to the preparation for processing of capsule.

Instructions of taking: each 2-3 grain, every day 3 times, 5 days courses for the treatment of.

The preparation of embodiment 4 facial paralysis, takes off and states primary raw material and be prepared from (getting 20g for every part): Stigma Maydis 13 parts; Radix Puerariae 11 parts; Bright calyx grass 8 parts; Caulis Bambusae In Taenia 10 parts; Herba Euphorbiae Humifusae 12 parts; Radix Hydrangeae Strigosae 10 parts; Scolopendra 4 parts; Chinese alpine rush 11 parts; Radix edgeworthiae 12 parts; Fructus Tribuli 9 parts; Cortex Corni macrophyllae 11 parts; Rhizoma Paridis 5 parts; Radix Cyanotis arachnoideae 12 parts; Ramulus et Folium Debregeasiae Edulis 9 parts.

The preparation method of the preparation granules machine of above-mentioned facial paralysis, step is as follows:

(1) be placed in frying pan by Fructus Tribuli and Rhizoma Paridis, moderate heat stir-fries 25 minutes, cools, pulverizes together with Scolopendra, crosses 160 mesh sieves;

(2) by Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae section, be placed in glass container, add yellow wine (consumption is 35% of Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae quality), moistening 4 hours;

(3) Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae are placed in container, add ethanol (consumption is 4 times of Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae quality), reflux, extract, 3 hours, filter, reclaim ethanol, obtain extracting solution;

(4) after bright calyx grass, Caulis Bambusae In Taenia, Herba Euphorbiae Humifusae, Chinese alpine rush and Ramulus et Folium Debregeasiae Edulis being fully uniformly mixed, be placed in non iron container, add with 8 times amount water soaking 3 hours, pour in marmite, add step (2) gains, decoct twice, each decoction 35 minutes, filters, merging filtrate;

(5) by step (3) gained extracting solution and step (4) gained filtrate mix homogeneously, add step (1) gained medicated powder, clockwise stirring 6 minutes, leave standstill 4 hours, filter, being condensed into relative density is 1.25(45 DEG C) thick paste, make uniform fine particle, carry out sterile packaged with the specification of often wrapping 10g.

Instructions of taking: wrap each serving with 1, every day 3 times, 5 days courses for the treatment of.

Model case two: Du XX, man, 29 years old, people from Handan in Hebei province.Feel there is significant discomfort after getting up early morning, catching sight of left side buccal when scrubbing can not be freely movable, face is crooked shape, obviously feel during speech that left side histrionic muscles is refused to budge, the drum cheek is asymmetric, so remove examination in hospital, be diagnosed as facial paralysis, adopt routine medication and coordinate acupuncture and moxibustion therapy not have material alterations after one week, poor effect, the crooked symptom of face is not obviously alleviated.

After taking 2 courses for the treatment of of preparation granules agent (embodiment 4) of facial paralysis of the present invention, histrionic muscles paralysis situation obviously alleviates.After continuing to take 2 courses for the treatment of, each side such as facial perception is good, cheek reaction is good.Later stage visits and learns and fully recover, and facial paralysis symptom there is no recurrence.

The preparation of embodiment 5 facial paralysis, takes off and states primary raw material and be prepared from (getting 30g for every part): Stigma Maydis 12 parts; Radix Puerariae 10 parts; Bright calyx grass 7 parts; Caulis Bambusae In Taenia 9 parts; Herba Euphorbiae Humifusae 11 parts; Radix Hydrangeae Strigosae 9 parts; Scolopendra 3.5 parts; Chinese alpine rush 10 parts; Radix edgeworthiae 11 parts; Fructus Tribuli 8 parts; Cortex Corni macrophyllae 10 parts; Rhizoma Paridis 4.5 parts; Radix Cyanotis arachnoideae 11 parts; Ramulus et Folium Debregeasiae Edulis 8 parts.

The preparation method of the preparation pill of above-mentioned facial paralysis, step is as follows:

(1) be placed in frying pan by Fructus Tribuli and Rhizoma Paridis, moderate heat stir-fries 25 minutes, cools, pulverizes together with Scolopendra, crosses 160 mesh sieves;

(2) by Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae section, be placed in glass container, add yellow wine (consumption is 35% of Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae quality), moistening 4 hours;

(3) Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae are placed in container, add ethanol (consumption is 4 times of Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae quality), reflux, extract, 3 hours, filter, reclaim ethanol, obtain extracting solution;

(4) after bright calyx grass, Caulis Bambusae In Taenia, Herba Euphorbiae Humifusae, Chinese alpine rush and Ramulus et Folium Debregeasiae Edulis being fully uniformly mixed, be placed in non iron container, add with 8 times amount water soaking 4 hours, pour in marmite, add step (2) gains, decoct twice, each decoction 35 minutes, filters, merging filtrate;

(5) by step (3) gained extracting solution and step (4) gained filtrate mix homogeneously, add step (1) gained medicated powder, stir 6 minutes clockwise, leave standstill 4 hours, filter, being condensed into relative density is 1.30(45 DEG C) thick paste, dry, pulverize, obtain medicated powder;

(6) Mel (consumption is 15% of medicated powder quality) is placed in pot, slow fire is tempered to thick, add the medicated powder of step (5) gained, fully mix into ointment thoroughly, make the elementary finished product ball of the consistent size of color and luster even (preferred diameter is 4mm), be placed in baking oven and slowly dry, take out, In Shadely naturally to dry in the shade, pack by pharmaceutically acceptable carrier.

Instructions of taking: each 5-8 ball, every day 3 times, 5 days courses for the treatment of.

The pharmacological effect of each raw material is respectively:

Stigma Maydis: sweet in the mouth, light, property is put down.Return kidney, stomach, liver, gallbladder meridian.For the zeistic style of grass and stigma.There is inducing diuresis to remove edema, effect of liver heat removing function of gallbladder promoting.For edema, dribbling urination, jaundice, cholecystitis, cholelithiasis, hypertension, diabetes, galactostasis.

Radix Puerariae: sweet in the mouth, pungent, cool in nature.Return spleen, stomach warp.For the dry root of legume pueraria lobata.There is expelling pathogenic factors from muscles for reducing heat, promote the production of body fluid, rash, effect of yang invigorating antidiarrheal.For fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, has loose bowels; Hypertension neck pain.

Bright calyx grass: mildly bitter flavor, pungent, cold in nature.For the herb of acanthaceous plant China Herba rungiae pectinatae.There is wind and heat dispersing, effect of dampness removing angle poison.For anemopyretic cold, coffee swells and ache, cough due to lung-heat, infantile malnutrition, dysentery, edema, furuncle carbuncle.

Caulis Bambusae In Taenia: sweet in the mouth, cold in nature.Attach to the lung and stomach meridians.For the dry intermediate layer of the stem stalk of grass bambusa breviflora Munro, major part allusion quotation bamboo or phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle.There is removing heat-phlegm, the effect relieved restlessness and prevented vomiting.For phlegm-heat cough, expectorant held under the arm by gallbladder fire, and dysphoria with smothery sensation is vomitted, palpitation with fear insomnia, middle wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement.

Herba Euphorbiae Humifusae: acrid in the mouth, property is put down.Return liver, large intestine channel.For the dry herb of euphorbia plant Radix seu Caulis Parthenocissi tricuspidatae or Herba Euphorbiae supinae.There is heat-clearing and toxic substances removing, effect of cooling blood for hemostasis.For dysentery, have loose bowels, spitting of blood, hematuria, has blood in stool, metrorrhagia, furuncle carbuncle.

Radix Hydrangeae Strigosae: acrid in the mouth, acid, cool in nature.Return spleen channel.For the root of the cured lotus silk ball of saxifragaceae plant and umbrella shape silk ball.There is preventing the attack (or recurrence) of malaria, help digestion, heat-clearing and toxic substances removing, effect of expectorant powder junction.For goiter, dyspeptic abdominal distention, laryngopharynx swelling and pain, tinea leprosy, furuncle toxic swelling, malaria.

Scolopendra: acrid in the mouth, warm in nature, poisonous.Return Liver Channel.For the dry body of Scolopendridae animal Scolopendpa Subspinipes Mutilans L. KOCH.There is endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain, move back effect that inflammation controls skin ulcer.For infantile convulsion, tic spasm, middle air port is drunk, hemiplegia, tetanus, rheumatoid arthritis stubborn, skin infection, scrofula, venom, hypertension, the clear stasis of blood, amenorrhea, traumatic injury.

Chinese alpine rush: sweet in the mouth, light, cool in nature.For grass intends herb or the rhizome of Jin Mao.Containing hemicellulose.There is heat-clearing and toxic substances removing, effect of cool the blood dissipate blood stasis.For flu, infantile pneumonia, pulmonary tuberculosis is spat blood, epistaxis, hematuria, blockage of menstruation, pyretic stranguria, mastitis, urticaria, traumatic hemorrhage.

Radix edgeworthiae: acrid in the mouth, property is put down.Return kidney channel.For root bark and the peel of stem of Isolated From Thymelaeaceae Species Edgeworthia chrysantha Lindl..There is dispelling wind and removing obstruction in the collateral, effect of nourishing the liver and kidney.For rheumatic arthralgia, traumatic injury, nocturnal emission, premature ejaculation, metrorrhagia, leucorrhea.

Fructus Tribuli: bitter in the mouth, pungent, property is put down.Return liver, lung, kidney, heart channel.For the fruit of zygophyllaceae plant Fructus Tribuli and Flos Caryophylli disease Herba chenopodii.There is suppressing the hyperactive liver, resolving depression, effect of dispelling pathogenic wind for improving eyesight.For headache, dizzy, distending pain in the chest and hypochondrium, distending pain of the breast, breast closes obstructed, amenorrhea, cataract, rubella pruritus, vitiligo, skin ulcer cellulitis, scrofula.

Cortex Corni macrophyllae: bitter in the mouth, property is put down.For the bark of Cornaceae plant (wood comes) wood.There is dispelling wind and removing obstruction in the collateral, effect of dampness removing antidiarrheal.For bones and muscles pain, quadriplegia, dysentery, watery diarrhea is suffered from abdominal pain.

Rhizoma Paridis: bitter in the mouth, cold in nature.Return Liver Channel.For the rhizome of liliaceous plantization Rhizoma Paridis, Rhizoma Paridis or Rhizoma Paridis.There is heat-clearing and toxic substances removing, reducing swelling and alleviating pain, effect of cool liver arresting convulsion.For carbuncle sore tumefacting virus, pharyngeal swelling sore throat, acute mastitis, snake bite and insect sting, traumatic pain, liver-heat is twitched.

Radix Cyanotis arachnoideae: acrid in the mouth, micro-hardship, warm in nature.For the root of the darkish blue Auricled Hedyotis Herb of the Commelianaceae plant spider's thread.There is removing obstruction in the collateral to relieve pain, inducing diuresis and reducing edema effect.For rheumatic arthralgia, lumbago and skelalgia, numb limbs and tense tendons, edema, eczema.

Ramulus et Folium Debregeasiae Edulis: acrid in the mouth, micro-hardship, cool in nature.For the branch and leaf of contrayerva Debregeasia orientalis C. J. Chen.There is dispelling wind cough-relieving, clearing heat for promoting eruption, effect of removing stasis to stop bleeding.For exogenous cough, hemoptysis, acute infantile convulsion wind, measles without adequate eruption, traumatic injury wound is swollen, enclosed mass in women's abdomen, traumatic hemorrhage.

Test example: in order to verify the curative effect of the preparation (embodiment 5) of facial paralysis of the present invention, we have done contrast test in April ,-2010 in July, 2008.

General data: screen 190 routine facial paralysis patients in Duo Suo hospital, man 101 example, female 89 example.Be divided into experimental group and matched group Liang Ge group (wherein, experimental group 140 people, matched group 50 people) at random.Two groups are compared there was no significant difference (P > 0.05), have comparability in sex, age, the course of disease, state of an illness scoring etc.

Diagnostic criteria: 1. facial perception feel nervous, stiff, numb or atrophy; 2. nasolabial fold shoals, disappears, and Face and cheek is asymmetric, smooth, thicken or twitch, bicker is asymmetric, sagging, on carry or twitch, deflection in people; 3. skin of forehead wrinkle shoals or disappears; 4. the size of palpebral fissure, anisopleual, and the sagging or palpebra inferior in upper eyelid turns up, and eyelid is twitched, swelling, conjunctival congestion ulcer, the symptom such as to shed tears, dry and astringent, sour, swollen.

Usage and dosage: two groups of patients unify dietary standards.Experimental group takes the preparation pill of facial paralysis of the present invention, each 6 balls, every day 3 times, 5 days courses for the treatment of.Matched group: adopt other treatment mode (as giant silkworm capsule, Huafeng pill etc.), wherein giant silkworm capsule: oral, a 2-5 grain, a secondary amounts can not more than 10,3 times on the one.Huafeng pill: oral, a 8-10 ball of being grown up, 2-3 time on the one 18 days is a course for the treatment of; Or follow the doctor's advice.

Criterion of therapeutical effect: cure: the phenomenons such as clinical symptoms and buccal action is ineffective, face is crooked, the paralysis of sick side surface part histrionic muscles all disappear, facial perception and muscular movement functional rehabilitation normally, are observed and are had no repeatedly for 1 year.Effective: the phenomenons such as clinical symptoms and buccal action is ineffective, face is crooked, the paralysis of sick side surface part histrionic muscles alleviate, and the state of an illness is controlled, but slightly feels blunt or deviation when doing expression action, lab testing improvement or normal.Invalid: clinical symptoms is without being clearly better or increasing the weight of.

The Comparison of therapeutic of the experimental group of the matched group adopting other treatment mode and the preparation taking facial paralysis of the present invention, result is as shown in table 1:

Table 1

Efficacy analysis: as can be seen from Table 1, take the effective percentage of the preparation of facial paralysis of the present invention up to 96.43%, and adopt other treatment mode only reach 78%, and take the cure rate of the preparation of facial paralysis of the present invention up to 68.57%, and adopt the cure rate of other treatment mode only to reach 42%.Show that the cure rate of the preparation of gained facial paralysis of the present invention is higher, inefficiency is low, and curative effect is more remarkable, and be the more desirable medicament of facial paralysis, clinic is promoted.

Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. the preparation of facial paralysis, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Stigma Maydis 9-15 part; Radix Puerariae 7-13 part; Bright calyx grass 4-10 part; Caulis Bambusae In Taenia 6-12 part; Herba Euphorbiae Humifusae 8-13 part; Radix Hydrangeae Strigosae 6-11 part; Scolopendra 2-5 part; Chinese alpine rush 7-12 part; Radix edgeworthiae 9-13 part; Fructus Tribuli 5-11 part; Cortex Corni macrophyllae 8-12 part; Rhizoma Paridis 3-6 part; Radix Cyanotis arachnoideae 7-14 part; Ramulus et Folium Debregeasiae Edulis 6-10 part.

2. preparation according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Stigma Maydis 11-13 part; Radix Puerariae 9-11 part; Bright calyx grass 6-8 part; Caulis Bambusae In Taenia 8-10 part; Herba Euphorbiae Humifusae 10-12 part; Radix Hydrangeae Strigosae 8-10 part; Scolopendra 3-4 part; Chinese alpine rush 9-11 part; Radix edgeworthiae 10-12 part; Fructus Tribuli 7-9 part; Cortex Corni macrophyllae 9-11 part; Rhizoma Paridis 4-5 part; Radix Cyanotis arachnoideae 10-12 part; Ramulus et Folium Debregeasiae Edulis 7-9 part.

3. preparation according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Stigma Maydis 12 parts; Radix Puerariae 10 parts; Bright calyx grass 7 parts; Caulis Bambusae In Taenia 9 parts; Herba Euphorbiae Humifusae 11 parts; Radix Hydrangeae Strigosae 9 parts; Scolopendra 3.5 parts; Chinese alpine rush 10 parts; Radix edgeworthiae 11 parts; Fructus Tribuli 8 parts; Cortex Corni macrophyllae 10 parts; Rhizoma Paridis 4.5 parts; Radix Cyanotis arachnoideae 11 parts; Ramulus et Folium Debregeasiae Edulis 8 parts.

4., according to the preparation method of the preparation decoction of the arbitrary described facial paralysis of claim 1-3, it is characterized in that, step is as follows:

(1) be placed in frying pan by Fructus Tribuli and Rhizoma Paridis, moderate heat stir-fries 20-30 minute, cools, pulverizes together with Scolopendra, crosses 140-180 mesh sieve (preferred cross 150-170 mesh sieve, be more preferably 160 mesh sieves);

(2) by Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae section, be placed in glass container, add yellow wine, moistening 3-5 hour;

(3) Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae are placed in container, (consumption of preferred alcohol is 3-5 times of Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae quality to add ethanol, the consumption being more preferably ethanol is Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae quality 4 times), reflux, extract, 2-3 hour, filter, reclaim ethanol, obtain extracting solution;

(4) after bright calyx grass, Caulis Bambusae In Taenia, Herba Euphorbiae Humifusae, Chinese alpine rush and Ramulus et Folium Debregeasiae Edulis being fully uniformly mixed, be placed in non iron container, add with 6-10 times amount water soaking 2-4 hour, pour in marmite, add step (2) gains, decoct twice, each decoction 30-40 minute, filters, merging filtrate;

(5) by step (3) gained extracting solution and step (4) gained filtrate mix homogeneously, add step (1) gained medicated powder, stir 5-7 minute clockwise, leave standstill 3-5 hour, filter, sterile packaged.

5. the preparation method of preparation decoction according to claim 4, it is characterized in that: the consumption of the preferred yellow wine of step (2) is the 30%-40% of Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae quality, and the consumption being more preferably yellow wine is 35% of Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae quality.

6., according to the arbitrary described preparation of claim 1-3, it is characterized in that, be made into pharmaceutically acceptable tablet, preparation method is as follows:

(1) be placed in frying pan by Fructus Tribuli and Rhizoma Paridis, moderate heat stir-fries 20-30 minute, cools, pulverizes together with Scolopendra, crosses 140-180 mesh sieve (preferred cross 150-170 mesh sieve, be more preferably 160 mesh sieves);

(2) by Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae section, be placed in glass container, (consumption of preferred yellow wine is the 30%-40% of Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae quality to add yellow wine, the consumption being more preferably yellow wine is 35% of Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae quality), moistening 3-5 hour;

(3) Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae are placed in container, (consumption of preferred alcohol is 3-5 times of Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae quality to add ethanol, the consumption being more preferably ethanol is Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae quality 4 times), reflux, extract, 2-3 hour, filter, reclaim ethanol, obtain extracting solution;

(4) after bright calyx grass, Caulis Bambusae In Taenia, Herba Euphorbiae Humifusae, Chinese alpine rush and Ramulus et Folium Debregeasiae Edulis being fully uniformly mixed, be placed in non iron container, add with 6-10 times amount water soaking 2-4 hour, pour in marmite, add step (2) gains, decoct twice, each decoction 30-40 minute, filters, merging filtrate;

(5) by step (3) gained extracting solution and step (4) gained filtrate mix homogeneously, add step (1) gained medicated powder, stir 5-7 minute clockwise, leave standstill 3-5 hour, filter, be condensed into the thick paste (be preferably condensed into the thick paste that relative density is 1.25-1.35, be more preferably and be condensed into the thick paste that relative density is 1.30) that relative density is 1.20-1.40, make the namely loose soft material that hands pinches agglomerating pressure, make uniform granule, drying, is pressed into lamellar, sugar coating.

7., according to the arbitrary described preparation of claim 1-3, it is characterized in that, be made into pharmaceutically acceptable capsule, preparation method is as follows:

(1) be placed in frying pan by Fructus Tribuli and Rhizoma Paridis, moderate heat stir-fries 20-30 minute, cools, pulverizes together with Scolopendra, crosses 140-180 mesh sieve (preferred cross 150-170 mesh sieve, be more preferably 160 mesh sieves);

(2) by Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae section, be placed in glass container, (consumption of preferred yellow wine is the 30%-40% of Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae quality to add yellow wine, the consumption being more preferably yellow wine is 35% of Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae quality), moistening 3-5 hour;

(3) Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae are placed in container, (consumption of preferred alcohol is 3-5 times of Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae quality to add ethanol, the consumption being more preferably ethanol is Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae quality 4 times), reflux, extract, 2-3 hour, filter, reclaim ethanol, obtain extracting solution;

(4) after bright calyx grass, Caulis Bambusae In Taenia, Herba Euphorbiae Humifusae, Chinese alpine rush and Ramulus et Folium Debregeasiae Edulis being fully uniformly mixed, be placed in non iron container, add with 6-10 times amount water soaking 2-4 hour, pour in marmite, add step (2) gains, decoct twice, each decoction 30-40 minute, filters, merging filtrate;

(5) by step (3) gained extracting solution and step (4) gained filtrate mix homogeneously, add step (1) gained medicated powder, stir 5-7 minute clockwise, leave standstill 3-5 hour, filter, be condensed into the thick paste that relative density is 1.20-1.40, dry, pulverize, obtain medicated powder;

(6) step (5) gained medicated powder is measured according to 0.4-0.6g/ grain (preferred 0.45-0.55g/ grain, is more preferably 0.5g/ grain), be processed into capsule according to the preparation for processing of capsule.

8., according to the arbitrary described preparation of claim 1-3, it is characterized in that, be made into pharmaceutically acceptable granule, preparation method is as follows:

(1) be placed in frying pan by Fructus Tribuli and Rhizoma Paridis, moderate heat stir-fries 20-30 minute, cools, pulverizes together with Scolopendra, crosses 140-180 mesh sieve (preferred cross 150-170 mesh sieve, be more preferably 160 mesh sieves);

(2) by Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae section, be placed in glass container, (consumption of preferred yellow wine is the 30%-40% of Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae quality to add yellow wine, the consumption being more preferably yellow wine is 35% of Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae quality), moistening 3-5 hour;

(3) Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae are placed in container, (consumption of preferred alcohol is 3-5 times of Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae quality to add ethanol, the consumption being more preferably ethanol is Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae quality 4 times), reflux, extract, 2-3 hour, filter, reclaim ethanol, obtain extracting solution;

(4) after bright calyx grass, Caulis Bambusae In Taenia, Herba Euphorbiae Humifusae, Chinese alpine rush and Ramulus et Folium Debregeasiae Edulis being fully uniformly mixed, be placed in non iron container, add with 6-10 times amount water soaking 2-4 hour, pour in marmite, add step (2) gains, decoct twice, each decoction 30-40 minute, filters, merging filtrate;

(5) by step (3) gained extracting solution and step (4) gained filtrate mix homogeneously, add step (1) gained medicated powder, clockwise stirring 5-7 minute, leave standstill 3-5 hour, filter, be condensed into the thick paste that relative density is 1.20-1.40, make uniform fine particle, carry out sterile packaged with the specification of often wrapping 10g.

9., according to the arbitrary described preparation of claim 1-3, it is characterized in that, be made into pharmaceutically acceptable pill, preparation method is as follows:

(1) be placed in frying pan by Fructus Tribuli and Rhizoma Paridis, moderate heat stir-fries 20-30 minute, cools, pulverizes together with Scolopendra, crosses 140-180 mesh sieve (preferred cross 150-170 mesh sieve, be more preferably 160 mesh sieves);

(2) by Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae section, be placed in glass container, (consumption of preferred yellow wine is the 30%-40% of Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae quality to add yellow wine, the consumption being more preferably yellow wine is 35% of Radix Puerariae, Radix Hydrangeae Strigosae and Radix Cyanotis arachnoideae quality), moistening 3-5 hour;

(3) Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae are placed in container, (consumption of preferred alcohol is 3-5 times of Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae quality to add ethanol, the consumption being more preferably ethanol is Stigma Maydis, Radix edgeworthiae and Cortex Corni macrophyllae quality 4 times), reflux, extract, 2-3 hour, filter, reclaim ethanol, obtain extracting solution;

(4) after bright calyx grass, Caulis Bambusae In Taenia, Herba Euphorbiae Humifusae, Chinese alpine rush and Ramulus et Folium Debregeasiae Edulis being fully uniformly mixed, be placed in non iron container, add with 6-10 times amount water soaking 2-4 hour, pour in marmite, add step (2) gains, decoct twice, each decoction 30-40 minute, filters, merging filtrate;

(5) by step (3) gained extracting solution and step (4) gained filtrate mix homogeneously, add step (1) gained medicated powder, clockwise stirring 5-7 minute, leave standstill 3-5 hour, filter, be condensed into the thick paste that relative density is 1.20-1.40 and (be preferably condensed into the thick paste that relative density is 1.25-1.35, be more preferably and be condensed into the thick paste that relative density is 1.30), dry, pulverize, obtain medicated powder;

(6) Mel is placed in pot, slow fire is tempered to thick, add the medicated powder of step (5) gained, fully mix into ointment thoroughly, make the elementary finished product ball of the consistent size of color and luster even (preferred diameter is 3-5mm, and being more preferably diameter is 4mm), be placed in baking oven and slowly dry, take out, In Shadely naturally to dry in the shade, pack by pharmaceutically acceptable carrier.

10. the preparation method of preparation pill according to claim 9, is characterized in that: the consumption of the preferred Mel of step (6) is the 10%-20% of medicated powder quality, and the consumption being more preferably Mel is 15% of medicated powder quality.