CN102357217B - Chinese patent medicine for treating gastric ulcer - Google Patents
Chinese patent medicine for treating gastric ulcer Download PDFInfo
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- CN102357217B CN102357217B CN2011103466828A CN201110346682A CN102357217B CN 102357217 B CN102357217 B CN 102357217B CN 2011103466828 A CN2011103466828 A CN 2011103466828A CN 201110346682 A CN201110346682 A CN 201110346682A CN 102357217 B CN102357217 B CN 102357217B
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Abstract
The invention discloses a Chinese patent medicine for treating gastric ulcer, which comprises the following components by weight: 9-11 parts of bletilla striata, 9-11 parts of radix ampelopsis, 9-11 parts of licorice, 4.5-6.5 parts of chicken gizzard membrane, 0.4-0.6 parts of calculus bovis, 9-11 parts of fried massa medicata fermentata fujianensis, 9-11 parts of malt, and 15-20 parts of tallow. The invention is prepared by the following steps: decocting bletilla striata, radix ampelopsis, licorice and chicken gizzard membrane with water, filtering, concentrating the filtrate, drying to prepare powder; crushing calculus bovis, fried massa medicata fermentata fujianensis and malt in a micronizer to obtain a particle size of below 5 microns; well mixing with tallow at 40 DEG C-45 DEG C, blending to prepare particles. Treatment tests are performed on rat acetic acid-induced gastric ulcer models; an average ulcer area pre-administration is up to 81.24 mm2; after treatment for 10 days, the average ulcer area is decreased to 0.05 mm2; after treatment for 14 days, all rats in a model control group are dead; rats in an administration group have very good mental state, can act freely with no difference from normal rats; the rats are dissected and observed; no ulcer is observed at all with naked eye; and the cure rate is nearly 100.00%.
Description
Technical field
The present invention relates to a kind of gastric ulcer Chinese patent medicine for the treatment of.
Background technology
(Gastric ulcer is a kind of commonly encountered diseases, frequently-occurring disease GU) to gastric ulcer, and complication is many, and it is slower to heal, and its pathogenesis still imperfectly understands at present, and directly harm humans health does not still have specificity radical cure measure so far.Any effect that causes the reinforcement of invasion and attack factor or protectiveness factor to weaken all can cause ulcer, and its complication has upper gastrointestinal hemorrhage, perforated ulcer, pyloric obstruction, canceration etc.
The whole world has 1/10 people to suffer from Symptomatic peptic ulcer in life approximately, if then real peptic ulcer prevalence may be up to 1/5 to consider asymptomatic ulcer simultaneously, annual newly-increased case 500,000 people of the U.S., about 4,000,000 people of recurrent cases, the over-65s old people accounts for 16% because of peptic ulcer hospitalization or dead person.There is the complication of dying from Peptic Ulcers about 15,000 people every year in the U.S., and the medical expense relevant with Peptic Ulcers then surpasses 15,000,000,000 U.S. dollars.
China at present annual chronic peptic ulcer state of an illness of suffering from reports and reaches 2,000 ten thousand people, has wrong treatment to prolong and controls, and is converted into gastric cancer, and death reaches more than 200 ten thousand people, serious harm people's health.
The medicine for the treatment of gastric ulcer has much at present, mainly can be divided into following several: (1) acid inhibitor: hydrotalcite, aluminium hydroxide, magnesium oxide, calcium carbonate etc.; (2) bisfentidine: cimetidine, ranitidine, famotidine etc.; (3) proton pump inhibitor: omeprazole, lansoprazole, pantoprazole, rabeprazole, esomeprazole etc.; (4) pyloric spirobacterium inhibitor: metronidazole, clarithromycin, amoxicillin etc.; (5) gastric mucosal protection agent: Colloidal Bismuth Tartrate capsule, bismuth citrate clock, sucralfate, teprenone etc.; (6) compound Chinese medicinal preparation: the new liquid of rehabilitation, stomach invigorating ulcer curing tablet, Weikang capsule for curing gastric disease, cyperus-amomum stomach sheet etc.; (7) medicine for stomach dynamic: JUYUANSUNMOSHABILI capsule, domperidone tablet, metoclopramide sheet, cisapride etc.
Along with increasing of medicament categories, clinical in treatment multi-joint medicine that share during gastric ulcer, drug combination prescription commonly used is as follows: (1) omeprazole enteric-coated capsules+domperidone tablet+new liquid of rehabilitation; (2) ranitidine capsule+metronidazole; (3) omeprazole enteric-coated capsules+sucralfate; (4) lansoprazole+hydrotalcite chewable tablet; (5) omeprazole+levofloxacin+clarithromycin; (6) omeprazole+amoxicillin+metronidazole; (7) lansoprazole+JUYUANSUNMOSHABILI capsule+Colloidal Bismuth Tartrate capsule.
Domestic compound Chinese medicinal preparation has also been brought into play irreplaceable effect in the treatment of gastric ulcer, especially improving aspect the symptom, and clinical compound Chinese medicinal preparation commonly used has stomach invigorating ulcer curing tablet and the new liquid of rehabilitation.
Stomach invigorating ulcer curing tablet: formulated by Radix Codonopsis, Radix Bupleuri, the Radix Paeoniae Alba, Rhizoma Corydalis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Margarita layer powder, Indigo Naturalis and Radix Glycyrrhizae etc.; relieving spasm to stop pain, hemostasia and promoting granulation effect are arranged; but can alleviate gastral cavilty distending pain, belch, acid regurgitation and gastric acid inhibitory; improve local blood circulation; the protection gastric mucosa accelerates ulcer healing.The effect that weakens the invasion and attack factor is significantly arranged, improve defensive factor simultaneously, both are coordinated, thus the effect of performance anti-peptic ulcer.
The new liquid of rehabilitation: be the solution that the dry polypide ethanol extraction of periplaneta americana is made, contain WHF (peptide class and polyalcohols, epidermal growth factor), glutinous sugared propylhomoserin and several amino acids isoreactivity material.Studies confirm that through relevant, the new liquid of rehabilitation can promote epidermal growth and granulation tissue hyperplasia, promote the mucosa blood capillary proliferation and improve local blood circulation, promote the wound surface slough to come off, accelerate wound repair, secrete the class interleukin simultaneously, interferon, materials such as Prostaglandins and Leukotrienes are eliminated inflammatory edema rapidly; Activation non-specific cell immunologic function; Increase macrophage and NK cell to the direct phagocytosis of cause of disease material; Can reduce gastric secretion, pepsin output, thereby play the antiulcer effect.
Show that according to the market survey data existing brand product all has the defective on " need satisfaction ability ".Most of brands solve stomachache, gastric acid, flatulence and the several cardinal symptoms of reparation gastric mucosa and strengthen demand at strengthening gastric motility.But the treatment of gastropathy and recovery are that solution table disease demand just can be finished anything but.Thoroughly recovering gastrointestinal health need be on the cause of disease, or even changes on the living habit.But the traditional Chinese medical science viewpoint of " gastropathy is supported for a long time " is accepted by consumers in general but can't be accomplished the medication of persevering ground.Consumer wishes that some products can accomplish reduce to use that difficulty, curative effect are fast, quickly alleviating pain, effect are remarkable, reaches and supports purpose for a long time.These all are new demand and chance that gastropathy medication market produces.
Summary of the invention
The purpose of this invention is to provide a kind of gastric ulcer Chinese patent medicine for the treatment of.
A kind of gastric ulcer Chinese patent medicine for the treatment of, it is by weight: Pseudobulbus Bletillae (Rhizoma Bletillae) 9-11, Radix Ampelopsis 9-11, Radix Glycyrrhizae 9-11, Endothelium Corneum Gigeriae Galli 4.5-6.5, Calculus Bovis 0.4-0.6, process Massa Medicata Fermentata 9-11, Fructus Hordei Germinatus 9-11 and Adeps Bovis seu Bubali 15-20; Described Adeps Bovis seu Bubali filters decontamination for Adeps Bovis seu Bubali is organized tallow rendering; Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Ampelopsis, Radix Glycyrrhizae and Endothelium Corneum Gigeriae Galli are decocted with water, filter, concentrated filtrate is also dry, makes powder; Calculus Bovis, process Massa Medicata Fermentata and Fructus Hordei Germinatus is pulverized in pulverizing mill, particle diameter is below 5um; Be added to mixing in 40 ℃-45 ℃ the Adeps Bovis seu Bubali, be modulated into granule;
Described weight portion is Pseudobulbus Bletillae (Rhizoma Bletillae) 11, Radix Ampelopsis 9, Radix Glycyrrhizae 11, Endothelium Corneum Gigeriae Galli 5.5, Calculus Bovis 0.6, processs Massa Medicata Fermentata 11, Fructus Hordei Germinatus 9 and Adeps Bovis seu Bubali 20;
Or Pseudobulbus Bletillae (Rhizoma Bletillae) 9, Radix Ampelopsis 11, Radix Glycyrrhizae 9, Endothelium Corneum Gigeriae Galli 6.5, Calculus Bovis 0.4, process Massa Medicata Fermentata 9, Fructus Hordei Germinatus 11 and Adeps Bovis seu Bubali 18;
Preferably Pseudobulbus Bletillae (Rhizoma Bletillae) 10, Radix Ampelopsis 10, Radix Glycyrrhizae 10, Endothelium Corneum Gigeriae Galli 6, Calculus Bovis 0.5, process Massa Medicata Fermentata 10, Fructus Hordei Germinatus 10 and Adeps Bovis seu Bubali 15;
Described Adeps Bovis seu Bubali is refined under 95-100 ℃ of temperature.
A kind of gastric ulcer Chinese patent medicine for the treatment of provided by the invention, it is by by weight following: Pseudobulbus Bletillae (Rhizoma Bletillae) 9-11, Radix Ampelopsis 9-11, Radix Glycyrrhizae 9-11, Endothelium Corneum Gigeriae Galli 4.5-6.5, Calculus Bovis 0.4-0.6, process Massa Medicata Fermentata 9-11, Fructus Hordei Germinatus 9-11 and Adeps Bovis seu Bubali 15-20; Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Ampelopsis, Radix Glycyrrhizae and Endothelium Corneum Gigeriae Galli are decocted with water, filter, concentrated filtrate is also dry, makes powder; Calculus Bovis, process Massa Medicata Fermentata and Fructus Hordei Germinatus is pulverized in pulverizing mill, particle diameter is below 5um; Be added to mixing in 40 ℃-45 ℃ the Adeps Bovis seu Bubali, be modulated into granule; Acetic acid rat gastric ulcer model is carried out therapeutic test, and average ulcer area can reach 81.24mm before the medication
2, treat and be reduced to 0.05mm after 10 days
2, to treat after 14 days, model control group is all dead; The medication group mental status is fine, and freedom of movement with normal no any difference, is dissected the back and observed, and naked eyes do not observe ulcer fully, cure rate nearly 100.00%.
Description of drawings
Fig. 1 is the rat stomach photo of acetic acid rat gastric ulcer modelling after 3 days;
Fig. 2 is the rat stomach photo of acetic acid rat gastric ulcer model control group treatment experiment after 10 days;
Fig. 3 is that acetic acid rat gastric ulcer model medication group is treated rat stomach photo after 10 days;
Fig. 4 is that acetic acid rat gastric ulcer model medication group is treated rat stomach photo after 14 days.
The specific embodiment
Embodiment 1 treatment gastric ulcer Chinese patent medicine
Take by weighing Pseudobulbus Bletillae (Rhizoma Bletillae) 10g, Radix Ampelopsis 10g, Radix Glycyrrhizae 10g, Endothelium Corneum Gigeriae Galli 6g, Calculus Bovis 0.5g, process Massa Medicata Fermentata 10g, Fructus Hordei Germinatus 10g and Adeps Bovis seu Bubali 15g; Described Adeps Bovis seu Bubali is for to be organized in Adeps Bovis seu Bubali under the 95-100 ℃ of temperature, all overflows to fat, and moisture content evaporates fully, is press-filtered out impurity and makes;
Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Ampelopsis, Radix Glycyrrhizae and Endothelium Corneum Gigeriae Galli were soaked 6 hours, and heating decocted 1 hour, filtered, and filtering residue adds water and decocted 1 hour again, merges filtrate twice, and concentrated filtrate is also dry, makes powder;
With Calculus Bovis, process Massa Medicata Fermentata and Fructus Hordei Germinatus is pulverized in pulverizing mill, become particle diameter below 5um;
Adeps Bovis seu Bubali is heated to 40 ℃-45 ℃, adds Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Ampelopsis, Radix Glycyrrhizae and Endothelium Corneum Gigeriae Galli water extract and Calculus Bovis, processs Massa Medicata Fermentata and Fructus Hordei Germinatus powder, and mixing is made granule.
Embodiment 2 treatment gastric ulcer Chinese patent medicines
Take by weighing Pseudobulbus Bletillae (Rhizoma Bletillae) 11g, Radix Ampelopsis 9g, Radix Glycyrrhizae 11g, Endothelium Corneum Gigeriae Galli 5.5g, Calculus Bovis 0.6g, process Massa Medicata Fermentata 11g, Fructus Hordei Germinatus 9g and Adeps Bovis seu Bubali 20g; Described Adeps Bovis seu Bubali filters decontamination for Adeps Bovis seu Bubali is organized tallow rendering;
Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Ampelopsis, Radix Glycyrrhizae and Endothelium Corneum Gigeriae Galli were soaked 6 hours, and heating decocted 1 hour, filtered, and filtering residue adds water and decocted 1 hour again, merges filtrate twice, and concentrated filtrate is also dry, makes powder;
With Calculus Bovis, process Massa Medicata Fermentata and Fructus Hordei Germinatus is pulverized in pulverizing mill, particle diameter is below 5um;
Adeps Bovis seu Bubali is heated to 40 ℃-45 ℃, adds Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Ampelopsis, Radix Glycyrrhizae and Endothelium Corneum Gigeriae Galli water extract and Calculus Bovis, processs Massa Medicata Fermentata and Fructus Hordei Germinatus powder, and mixing is made granule.
3 one kinds of Chinese patent medicines for the treatment of gastric ulcer of embodiment
Take by weighing Pseudobulbus Bletillae (Rhizoma Bletillae) 9g, Radix Ampelopsis 11g, Radix Glycyrrhizae 9g, Endothelium Corneum Gigeriae Galli 6.5g, Calculus Bovis 0.4g, process Massa Medicata Fermentata 9g, Fructus Hordei Germinatus 11g and Adeps Bovis seu Bubali 18g; Described Adeps Bovis seu Bubali filters decontamination for the Adeps Bovis seu Bubali tissue is organized tallow rendering with Adeps Bovis seu Bubali.
Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Ampelopsis, Radix Glycyrrhizae and Endothelium Corneum Gigeriae Galli are added the water heating decocted 2 hours, filter, filtering residue adds water and decocted 2 hours again, merges filtrate twice, and concentrated filtrate is also dry, makes powder;
With Calculus Bovis, process Massa Medicata Fermentata and Fructus Hordei Germinatus is pulverized in pulverizing mill, particle diameter is below 5um;
Adeps Bovis seu Bubali is heated to 40 ℃-45 ℃, adds Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Ampelopsis, Radix Glycyrrhizae and Endothelium Corneum Gigeriae Galli water extract and Calculus Bovis, processs Massa Medicata Fermentata and Fructus Hordei Germinatus powder, and mixing is made granule.
The foundation of experimental example 1 acetic acid rat gastric ulcer model
Rat (available from Changchun Biological Products Institute) fasting (can't help water) 24h, after injecting 10% chloral hydrate 1ml anesthesia, lie on the back and be fixed on the operating-table, the alcohol disinfecting abdominal part, about xiphoid-process median incision of lower abdomen 1.5cm, after opening abdomen stomach is pulled out, at the facies ventralis of stomach, body of stomach and pyloric part intersection thrust 0.5～0.6mm under the serous coat with microsyringe is flat, inject 20% acetic acid 0.05ml and form pimple, with sending stomach back to abdominal cavity behind the normal saline flushing, sew up stomach wall, the sterilization wound, the rat fasting on the same day (can't help water) of operation begins conventional the raising next day;
Extract the part rat at random out, rat is put to death in the cervical vertebra dislocation after 3 days, opens the abdominal cavity, stomach is pulled out, cut along greater gastric curvature after taking out stomach, with 37 ℃ of normal saline gastric mucosa is rinsed well, blot with filter paper, flatten, be placed on the ice platform, with major diameter (DL) and the minor axis (DS) of vernier caliper measurement ulcer, calculate the area of ulcer, by formula calculate S=DL * DS * π/4, and π gets 3.14;
Form typical circle or oval volcanic crater sample gastric ulcer in the rat stomach, around the ulcer because congestion and edema swells, intermediate recess, and mucosal fold chap around the ulcer, part is the asterism shape centered by ulcer, and ulcer can reach the flesh layer deeply, has one deck ash white fur on it; Average 81.24mm
2See Fig. 1.
2 one kinds of treatments of experimental example gastric ulcer Chinese patent medicine is to acetic acid rat gastric ulcer model treatment experiment
The acetic acid rat gastric ulcer model that embodiment 1 is set up is divided into two groups at random after 3 days: model control group and model medication group, matched group gavage 3 times aquae destillata, medication group administration every day 3 times every day; Medication group 1 is adopted the treatment gastric ulcer Chinese patent medicine of embodiment 1; Medication group 2 adopts the gastric ulcer Chinese patent medicine of embodiment 2; Medication group 2 adopts the gastric ulcer Chinese patent medicine of embodiment 2.
Behind the successive administration 10 days, the model control group mental status is not good enough, the movable minimizing, drowsiness, irritant reaction is insensitive to external world, defecation urine is normal substantially, during death condition is arranged; The medication group mental status is good, and is free movable, and the irritant reaction sensitivity is discharged feces urine normally to external world.Each is organized stochastic sampling and dissects rat observation ulcer situation, calculates the ulcer area, and model control group ulcer is still very serious, and the surface is covered with white fur, and average ulcer area reaches 73.96mm
2See Fig. 2.Medication group 1 ulcer ulcer area obviously reduces, and naked eyes have not almost observed ulcer, and average ulcer area reduces to 0.05mm
2, see Fig. 3; Medication group 2 average ulcer area 0.10mm
2Medication group 3 average ulcer area 0.15mm
2
Treat after 14 days, model control group is all dead, and the medication group mental status is fine, and freedom of movement is dissected the back and observed, and medication group 1 naked eyes do not observe ulcer fully, see Fig. 4; Medication group 2 average ulcer area 0.10mm
260% perusal is less than ulcer; Medication group 3 average ulcer area 0.15mm
240% perusal is less than ulcer;
The ulcer area respectively organized by table 1 and ulcer inhibition rate compares
Table?1?Comparison?of?ulcer?area?and?ulcer?inhibition?rate
Claims (5)
1. treatment gastric ulcer Chinese patent medicine, it is by weight: Pseudobulbus Bletillae (Rhizoma Bletillae) 9-11, Radix Ampelopsis 9-11, Radix Glycyrrhizae 9-11, Endothelium Corneum Gigeriae Galli 4.5-6.5, Calculus Bovis 0.4-0.6, process Massa Medicata Fermentata 9-11, Fructus Hordei Germinatus 9-11 and Adeps Bovis seu Bubali 15-20; Described Adeps Bovis seu Bubali filters decontamination for Adeps Bovis seu Bubali is organized tallow rendering; Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Ampelopsis, Radix Glycyrrhizae and Endothelium Corneum Gigeriae Galli are decocted with water, filter, concentrated filtrate is also dry, makes powder; Calculus Bovis, process Massa Medicata Fermentata and Fructus Hordei Germinatus is pulverized in pulverizing mill, particle diameter is below 5um; Be added to mixing in 40 ℃-45 ℃ the Adeps Bovis seu Bubali, be modulated into granule.
2. a kind of gastric ulcer Chinese patent medicine for the treatment of according to claim 1, it is characterized in that: described weight portion is Pseudobulbus Bletillae (Rhizoma Bletillae) 11, Radix Ampelopsis 9, Radix Glycyrrhizae 11, Endothelium Corneum Gigeriae Galli 5.5, Calculus Bovis 0.6, processs Massa Medicata Fermentata 11, Fructus Hordei Germinatus 9 and Adeps Bovis seu Bubali 20.
3. a kind of gastric ulcer Chinese patent medicine for the treatment of according to claim 1, it is characterized in that: described weight portion is Pseudobulbus Bletillae (Rhizoma Bletillae) 9, Radix Ampelopsis 11, Radix Glycyrrhizae 9, Endothelium Corneum Gigeriae Galli 6.5, Calculus Bovis 0.4, processs Massa Medicata Fermentata 9, Fructus Hordei Germinatus 11 and Adeps Bovis seu Bubali 18.
4. a kind of gastric ulcer Chinese patent medicine for the treatment of according to claim 1, it is characterized in that: described weight portion is Pseudobulbus Bletillae (Rhizoma Bletillae) 10, Radix Ampelopsis 10, Radix Glycyrrhizae 10, Endothelium Corneum Gigeriae Galli 6, Calculus Bovis 0.5, processs Massa Medicata Fermentata 10, Fructus Hordei Germinatus 10 and Adeps Bovis seu Bubali 15.
5. according to claim 1,2,3 or 4 described a kind of gastric ulcer Chinese patent medicines for the treatment of, it is characterized in that: described Adeps Bovis seu Bubali is refined under 95-100 ℃ of temperature.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011103466828A CN102357217B (en) | 2011-11-07 | 2011-11-07 | Chinese patent medicine for treating gastric ulcer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103466828A CN102357217B (en) | 2011-11-07 | 2011-11-07 | Chinese patent medicine for treating gastric ulcer |
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| CN102357217A CN102357217A (en) | 2012-02-22 |
| CN102357217B true CN102357217B (en) | 2013-07-03 |
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| CN1243733A (en) * | 1998-08-03 | 2000-02-09 | 阎天玉 | Chinese medicine for treating gastric ulcer |
| CN1067272C (en) * | 1998-12-02 | 2001-06-20 | 曾庆湘 | Powder for curing gastric ulcer |
| CN1236802C (en) * | 2002-02-02 | 2006-01-18 | 王桂英 | Medicine for treating gastritis and gastric ulcer |
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