CN105764334B - 加强肿瘤生长的方法 - Google Patents

加强肿瘤生长的方法 Download PDF

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Publication number
CN105764334B
CN105764334B CN201480055352.5A CN201480055352A CN105764334B CN 105764334 B CN105764334 B CN 105764334B CN 201480055352 A CN201480055352 A CN 201480055352A CN 105764334 B CN105764334 B CN 105764334B
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cells
human
nme7
cancer
cancer cells
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Chinese (zh)
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CN105764334A (zh
Inventor
辛席亚·C·班姆达德
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Minawa Biotechnology
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Minerva Biotechnologies Corp
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Priority claimed from PCT/US2014/017515 external-priority patent/WO2014130741A2/en
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Publication of CN105764334A publication Critical patent/CN105764334A/zh
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/12—Animals modified by administration of exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Compounds Of Unknown Constitution (AREA)
CN201480055352.5A 2013-08-12 2014-08-12 加强肿瘤生长的方法 Active CN105764334B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361865092P 2013-08-12 2013-08-12
US61/865,092 2013-08-12
PCT/US2014/017515 WO2014130741A2 (en) 2013-02-20 2014-02-20 Nme inhibitors and methods of using nme inhibitors
USPCT/US14/17515 2014-02-20
PCT/US2014/050773 WO2015023694A2 (en) 2013-08-12 2014-08-12 Method for enhancing tumor growth

Publications (2)

Publication Number Publication Date
CN105764334A CN105764334A (zh) 2016-07-13
CN105764334B true CN105764334B (zh) 2020-07-28

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CN201480055352.5A Active CN105764334B (zh) 2013-08-12 2014-08-12 加强肿瘤生长的方法

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EP (2) EP3038462B1 (enExample)
JP (2) JP6640086B2 (enExample)
CN (1) CN105764334B (enExample)
AU (2) AU2014306778B2 (enExample)
CA (1) CA2921187A1 (enExample)
IL (1) IL244093B (enExample)
TW (1) TWI659210B (enExample)
WO (1) WO2015023694A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108513537A (zh) * 2015-09-23 2018-09-07 米纳瓦生物技术公司 筛选分化干细胞的试剂的方法
WO2018183654A1 (en) * 2017-03-29 2018-10-04 Minerva Biotechnologies Corporation Agents for differentiating stem cells and treating cancer
CN108434452A (zh) * 2018-03-13 2018-08-24 安徽瀚海博兴生物技术有限公司 一种将pd-1抗体和jmjd6联合用于制备抗癌药物的应用
CN116075318A (zh) 2020-06-26 2023-05-05 米纳瓦生物技术公司 抗nme抗体及治疗癌症或癌症转移的方法
WO2023201234A2 (en) 2022-04-12 2023-10-19 Minerva Biotechnologies Corporation Anti-variable muc1* antibodies and uses thereof
WO2025049494A1 (en) 2023-08-29 2025-03-06 Minerva Biotechnologies Corporation Bacterial nme7 orthologs and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100093092A1 (en) * 2008-10-09 2010-04-15 Bamdad Cynthia C Method for inducing pluripotency in cells
US20100189641A1 (en) * 2005-10-19 2010-07-29 Immunomedics, Inc. Novel Strategies for Improved Cancer Vaccines
US20120258084A1 (en) * 2005-06-30 2012-10-11 Weinberg Robert A Progenitor cells and uses thereof
WO2013081188A1 (ja) * 2011-11-30 2013-06-06 独立行政法人国立がん研究センター 誘導悪性幹細胞

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2008015492A (es) * 2006-06-06 2009-02-12 Univ Tennessee Res Foundation Composiciones enriquecidas en celulas madre neoplasicas y metodos que las contienen.
CN101855339A (zh) * 2007-01-22 2010-10-06 雷文生物技术公司 人类癌症干细胞
EP4086338A1 (en) * 2011-03-17 2022-11-09 Minerva Biotechnologies Corporation Method for making pluripotent stem cells
WO2012165287A1 (ja) * 2011-05-27 2012-12-06 公立大学法人横浜市立大学 人工癌幹細胞の作製方法及びその分化誘導方法
WO2013059373A2 (en) * 2011-10-17 2013-04-25 Minerva Biotechnologies Corporation Media for stem cell proliferation and induction
CA2880010A1 (en) * 2012-07-24 2014-01-30 Minerva Biotechnologies Corporation Nme variant species expression and suppression
KR20210082547A (ko) * 2013-02-20 2021-07-05 미네르바 바이오테크놀로지 코포레이션 Ｎｍｅ 저해제 및 ｎｍｅ 저해제의 사용 방법

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120258084A1 (en) * 2005-06-30 2012-10-11 Weinberg Robert A Progenitor cells and uses thereof
US20100189641A1 (en) * 2005-10-19 2010-07-29 Immunomedics, Inc. Novel Strategies for Improved Cancer Vaccines
US20100093092A1 (en) * 2008-10-09 2010-04-15 Bamdad Cynthia C Method for inducing pluripotency in cells
CN102272290A (zh) * 2008-10-09 2011-12-07 米纳瓦生物技术公司 用于在细胞中诱导多能性的方法
WO2013081188A1 (ja) * 2011-11-30 2013-06-06 独立行政法人国立がん研究センター 誘導悪性幹細胞

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
A shRNA Functional Screen Reveals Nme6 and Nme7 are Crucial for Embryonic Stem Cell Renewal;CHIA-HUI WANG et al;《stem cells》;20120816;第30卷;第2199-2211页 *
Benoit J. Smagghe at el.MUC1* Ligand, NM23-H1, Is a Novel Growth Factor That Maintains Human Stem Cells in a More Naïve State.《plos one》.2013,第8卷(第3期),第1-15页. *
Local Effects of Regulatory T Cells in MUC1 Transgenic Mice Potentiate Growth of MUC1 Expressing Tumor Cells In Vivo;Daisuke Sugiura et al;《plos one》;20120917;第7卷(第9期);摘要 *
NuRD Blocks Reprogramming of Mouse Somatic Cells into Pluripotent Stem Cells;MIN LUO et al;《stem cells》;20130326;第31卷;第1278-1286页 *

Also Published As

Publication number Publication date
EP4233536A3 (en) 2023-10-25
AU2021200429B2 (en) 2023-05-11
IL244093A0 (en) 2016-04-21
AU2021200429A1 (en) 2021-02-25
CA2921187A1 (en) 2015-02-19
EP3038462B1 (en) 2023-03-15
JP6640086B2 (ja) 2020-02-05
AU2014306778B2 (en) 2020-10-29
TWI659210B (zh) 2019-05-11
AU2014306778A1 (en) 2016-03-03
JP6902577B2 (ja) 2021-07-14
IL244093B (en) 2022-01-01
JP2019213551A (ja) 2019-12-19
EP3038462A4 (en) 2017-06-14
WO2015023694A2 (en) 2015-02-19
JP2016527901A (ja) 2016-09-15
CN105764334A (zh) 2016-07-13
TW201537172A (zh) 2015-10-01
EP3038462A2 (en) 2016-07-06
WO2015023694A3 (en) 2015-04-23
EP4233536A2 (en) 2023-08-30
AU2021200429C1 (en) 2023-11-30

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