CN105755112B - 结肠直肠癌的诊断 - Google Patents

结肠直肠癌的诊断 Download PDF

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CN105755112B
CN105755112B CN201511009181.5A CN201511009181A CN105755112B CN 105755112 B CN105755112 B CN 105755112B CN 201511009181 A CN201511009181 A CN 201511009181A CN 105755112 B CN105755112 B CN 105755112B
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colorectal cancer
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m2pk
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CN105755112A (zh
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利亚·简·科斯格罗夫
布鲁斯·塔博尔
安东尼·W·伯吉斯
埃都阿德·柯林斯·尼斯
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    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/57419Specifically defined cancers of colon
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    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/118Prognosis of disease development
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Bioinformatics & Cheminformatics (AREA)
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CN201511009181.5A 2010-07-14 2011-07-14 结肠直肠癌的诊断 Active CN105755112B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2010903140 2010-07-14
AU2010903140A AU2010903140A0 (en) 2010-07-14 Diagnostic for colorectal cancer
CN201180034158.5A CN103140760B (zh) 2010-07-14 2011-07-14 结肠直肠癌的诊断

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CN105755112B true CN105755112B (zh) 2019-06-07

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EP (2) EP2829881B1 (enExample)
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CN (2) CN105755112B (enExample)
AU (1) AU2011279555B2 (enExample)
BR (1) BR112013000745B1 (enExample)
DK (1) DK2829881T3 (enExample)
ES (1) ES2653646T3 (enExample)
IN (1) IN2013CN01129A (enExample)
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Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2829881T3 (en) * 2010-07-14 2017-12-04 Vision Tech Bio Pty Ltd Colorectal cancer diagnostic
US9141756B1 (en) 2010-07-20 2015-09-22 University Of Southern California Multi-scale complex systems transdisciplinary analysis of response to therapy
WO2012106556A2 (en) 2011-02-02 2012-08-09 Amgen Inc. Methods and compositons relating to inhibition of igf-1r
JP6298054B2 (ja) 2012-08-09 2018-03-20 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 心不全の診断
GB201218341D0 (en) * 2012-10-12 2012-11-28 Orign Sciences Ltd Diagnostic method
JP2017520775A (ja) * 2014-03-28 2017-07-27 アプライド プロテオミクス,インク. 結腸直腸腫瘍を検出するためのタンパク質バイオマーカープロファイル
ES2732925T3 (es) * 2014-07-18 2019-11-26 Sanofi Sa Método para predecir el resultado de un tratamiento con aflibercept de un paciente que se sospecha que padece un cáncer
CN106191215B (zh) * 2015-04-29 2020-03-24 中国科学院上海生命科学研究院 肌肉萎缩相关的蛋白质分子标记Dkk-3的筛选及其应用
TWI728975B (zh) * 2015-05-12 2021-06-01 英屬維爾京群島商遠東超級實驗室有限公司 鑒定對腫瘤具有直接抑制作用的干擾素的方法及其用途
CN105219844B (zh) * 2015-06-08 2018-12-14 华夏京都医疗投资管理有限公司 一种筛查十一种疾病的基因标志物组合、试剂盒以及疾病风险预测模型
CN105021828B (zh) * 2015-07-20 2017-07-28 上海交通大学医学院附属新华医院 通过检测三期结直肠肿瘤患者血清预测肿瘤患者预后
CN105567846A (zh) * 2016-02-14 2016-05-11 上海交通大学医学院附属仁济医院 检测粪便中细菌dna的试剂盒及其在大肠癌诊断中的应用
JP6984862B2 (ja) * 2017-03-15 2021-12-22 国立大学法人金沢大学 血中ケモカインをマーカーとして用いた大腸癌の検出
CN107164535A (zh) * 2017-07-07 2017-09-15 沈阳宁沪科技有限公司 一种无创高通量甲基化结肠癌诊断、研究和治疗方法
CN110540588B (zh) * 2018-05-28 2022-08-23 香港中文大学 一种基于肿瘤干细胞标志物EpCAM的抗原表位多肽及其应用
CN108957014A (zh) * 2018-09-27 2018-12-07 郑州大学第附属医院 结直肠癌血清标志物、表达评估方法、试剂盒及应用
EP3870030A4 (en) * 2018-10-23 2022-08-03 Blackthorn Therapeutics, Inc. SYSTEMS AND METHODS FOR SCREENING, DIAGNOSIS AND STRATIFICATION OF PATIENTS
CN109504778B (zh) * 2019-01-11 2021-11-09 复旦大学附属中山医院 一种基于表观修饰的5hmC多分子标志物及结直肠癌早期诊断模型
EP3931571B1 (en) * 2019-03-01 2023-06-07 Advanced Marker Discovery, S.L. Protein signature for the diagnosis of colorectal cancer and/or pre-cancerous stage thereof
JP7300660B2 (ja) * 2019-04-03 2023-06-30 京都府公立大学法人 大腸がんの検出方法
JP7032764B2 (ja) * 2019-04-03 2022-03-09 京都府公立大学法人 大腸がんの検出方法
GB201906199D0 (en) * 2019-05-02 2019-06-19 Belgian Volition Sprl Method for the detection of cancer
US20220378877A1 (en) * 2019-11-13 2022-12-01 University Of Virginia Patent Foundation Treatment of clostridium difficile infections
EP3835789A1 (en) 2019-12-13 2021-06-16 Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts Biomarker panel for diagnosing colorectal cancer
WO2022130597A1 (ja) * 2020-12-18 2022-06-23 国立大学法人東北大学 推定装置、推定方法、推定プログラム、生成装置、及び、推定システム
WO2022140116A1 (en) * 2020-12-21 2022-06-30 Freenome Holdings, Inc. Markers for the early detection of colon cell proliferative disorders
US20240393336A1 (en) * 2021-04-20 2024-11-28 Vision Tech Bio Pty Ltd Biomarkers for colorectal cancer
EP4384830A4 (en) * 2021-08-11 2025-09-24 Vision Tech Bio Pty Ltd METHOD FOR DETECTING ADENOMA
WO2023128419A1 (ko) * 2021-12-31 2023-07-06 주식회사 이노제닉스 대장암 및 대장 용종 또는 진행 선종의 선별 방법 및 그 응용
WO2023128429A1 (ko) * 2021-12-31 2023-07-06 주식회사 이노제닉스 대장암 및 진행 선종의 선별 검사 방법 및 그 응용
CN114594259B (zh) * 2022-04-22 2022-09-13 北京易科拜德科技有限公司 一种新型的用于结直肠癌预后预测和诊断的模型及其应用
PL441319A1 (pl) * 2022-05-31 2023-12-04 Uniwersytet Medyczny Im. Piastów Śląskich We Wrocławiu Zestaw biomarkerów białkowych i sposób diagnostyki raka jelita grubego in vitro
CN116219007A (zh) * 2022-09-15 2023-06-06 绍兴积准生物科技有限公司 检测结直肠癌的生物标志物组及其应用
CN119688988A (zh) * 2024-11-25 2025-03-25 中国医学科学院肿瘤医院 Timp1和foxp3作为诊断结直肠癌的生物标志物组合及其应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009037572A2 (en) * 2007-06-04 2009-03-26 Diagnoplex Biomarker combinations for colorectal cancer
WO2009126543A1 (en) * 2008-04-08 2009-10-15 Nuclea Biomarkers, Llc Biomarker panel for prediction of recurrent colorectal cancer
EP2145190A1 (en) * 2007-05-10 2010-01-20 Roche Diagnostics GmbH Use of timp-1 as a marker for colorectal cancer
CN103140760B (zh) * 2010-07-14 2016-01-27 联邦科学与工业研究组织 结肠直肠癌的诊断

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
JP2004198419A (ja) * 2002-12-13 2004-07-15 Bayer Healthcare Llc Timp1を用いた検出方法
US20050014165A1 (en) * 2003-07-18 2005-01-20 California Pacific Medical Center Biomarker panel for colorectal cancer
ATE491953T1 (de) * 2003-09-15 2011-01-15 Oklahoma Med Res Found Verfahren zur verwendung von cytokintests zur diagnose, behandlung und beurteilung von ankyloider spondylitis
BRPI0401830A (pt) 2004-05-25 2006-01-17 Bentonit Uniao Nordeste Sa Processo de produção de pós granulados secos
JP5399900B2 (ja) * 2006-06-30 2014-01-29 メルク・シャープ・アンド・ドーム・コーポレーション Igfbp2インヒビター
WO2008073660A1 (en) 2006-11-09 2008-06-19 University Of Washington Molecules and methods for treatment and detection of cancer
WO2008079269A2 (en) * 2006-12-19 2008-07-03 Genego, Inc. Novel methods for functional analysis of high-throughput experimental data and gene groups identified therfrom
JP2010517582A (ja) 2007-02-12 2010-05-27 ザ・ジョンズ・ホプキンス・ユニバーシティー 結腸癌の早期検出および予後診断の方法
RU2489720C2 (ru) * 2007-02-27 2013-08-10 Сентоклон Интернэшнл Аб Мультиплексная детекция опухолевых клеток с использованием панели агентов, связывающихся с внеклеточными маркерами
WO2008116178A2 (en) * 2007-03-21 2008-09-25 Vanderbilt University Systems and methods for diagnosis and prognosis of colorectal cancer
WO2008144345A2 (en) * 2007-05-17 2008-11-27 Bristol-Myers Squibb Company Biomarkers and methods for determining sensitivity to insulin growth factor-1 receptor modulators
US20090017463A1 (en) * 2007-07-10 2009-01-15 Vanderbilt University Methods for predicting prostate cancer recurrence
US20100111969A1 (en) * 2008-10-31 2010-05-06 Apogenix Gmbh Il-4 receptor and il-13 as prognostic markers for colon and pancreas tumors
CA2745376A1 (en) * 2008-12-01 2010-06-10 Lifespan Extension Llc Methods and compositions for altering health, wellbeing, and lifespan
CA2745961A1 (en) * 2008-12-04 2010-06-10 The Regents Of The University Of California Materials and methods for determining diagnosis and prognosis of prostate cancer
CN102326080B (zh) * 2009-02-20 2015-08-05 加利福尼亚大学董事会 A+生物标志物的试验
US20110177525A1 (en) * 2010-01-19 2011-07-21 Predictive Biosciences, Inc. Antibodies and methods of diagnosing diseases

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2145190A1 (en) * 2007-05-10 2010-01-20 Roche Diagnostics GmbH Use of timp-1 as a marker for colorectal cancer
WO2009037572A2 (en) * 2007-06-04 2009-03-26 Diagnoplex Biomarker combinations for colorectal cancer
WO2009126543A1 (en) * 2008-04-08 2009-10-15 Nuclea Biomarkers, Llc Biomarker panel for prediction of recurrent colorectal cancer
CN103140760B (zh) * 2010-07-14 2016-01-27 联邦科学与工业研究组织 结肠直肠癌的诊断

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BR112013000745A2 (pt) 2016-05-24
IN2013CN01129A (enExample) 2015-07-31
CN103140760B (zh) 2016-01-27
BR112013000745B1 (pt) 2021-02-02
AU2011279555B2 (en) 2016-10-20
EP2829881A2 (en) 2015-01-28
US20170205414A1 (en) 2017-07-20
AU2011279555A1 (en) 2013-01-31
EP2829881B1 (en) 2017-08-23
CN103140760A (zh) 2013-06-05
PT2829881T (pt) 2017-11-29
EP2829881A3 (en) 2015-05-13
JP6061344B2 (ja) 2017-01-18
RU2013103995A (ru) 2014-08-20
ES2653646T3 (es) 2018-02-08
CN105755112A (zh) 2016-07-13
DK2829881T3 (en) 2017-12-04
JP2013533977A (ja) 2013-08-29
NO2829881T3 (enExample) 2018-01-20
WO2012006681A1 (en) 2012-01-19
US10877039B2 (en) 2020-12-29
EP2593795A1 (en) 2013-05-22
US20130345322A1 (en) 2013-12-26
EP2593795A4 (en) 2014-01-22

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