CN105722835B - 3-芳基-5-取代的-异喹啉-1-酮化合物及它们的疗法应用 - Google Patents

3-芳基-5-取代的-异喹啉-1-酮化合物及它们的疗法应用 Download PDF

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CN105722835B
CN105722835B CN201480061828.6A CN201480061828A CN105722835B CN 105722835 B CN105722835 B CN 105722835B CN 201480061828 A CN201480061828 A CN 201480061828A CN 105722835 B CN105722835 B CN 105722835B
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CN105722835A (zh
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艾伦·艾史沃斯
克勒斯托弗·詹姆斯·洛德
理查德·詹姆斯·罗兰·埃利奥特
丹·尼库列斯库-杜瓦斯
罗德里克·艾伦·波特
里恩·阿吉尔
雷蒙德·约翰·博费
梅拉妮·杰恩·拜福德
斯图尔特·弗思-克拉克
安娜·霍普金斯
阿什利·尼古拉斯·加尔维斯
特雷弗·罗伯特·佩里奥尔
菲利普·艾伦·斯科恩
丽贝卡·伊丽莎白·基
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Institute of Cancer Research Royal Cancer Hospital
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Institute of Cancer Research Royal Cancer Hospital
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Priority claimed from GBGB1316173.2A external-priority patent/GB201316173D0/en
Priority claimed from GBGB1403496.1A external-priority patent/GB201403496D0/en
Priority claimed from GB201410387A external-priority patent/GB201410387D0/en
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CN201480061828.6A 2013-09-11 2014-09-11 3-芳基-5-取代的-异喹啉-1-酮化合物及它们的疗法应用 Expired - Fee Related CN105722835B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB1316173.2A GB201316173D0 (en) 2013-09-11 2013-09-11 Compounds and their therapeutic use
GB1316173.2 2013-09-11
GBGB1403496.1A GB201403496D0 (en) 2014-02-27 2014-02-27 Compounds and their therapeutic use
GB1403496.1 2014-02-27
GB1410387.3 2014-06-11
GB201410387A GB201410387D0 (en) 2014-06-11 2014-06-11 Compounds and their therapeutic use
PCT/GB2014/052752 WO2015036759A1 (en) 2013-09-11 2014-09-11 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use

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CN105722835A CN105722835A (zh) 2016-06-29
CN105722835B true CN105722835B (zh) 2018-07-31

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Publication number Priority date Publication date Assignee Title
WO2017079641A1 (en) * 2015-11-06 2017-05-11 Neurocrine Biosciences, Inc. N-[2-(1 -benzylpiperidin-4-yl)ethyl]-4-(pyrazin-2-yl)-piperazine-1 -carboxamide derivatives and related compounds as muscarinic receptor 4 (m4) antagonists for treating neurological diseases
EA039638B1 (ru) * 2016-01-06 2022-02-21 Нейрокрин Байосайенсиз, Инк. Антагонисты мускаринового рецептора 4 и способы их применения
CN107286169B (zh) * 2016-04-05 2020-11-24 北京四环制药有限公司 端锚聚合酶抑制剂
GB201615282D0 (en) * 2016-09-08 2016-10-26 Univ Bath Tankyrase inhibitors
EP3459469A1 (en) 2017-09-23 2019-03-27 Universität Zürich Medical occluder device
US12402885B2 (en) 2017-09-23 2025-09-02 Universität Zürich Medical occlusion device
CN110003049A (zh) * 2019-05-13 2019-07-12 苏州山青竹生物医药有限公司 一种制备4-氰基-1-茚酮的方法
CN110407740A (zh) * 2019-09-04 2019-11-05 上海毕得医药科技有限公司 一种3-溴-2-乙基吡啶的合成方法
JP7531236B2 (ja) 2019-09-26 2024-08-09 ウニベルシタット チューリッヒ 左心耳閉鎖デバイス
WO2021113478A1 (en) 2019-12-06 2021-06-10 Neurocrine Biosciences, Inc. Muscarinic receptor 4 antagonists and methods of use
WO2022235492A1 (en) * 2021-05-04 2022-11-10 Board Of Regents, The University Of Texas System Indanone and tetralone-keto or hydroxyl oximes as cancer therapeutics
WO2023156386A2 (en) * 2022-02-16 2023-08-24 Duke Street Bio Limited Pharmaceutical compound
GB2634228A (en) * 2023-10-02 2025-04-09 Duke Street Bio Ltd PARP1 inhibitor compounds

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1671668A (zh) * 2002-07-24 2005-09-21 杏林制药株式会社 4－取代芳基－5－羟基异喹啉酮衍生物
CN1703410A (zh) * 2002-10-01 2005-11-30 三菱制药株式会社 异喹啉化合物及其医药用途
US20060094743A1 (en) * 2002-11-22 2006-05-04 Mitsubishi Pharma Corporation Isoquinoline compounds and medicinal use thereof
CN101500997A (zh) * 2006-06-15 2009-08-05 库多斯药物有限公司 Parp抑制剂
CN102438986A (zh) * 2009-05-21 2012-05-02 内尔维阿诺医学科学有限公司 作为parp-1 抑制剂的异喹啉-1(2h)-酮衍生物
WO2013076090A1 (en) * 2011-11-25 2013-05-30 Nerviano Medical Sciences S.R.L. 3-phenyl-isoquinolin-1(2h)-one derivatives as parp-1 inhibitors

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2851458A (en) 1955-06-08 1958-09-09 Burroughs Wellcome Co Diquaternary compounds and the manufacture thereof
US4678500A (en) 1984-06-29 1987-07-07 E. I. Du Pont De Nemours And Company Herbicidal 2,6-disubstituted benzylsulfonamides and benzenesulfamates
US5177075A (en) 1988-08-19 1993-01-05 Warner-Lambert Company Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process
US4942163A (en) 1989-03-07 1990-07-17 E. I. Du Pont De Nemours And Company 1(2H)-isoquinolinones and 1-isoquinolineamines as cancer chemotherapeutic agents
US6340759B1 (en) 1997-10-02 2002-01-22 Eisai Co., Ltd. Fused pyridine derivatives
US6878714B2 (en) 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
EP1396488A1 (en) 2001-05-23 2004-03-10 Mitsubishi Pharma Corporation Fused heterocyclic compound and medicinal use thereof
AU2002341693B2 (en) 2001-09-21 2008-05-29 Bristol-Myers Squibb Holdings Ireland Unlimited Company Lactam-containing compounds and derivatives thereof as factor Xa inhibitors
MY140680A (en) 2002-05-20 2010-01-15 Bristol Myers Squibb Co Hepatitis c virus inhibitors
MXPA05004432A (es) 2002-10-23 2005-11-23 Glenmark Pharmaceuticals Ltd Compuestos triciclicos novedosos utiles para el tratamiento de desordenes inflamatorios y alergicos, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
AU2003301020A1 (en) 2002-12-20 2004-07-22 Sankyo Company, Limited Isoquinolinone derivatives and their use as therapeutic agents
EP2033654B1 (en) 2003-04-16 2012-05-16 Bristol-Myers Squibb Company Process for resolving a mixture of alkyl ester enantiomers using an enzyme
WO2005075432A1 (ja) 2004-02-06 2005-08-18 Chugai Seiyaku Kabushiki Kaisha １−（２ｈ）−イソキノロン誘導体およびその抗ガン剤としての使用
TW200536830A (en) * 2004-02-06 2005-11-16 Chugai Pharmaceutical Co Ltd 1-(2H)-isoquinolone derivative
WO2005113540A1 (ja) 2004-05-20 2005-12-01 Mitsubishi Pharma Corporation イソキノリン化合物及びその医薬用途
EP2332527A3 (en) 2004-10-20 2011-11-16 Resverlogix Corp. Flavanoids and Isoflavanoids for the prevention and treatment of cardiovascular diseases
JP5046950B2 (ja) 2004-10-22 2012-10-10 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｃ−ｆｍｓキナーゼのインヒビター
DE602005010744D1 (de) 2004-12-16 2008-12-11 Hoffmann La Roche Piperazinylpyridinderivate als mittel gegen adipositas
TWI389897B (zh) 2005-02-22 2013-03-21 Chugai Pharmaceutical Co Ltd 1- (2H) -isoquinolinone derivatives
NZ561387A (en) 2005-03-31 2010-07-30 Astellas Pharma Inc 1,3-dihydro-2H-benzimidazol-2-ylidene derivatives
CA2617213C (en) 2005-07-29 2014-01-28 Resverlogix Corp. Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
AU2006283078A1 (en) 2005-08-24 2007-03-01 Inotek Pharmaceuticals Corporation Indenoisoquinolinone Analogs and methods of use thereof
ATE532770T1 (de) 2006-09-05 2011-11-15 Kyowa Hakko Kirin Co Ltd Imidazolderivat
US7772180B2 (en) 2006-11-09 2010-08-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
KR101444489B1 (ko) 2007-02-01 2014-09-24 리스버로직스 코퍼레이션 심혈관 질환을 예방 및 치료하기 위한 화합물
FR2919286A1 (fr) 2007-07-27 2009-01-30 Sanofi Aventis Sa Derives de derives de 1-oxo-1,2-dihydroisoquinoleine-5- carboxamides et de 4-oxo-3,4-dihydroquinazoline-8- carboxamides,leur preparation et leur application en therapeutique.
US20090054392A1 (en) * 2007-08-20 2009-02-26 Wyeth Naphthylpyrimidine, naphthylpyrazine and naphthylpyridazine analogs and their use as agonists of the wnt-beta-catenin cellular messaging system
WO2009027650A1 (en) 2007-08-24 2009-03-05 The Institute Of Cancer: Royal Cancer Hospital Materials and methods for exploiting synthetic lethality in brca-associated cancers
US20100267626A1 (en) 2007-11-05 2010-10-21 Novartis Ag Methods and compositions for measuring wnt activation and for treating wnt-related cancers
DE102008019838A1 (de) 2008-04-19 2009-12-10 Boehringer Ingelheim International Gmbh Neue Arylsulfonylglycin-Derivate, deren Herstellung und deren Verwendung als Arzneimittel
JP5369173B2 (ja) 2008-04-22 2013-12-18 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ キノリン若しくはイソキノリン置換ｐ２ｘ７アンタゴニスト
UY32251A (es) 2008-11-20 2010-05-31 Glaxosmithkline Llc Compuestos quimicos
CA2752443A1 (en) 2009-03-06 2010-09-10 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds
KR101803259B1 (ko) 2009-03-18 2017-11-30 리스버로직스 코퍼레이션 신규한 소염제
CN107252429B (zh) 2009-04-22 2023-06-16 雷斯韦洛吉克斯公司 新抗炎剂
IN2012DN02968A (enExample) 2009-10-13 2015-07-31 Msd Oss Bv
US8604032B2 (en) 2010-05-21 2013-12-10 Infinity Pharmaceuticals, Inc. Chemical compounds, compositions and methods for kinase modulation
WO2011157787A1 (en) 2010-06-17 2011-12-22 Novartis Ag Biphenyl substituted 1,3-dihydro-benzoimidazol-2-ylideneamine derivatives
CN103797006B (zh) 2011-07-13 2016-01-27 诺华股份有限公司 用作端锚聚合酶抑制剂的4-哌啶基化合物
US9227982B2 (en) 2011-07-13 2016-01-05 Novartis Ag 4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrminidinyl compounds for use as tankyrase inhibitors
EP2731942B1 (en) 2011-07-13 2015-09-23 Novartis AG Novel 2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors
CN106083849A (zh) 2011-12-31 2016-11-09 百济神州有限公司 作为parp抑制剂的稠合的四元或五元环吡啶并酞嗪酮类化合物
US9260440B2 (en) 2011-12-31 2016-02-16 Beigene, Ltd. Fused tetra or penta-cyclic dihydrodiazepinocarbazolones as PARP inhibitors
SG11201404217XA (en) 2012-01-28 2014-08-28 Merck Patent Gmbh Azaheterocyclic compounds
US9174980B2 (en) 2012-01-31 2015-11-03 Boehringer Ingelheim International Gmbh Heterocyclic compounds as inhibitors of leukotriene production
UA116627C2 (uk) 2012-02-09 2018-04-25 Мерк Патент Гмбх Похідні тетрагідрохіназоліну як інгібітори tank та parp
WO2013134079A1 (en) 2012-03-05 2013-09-12 Amgen Inc. Oxazolidinone compounds and derivatives thereof
EP2822656B1 (en) 2012-03-07 2016-10-19 Institute of Cancer Research: Royal Cancer Hospital (The) 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use
KR102070567B1 (ko) 2012-03-28 2020-01-29 메르크 파텐트 게엠베하 바이시클릭 피라지논 유도체
US20130281397A1 (en) 2012-04-19 2013-10-24 Rvx Therapeutics Inc. Treatment of diseases by epigenetic regulation
US9174995B2 (en) 2012-05-04 2015-11-03 Merck Patent Gmbh Pyrrolotriazinone derivatives
WO2013177349A2 (en) 2012-05-25 2013-11-28 Glaxosmithkline Llc Quinazolinediones as tankyrase inhibitors
RU2014151009A (ru) 2012-06-07 2016-08-10 Ф. Хоффманн-Ля Рош Аг Пиразолопиримидоновые и пиразолопиридоновые ингибиторы танкиразы
AR091271A1 (es) 2012-06-07 2015-01-21 Hoffmann La Roche Pirrolopirimidona y pirrolopiridona, inhibidores de tanquirasa
WO2013189905A1 (en) 2012-06-20 2013-12-27 F. Hoffmann-La Roche Ag Pyrrolopyrazone inhibitors of tankyrase
JP2015520204A (ja) 2012-06-20 2015-07-16 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト タンキラーゼのピラノピリドン阻害剤
HRP20200180T1 (hr) 2012-08-08 2020-05-01 Merck Patent Gmbh Derivati (aza-)izokinolinona
WO2014036022A1 (en) 2012-08-29 2014-03-06 Amgen Inc. Quinazolinone compounds and derivatives thereof
WO2014045101A1 (en) 2012-09-21 2014-03-27 Cellzome Gmbh Tetrazolo quinoxaline derivatives as tankyrase inhibitors
AR092211A1 (es) 2012-09-24 2015-04-08 Merck Patent Ges Mit Beschränkter Haftung Derivados de hidropirrolopirrol
RU2650107C2 (ru) 2012-09-26 2018-04-09 Мерк Патент Гмбх Производные хиназолинона в качестве ингибиторов parp
WO2014087165A1 (en) 2012-12-06 2014-06-12 University Of Bath Tankyrase inhibitors

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1671668A (zh) * 2002-07-24 2005-09-21 杏林制药株式会社 4－取代芳基－5－羟基异喹啉酮衍生物
CN1703410A (zh) * 2002-10-01 2005-11-30 三菱制药株式会社 异喹啉化合物及其医药用途
US20060094743A1 (en) * 2002-11-22 2006-05-04 Mitsubishi Pharma Corporation Isoquinoline compounds and medicinal use thereof
CN101500997A (zh) * 2006-06-15 2009-08-05 库多斯药物有限公司 Parp抑制剂
CN102438986A (zh) * 2009-05-21 2012-05-02 内尔维阿诺医学科学有限公司 作为parp-1 抑制剂的异喹啉-1(2h)-酮衍生物
WO2013076090A1 (en) * 2011-11-25 2013-05-30 Nerviano Medical Sciences S.R.L. 3-phenyl-isoquinolin-1(2h)-one derivatives as parp-1 inhibitors

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