CN105683162A - N-(4-氯-2-羟基-3((3s)-3-哌啶基磺酰基)苯基)-n’-(3-氟-2-甲基苯基)脲的氢溴酸盐 - Google Patents
N-(4-氯-2-羟基-3((3s)-3-哌啶基磺酰基)苯基)-n’-(3-氟-2-甲基苯基)脲的氢溴酸盐 Download PDFInfo
- Publication number
- CN105683162A CN105683162A CN201480061455.2A CN201480061455A CN105683162A CN 105683162 A CN105683162 A CN 105683162A CN 201480061455 A CN201480061455 A CN 201480061455A CN 105683162 A CN105683162 A CN 105683162A
- Authority
- CN
- China
- Prior art keywords
- disease
- situation
- compound
- compounds
- treating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4462—Non condensed piperidines, e.g. piperocaine only substituted in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/452—Piperidinium derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1320021.7 | 2013-11-13 | ||
| GBGB1320021.7A GB201320021D0 (en) | 2013-11-13 | 2013-11-13 | Novel Compounds |
| PCT/EP2014/074222 WO2015071235A1 (en) | 2013-11-13 | 2014-11-11 | Hydrobromide salt ofn-(4-chloro-2-hydroxy-3-((3s)-3-piperidinylsulfonyl)phenyl-n'-(3-fluoro-2-methylphenyl)urea |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105683162A true CN105683162A (zh) | 2016-06-15 |
Family
ID=49818555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480061455.2A Pending CN105683162A (zh) | 2013-11-13 | 2014-11-11 | N-(4-氯-2-羟基-3((3s)-3-哌啶基磺酰基)苯基)-n’-(3-氟-2-甲基苯基)脲的氢溴酸盐 |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US9809540B2 (enExample) |
| EP (1) | EP3068763B1 (enExample) |
| JP (1) | JP6401265B2 (enExample) |
| KR (1) | KR20160083950A (enExample) |
| CN (1) | CN105683162A (enExample) |
| AU (1) | AU2014350334B2 (enExample) |
| BR (1) | BR112016010409A8 (enExample) |
| CA (1) | CA2929907A1 (enExample) |
| CY (1) | CY1121581T1 (enExample) |
| DK (1) | DK3068763T3 (enExample) |
| ES (1) | ES2714721T3 (enExample) |
| GB (1) | GB201320021D0 (enExample) |
| HR (1) | HRP20190449T1 (enExample) |
| HU (1) | HUE041873T2 (enExample) |
| LT (1) | LT3068763T (enExample) |
| ME (1) | ME03328B (enExample) |
| PL (1) | PL3068763T3 (enExample) |
| PT (1) | PT3068763T (enExample) |
| RS (1) | RS58382B1 (enExample) |
| RU (1) | RU2685408C1 (enExample) |
| SI (1) | SI3068763T1 (enExample) |
| SM (1) | SMT201900156T1 (enExample) |
| TR (1) | TR201902981T4 (enExample) |
| WO (1) | WO2015071235A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107072976A (zh) * | 2014-05-12 | 2017-08-18 | 葛兰素史克知识产权第二有限公司 | 用于治疗传染性疾病的包含Danirixin的药物组合物 |
| BR112018011138A2 (pt) * | 2015-11-30 | 2018-11-21 | Glaxosmithkline Intellectual Property (No. | formulações para administração intravenosa |
| WO2018073248A1 (en) | 2016-10-17 | 2018-04-26 | Icm (Institut Du Cerveau Et De La Moelle Épinière) | Prognosis of demyelinating diseases patients and treatment thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101472477A (zh) * | 2006-04-21 | 2009-07-01 | 史密丝克莱恩比彻姆公司 | Il-8受体拮抗剂 |
-
2013
- 2013-11-13 GB GBGB1320021.7A patent/GB201320021D0/en not_active Ceased
-
2014
- 2014-11-11 ES ES14799988T patent/ES2714721T3/es active Active
- 2014-11-11 AU AU2014350334A patent/AU2014350334B2/en not_active Ceased
- 2014-11-11 PL PL14799988T patent/PL3068763T3/pl unknown
- 2014-11-11 ME MEP-2019-47A patent/ME03328B/me unknown
- 2014-11-11 TR TR2019/02981T patent/TR201902981T4/tr unknown
- 2014-11-11 PT PT14799988T patent/PT3068763T/pt unknown
- 2014-11-11 JP JP2016529894A patent/JP6401265B2/ja not_active Expired - Fee Related
- 2014-11-11 SM SM20190156T patent/SMT201900156T1/it unknown
- 2014-11-11 RS RS20190230A patent/RS58382B1/sr unknown
- 2014-11-11 RU RU2016116955A patent/RU2685408C1/ru not_active IP Right Cessation
- 2014-11-11 KR KR1020167015530A patent/KR20160083950A/ko not_active Withdrawn
- 2014-11-11 EP EP14799988.2A patent/EP3068763B1/en active Active
- 2014-11-11 DK DK14799988.2T patent/DK3068763T3/en active
- 2014-11-11 HR HRP20190449TT patent/HRP20190449T1/hr unknown
- 2014-11-11 US US15/034,583 patent/US9809540B2/en not_active Expired - Fee Related
- 2014-11-11 WO PCT/EP2014/074222 patent/WO2015071235A1/en not_active Ceased
- 2014-11-11 SI SI201431125T patent/SI3068763T1/sl unknown
- 2014-11-11 CA CA2929907A patent/CA2929907A1/en not_active Abandoned
- 2014-11-11 LT LTEP14799988.2T patent/LT3068763T/lt unknown
- 2014-11-11 CN CN201480061455.2A patent/CN105683162A/zh active Pending
- 2014-11-11 BR BR112016010409A patent/BR112016010409A8/pt not_active IP Right Cessation
- 2014-11-11 HU HUE14799988A patent/HUE041873T2/hu unknown
-
2017
- 2017-10-05 US US15/725,429 patent/US20180079722A1/en not_active Abandoned
-
2018
- 2018-12-13 US US16/218,602 patent/US10604485B2/en not_active Expired - Fee Related
-
2019
- 2019-02-26 CY CY20191100237T patent/CY1121581T1/el unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101472477A (zh) * | 2006-04-21 | 2009-07-01 | 史密丝克莱恩比彻姆公司 | Il-8受体拮抗剂 |
Non-Patent Citations (2)
| Title |
|---|
| JACKIE C.BLOOMER，ET AL.: "Assessment of potential drug interactions by characterization of human drug metabolism pathways using non-invasive bile sampling", 《BR J CLIN PHARMACOL》 * |
| STEPHEN M. BERGE，ET AL.: "Pharmaceutical Salts", 《JOURNAL OF PHARMACEUTICAL SCIENCES》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CY1121581T1 (el) | 2020-05-29 |
| HUE041873T2 (hu) | 2019-05-28 |
| US10604485B2 (en) | 2020-03-31 |
| LT3068763T (lt) | 2019-03-12 |
| JP6401265B2 (ja) | 2018-10-10 |
| EP3068763A1 (en) | 2016-09-21 |
| AU2014350334B2 (en) | 2017-08-10 |
| JP2016537344A (ja) | 2016-12-01 |
| US20190112269A1 (en) | 2019-04-18 |
| PL3068763T3 (pl) | 2019-05-31 |
| RU2685408C1 (ru) | 2019-04-18 |
| ES2714721T3 (es) | 2019-05-29 |
| TR201902981T4 (tr) | 2019-03-21 |
| US20160264525A1 (en) | 2016-09-15 |
| PT3068763T (pt) | 2019-03-20 |
| CA2929907A1 (en) | 2015-05-21 |
| ME03328B (me) | 2019-10-20 |
| RS58382B1 (sr) | 2019-04-30 |
| AU2014350334A1 (en) | 2016-06-02 |
| EP3068763B1 (en) | 2018-12-19 |
| SMT201900156T1 (it) | 2019-05-10 |
| WO2015071235A1 (en) | 2015-05-21 |
| BR112016010409A8 (pt) | 2020-04-22 |
| SI3068763T1 (sl) | 2019-04-30 |
| RU2016116955A (ru) | 2017-12-19 |
| US20180079722A1 (en) | 2018-03-22 |
| HRP20190449T1 (hr) | 2019-04-19 |
| DK3068763T3 (en) | 2019-03-18 |
| KR20160083950A (ko) | 2016-07-12 |
| GB201320021D0 (en) | 2013-12-25 |
| US9809540B2 (en) | 2017-11-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160615 |
|
| RJ01 | Rejection of invention patent application after publication |