AU2014350334B2 - Hydrobromide salt ofN-(4-chloro-2-hydroxy-3-((3S)-3-piperidinylsulfonyl)phenyl-N'-(3-fluoro-2-methylphenyl)urea - Google Patents

Hydrobromide salt ofN-(4-chloro-2-hydroxy-3-((3S)-3-piperidinylsulfonyl)phenyl-N'-(3-fluoro-2-methylphenyl)urea Download PDF

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Publication number
AU2014350334B2
AU2014350334B2 AU2014350334A AU2014350334A AU2014350334B2 AU 2014350334 B2 AU2014350334 B2 AU 2014350334B2 AU 2014350334 A AU2014350334 A AU 2014350334A AU 2014350334 A AU2014350334 A AU 2014350334A AU 2014350334 B2 AU2014350334 B2 AU 2014350334B2
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AU
Australia
Prior art keywords
disease
compound
condition
treating
indicated
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Ceased
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AU2014350334A
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English (en)
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AU2014350334A1 (en
Inventor
Francis Dominic Sanderson
Sarah Mary VALLANCE
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GlaxoSmithKline Intellectual Property No 2 Ltd
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GlaxoSmithKline Intellectual Property No 2 Ltd
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Publication of AU2014350334A1 publication Critical patent/AU2014350334A1/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4462—Non condensed piperidines, e.g. piperocaine only substituted in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/452—Piperidinium derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2014350334A 2013-11-13 2014-11-11 Hydrobromide salt ofN-(4-chloro-2-hydroxy-3-((3S)-3-piperidinylsulfonyl)phenyl-N'-(3-fluoro-2-methylphenyl)urea Ceased AU2014350334B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1320021.7A GB201320021D0 (en) 2013-11-13 2013-11-13 Novel Compounds
GB1320021.7 2013-11-13
PCT/EP2014/074222 WO2015071235A1 (en) 2013-11-13 2014-11-11 Hydrobromide salt ofn-(4-chloro-2-hydroxy-3-((3s)-3-piperidinylsulfonyl)phenyl-n'-(3-fluoro-2-methylphenyl)urea

Publications (2)

Publication Number Publication Date
AU2014350334A1 AU2014350334A1 (en) 2016-06-02
AU2014350334B2 true AU2014350334B2 (en) 2017-08-10

Family

ID=49818555

Family Applications (1)

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AU2014350334A Ceased AU2014350334B2 (en) 2013-11-13 2014-11-11 Hydrobromide salt ofN-(4-chloro-2-hydroxy-3-((3S)-3-piperidinylsulfonyl)phenyl-N'-(3-fluoro-2-methylphenyl)urea

Country Status (24)

Country Link
US (3) US9809540B2 (enExample)
EP (1) EP3068763B1 (enExample)
JP (1) JP6401265B2 (enExample)
KR (1) KR20160083950A (enExample)
CN (1) CN105683162A (enExample)
AU (1) AU2014350334B2 (enExample)
BR (1) BR112016010409A8 (enExample)
CA (1) CA2929907A1 (enExample)
CY (1) CY1121581T1 (enExample)
DK (1) DK3068763T3 (enExample)
ES (1) ES2714721T3 (enExample)
GB (1) GB201320021D0 (enExample)
HR (1) HRP20190449T1 (enExample)
HU (1) HUE041873T2 (enExample)
LT (1) LT3068763T (enExample)
ME (1) ME03328B (enExample)
PL (1) PL3068763T3 (enExample)
PT (1) PT3068763T (enExample)
RS (1) RS58382B1 (enExample)
RU (1) RU2685408C1 (enExample)
SI (1) SI3068763T1 (enExample)
SM (1) SMT201900156T1 (enExample)
TR (1) TR201902981T4 (enExample)
WO (1) WO2015071235A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015173701A2 (en) * 2014-05-12 2015-11-19 Glaxosmithkline Intellectual Property (No. 2) Limited Pharmaceutical compositions for treating infectious diseases
RU2018123711A (ru) 2015-11-30 2020-01-09 Глэксосмитклайн Интеллекчуал Проперти (Но.2) Лимитед Композиции для внутривенного введения
WO2018073248A1 (en) 2016-10-17 2018-04-26 Icm (Institut Du Cerveau Et De La Moelle Épinière) Prognosis of demyelinating diseases patients and treatment thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007240365B2 (en) 2006-04-21 2011-12-15 Glaxosmithkline Llc IL-8 receptor antagonists

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
D1 : WO 2007/124424 A1 *
D2 : STEPHEN M BERGE ET AL: "Pharmaceutical salts", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION, WASHINGTON, US, vol. 66, no. 1, 1 January 1977, pages 1-19 *

Also Published As

Publication number Publication date
EP3068763B1 (en) 2018-12-19
EP3068763A1 (en) 2016-09-21
SMT201900156T1 (it) 2019-05-10
PT3068763T (pt) 2019-03-20
CA2929907A1 (en) 2015-05-21
CY1121581T1 (el) 2020-05-29
KR20160083950A (ko) 2016-07-12
ME03328B (me) 2019-10-20
US20160264525A1 (en) 2016-09-15
DK3068763T3 (en) 2019-03-18
ES2714721T3 (es) 2019-05-29
HUE041873T2 (hu) 2019-05-28
RS58382B1 (sr) 2019-04-30
AU2014350334A1 (en) 2016-06-02
GB201320021D0 (en) 2013-12-25
CN105683162A (zh) 2016-06-15
RU2016116955A (ru) 2017-12-19
WO2015071235A1 (en) 2015-05-21
PL3068763T3 (pl) 2019-05-31
US20190112269A1 (en) 2019-04-18
JP2016537344A (ja) 2016-12-01
TR201902981T4 (tr) 2019-03-21
US10604485B2 (en) 2020-03-31
JP6401265B2 (ja) 2018-10-10
US20180079722A1 (en) 2018-03-22
HRP20190449T1 (hr) 2019-04-19
BR112016010409A8 (pt) 2020-04-22
US9809540B2 (en) 2017-11-07
RU2685408C1 (ru) 2019-04-18
LT3068763T (lt) 2019-03-12
SI3068763T1 (sl) 2019-04-30

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