KR20160083950A - N-(4-클로로-2-하이드록시-3-((3s)-3-피페리디닐설포닐)페닐-n′-(3-플루오로-2-메틸페닐)우레아의 하이드로브로마이드 염 - Google Patents

N-(4-클로로-2-하이드록시-3-((3s)-3-피페리디닐설포닐)페닐-n′-(3-플루오로-2-메틸페닐)우레아의 하이드로브로마이드 염 Download PDF

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KR20160083950A
KR20160083950A KR1020167015530A KR20167015530A KR20160083950A KR 20160083950 A KR20160083950 A KR 20160083950A KR 1020167015530 A KR1020167015530 A KR 1020167015530A KR 20167015530 A KR20167015530 A KR 20167015530A KR 20160083950 A KR20160083950 A KR 20160083950A
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South Korea
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disease
disorder
compound
cxcr2
treatment
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Korean (ko)
Inventor
프란시스 도미닉 샌더슨
사라흐 메리 밸런스
Original Assignee
글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드
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Publication of KR20160083950A publication Critical patent/KR20160083950A/ko
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54Sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4462Non condensed piperidines, e.g. piperocaine only substituted in position 3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/452Piperidinium derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
KR1020167015530A 2013-11-13 2014-11-11 N-(4-클로로-2-하이드록시-3-((3s)-3-피페리디닐설포닐)페닐-n′-(3-플루오로-2-메틸페닐)우레아의 하이드로브로마이드 염 Withdrawn KR20160083950A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1320021.7 2013-11-13
GBGB1320021.7A GB201320021D0 (en) 2013-11-13 2013-11-13 Novel Compounds
PCT/EP2014/074222 WO2015071235A1 (en) 2013-11-13 2014-11-11 Hydrobromide salt ofn-(4-chloro-2-hydroxy-3-((3s)-3-piperidinylsulfonyl)phenyl-n'-(3-fluoro-2-methylphenyl)urea

Publications (1)

Publication Number Publication Date
KR20160083950A true KR20160083950A (ko) 2016-07-12

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ID=49818555

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020167015530A Withdrawn KR20160083950A (ko) 2013-11-13 2014-11-11 N-(4-클로로-2-하이드록시-3-((3s)-3-피페리디닐설포닐)페닐-n′-(3-플루오로-2-메틸페닐)우레아의 하이드로브로마이드 염

Country Status (24)

Country Link
US (3) US9809540B2 (enExample)
EP (1) EP3068763B1 (enExample)
JP (1) JP6401265B2 (enExample)
KR (1) KR20160083950A (enExample)
CN (1) CN105683162A (enExample)
AU (1) AU2014350334B2 (enExample)
BR (1) BR112016010409A8 (enExample)
CA (1) CA2929907A1 (enExample)
CY (1) CY1121581T1 (enExample)
DK (1) DK3068763T3 (enExample)
ES (1) ES2714721T3 (enExample)
GB (1) GB201320021D0 (enExample)
HR (1) HRP20190449T1 (enExample)
HU (1) HUE041873T2 (enExample)
LT (1) LT3068763T (enExample)
ME (1) ME03328B (enExample)
PL (1) PL3068763T3 (enExample)
PT (1) PT3068763T (enExample)
RS (1) RS58382B1 (enExample)
RU (1) RU2685408C1 (enExample)
SI (1) SI3068763T1 (enExample)
SM (1) SMT201900156T1 (enExample)
TR (1) TR201902981T4 (enExample)
WO (1) WO2015071235A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015260841A1 (en) * 2014-05-12 2016-12-01 Glaxosmithkline Intellectual Property (No. 2) Limited Pharmaceutical compositions comprising danirixin for treating infectious diseases
US20180369135A1 (en) * 2015-11-30 2018-12-27 Glaxosmithkline Intellectual Property (No.2) Limited Formulations for intravenous administration
WO2018073248A1 (en) 2016-10-17 2018-04-26 Icm (Institut Du Cerveau Et De La Moelle Épinière) Prognosis of demyelinating diseases patients and treatment thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5269763B2 (ja) 2006-04-21 2013-08-21 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー Il−8受容体アンタゴニスト

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Publication number Publication date
AU2014350334B2 (en) 2017-08-10
SMT201900156T1 (it) 2019-05-10
AU2014350334A1 (en) 2016-06-02
BR112016010409A8 (pt) 2020-04-22
ME03328B (me) 2019-10-20
SI3068763T1 (sl) 2019-04-30
CN105683162A (zh) 2016-06-15
LT3068763T (lt) 2019-03-12
US20180079722A1 (en) 2018-03-22
CY1121581T1 (el) 2020-05-29
RU2016116955A (ru) 2017-12-19
RS58382B1 (sr) 2019-04-30
TR201902981T4 (tr) 2019-03-21
PT3068763T (pt) 2019-03-20
RU2685408C1 (ru) 2019-04-18
EP3068763A1 (en) 2016-09-21
PL3068763T3 (pl) 2019-05-31
JP6401265B2 (ja) 2018-10-10
US9809540B2 (en) 2017-11-07
US20160264525A1 (en) 2016-09-15
US20190112269A1 (en) 2019-04-18
CA2929907A1 (en) 2015-05-21
HUE041873T2 (hu) 2019-05-28
US10604485B2 (en) 2020-03-31
DK3068763T3 (en) 2019-03-18
ES2714721T3 (es) 2019-05-29
GB201320021D0 (en) 2013-12-25
HRP20190449T1 (hr) 2019-04-19
WO2015071235A1 (en) 2015-05-21
JP2016537344A (ja) 2016-12-01
EP3068763B1 (en) 2018-12-19

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PA0105 International application

Patent event date: 20160610

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid