CN105663997A - 用于肾阳虚证型不孕症的中药组合物 - Google Patents

用于肾阳虚证型不孕症的中药组合物 Download PDF

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CN105663997A
CN105663997A CN201610258073.XA CN201610258073A CN105663997A CN 105663997 A CN105663997 A CN 105663997A CN 201610258073 A CN201610258073 A CN 201610258073A CN 105663997 A CN105663997 A CN 105663997A
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史后元
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Abstract

本发明公开一种用于肾阳虚证型不孕症的中药组合物，包括以质量份数表示的原料：黄芪10-20份、当归5-12份、枸杞10-20份、女贞子10-20份、淫羊藿8-15份、首乌6-12份、熟地8-15份、牛膝8-15份、杜仲8-15份、巴戟天8-15份、锁阳8-15份、炮附子8-15份、茯苓8-15份、肉苁蓉8-15份、桑螵蛸8-15份、炒白术8-15份、砂仁5-10份、黄精15-30份、猪屎豆8-15份、荜茇根10-20份、远志8-15份、柴胡5-10份、益智仁10-20份。上述中药组合物中的各原料能相互配合，协同作用，共凑温肾助阳，化湿固精，补肾暖宫，填精助孕的功效，能有效治疗肾阳虚证型不孕症。经临床检验，有效率高达约九成，有疗效显著的优点。

Description

用于肾阳虚证型不孕症的中药组合物
技术领域
本发明涉及一种中药组合物，尤其是涉及一种用于肾阳虚证型不孕症的中药组合物。
背景技术
中医认为不孕症一般与肾虚、血虚、胞宫冷、肝气郁、脾胃寒、痰气盛、代脉急、任督病、火汪、血瘀、膀胱气化不行等相关。根据患者的症状、体征及舌脉象情况，中医将不孕症分为肾气(阳)不足、肾精(血)虚、肝气郁结、痰湿阻塞、瘀滞胞宫、湿热雍塞等类型。目前，治疗不孕症的中药有许多种，但目前还没有针对于肾阳虚证型不孕证治疗的中成药。
发明内容
本发明提出一种用于肾阳虚证型不孕症的中药组合物，疗效显著。
本发明采用如下技术方案实现：
一种用于肾阳虚证型不孕症的中药组合物，包括以质量份数表示的原料：黄芪10-20份、当归5-12份、枸杞10-20份、女贞子10-20份、淫羊藿8-15份、首乌6-12份、熟地8-15份、牛膝8-15份、杜仲8-15份、巴戟天8-15份、锁阳8-15份、炮附子8-15份、茯苓8-15份、肉苁蓉8-15份、桑螵蛸8-15份、炒白术8-15份、砂仁5-10份、黄精15-30份、猪屎豆8-15份、荜茇根10-20份、远志8-15份、柴胡5-10份、益智仁10-20份。
其中，所述用于肾阳虚证型不孕症的中药组合物，包括以质量份数表示的各原料：黄芪15份、当归10份、枸杞15份、女贞子15份、淫羊藿12份、首乌8份、熟地12份、牛膝10份、杜仲10份、巴戟天12份、锁阳12份、炮附子12份、茯苓12份、肉苁蓉12份、桑螵蛸12份、炒白术12份、砂仁8份、黄精20份、猪屎豆10份、荜茇根15份、远志10份、柴胡8份、益智仁15份。
与现有技术相比，本发明具有如下有益效果：
上述中药组合物中的各原料能相互配合，协同作用，共凑温肾助阳，化湿固精，补肾暖宫，填精助孕的功效，能有效治疗肾阳虚证型不孕症。经临床检验，有效率高达约九成，有疗效显著的优点。
具体实施方式
一种用于肾阳虚证型不孕症的中药组合物，包括以质量份数表示的原料：黄芪10-20份、当归5-12份、枸杞10-20份、女贞子10-20份、淫羊藿8-15份、首乌6-12份、熟地8-15份、牛膝8-15份、杜仲8-15份、巴戟天8-15份、锁阳8-15份、炮附子8-15份、茯苓8-15份、肉苁蓉8-15份、桑螵蛸8-15份、炒白术8-15份、砂仁5-10份、黄精15-30份、猪屎豆8-15份、荜茇根10-20份、远志8-15份、柴胡5-10份、益智仁10-20份。
上述原料中还可以加入红枣15-30份、桂圆肉15-30份。
实施例1
取以质量份数表示的各原料：黄芪10g、当归5g、枸杞10g、女贞子10g、淫羊藿8g、首乌6g、熟地8g、牛膝8g、杜仲8g、巴戟天8g、锁阳8g、炮附子8g、茯苓8g、肉苁蓉8g、桑螵蛸8g、炒白术8g、砂仁5g、黄精15g、猪屎豆8g、荜茇根10g、远志8g、柴胡5g、益智仁10g，加入上述原料总质量8倍的清水分两次煎熬、过滤后合并药液，每次喝药液50ml，早、晚各一次。疗程1-3个月。
上述原料中还可以加入红枣15g、桂圆肉15g。
以3个月疗程对年龄端25-45岁的20个患者服用上述中药组合物以3个月后，停药1年之内，其中17人成功怀孕，2人的肾阳虚临床症状完全消失但由于其他原因未能成功怀孕，1人无效。由此可见本发明的中药组合物的疗效显著。
实施例2
取以质量份数表示的各原料：黄芪20份、当归12份、枸杞20份、女贞子20份、淫羊藿15份、首乌12份、熟地15份、牛膝15份、杜仲15份、巴戟天15份、锁阳15份、炮附子15份、茯苓15份、肉苁蓉15份、桑螵蛸15份、炒白术15份、砂仁10份、黄精30份、猪屎豆15份、荜茇根20份、远志15份、柴胡10份、益智仁20份，加入以上原料总质量10倍的米酒浸泡1个月，制成用于肾阳虚证型不孕症的中药米酒。每次取上述中药米酒50ml加入适量的蜂蜜或红糖，加热后趁热饮用，早晚各一次。疗程1-3个月，可夫妻同饮以提高怀孕机会。
当然，上述原料中还可以加入红枣30份、桂圆肉30份一起在米酒中浸泡。
典型病例：谭某，35岁，结婚逾10年了后多次怀孕流产。经多次检查，丈夫各项指标正常，具有生育生力。其本人曾到过多家医院治疗过，但均未怀孕。谭某平时白带量多，腰痛，腹冷肢寒，性欲淡漠，小便频数，有时还会失禁，面色晦黯，舌淡，苔白滑，沉迟无力。诊断为肾阳虚证型不孕症。服用本发明按照实施例2制得的中药米酒2个月后，停服3个月后，成功怀孕并足月分娩一健康男婴孩。
实施例3
取以质量份数表示的各原料：黄芪15份、当归10份、枸杞15份、女贞子15份、淫羊藿12份、首乌8份、熟地12份、牛膝10份、杜仲10份、巴戟天12份、锁阳12份、炮附子12份、茯苓12份、肉苁蓉12份、桑螵蛸12份、炒白术12份、砂仁8份、黄精20份、猪屎豆10份、荜茇根15份、远志10份、柴胡8份、益智仁15份，放入上述原料总质量3倍的70度以上白酒中浸泡10～15天，过滤，滤液备用；滤渣加水煎煮2次，每次煮沸30～60分钟，过滤；将三次滤液合并在一起，加热浓缩至糊状，放入烘箱70℃～80℃烘干，烘干后冷却得到药粉，将药粉与蜂蜜按2:3的混合在一起搓成细条，再以2g为一丸腊封包装，得到用于肾阳虚证型不孕症的中药蜜丸。
上述中药蜜丸早晚各一粒，1-3月为一疗程。
上述原料中还可以加入红枣30份、桂圆肉30份。
典型病例：姜某，42岁，于23岁时生得一个女孩，现在想生二胎，多年一直未遂愿。丈夫各项指标正常。姜某的月经量少色淡，平时白带量较多，腰痛，腹冷肢寒，临床诊断为肾阳虚证型不孕症。服用本发明按照实施例3制得的中药蜜丸3个月，停服十个月后，成功怀孕足月分娩一健康男婴。
实施例4
取以质量份数表示的各原料：黄芪15份、当归12份、枸杞20份、女贞子10份、淫羊藿8份、首乌6份、熟地15份、牛膝8份、杜仲8份、巴戟天8份、锁阳12份、炮附子8份、茯苓15份、肉苁蓉15份、桑螵蛸15份、炒白术8份、砂仁5份、黄精15份、猪屎豆8份、荜茇根20份、远志15份、柴胡10份、益智仁10份，将上述各原料放入10倍量乙醇中，加热回流提取2次，每次1～2小时，将2次提取液合并静置；再将上述乙醇提取过的组份原料药材的药渣加10倍量水加热回流提取2次，每次1～2小时，将2次提取液合并静置；将上述两种提取液合并，减压浓缩相对密度为1.35(80℃)的滤液，回收乙醇，将所得滤液调整比重到1.06，减压得浸膏，放入烘干机中烘干得到药粉，加适量蜂蜜调和，放入制粒机中制成用于肾阳虚证型不孕症的中药颗粒剂。将上述中药颗粒剂按2g一袋封装，可以兑温水冲服，早晚各一次。疗程1-3个月。
上述原料中还可以加入红枣20份、桂圆肉20份。
典型病例：王某，32岁，结婚8年了一直未孕过，经多次检查，丈夫精子活力不强但具有生育生力。王本人曾到过多家医院治疗过，但均未怀孕。其月经不规律，偶尔伴有腰痛、腹冷、畏寒、失眠、易分神及情绪较为低落，舌淡，苔白滑，脉沉细而迟。诊断为肾阳虚证型不孕症。王某服用上述中药颗粒剂3个月后停药；同时其丈夫服用1个月后停药检查精子活力明显有提高。夫妻俩均停药后半年，王某成功怀孕并分娩。
实施例5
取以质量份数表示的各原料：黄芪20份、当归5份、枸杞20份、女贞子10份、淫羊藿8份、首乌12份、熟地15份、牛膝15份、杜仲12份、巴戟天15份、锁阳15份、炮附子15份、茯苓15份、肉苁蓉12份、桑螵蛸10份、炒白术10份、砂仁6份、黄精25份、猪屎豆10份、荜茇根18份、远志12份、柴胡6份、益智仁15份，将上述原料放入10倍量水中浸泡。投入多功能提取罐提取两次，第一次加8-10倍量水煎煮1-2小时，第二次加4-8倍量水煎煮1-2小时，合并两次煎液，过滤得滤液；加热浓缩至糊状，放入烘箱80℃烘干后冷却，粉碎成粉末，掺入淀粉制成用于肾阳虚证型不孕症的中药片剂。上述中药片剂10ug为一粒。每次2-4粒，早晚各一次。疗程1-3个月。
其中，上述原料中还可以加入红枣30份、桂圆肉30份。
实施例6
取以质量份数表示的各原料：黄芪10份、当归8份、枸杞12份、女贞子12份、淫羊藿10份、首乌6份、熟地10份、牛膝10份、杜仲12份、巴戟天15份、锁阳15份、炮附子13份、茯苓15份、肉苁蓉15份、桑螵蛸13份、炒白术15份、砂仁7份、黄精20份、猪屎豆9份、荜茇根17份、远志10份、柴胡7份、益智仁15份，加上述各原料总质量10倍量乙醇，加热回流提取3次，每次2小时，将3次提取液合并，减压回收乙醇并浓缩至药液浓度为0.5g生药/mL，抽滤后，滤液的相对密度约为1.06(20℃)；上述滤液先用去离子水或蒸馏水洗脱，再用95％乙醇洗脱，收集乙醇洗脱液，去除乙醇后得到组份药，将组份药装入胶囊制为胶囊剂，每粒胶囊装0.2g生药。可以每12粒为一板包装。使用时每天早晚各一次每次1-2粒。疗程1-3个月。
当然，上述原料中还可以加入红枣20份、桂圆肉20份。
以上所述仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发明的精神和原则之内所作的任何修改、等同替换和改进等，均应包含在本发明的保护范围之内。

Claims (2)

1.一种用于肾阳虚证型不孕症的中药组合物，其特征在于，包括以质量份数表示的原料：黄芪10-20份、当归5-12份、枸杞10-20份、女贞子10-20份、淫羊藿8-15份、首乌6-12份、熟地8-15份、牛膝8-15份、杜仲8-15份、巴戟天8-15份、锁阳8-15份、炮附子8-15份、茯苓8-15份、肉苁蓉8-15份、桑螵蛸8-15份、炒白术8-15份、砂仁5-10份、黄精15-30份、猪屎豆8-15份、荜茇根10-20份、远志8-15份、柴胡5-10份、益智仁10-20份。
2.根据权利要求1所述用于肾阳虚证型不孕症的中药组合物，其特征在于，包括以质量份数表示的各原料：黄芪15份、当归10份、枸杞15份、女贞子15份、淫羊藿12份、首乌8份、熟地12份、牛膝10份、杜仲10份、巴戟天12份、锁阳12份、炮附子12份、茯苓12份、肉苁蓉12份、桑螵蛸12份、炒白术12份、砂仁8份、黄精20份、猪屎豆10份、荜茇根15份、远志10份、柴胡8份、益智仁15份。
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* Cited by examiner, † Cited by third party
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