CN105658211A - 左旋多巴和/或左旋多巴的酯的粘膜粘附性、控制释放调配物和其用途 - Google Patents
左旋多巴和/或左旋多巴的酯的粘膜粘附性、控制释放调配物和其用途 Download PDFInfo
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- CN105658211A CN105658211A CN201480055451.3A CN201480055451A CN105658211A CN 105658211 A CN105658211 A CN 105658211A CN 201480055451 A CN201480055451 A CN 201480055451A CN 105658211 A CN105658211 A CN 105658211A
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- Prior art keywords
- levodopa
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- per
- solid composite
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- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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| PCT/US2014/059554 WO2015054302A1 (en) | 2013-10-07 | 2014-10-07 | Muco-adhesive, controlled release formulations of levodopa and/or esters of levodopa and uses thereof |
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| EP2515876B1 (en) | 2009-11-09 | 2016-01-06 | XenoPort, Inc. | Pharmaceutical compositions and oral dosage forms of a levodopa prodrug and methods of use |
| HUE030922T2 (en) | 2011-04-05 | 2017-06-28 | Annexin Pharmaceuticals Ab | Therapeutic and prophylactic procedures, applications and preparations containing annexin A5 |
| EP2508174A1 (en) | 2011-04-06 | 2012-10-10 | Ljiljana Sovic Brkicic | Pharmaceutical composition |
| US20130195973A1 (en) | 2012-01-30 | 2013-08-01 | Ranbaxy Laboratories Limited | Extended release pharmaceutical dosage forms of carbidopa and levodopa and process of preparation thereof |
| EP3782614A1 (en) | 2013-10-07 | 2021-02-24 | Impax Laboratories, LLC | Muco-adhesive, controlled release formulations of levodopa and/or esters of levodopa and uses thereof |
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2014
- 2014-10-07 EP EP20186769.4A patent/EP3782614A1/en active Pending
- 2014-10-07 WO PCT/US2014/059554 patent/WO2015054302A1/en not_active Ceased
- 2014-10-07 JP JP2016521328A patent/JP6506271B2/ja active Active
- 2014-10-07 KR KR1020167011939A patent/KR102266091B1/ko active Active
- 2014-10-07 MX MX2019013171A patent/MX393588B/es unknown
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| CN111526872A (zh) * | 2018-02-28 | 2020-08-11 | 上海汉都医药科技有限公司 | 一种药物组合物及其制备方法和应用 |
| CN111526872B (zh) * | 2018-02-28 | 2022-05-17 | 上海汉都医药科技有限公司 | 一种药物组合物及其制备方法和应用 |
| US11759417B2 (en) | 2018-02-28 | 2023-09-19 | Shanghai Wd Pharmaceutical Co., Ltd | Pharmaceutical composition and preparation method therefor and use thereof |
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| CN114762684B (zh) * | 2021-01-14 | 2023-11-21 | 华益泰康药业股份有限公司 | 一种治疗帕金森的缓释胶囊及其制备方法 |
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