CN105646261A - 一种制备丁卡因的方法 - Google Patents
一种制备丁卡因的方法 Download PDFInfo
- Publication number
- CN105646261A CN105646261A CN201610170954.6A CN201610170954A CN105646261A CN 105646261 A CN105646261 A CN 105646261A CN 201610170954 A CN201610170954 A CN 201610170954A CN 105646261 A CN105646261 A CN 105646261A
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- CN
- China
- Prior art keywords
- tetracaine
- benzoic acid
- method preparing
- amino benzoic
- sodium hydroxide
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
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CN201610170954.6A CN105646261B (zh) | 2016-03-24 | 2016-03-24 | 一种制备丁卡因的方法 |
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CN201610170954.6A CN105646261B (zh) | 2016-03-24 | 2016-03-24 | 一种制备丁卡因的方法 |
Publications (2)
Publication Number | Publication Date |
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CN105646261A true CN105646261A (zh) | 2016-06-08 |
CN105646261B CN105646261B (zh) | 2018-02-16 |
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CN201610170954.6A Active CN105646261B (zh) | 2016-03-24 | 2016-03-24 | 一种制备丁卡因的方法 |
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CN (1) | CN105646261B (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106518697A (zh) * | 2016-09-20 | 2017-03-22 | 北京万全德众医药生物技术有限公司 | 一种制备盐酸丁卡因的方法 |
CN109180511A (zh) * | 2018-08-22 | 2019-01-11 | 辽宁东科药业有限公司 | 一种盐酸丁卡因的制备方法 |
CN109761835A (zh) * | 2018-12-29 | 2019-05-17 | 江苏尚莱特医药化工材料有限公司 | 盐酸丁卡因的制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102675137A (zh) * | 2012-05-29 | 2012-09-19 | 济南诚汇双达化工有限公司 | 一种制备n-丁基对氨基苯甲酸的方法 |
US20140018422A1 (en) * | 2011-12-16 | 2014-01-16 | Willamette University | Derivatives of tetracaine |
CN105037193A (zh) * | 2015-08-25 | 2015-11-11 | 浙江三门恒康制药有限公司 | 一种奥替溴铵的制备方法 |
-
2016
- 2016-03-24 CN CN201610170954.6A patent/CN105646261B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20140018422A1 (en) * | 2011-12-16 | 2014-01-16 | Willamette University | Derivatives of tetracaine |
CN102675137A (zh) * | 2012-05-29 | 2012-09-19 | 济南诚汇双达化工有限公司 | 一种制备n-丁基对氨基苯甲酸的方法 |
CN105037193A (zh) * | 2015-08-25 | 2015-11-11 | 浙江三门恒康制药有限公司 | 一种奥替溴铵的制备方法 |
Non-Patent Citations (4)
Title |
---|
ADRIANA L.ANDRADE等: "Cyclic Nucleotide-Gated Channel Block by Hydrolysis-Resistant Tetracaine Derivatives", 《J.MED.CHEM.》 * |
SHINYA SATO等: "One-pot reductive amination of aldehydes and ketones with α-picoline-borane in methanol, in water, and in neat conditions", 《TETRAHEDRON》 * |
ZHANXING HU等: "Identification, Synthesis, and Strategy for Minimization of Potential Impurities in the Preclinical Anti-HBV Drug Y101", 《ORG.PROCESS RES.DEV.》 * |
四川医学院: "《药物化学》", 31 January 1981 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106518697A (zh) * | 2016-09-20 | 2017-03-22 | 北京万全德众医药生物技术有限公司 | 一种制备盐酸丁卡因的方法 |
CN109180511A (zh) * | 2018-08-22 | 2019-01-11 | 辽宁东科药业有限公司 | 一种盐酸丁卡因的制备方法 |
CN109761835A (zh) * | 2018-12-29 | 2019-05-17 | 江苏尚莱特医药化工材料有限公司 | 盐酸丁卡因的制备方法 |
CN109761835B (zh) * | 2018-12-29 | 2021-10-15 | 常州市阳光药业有限公司 | 盐酸丁卡因的制备方法 |
Also Published As
Publication number | Publication date |
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CN105646261B (zh) | 2018-02-16 |
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Denomination of invention: Tetracaine preparation method Effective date of registration: 20180718 Granted publication date: 20180216 Pledgee: Qilu bank Limited by Share Ltd. Ji'nan high tech branch Pledgor: JINAN CHENGHUISHUANGDA CHEMICAL INDUSTRY Co.,Ltd. Registration number: 2018370000131 |
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PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20230811 Granted publication date: 20180216 Pledgee: Qilu bank Limited by Share Ltd. Ji'nan high tech branch Pledgor: JINAN CHENGHUISHUANGDA CHEMICAL INDUSTRY Co.,Ltd. Registration number: 2018370000131 |