CN105593242B - 卷曲螺旋免疫球蛋白融合蛋白及其组合物 - Google Patents

卷曲螺旋免疫球蛋白融合蛋白及其组合物 Download PDF

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CN105593242B
CN105593242B CN201480050383.1A CN201480050383A CN105593242B CN 105593242 B CN105593242 B CN 105593242B CN 201480050383 A CN201480050383 A CN 201480050383A CN 105593242 B CN105593242 B CN 105593242B
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immunoglobulin
peptide
amino acid
antibody region
antibody
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CN105593242A (zh
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峰·王
勇·张
英·王
岩·刘
彼得·G·舒尔茨
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Scripps Research Institute
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California Institute for Biomedical Research
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    • A61K47/6889Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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CN201480050383.1A 2013-07-11 2014-07-11 卷曲螺旋免疫球蛋白融合蛋白及其组合物 Active CN105593242B (zh)

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US201461925904P 2014-01-10 2014-01-10
US61/925,904 2014-01-10
US201462017713P 2014-06-26 2014-06-26
US62/017,713 2014-06-26
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Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7495087B2 (en) 1997-07-14 2009-02-24 Bolder Biotechnology, Inc. Cysteine muteins in the C-D loop of human interleukin-11
ES2297889T3 (es) 1997-07-14 2008-05-01 Bolder Biotechnology, Inc. Derivados de hormona de crecimiento y proteinas relacionadas.
CA2359345A1 (en) 1999-01-14 2000-07-20 Bolder Biotechnology, Inc. Methods for making proteins containing free cysteine residues
CA2863224A1 (en) 2012-01-09 2013-07-18 The Scripps Research Institute Ultralong complementarity determining regions and uses thereof
JP2015509091A (ja) 2012-01-09 2015-03-26 ザ スクリプス リサーチ インスティテュート ヒト化抗体
EP2943512A4 (en) 2013-01-11 2016-06-01 California Inst Biomedical Res BOVINE FUSION ANTIBODY
WO2015006744A1 (en) 2013-07-11 2015-01-15 The California Institute For Biomedical Research Immunoglobulin fusion proteins and compositions thereof
CA2918370A1 (en) 2013-07-18 2015-01-22 Fabrus, Inc. Humanized antibodies with ultralong complementarity determining regions
PL3344647T3 (pl) 2015-09-01 2025-03-17 Oncoqr Ml Gmbh Łącznik coiled-coil
WO2017062334A1 (en) * 2015-10-05 2017-04-13 Merck Sharp & Dohme Corp. Antibody peptide conjugates that have agonist activity at both the glucagon and glucagon-like peptide 1 receptors
US11510993B2 (en) 2015-10-06 2022-11-29 Merck Sharp & Dohme Llc Antibody drug conjugate for anti-inflammatory applications
RU2018124307A (ru) 2015-12-04 2020-01-14 Новартис Аг Антительно-цитокиновые привитые композиции и способы применения для иммунорегуляции
PT3387019T (pt) * 2015-12-09 2022-01-14 Scripps Research Inst Proteínas de fusão de imunoglobulina de relaxina e métodos de uso
CN105505884B (zh) * 2016-01-26 2017-10-03 郑州师范学院 进行抗体表达和组装的重组系统及应用
US10869929B2 (en) 2016-01-29 2020-12-22 Merck Sharp & Dohme Corp. Phosphonate linkers and their use to facilitate cellular retention of compounds
IL263079B2 (en) 2016-05-18 2024-05-01 Modernatx Inc Polynucleotides encoding relaxin
TW201809013A (zh) * 2016-06-06 2018-03-16 艾斯克立必恩股份有限公司 用於藥物遞送之抗體融合蛋白
WO2018013483A1 (en) * 2016-07-11 2018-01-18 The California Institute For Biomedical Research Kv1.3 channel blocking peptides and uses thereof
BR112019011564A2 (pt) * 2016-12-09 2019-10-22 Seattle Genetics Inc anticorpos bivalentes mascarados por hélices superenroladas
US20200188528A1 (en) * 2016-12-19 2020-06-18 Fred Hutchinson Cancer Research Center Peptide-antibody compositions and methods of use thereof
WO2018160739A1 (en) 2017-02-28 2018-09-07 The Board Of Trustees Of The Leland Stanford Junior University Antifibrotic activity of cd47 blockade
MY206158A (en) 2017-05-24 2024-12-02 Novartis Ag Antibody-cytokine engrafted proteins and methods of use in the treatment of cancer
JOP20190271A1 (ar) 2017-05-24 2019-11-21 Novartis Ag بروتينات مطعّمة بسيتوكين- الجسم المضاد وطرق الاستخدام للاضطرابات المتعلقة بالمناعة
EP4029877B1 (en) 2017-08-03 2024-01-17 Amgen Inc. Interleukin-21 muteins and methods of treatment
TW201930344A (zh) 2018-01-12 2019-08-01 美商安進公司 抗pd-1抗體及治療方法
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
JP2022512688A (ja) * 2018-10-24 2022-02-07 シャイア-エヌピーエス ファーマシューティカルズ インコーポレイテッド Glp-2融合ポリペプチドならびに消化管の状態の処置および予防のための使用
CN111234000B (zh) * 2018-11-28 2023-05-26 鲁南制药集团股份有限公司 艾塞纳肽类似物
US20230242655A1 (en) 2019-12-03 2023-08-03 Evotec International Gmbh Interferon-associated antigen binding proteins and uses thereof
MX2022006861A (es) 2019-12-04 2022-07-11 Scripps Research Inst Agonistas del receptor glp2 y metodos de uso.
JP2023514972A (ja) * 2020-02-12 2023-04-12 ザ スクリプス リサーチ インスティテュート 長時間作用型gm-csfおよび使用方法
WO2021195672A1 (en) * 2020-03-26 2021-09-30 The Regents Of The University Of California Detection and treatment of intestinal fibrosis
CN116438206B (zh) 2020-12-08 2024-03-12 切弗朗菲利浦化学公司 环流淤浆聚合反应器中负载型铬催化剂的粒度控制
US20250197525A1 (en) * 2021-04-28 2025-06-19 Minotaur Therapeutics, Inc. Humanized chimeric bovine antibodies and methods of use
KR20240032010A (ko) 2021-06-09 2024-03-08 더 스크립스 리서치 인스티튜트 장기 지속형 이중 gip/glp-1 펩타이드 접합체 및 사용 방법
WO2025235931A2 (en) * 2024-05-09 2025-11-13 Aptamino, Llc Antibody structures comprising helical complementarity determining regions
WO2026069258A1 (en) * 2024-09-30 2026-04-02 Consiglio Nazionale Delle Ricerche Effect of ctx-cnf1 on the switch of macrophages towards a pro- inflammatory phenotype

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200734354A (en) * 2005-12-15 2007-09-16 Ind Tech Res Inst Recombinant triplex scaffold-based polypeptides
US20100136032A1 (en) * 2005-05-06 2010-06-03 Providence Health System Trimeric ox40-immunoglobulin fusion protein and methods of use
WO2013055404A1 (en) * 2011-10-10 2013-04-18 City Of Hope Meditopes and meditope-binding antibodies and uses thereof

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
HUT35524A (en) 1983-08-02 1985-07-29 Hoechst Ag Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
JP3040121B2 (ja) 1988-01-12 2000-05-08 ジェネンテク,インコーポレイテッド 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法
US6565841B1 (en) 1991-03-15 2003-05-20 Amgen, Inc. Pulmonary administration of granulocyte colony stimulating factor
US5470582A (en) 1992-02-07 1995-11-28 Syntex (U.S.A.) Inc. Controlled delivery of pharmaceuticals from preformed porous polymeric microparticles
US6372716B1 (en) 1994-04-26 2002-04-16 Genetics Institute, Inc. Formulations for factor IX
GB9501079D0 (en) 1995-01-19 1995-03-08 Bioinvent Int Ab Activation of T-cells
US6685940B2 (en) 1995-07-27 2004-02-03 Genentech, Inc. Protein formulation
JPH10245397A (ja) 1997-03-03 1998-09-14 Seibutsu Bunshi Kogaku Kenkyusho:Kk α−ヘリカルコイルドコイル構造を有するペプチド
GB9714680D0 (en) * 1997-07-11 1997-09-17 Medical Res Council Recombinant production of proteins
US6566329B1 (en) 1999-06-28 2003-05-20 Novo Nordisk A/S Freeze-dried preparation of human growth hormone
US20030143234A1 (en) * 1999-08-20 2003-07-31 Wenyuan Shi Anti-microbial targeting chimeric pharmaceutical
CA2382766A1 (en) 2001-04-20 2002-10-20 Azad Kaushik Novel bovine vdj cassette, bf1h1, suitable for antigenization
US7736652B2 (en) 2002-03-21 2010-06-15 The Regents Of The University Of California Antibody fusion proteins: effective adjuvants of protein vaccination
CN100389128C (zh) * 2004-06-18 2008-05-21 上海美恩生物技术有限公司 肿瘤坏死治疗单抗-白细胞介素2的融合蛋白及其制法和用途
US7947839B2 (en) 2004-12-01 2011-05-24 Genentech, Inc. Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use
DK1912677T3 (da) 2005-06-20 2014-01-13 Psma Dev Company L L C PSMA-antistof-lægemiddel-konjugater
US20090214541A1 (en) * 2006-01-04 2009-08-27 L'instut National De La Sante Et De La Recherche Medicale Combination Therapy Using Anti-EGFR and Anti-HER2 Antibodies
CN101868246A (zh) * 2007-09-21 2010-10-20 加利福尼亚大学董事会 被导靶的干扰素显示强的细胞凋亡和抗肿瘤活性
JP5780951B2 (ja) * 2008-04-24 2015-09-16 ダイアックス コーポレーション 新規のhccdr1、cdr2、およびcdr3設計、ならびに新規のlccdr1、cdr2、およびcdr3設計を含む、遺伝子パッケージのライブラリ
EP2113255A1 (en) 2008-05-02 2009-11-04 f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. Cytotoxic immunoglobulin
EP2478013B1 (en) * 2009-09-16 2018-10-24 F.Hoffmann-La Roche Ag Coiled coil and/or tether containing protein complexes and uses thereof
JP2011231085A (ja) * 2010-04-30 2011-11-17 Osaka Prefecture Univ 環状ペプチド
EP2407487A1 (en) 2010-07-14 2012-01-18 F-Star Biotechnologische Forschungs - und Entwicklungsges. M.B.H. Multispecific modular antibody
US8481038B2 (en) * 2010-11-15 2013-07-09 Five Prime Therapeutics, Inc. Treatment of cancer with elevated dosages of soluble FGFR1 fusion proteins
CA2863224A1 (en) 2012-01-09 2013-07-18 The Scripps Research Institute Ultralong complementarity determining regions and uses thereof
JP2015509091A (ja) 2012-01-09 2015-03-26 ザ スクリプス リサーチ インスティテュート ヒト化抗体
US8956000B2 (en) 2012-07-20 2015-02-17 Stephane Martinez System and method for illumination of a rain gutter
EP2943512A4 (en) 2013-01-11 2016-06-01 California Inst Biomedical Res BOVINE FUSION ANTIBODY
WO2015006744A1 (en) 2013-07-11 2015-01-15 The California Institute For Biomedical Research Immunoglobulin fusion proteins and compositions thereof
WO2015017146A2 (en) 2013-07-18 2015-02-05 Fabrus, Inc. Antibodies with ultralong complementarity determining regions
US20150192971A1 (en) 2014-01-08 2015-07-09 Bhavesh Ramesh Shah High power portable device and docking station
EP2980512B1 (en) 2014-07-31 2017-03-29 Plastic Frost B.V. Spacer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100136032A1 (en) * 2005-05-06 2010-06-03 Providence Health System Trimeric ox40-immunoglobulin fusion protein and methods of use
TW200734354A (en) * 2005-12-15 2007-09-16 Ind Tech Res Inst Recombinant triplex scaffold-based polypeptides
WO2013055404A1 (en) * 2011-10-10 2013-04-18 City Of Hope Meditopes and meditope-binding antibodies and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Functional Antibody CDR3 Fusion Proteins with Enhanced Pharmacological Properties;YONG ZHANG等;《Angew. Chem. Int. Ed》;20130621;第52卷(第32期);全文 *

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