HK1224309A1 - 捲曲螺旋免疫球蛋白融合蛋白及其組合物 - Google Patents
捲曲螺旋免疫球蛋白融合蛋白及其組合物Info
- Publication number
- HK1224309A1 HK1224309A1 HK16112507.3A HK16112507A HK1224309A1 HK 1224309 A1 HK1224309 A1 HK 1224309A1 HK 16112507 A HK16112507 A HK 16112507A HK 1224309 A1 HK1224309 A1 HK 1224309A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- compositions
- fusion proteins
- coiled coil
- immunoglobulin fusion
- coil immunoglobulin
- Prior art date
Links
- 108060003951 Immunoglobulin Proteins 0.000 title 1
- 102000037865 fusion proteins Human genes 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 title 1
- 102000018358 immunoglobulin Human genes 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
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- Health & Medical Sciences (AREA)
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- Organic Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
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- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
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- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Insects & Arthropods (AREA)
- Virology (AREA)
- Child & Adolescent Psychology (AREA)
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Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361845287P | 2013-07-11 | 2013-07-11 | |
US201361845280P | 2013-07-11 | 2013-07-11 | |
US201461925904P | 2014-01-10 | 2014-01-10 | |
US201462017713P | 2014-06-26 | 2014-06-26 | |
PCT/US2014/046419 WO2015006736A2 (en) | 2013-07-11 | 2014-07-11 | Coiled coil immunoglobulin fusion proteins and compositions thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1224309A1 true HK1224309A1 (zh) | 2017-08-18 |
Family
ID=52280653
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16112507.3A HK1224309A1 (zh) | 2013-07-11 | 2016-10-31 | 捲曲螺旋免疫球蛋白融合蛋白及其組合物 |
Country Status (12)
Country | Link |
---|---|
US (4) | US10683353B2 (zh) |
EP (3) | EP3693397B1 (zh) |
JP (2) | JP6704101B2 (zh) |
KR (1) | KR102361237B1 (zh) |
CN (2) | CN105593242B (zh) |
AU (1) | AU2014286998B2 (zh) |
CA (1) | CA2917814C (zh) |
DK (1) | DK3019533T3 (zh) |
ES (1) | ES2780948T3 (zh) |
HK (1) | HK1224309A1 (zh) |
PT (1) | PT3019533T (zh) |
WO (2) | WO2015006736A2 (zh) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2297889T3 (es) | 1997-07-14 | 2008-05-01 | Bolder Biotechnology, Inc. | Derivados de hormona de crecimiento y proteinas relacionadas. |
US7495087B2 (en) | 1997-07-14 | 2009-02-24 | Bolder Biotechnology, Inc. | Cysteine muteins in the C-D loop of human interleukin-11 |
BR122013003013B8 (pt) | 1999-01-14 | 2021-07-06 | Bolder Biotechnology Inc | proteína isolada monopeguilada do hormônio do crescimento e método para sua obtenção |
US10774132B2 (en) | 2012-01-09 | 2020-09-15 | The Scripps Research Instittue | Ultralong complementarity determining regions and uses thereof |
CA2862979A1 (en) | 2012-01-09 | 2013-07-18 | The Scripps Research Institute | Humanized antibodies with ultralong cdr3s |
EP2943512A4 (en) | 2013-01-11 | 2016-06-01 | California Inst Biomedical Res | FUSION BOVINE ANTIBODIES |
WO2015006736A2 (en) | 2013-07-11 | 2015-01-15 | The California Institute For Biomedical Research | Coiled coil immunoglobulin fusion proteins and compositions thereof |
WO2015010100A2 (en) | 2013-07-18 | 2015-01-22 | Fabrus, Inc. | Humanized antibodies with ultralong complementarity determining regions |
US11090381B2 (en) | 2015-09-01 | 2021-08-17 | Oncoqr Ml Gmbh | Coiled-coil connector |
US10800826B2 (en) | 2015-10-05 | 2020-10-13 | Merck Sharp & Dohme Corp. | Antibody peptide conjugates that have agonist activity at both the glucagon and glucagon-like peptide 1 receptors |
US11510993B2 (en) | 2015-10-06 | 2022-11-29 | Merck Sharp & Dohme Llc | Antibody drug conjugate for anti-inflammatory applications |
RU2018124307A (ru) | 2015-12-04 | 2020-01-14 | Новартис Аг | Антительно-цитокиновые привитые композиции и способы применения для иммунорегуляции |
WO2017100540A2 (en) | 2015-12-09 | 2017-06-15 | The California Institute For Biomedical Research | Relaxin immunoglobulin fusion proteins and methods of use |
CN105505884B (zh) * | 2016-01-26 | 2017-10-03 | 郑州师范学院 | 进行抗体表达和组装的重组系统及应用 |
EP3407916B1 (en) | 2016-01-29 | 2023-12-20 | Merck Sharp & Dohme LLC | Phosphonate linkers and their use to facilitate cellular retention of compounds |
MA45051A (fr) | 2016-05-18 | 2019-03-27 | Modernatx Inc | Polynucléotides codant la relaxine |
CN109312367B (zh) * | 2016-06-06 | 2023-04-11 | 艾斯克立必恩股份有限公司 | 用于药物递送的抗体融合蛋白 |
WO2018013483A1 (en) * | 2016-07-11 | 2018-01-18 | The California Institute For Biomedical Research | Kv1.3 channel blocking peptides and uses thereof |
MX2019006624A (es) * | 2016-12-09 | 2019-08-01 | Seattle Genetics Inc | Anticuerpos bivalentes enmascarados por helices superenrolladas. |
US20200188528A1 (en) * | 2016-12-19 | 2020-06-18 | Fred Hutchinson Cancer Research Center | Peptide-antibody compositions and methods of use thereof |
CA3053392A1 (en) | 2017-02-28 | 2018-09-07 | The Board Of Trustees Of The Leland Stanford Junior University | Antifibrotic activity of cd47 blockade |
JOP20190271A1 (ar) | 2017-05-24 | 2019-11-21 | Novartis Ag | بروتينات مطعّمة بسيتوكين- الجسم المضاد وطرق الاستخدام للاضطرابات المتعلقة بالمناعة |
AU2018274216A1 (en) | 2017-05-24 | 2019-12-12 | Novartis Ag | Antibody-cytokine engrafted proteins and methods of use in the treatment of cancer |
CN118126157A (zh) | 2017-08-03 | 2024-06-04 | 美国安进公司 | 白介素-21突变蛋白和治疗方法 |
US11518808B2 (en) | 2018-01-12 | 2022-12-06 | Amgen Inc. | Anti-PD-1 antibodies and methods of treatment |
AU2019365212A1 (en) * | 2018-10-24 | 2021-04-29 | Shire-Nps Pharmaceuticals, Inc. | GLP-2 fusion polypeptides and uses for treating and preventing gastrointestinal conditions |
CN111234000B (zh) * | 2018-11-28 | 2023-05-26 | 鲁南制药集团股份有限公司 | 艾塞纳肽类似物 |
EP4103618A4 (en) * | 2020-02-12 | 2024-05-01 | The Scripps Research Institute | LONG-ACTING GM-CSF AND METHODS OF USE |
EP4125988A4 (en) * | 2020-03-26 | 2024-04-24 | The Regents of University of California | DETECTION AND TREATMENT OF INTESTINAL FIBROSIS |
WO2022125581A2 (en) | 2020-12-08 | 2022-06-16 | Chevron Phillips Chemical Company Lp | Particle size control of supported chromium catalysts in loop slurry polymerization reactors |
EP4329887A1 (en) * | 2021-04-28 | 2024-03-06 | Minotaur Therapeutics, Inc. | Humanized chimeric bovine antibodies and methods of use |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
WO1989006692A1 (en) | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Method of treating tumor cells by inhibiting growth factor receptor function |
US6565841B1 (en) | 1991-03-15 | 2003-05-20 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
WO1993015722A1 (en) | 1992-02-07 | 1993-08-19 | Syntex (Usa) Inc. | Controlled delivery of pharmaceuticals from preformed porous microparticles |
US6372716B1 (en) | 1994-04-26 | 2002-04-16 | Genetics Institute, Inc. | Formulations for factor IX |
GB9501079D0 (en) | 1995-01-19 | 1995-03-08 | Bioinvent Int Ab | Activation of T-cells |
US6685940B2 (en) | 1995-07-27 | 2004-02-03 | Genentech, Inc. | Protein formulation |
JPH10245397A (ja) | 1997-03-03 | 1998-09-14 | Seibutsu Bunshi Kogaku Kenkyusho:Kk | α−ヘリカルコイルドコイル構造を有するペプチド |
GB9714680D0 (en) * | 1997-07-11 | 1997-09-17 | Medical Res Council | Recombinant production of proteins |
US6566329B1 (en) | 1999-06-28 | 2003-05-20 | Novo Nordisk A/S | Freeze-dried preparation of human growth hormone |
US20030143234A1 (en) * | 1999-08-20 | 2003-07-31 | Wenyuan Shi | Anti-microbial targeting chimeric pharmaceutical |
US6740747B2 (en) * | 2001-04-20 | 2004-05-25 | Azad Kaushik | Bovine VDJ cassette, BF1H1, suitable for antigenization |
US7736652B2 (en) | 2002-03-21 | 2010-06-15 | The Regents Of The University Of California | Antibody fusion proteins: effective adjuvants of protein vaccination |
CN100389128C (zh) * | 2004-06-18 | 2008-05-21 | 上海美恩生物技术有限公司 | 肿瘤坏死治疗单抗-白细胞介素2的融合蛋白及其制法和用途 |
US7947839B2 (en) | 2004-12-01 | 2011-05-24 | Genentech, Inc. | Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use |
EP1877090B1 (en) * | 2005-05-06 | 2014-01-15 | Providence Health System | Trimeric ox40-immunoglobulin fusion protein and methods of use |
DK1912677T3 (da) | 2005-06-20 | 2014-01-13 | Psma Dev Company L L C | PSMA-antistof-lægemiddel-konjugater |
US20070264687A1 (en) | 2005-12-15 | 2007-11-15 | Min-Yuan Chou | Recombinant triplex scaffold-based polypeptides |
EP1968633B2 (en) * | 2006-01-04 | 2017-11-01 | Institut National de la Santé et de la Recherche Medicale | Combination therapy using anti-egfr and anti-her2 antibodies |
EP2200634B1 (en) * | 2007-09-21 | 2015-02-11 | The Regents of The University of California | Targeted interferon demonstrates potent apoptotic and anti-tumor activities |
CA2968164C (en) * | 2008-04-24 | 2019-08-20 | Dyax Corp. | Libraries of genetic packages comprising novel hc cdr1, cdr2, and cdr3 and novel lc cdr1, cdr2, and cdr3 designs |
EP2113255A1 (en) | 2008-05-02 | 2009-11-04 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Cytotoxic immunoglobulin |
CA2781519A1 (en) | 2009-09-16 | 2011-03-24 | Genentech, Inc. | Coiled coil and/or tether containing protein complexes and uses thereof |
JP2011231085A (ja) | 2010-04-30 | 2011-11-17 | Osaka Prefecture Univ | 環状ペプチド |
EP2407487A1 (en) | 2010-07-14 | 2012-01-18 | F-Star Biotechnologische Forschungs - und Entwicklungsges. M.B.H. | Multispecific modular antibody |
US8481038B2 (en) | 2010-11-15 | 2013-07-09 | Five Prime Therapeutics, Inc. | Treatment of cancer with elevated dosages of soluble FGFR1 fusion proteins |
EP3741773A1 (en) | 2011-10-10 | 2020-11-25 | City of Hope | Meditopes and meditope-binding antibodies and uses thereof |
US10774132B2 (en) | 2012-01-09 | 2020-09-15 | The Scripps Research Instittue | Ultralong complementarity determining regions and uses thereof |
CA2862979A1 (en) | 2012-01-09 | 2013-07-18 | The Scripps Research Institute | Humanized antibodies with ultralong cdr3s |
US8956000B2 (en) | 2012-07-20 | 2015-02-17 | Stephane Martinez | System and method for illumination of a rain gutter |
EP2943512A4 (en) | 2013-01-11 | 2016-06-01 | California Inst Biomedical Res | FUSION BOVINE ANTIBODIES |
WO2015006736A2 (en) | 2013-07-11 | 2015-01-15 | The California Institute For Biomedical Research | Coiled coil immunoglobulin fusion proteins and compositions thereof |
US20160168231A1 (en) | 2013-07-18 | 2016-06-16 | Fabrus, Inc. | Antibodies with ultralong complementarity determining regions |
CN106031321A (zh) | 2014-01-08 | 2016-10-12 | 探戈科技公司 | 高功率便携装置和对接系统 |
EP2980512B1 (en) | 2014-07-31 | 2017-03-29 | Plastic Frost B.V. | Spacer |
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CA2917814C (en) | 2022-12-13 |
KR102361237B1 (ko) | 2022-02-09 |
CN105593242B (zh) | 2020-11-06 |
US20160159920A1 (en) | 2016-06-09 |
WO2015006744A1 (en) | 2015-01-15 |
KR20160055133A (ko) | 2016-05-17 |
JP2016529229A (ja) | 2016-09-23 |
JP2020023520A (ja) | 2020-02-13 |
EP3693397A1 (en) | 2020-08-12 |
EP3693397B1 (en) | 2024-06-12 |
CA2917814A1 (en) | 2015-01-15 |
CN112225817A (zh) | 2021-01-15 |
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WO2015006736A3 (en) | 2015-03-12 |
ES2780948T3 (es) | 2020-08-27 |
EP3019533B1 (en) | 2020-01-08 |
EP3019533A4 (en) | 2017-04-12 |
EP3019531A1 (en) | 2016-05-18 |
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