CN105582052A - Preparation for preventing and treating gingival atrophy - Google Patents
Preparation for preventing and treating gingival atrophy Download PDFInfo
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- CN105582052A CN105582052A CN201510597035.2A CN201510597035A CN105582052A CN 105582052 A CN105582052 A CN 105582052A CN 201510597035 A CN201510597035 A CN 201510597035A CN 105582052 A CN105582052 A CN 105582052A
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Abstract
The invention discloses a preparation for preventing and treating gingival atrophy. The preparation is prepared from dilantin or Hydroxy Phenytoin, a radix scutellariae extracting solution and a common andrographis herb extracting solution, wherein 10-50 mL of radix scutellariae extracting solution and 5-25 mL of common andrographis herb extracting solution are adopted for each gram of dilantin or Hydroxy Phenytoin. Oral anaerobes can be restrained, dental calculus can be prevented, atrophic gingival can be recovered, and normal functions of gingival can be kept.
Description
Technical field
The present invention relates to oral hygiene, particularly a kind of preparation of preventing and treating gingival atrophy.
Background technology
Gingival atrophy is the disease of clinical common refractory, and gingival atrophy is the retractility pathology of gum and Level of Alveolar Bone tissue, shows as gingival recession, neck portion or Root exposnre. The main cause that periodontal atrophy occurs is: the compressing of neck portion dental calculus to gum; Due to the long-term useless use or general factor of this position tooth; The mechanical irritation that incorrect method for brushing teeth brings; Dummy compressing gum etc. To a certain extent, Root exposnre will cause tooth mobility to gingival atrophy, is to cause loss of tooth and an irritated major reason.
There is no in the market a kind of special control pharmaceutical preparation for gingival atrophy. Therefore, develop a kind of preparation that can prevent and treat gingival atrophy significant to preventing and treating mouth disease.
Summary of the invention
The object of the present invention is to provide a kind of preparation of preventing and treating gingival atrophy, can suppress oral cavity anaerobium, prevent that calculus dentalis from forming, can recover atrophy gum, maintain gum normal function.
The technical solution adopted for the present invention to solve the technical problems is:
Prevent and treat a preparation for gingival atrophy, mixed and formed by dilantin sodium or hydroxyphenytoin, root of large-flowered skullcap extract, Herba Andrographitis extract, concrete proportioning is as follows:
Every 1g dilantin sodium or hydroxyphenytoin, join root of large-flowered skullcap extract 10-50mL, Herba Andrographitis extract 5-25mL.
Dilantin sodium routine act as antiepileptic, antiarrhymic. Hydroxyphenytoin is dilantin sodium metabolite, has same function. Inventor is through studying unexpected discovery for a long period of time, and dilantin sodium or hydroxyphenytoin can play the effect that recovers atrophy gum, maintains gum normal function for oral cavity. The Radix Astragali of the present invention and Herba Andrographitis are the traditional Chinese medicines of anti-bacteria propagation, removing oral peculiar smell, and its extract has the effect that suppresses oral cavity anaerobium, prevents calculus dentalis formation. Active ingredient of the present invention is dilantin sodium or hydroxyphenytoin. Dilantin sodium or hydroxyphenytoin, root of large-flowered skullcap extract, Herba Andrographitis extract three are combined use by the present invention, and collaborative onset prevents and treats gingival atrophy effect remarkable.
As preferably, described root of large-flowered skullcap extract preparation method is as follows: after radix scutellariae medicinal materials 1kg cleans, pulverize, soak 1h after poach 30min obtain water cooking liquid, extract each 10 times of water yields for continuous 3 times; Merge the water cooking liquid extracting for 3 times, rotary evaporation is concentrated, collects supernatant, after filtration sterilization, and the aseptic 0.5g/mL that is concentrated into.
As preferably, described Herba Andrographitis extract preparation method is as follows: after Herba Andrographitis medicinal material 1kg cleans, pulverize, soak 1h after poach 30min obtain water cooking liquid, extract each 10 times of water yields for continuous 3 times; Merge the water cooking liquid extracting for 3 times, rotary evaporation is concentrated, collects supernatant, after filtration sterilization, and the aseptic 0.5g/mL that is concentrated into.
A kind of formulation application of preventing and treating gingival atrophy is in mouthwash.
A kind of formulation application of preventing and treating gingival atrophy is in toothpaste.
Prevent and treat a water formulation for gingival atrophy, the proportioning of each component is as follows:
Dilantin sodium or hydroxyphenytoin 0.1-10g/L, root of large-flowered skullcap extract 0.01-5vol%, Herba Andrographitis extract 0.01-5vol%, water surplus.
Dilantin sodium or hydroxyphenytoin, root of large-flowered skullcap extract, Herba Andrographitis extract are diluted with water the direct applied water formulation form that is more suitable for that is adjusted to by the present invention.
The invention has the beneficial effects as follows: can suppress oral cavity anaerobium, prevent that calculus dentalis from forming, can recover atrophy gum, maintain gum normal function.
Detailed description of the invention
Below by specific embodiment, technical scheme of the present invention is described in further detail.
In the present invention, if not refer in particular to, raw material and the equipment etc. adopting all can be buied from market or this area is conventional. Method in following embodiment, if no special instructions, is the conventional method of this area.
Embodiment 1:
Prevent and treat a preparation for gingival atrophy, by dilantin sodium (commercially available) 1g, root of large-flowered skullcap extract 10mL, Herba Andrographitis extract 5mL, three mixes composition.
Described root of large-flowered skullcap extract preparation method is as follows: after radix scutellariae medicinal materials 1kg cleans, pulverize, soak 1h after poach 30min obtain water cooking liquid, extract each 10 times of water yields (be medicinal material 1kg add water 10L) for continuous 3 times; Merge the water cooking liquid extracting for 3 times, rotary evaporation is concentrated, collects supernatant, after filtration sterilization, and the aseptic solid content 0.5g/mL that is concentrated into.
Described Herba Andrographitis extract preparation method is as follows: after Herba Andrographitis medicinal material 1kg cleans, pulverize, soak 1h after poach 30min obtain water cooking liquid, extract each 10 times of water yields (be medicinal material 1kg add water 10L) for continuous 3 times; Merge the water cooking liquid extracting for 3 times, rotary evaporation is concentrated, collects supernatant, after filtration sterilization, and the aseptic solid content 0.5g/mL that is concentrated into.
Embodiment 2:
Prevent and treat a preparation for gingival atrophy, by dilantin sodium (commercially available) 1g, root of large-flowered skullcap extract 50mL, Herba Andrographitis extract 25mL, three mixes composition.
Described root of large-flowered skullcap extract preparation method is as follows: after radix scutellariae medicinal materials 1kg cleans, pulverize, soak 1h after poach 30min obtain water cooking liquid, extract each 10 times of water yields (be medicinal material 1kg add water 10L) for continuous 3 times; Merge the water cooking liquid extracting for 3 times, rotary evaporation is concentrated, collects supernatant, after filtration sterilization, and the aseptic solid content 0.5g/mL that is concentrated into.
Described Herba Andrographitis extract preparation method is as follows: after Herba Andrographitis medicinal material 1kg cleans, pulverize, soak 1h after poach 30min obtain water cooking liquid, extract each 10 times of water yields (be medicinal material 1kg add water 10L) for continuous 3 times; Merge the water cooking liquid extracting for 3 times, rotary evaporation is concentrated, collects supernatant, after filtration sterilization, and the aseptic solid content 0.5g/mL that is concentrated into.
Embodiment 3:
Prevent and treat a preparation for gingival atrophy, by dilantin sodium (commercially available) 1g, root of large-flowered skullcap extract 30mL, Herba Andrographitis extract 15mL, three mixes composition.
Described root of large-flowered skullcap extract preparation method is as follows: after radix scutellariae medicinal materials 1kg cleans, pulverize, soak 1h after poach 30min obtain water cooking liquid, extract each 10 times of water yields (be medicinal material 1kg add water 10L) for continuous 3 times; Merge the water cooking liquid extracting for 3 times, rotary evaporation is concentrated, collects supernatant, after filtration sterilization, and the aseptic solid content 0.5g/mL that is concentrated into.
Described Herba Andrographitis extract preparation method is as follows: after Herba Andrographitis medicinal material 1kg cleans, pulverize, soak 1h after poach 30min obtain water cooking liquid, extract each 10 times of water yields (be medicinal material 1kg add water 10L) for continuous 3 times; Merge the water cooking liquid extracting for 3 times, rotary evaporation is concentrated, collects supernatant, after filtration sterilization, and the aseptic solid content 0.5g/mL that is concentrated into.
Embodiment 4:
Prevent and treat a preparation for gingival atrophy, by hydroxyphenytoin (commercially available) 1g, root of large-flowered skullcap extract 20mL, Herba Andrographitis extract 15mL, three mixes composition.
Described root of large-flowered skullcap extract preparation method is as follows: after radix scutellariae medicinal materials 1kg cleans, pulverize, soak 1h after poach 30min obtain water cooking liquid, extract each 10 times of water yields (be medicinal material 1kg add water 10L) for continuous 3 times; Merge the water cooking liquid extracting for 3 times, rotary evaporation is concentrated, collects supernatant, after filtration sterilization, and the aseptic solid content 0.5g/mL that is concentrated into.
Described Herba Andrographitis extract preparation method is as follows: after Herba Andrographitis medicinal material 1kg cleans, pulverize, soak 1h after poach 30min obtain water cooking liquid, extract each 10 times of water yields (be medicinal material 1kg add water 10L) for continuous 3 times; Merge the water cooking liquid extracting for 3 times, rotary evaporation is concentrated, collects supernatant, after filtration sterilization, and the aseptic solid content 0.5g/mL that is concentrated into.
Embodiment 5:
Prevent and treat a water formulation for gingival atrophy, the proportioning of each component is as follows:
Dilantin sodium 0.1g/L, root of large-flowered skullcap extract 0.01vol%, Herba Andrographitis extract 0.01vol%, water surplus.
Described root of large-flowered skullcap extract preparation method is as follows: after radix scutellariae medicinal materials 1kg cleans, pulverize, soak 1h after poach 30min obtain water cooking liquid, extract each 10 times of water yields (be medicinal material 1kg add water 10L) for continuous 3 times; Merge the water cooking liquid extracting for 3 times, rotary evaporation is concentrated, collects supernatant, after filtration sterilization, and the aseptic solid content 0.5g/mL that is concentrated into.
Described Herba Andrographitis extract preparation method is as follows: after Herba Andrographitis medicinal material 1kg cleans, pulverize, soak 1h after poach 30min obtain water cooking liquid, extract each 10 times of water yields (be medicinal material 1kg add water 10L) for continuous 3 times; Merge the water cooking liquid extracting for 3 times, rotary evaporation is concentrated, collects supernatant, after filtration sterilization, and the aseptic solid content 0.5g/mL that is concentrated into.
Embodiment 6:
Prevent and treat a water formulation for gingival atrophy, the proportioning of each component is as follows:
Dilantin sodium 10g/L, root of large-flowered skullcap extract 5vol%, Herba Andrographitis extract 5vol%, water surplus.
Described root of large-flowered skullcap extract preparation method is as follows: after radix scutellariae medicinal materials 1kg cleans, pulverize, soak 1h after poach 30min obtain water cooking liquid, extract each 10 times of water yields (be medicinal material 1kg add water 10L) for continuous 3 times; Merge the water cooking liquid extracting for 3 times, rotary evaporation is concentrated, collects supernatant, after filtration sterilization, and the aseptic solid content 0.5g/mL that is concentrated into.
Described Herba Andrographitis extract preparation method is as follows: after Herba Andrographitis medicinal material 1kg cleans, pulverize, soak 1h after poach 30min obtain water cooking liquid, extract each 10 times of water yields (be medicinal material 1kg add water 10L) for continuous 3 times; Merge the water cooking liquid extracting for 3 times, rotary evaporation is concentrated, collects supernatant, after filtration sterilization, and the aseptic solid content 0.5g/mL that is concentrated into.
Embodiment 7:
Prevent and treat a water formulation for gingival atrophy, the proportioning of each component is as follows:
Dilantin sodium 1g/L, root of large-flowered skullcap extract 1vol%, Herba Andrographitis extract 1vol%, water surplus.
Described root of large-flowered skullcap extract preparation method is as follows: after radix scutellariae medicinal materials 1kg cleans, pulverize, soak 1h after poach 30min obtain water cooking liquid, extract each 10 times of water yields (be medicinal material 1kg add water 10L) for continuous 3 times; Merge the water cooking liquid extracting for 3 times, rotary evaporation is concentrated, collects supernatant, after filtration sterilization, and the aseptic solid content 0.5g/mL that is concentrated into.
Described Herba Andrographitis extract preparation method is as follows: after Herba Andrographitis medicinal material 1kg cleans, pulverize, soak 1h after poach 30min obtain water cooking liquid, extract each 10 times of water yields (be medicinal material 1kg add water 10L) for continuous 3 times; Merge the water cooking liquid extracting for 3 times, rotary evaporation is concentrated, collects supernatant, after filtration sterilization, and the aseptic solid content 0.5g/mL that is concentrated into.
Embodiment 8:
Be applied to mouthwash:
Dilantin sodium (commercially available) 1g, root of large-flowered skullcap extract 10mL, Herba Andrographitis extract 5mL, sodium chloride 8.5g puts into 1L pure water, adds after fully dissolving after 0.1g essence to obtain mouthwash.
Using method: after clear water is gargled, contain after the above-mentioned solution of a bite is gargled more than 5 seconds and spue, repeat twice, every day 1 ~ 2 time.
Embodiment 9:
Be applied to toothpaste:
Prevent and treat the preparation 1.5-3% of gingival atrophy, abrasive (calcium monohydrogen phosphate, calcium carbonate) 40-50%, NMF (polyethylene glycol) 10-30%, thickener (sodium cellulose glycolate, hydroxyethylcellulose, carragheen, xanthans, guar gum) 1-2%, essence 0.5-1.5%, blowing agent (lauryl sodium sulfate) 1.5-2.5%, sweetener (asccharin) 0.1-0.5%, water surplus.
Used every day for 1 ~ 3 time.
Animal experiment
Adult SD rats, body weight 200 ± 20g, female half and half, be divided into Normal group, model group, medication therapy groups, 10 every group. By to rat ligation bilateral maxillary first molar, high sugared high viscosity forage feed copies gingival atrophy model after 4 weeks, the group of administration is simultaneously used the said preparation aqueous solution once a day: containing root of large-flowered skullcap extract 2vol%, Herba Andrographitis extract 1vol%, dilantin sodium 0.5g/L, (after converting, dilantin sodium, root of large-flowered skullcap extract, Herba Andrographitis extract three proportioning are water surplus: dilantin sodium 1g: root of large-flowered skullcap extract 40mL: Herba Andrographitis extract 20mL). Be applied to rat affected part, control group and model group administration physiological saline. Reddening and swelling of mucosa, gingival papilla erosion, necrosis form ulcer between experimental result display model group maxillary molar gum, crest of alveolar ridge has absorption sign, and osteoclast is active; The disorder of submucous tissue fiber, has dark oral pocket to form, and gingival connective tissue has obvious inflammatory cell infiltration, and interval fiber is destroyed. Administration processed group above-mentioned symptom is not obvious, improves obviously aspect destroyed especially at absorption of alveolar bone, osteoclast and fibr tissue.
Above-described embodiment is preferably scheme of one of the present invention, not the present invention is done to any pro forma restriction, also has other variant and remodeling under the prerequisite that does not exceed the technical scheme that claim records.
Claims (8)
1. a preparation of preventing and treating gingival atrophy, is characterized in that: mixed and formed by dilantin sodium or hydroxyphenytoin, root of large-flowered skullcap extract, Herba Andrographitis extract, concrete proportioning is as follows:
Every 1g dilantin sodium or hydroxyphenytoin, join root of large-flowered skullcap extract 10-50mL, Herba Andrographitis extract 5-25mL.
2. a kind of preparation of preventing and treating gingival atrophy according to claim 1, it is characterized in that: described root of large-flowered skullcap extract preparation method is as follows: radix scutellariae medicinal materials 1kg clean after, pulverize, soak 1h after poach 30min obtain water cooking liquid, extract each 10 times of water yields for continuous 3 times; Merge the water cooking liquid extracting for 3 times, rotary evaporation is concentrated, collects supernatant, after filtration sterilization, and the aseptic 0.5g/mL that is concentrated into.
3. a kind of preparation of preventing and treating gingival atrophy according to claim 1 and 2, it is characterized in that: described Herba Andrographitis extract preparation method is as follows: Herba Andrographitis medicinal material 1kg clean after, pulverize, soak 1h after poach 30min obtain water cooking liquid, extract each 10 times of water yields for continuous 3 times; Merge the water cooking liquid extracting for 3 times, rotary evaporation is concentrated, collects supernatant, after filtration sterilization, and the aseptic 0.5g/mL that is concentrated into.
4. a kind of formulation application of preventing and treating gingival atrophy as claimed in claim 1 is in mouthwash.
5. a kind of formulation application of preventing and treating gingival atrophy as claimed in claim 1 is in toothpaste.
6. a water formulation of preventing and treating gingival atrophy, is characterized in that, the proportioning of each component is as follows:
Dilantin sodium or hydroxyphenytoin 0.1-10g/L, root of large-flowered skullcap extract 0.01-5vol%, Herba Andrographitis extract 0.01-5vol%, water surplus.
7. a kind of preparation of preventing and treating gingival atrophy according to claim 6, it is characterized in that: described root of large-flowered skullcap extract preparation method is as follows: radix scutellariae medicinal materials 1kg clean after, pulverize, soak 1h after poach 30min obtain water cooking liquid, extract each 10 times of water yields for continuous 3 times; Merge the water cooking liquid extracting for 3 times, rotary evaporation is concentrated, collects supernatant, after filtration sterilization, and the aseptic 0.5g/mL that is concentrated into.
8. a kind of preparation of preventing and treating gingival atrophy according to claim 6, it is characterized in that: described Herba Andrographitis extract preparation method is as follows: Herba Andrographitis medicinal material 1kg clean after, pulverize, soak 1h after poach 30min obtain water cooking liquid, extract each 10 times of water yields for continuous 3 times; Merge the water cooking liquid extracting for 3 times, rotary evaporation is concentrated, collects supernatant, after filtration sterilization, and the aseptic 0.5g/mL that is concentrated into.
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| CN201510597035.2A CN105582052A (en) | 2015-09-18 | 2015-09-18 | Preparation for preventing and treating gingival atrophy |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108066412A (en) * | 2018-01-29 | 2018-05-25 | 浙江华润三九众益制药有限公司 | A kind of preparation for preventing gingival recession and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101156849A (en) * | 2007-09-20 | 2008-04-09 | 山东大学 | An alepsin slow-releasing gel for promoting paradontal part reborn as well as preparation method and application |
| CN101249236A (en) * | 2008-03-17 | 2008-08-27 | 石华 | Chinese and western medicinalcombine preparations for curing epileptic |
-
2015
- 2015-09-18 CN CN201510597035.2A patent/CN105582052A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101156849A (en) * | 2007-09-20 | 2008-04-09 | 山东大学 | An alepsin slow-releasing gel for promoting paradontal part reborn as well as preparation method and application |
| CN101249236A (en) * | 2008-03-17 | 2008-08-27 | 石华 | Chinese and western medicinalcombine preparations for curing epileptic |
Non-Patent Citations (1)
| Title |
|---|
| 徐立等: "复方甲硝哒唑糊剂治疗牙周病的临床疗效观察", 《厂矿医药卫生》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108066412A (en) * | 2018-01-29 | 2018-05-25 | 浙江华润三九众益制药有限公司 | A kind of preparation for preventing gingival recession and preparation method thereof |
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Application publication date: 20160518 |