CN101249236A - Chinese and western medicinalcombine preparations for curing epileptic - Google Patents
Chinese and western medicinalcombine preparations for curing epileptic Download PDFInfo
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Abstract
The invention relates to a Chinese and Western medicine composite preparation for curing falling sickness. The preparation is composed of the Chinese medicine calculated according to the mass ratio as follows: 14 to 18 parts of rhizome of Chinese nardostachys, 0.4 to 0.6 parts of pepper, 11 to 13 parts of rhizoma valerianae latifoliae, 18 to 22 parts of red sage root, 14 to 18 parts of burred tuber, 14 to 18 parts of zedoary, 4.8 to 5.4 parts of kaladana, 14 to 16 parts of dried body of scorpion, 15 to 16 parts of medicinal leech, 4 to 6 parts of batryticated silkworm and 0.4 to 0.6 parts of drimy; normal formulations of troches or capsules or granules or oral solution are produced according to the normal formulation producing method; the preparation is tested through the efficacy test and the clinical test; during the treatment for the patient with falling sickness, the Chinese and Western medicine composite preparation which combines Chinese medicine which has the functions of supplementing qi, activating blood circulation, and tranquilizing and allaying excitement with the Western medicine of drimy has obvious curative effects, good curative effect is achieved with the effective percentage as 80 percent, the Chinese and Western medicine is easy to be obtained and is popular with patients, the reliable curative effect is verified, and the preparation is worthy of popularization and application.
Description
Technical field
The present invention relates to a kind of pharmaceutical preparation for the treatment of epileptics, be specifically related to a kind of Chinese and western medical of epilepsy for the treatment of in conjunction with preparation.
Background technology
Epileptics is a refractory disease, also is a kind of commonly encountered diseases.According to world medicine tissue statistics, the sickness rate of epileptics is 1%; Prevalence is 4%; If the prevalence statistics by epileptics in about 1,400,000,000 populations of China, has epileptic 5,600,000 approximately.To the treatment of epileptics, the past is exhausted most by the control of seizures of taking medicine for a long time, or alleviates the outbreak symptom; Few partly epileptic needs the treatment that undergos surgery in hospital.
The classification of epileptics:, be divided into the sick and secondary epilepsy disease of essential epilepsy according to the pathogenic factor of epileptics; According to treatment difficulty, be divided into again and only control the sick and general epileptics of epilepsy insane pain.
A large amount of research datas prove, though cause that psychomotor reason is varied.But induced seizures all is because the irritability of axoneure is too high, thereby takes place widely, the result of synchronicity high-frequency discharge.According to the achievement in research in past, think to various epilepsy it all is identical, therefore, the corresponding treatment measure is the utilization tranquilizer, suppresses the rapid diffusion of the exaltation and the inhibition high-frequency discharge of axoneure, outbreak has positive effect to Taking Control of Epilepsy for this.
Disease-resistant medicine commonly used now all is to belong to tranquilizer.The inhibitory action that zona rolandica is had high selectivity as phenytoin Sodium; Sodium valproate can suppress the propagation of axoneure high-frequency discharge; Clonazepam has inhibitory action to the paradoxical discharge of axoneure, and is more obvious to the effect that suppresses high-frequency discharge especially.
But according to long-term clinical application statistics, the patient shows toxicity in various degree in taking medicine for a long time, as drowsy, hypomnesis, distractibility.Bradykinesia, mood change even cause thought disturbance are as melancholy, personality metamorphosis etc.Document announcement is taken among the patient of clonazepam for a long time according to statistics, has 60% patient toxicity to occur approximately, and more common toxicity is drowsiness, dizzy, excited, emotional etc.; Long-term clothes phenytoin Sodium can make gingival hyperplasia, and the mutual aid husband transfers even causes cerebellar lesion; The maternity dress phenytoin Sodium has found to cause this abnormal effect, and what the deformity performance was more is that lip appears exempting from the baby; Topic can appear having a liking in long-term clothes desoxyphenobarbital (claim primidone again, formed by the phenobarbital deoxidation).Dizzy, diplopia even megaloblastic anemia etc. occurs.
More than the sick medicine commonly used of cited epilepsy; though effectively, inevitably serious toxicity appears again simultaneously, in the misery that the patient is in can't adhere to taking medicine; the doctor is unable again to leave better good recipe, makes that doctor and patient go out simultaneously, serious doctors and patients' crisis.Say as " Records of the Historian Bian Que biographies ": people's trouble, it is many to take a disease, doctor's trouble, the trouble road is few.The medical treatment reality to epileptics of above-mentioned objective reality has been reacted 2 deficiencies, promptly passes by epileptics is gone back imperfection because of the research of each side; Reflect merely and exist major defect with depressor of nerve centre treatment epileptics.
The inventor studies from the Chinese medicine theoretical side the outbreak of epileptics, and the traditional Chinese medical science takes much count of the effect of QI and blood.Errors in Medicine Corrected is said: " deficiency of vital energy can cause blood stasis, and blood stasis due to qi deficiency can cause convulsion ".In the treatment to insane pain patient, the inventor often obtains good therapeutic effect with benefiting QI for activating blood circulation, medicines for relieving muscular spasm and tranquilizing the mind.In the practice of epileptic's treatment,, the importance of drug for invigorating blood circulation and eliminating stasis in prescription is described from some patients' therapeutic effect.The inventor succeeds in developing a kind of pure Chinese medicinal preparation that can the general epilepsy of treatment from Chinese medicine 1985 in Yunnan, a kind of oral glucose garment piece-epileptics is peaceful, produces at the utilization Chinese medicine and has strided forward major step aspect the disease.In Chinese patent literature, also there is the patent application of some treatment epilepsies to occur: to be (200610017446.0) as application number, the application that name is called " capsule and the preparation method of treatment epileptics " occurs, also having application number is (96119429.4), name is called " Zhiyuling-medicine for curing epilepsia ", application number is (01109327.7), the patent application that name is called the Chinese medicine preparation of " epilepsy treating medicine powder " occurs, and some Western medicine applications are also arranged but does not have same preparation to occur.
The achievement of inventor from having obtained, target are to grind to control the intractable epilepsy novel formulation of a kind of energy treatment.Introduce the nature and flavor of having obtained the Chinese medicine and western medicine that uses in the successful bonded preparation of Chinese medicine and western medicine of research below and cure mainly the function situation, unreceipted title, release's is the page number of Pharmacopoeia of the People's Republic of China nineteen ninety version book in the introduction.
(Nardostachys Chinensis Batal. or spoon Ye Gansong (N.jatamansi DC.) are the dry rhizome or the root of Valerianaceae plant Radix Et Rhizoma Nardostachyos to Radix Et Rhizoma Nardostachyos.Spring, two seasons of autumn excavate, and remove silt and dry usefulness.Function cures mainly: regulating QI to relieve pain, relieving stagnation and activating the spleen.Treat for stomachache, be used for distension and fullness of the chest and abdomen, inappetence, vomiting; Toothache, swelling of the feet are controlled in external.P70。Piperaceae plant Fructus Piperis almost ripe fruit or the mature fruit of Fructus Piperis (Piper nigrum L.).Autumn Mo gathers when time the spring, fruit was dirty-green, dries, and is black pepper, gathers when fruit reddens and uses the water retting a few days, wipes sarcocarp and dries and be Radix orixae japonicae.Character: black pepper is spherical in shape, surperficial pitchy.Matter is hard, gas fragrance, and acrid in the mouth is peppery.Radix orixae japonicae surface canescence or yellowish white are level and smooth.Function cures mainly: warming middle-JIAO, and cold expelling, therapeutic method to keep the adverse QI flowing downwards expectorant is used for gastrofrigid vomiting, controls the stomachache dysentery, epilepsy.P633.。Rhizoma valerianae latifoliae (Valerianajatamansi) is the dry root rhizome of Valerianaceae plant Rhizoma valerianae latifoliae.Nature and flavor: hot, warm.Function cures mainly: regulating QI to relieve pain, expelling wind and removing dampness is used for abdominal distention, dyspepsia, diarrhoea.Rheumatic arthralgia.77 years versions, P633..Radix Salviae Miltiorrhizae (Salvia miltiorrhiz) is the dry root rhizome of labiate Radix Salviae Miltiorrhizae.Nature and flavor: bitter, tepor.Function cures mainly: can blood circulation promoting and blood stasis dispelling, dredge the meridian passage, relieving restlessness, Raising heart and tranquilizing mind clears away heart-fire.Be used for dysphoria and insomnia, hepatosplenomegaly ， lumps in the chest and abdomen.Should not use together with Herba chenopodii Lu.P62。Rhizoma sparganic (Spmpanium stolonlferumBuch.Ham.) is the dry tuber of Sparganiaceae plant rhizoma scirpi.Function cures mainly: removing blood stasis repercussive, removing food stagnancy pain relieving.Control blood stasis amenorrhea ， mass in the abdomen mass in the abdomen, breast abdomen pain.P8。Rhizoma Curcumae is the zingiberaceous plant Rhizoma Curcumae, Guangxi zedoary, and Wen Curcuma Shu claims RADIX CURCUMAE again, medicinal is dry rhizome, section, living using or vinegar stir-fry usefulness.Function cures mainly: circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.Cure mainly blood stasis amenorrhea ， lumps in the chest and abdomen, stagnation of QI due to dyspepsia, food stagnation distension.P250。Semen Pharbitidis (Pharbitis hederacea cholsy) splits for convolvulaceous plant leads a cow or the dry mature seed of Pharbitis purpurea etc.Nature and flavor: bitter, cold.Poisonous.Function cures mainly: relieving constipation by purgation, the detumescence of relieving oedema or abdominal distension through diuresis or purgation, parasite killing pain relieving.Cure mainly edema abdominal distention, parasite killing parasite removing, abdominal pain due to worm stagnation.Act on strong to killing of ascarid and cestode.P220。Scorpio (Buthus martensl karsch) this product is the dry body of Buthidae animal Scorpio.Function cures mainly: the endogenous wind stopping relieving convulsion.Be used for infantile convulsion, epilepsy clonus.P85。Hirudo (Whitmania pigrawhitman) different name Zhi Nao, the ant trematodiasis, Hirudoes etc. are Hirudinidae animal ant trematodiasis, the dry body of Hirudo is used as medicine.Function cures mainly: blood circulation promoting and blood stasis dispelling, dredge the meridian passage cures mainly the blood stasis amenorrhea, traumatic injury.P67。Bombyx Batryticatus (Bambyxmorl Llnnaeus) different name, Bombyx Batryticatus, flying worm, Bombyx Batryticatus.Former animal is a Bombycis mori.The larva of Bombycidae insecticide bombyx mori infects muscardine and dead dry polypide.Function cures mainly, endogenous wind stopping relieving convulsion, dissipating phlegm and resolving masses.Control apoplectic aphasia, frightened Epilepsy, wind syndrome of head, acute throat trouble. sucutaneous nodule scrofula, rubella pruritus.P445。Phenobarbital (phenobarbital) (Phenobarbitalum) (Luminal) is used always in traditional epileptics treatment for the Western medicine of calm function is arranged.
Summary of the invention
The objective of the invention is the achievement of inventor,, solve the sick medicine commonly used of above cited epilepsy, though effectively, occur inevitably serious toxicity simultaneously again intractable epilepsy from having obtained.Reflect merely to exist major defect, in long-term traditional medical practice,, take much count of the effect " deficiency of vital energy can cause blood stasis, and blood stasis due to qi deficiency can cause convulsion " of QI and blood the outbreak of epileptics according to the inventor with depressor of nerve centre treatment epileptics.Targetedly in treatment to insane pain patient, use benefiting QI for activating blood circulation, tranquillizing the mind by relieving convulsion Chinese crude drug, often obtain good therapeutic effect, through research for many years, comparative study to various prescriptions is achieved success, determine the intractable epilepsy novel formulation of this energy treatment, be the bonded preparation of Chinese medicine and western medicine.
A kind of Chinese and western medical of epilepsy for the treatment of is in conjunction with preparation, the mass ratio of its formulation of drug is: Radix Et Rhizoma Nardostachyos 14～18, Fructus Piperis 0.4～0.6, Rhizoma valerianae latifoliae 11～13, Radix Salviae Miltiorrhizae 18～22, rhizoma sparganic 14～18, Rhizoma Curcumae 14～18, Semen Pharbitidis 4.8～5.4, Scorpio 14～16, Hirudo 15～16, Bombyx Batryticatus 4～6, phenobarbital 0.4～0.6; According to above-mentioned prescription, according to the conventional dose production method, produce tablet, or capsule, or granule, or conventional formulation such as oral administration solution.
A kind of Chinese and western medical for the treatment of epilepsy is in conjunction with preparation, and the mass ratio of its formulation of drug is: Radix Et Rhizoma Nardostachyos 16, Fructus Piperis 0.5, Rhizoma valerianae latifoliae 12, Radix Salviae Miltiorrhizae 20, rhizoma sparganic 16, Rhizoma Curcumae 16, Semen Pharbitidis 5.2, Scorpio 15, Hirudo 15, Bombyx Batryticatus 5, phenobarbital 0.5.
Beneficial effect of the present invention, in treatment to insane pain patient, use benefiting QI for activating blood circulation, tranquillizing the mind by relieving convulsion Chinese crude drug, the Chinese-western medicine preparation that the combined with westem phenobarbital obtains in practice, evident in efficacy, obtain good therapeutic effect, effective percentage reaches 80%, the Chinese medicine and western medicine that uses is easy to get, and is subjected to very much patient's welcome.
Below introduce the using method of this preparation:
By fill a prescription 100 of " preparation " every bottles of making of the present invention, every 300mg, every includes phenobarbital 4.5～5.5mg.
Instructions about how to take medicine: 1～5 for oral administration at every turn: child below 10 years old obeys 05～2, day clothes 2 times at every turn; 2～3 of juvenile each clothes below 17 years old; Adult more than 18 years old obeys 5 at every turn, day clothes secondary.
Use and note: must not arbitrarily subtract medicine in the drug administration process, more arbitrarily drug withdrawal must be taken medicine under physician guidance, otherwise easily affect the treatment, the extended treatment time.
The specific embodiment
Embodiment 1: according to the quality proportioning of formulation of drug: Radix Et Rhizoma Nardostachyos 16, Fructus Piperis 0.5, Rhizoma valerianae latifoliae 12, Radix Salviae Miltiorrhizae 20, rhizoma sparganic 16, Rhizoma Curcumae 16, Semen Pharbitidis 5.2, Scorpio 15, Hirudo 15, Bombyx Batryticatus 5, phenobarbital 0.5, preparation is a unit with kg, simultaneously the conventional production process of tablet is carried out production and processing, can produce the oral glucose garment piece about 1000 boxes according to the pharmaceutical factory.
Embodiment 2: according to formulation of drug quality proportioning: Radix Et Rhizoma Nardostachyos 14, Fructus Piperis 0.4, Rhizoma valerianae latifoliae 13, Radix Salviae Miltiorrhizae 22, rhizoma sparganic 14, Rhizoma Curcumae 14, Semen Pharbitidis 5.4, Scorpio 15, Hirudo 15, Bombyx Batryticatus 4, phenobarbital 0.4, preparation is a unit with kg, simultaneously the conventional production process of tablet is carried out production and processing, can produce 1000 box left and right sides capsule preparations according to the pharmaceutical factory.
Embodiment 3: according to formulation of drug quality proportioning: Radix Et Rhizoma Nardostachyos 18, Fructus Piperis 0.4, Rhizoma valerianae latifoliae 13, Radix Salviae Miltiorrhizae 19, rhizoma sparganic 17, Rhizoma Curcumae 17, Semen Pharbitidis 4.8, Scorpio 14, Hirudo 16, Bombyx Batryticatus 6, phenobarbital 0.5, preparation is a unit with kg, simultaneously the conventional production process of tablet is carried out production and processing, can produce 1000 box left and right sides capsule preparations according to the pharmaceutical factory.
Embodiment 4: according to formulation of drug quality proportioning: Radix Et Rhizoma Nardostachyos 15, Fructus Piperis 0.6, Rhizoma valerianae latifoliae 11, Radix Salviae Miltiorrhizae 18, rhizoma sparganic 18, Rhizoma Curcumae 18, Semen Pharbitidis 5.2, Scorpio 16, Hirudo 14, Bombyx Batryticatus 5, phenobarbital 0.5, preparation is a unit with kg, simultaneously the conventional production process of tablet is carried out production and processing, can produce 1000 box left and right sides sugar coated tablets according to the pharmaceutical factory.
Instructions about how to take medicine: 0.5～5 of each oral dosage; 0.5～2 of the each clothes of child below 10 years old, day clothes 2 times; 2～3 of juvenile each clothes below 17 years old, day clothes 2 times; The each clothes of adult are 5 more than 18 years old, day clothes 2 times.
Below for the curative effect introduction of the Chinese and western medical of treatment epilepsy of the present invention in conjunction with preparation:
Through the medical record statistics, for many years, use " preparation " of the present invention to treat domestic and international epileptic 5400 people, totally 25000 person-times altogether.Effective percentage reaches 80%, cures 1080 people altogether.The standard of Zhi Yuing is not shown effect more than 3 years after being meant drug withdrawal at interval fully.Healing person is all by detecting EEG (electroencephalogram), CT (mRI), TCD (through the cranium Doppler scanning), all normal person of conclusion.
The inventor once to the epileptic that (comprising area, Kunming and each special county), 100 examples were thoroughly cured of Yunnan Province, visited by phone for a long time, not outbreak the longest existing 18 years of blanking time after the drug withdrawal; Blanking time is the shortest, does not reaccess in existing 12 years, and any toxicity appears in none example.
The inventor has finished " preparation technology and research ", " chemical constituent and pharmacological research of main Chinese medicine in the preparation ", " curing mainly relevant Pharmacodynamic test of active extract ", " animal acute toxicity test ", " research of epilepsy case history " with effect, " preliminary clinical research (test or demonstration) ".
Below be individual case: old XX, woman, 25 years old, accounting, JIUYUE in 1998 first visit on the 5th.Unit address: Yuxi, Yunnan.Main suit: the large and small outbreak of epilepsy 10 years.Medical history: show effect in April, 1988 for the first time, and symptom was lighter at that time, giddy only occurs, dark and dim eyesight, and the shake of two handss, but understand in the heart, do not faint, continue about 1 minute.Just obey carbamazepine, can control of seizures.But after in February, 1989, though still adhere to obeying carbamazepine, can not control of seizures.After change clothes phenytoin Sodium, sodium valproate, stable, phenobarbital etc., grand mal still will appear 3-4 time every year, stupor, tic of the limbs occur, spit out white foams, lasting 1-2 minute at every turn.Absence petit mal appears once in a while.
Previously do not have the head trauma history, do not have similar family medical history.Second tire, natural labor.Suffered from scarlet fever in the time of five years old.Hospital's functional compartments check result:
EEG: moderate unusual (in August, 1998), CT: no abnormality seen (in JIUYUE, 1998), blood vessel doppler ultrasound: (in October, 1998).1, the carotid canal wall construction is normal.2. carotid artery flow kinetics changes prompting: antiotasis obviously increases, and compliance reduces, the vasospasm performance.
Diagnosis: the sick large and small outbreak of essential epilepsy.
The treatment process: clothes the present invention's " preparation " (is named: the Radix Et Rhizoma Nardostachyos antiepilepsirine), obey 5, day clothes 3 times certainly at every turn.(withdrawing whole Western medicine that former clothes are crossed), further consultation on October 11 in 2000: take medicine certainly so far, do not reaccess in 2 years at interval.Once arrived the inspection of hospital's functional compartments.Result: EEG (on October 5th, 2000): normal range.Blood vessel doppler ultrasound: (on November 12nd, 2000).(1) neck, vertebral artery tube wall, pipe lung structure are normal.(2). neck, vertebral artery hemodynamics have not had the performance of blood vessel spasm.Advise it to continue decrement clothes Radix Et Rhizoma Nardostachyos antiepilepsirine.
Calendar year 2001 December its parent phase on the 10th is accused, and does not reaccess 3 year at interval more, withdraws Radix Et Rhizoma Nardostachyos antiepilepsirine eight wheat harvesting periods automatically, uncomfortable reaction do not occur.After long-term phone is visited, nine and half do not reaccess at interval.
Experimental data proves that it is to cause the important of insane pain discharge and inevitable factor that the cerebral tissue blood circulation changes.Because the cerebral blood circulation disorder reduces the oxidation of brain cell and the supply of glucose, metabolite is accumulated, and can cause insane pain outbreak; The ischemia of the corpus amygdaloideum that cerebral edema and cerebral hernia cause---hippocampus and sclerosis can form the sick focus of Chronic Epilepsy.
A plurality of patients' inspection statistical data shows cerebral vasospasm.Blood flow rate changes, cerebral tissue blood supply insufficiency proportion, and is approaching with the ratio that electroencephalogram is unusual.So both are both the common pathologic basis of epilepsy.Based on studying for a long period of time, epilepsy definition in the former medical literature is complemented at down: as the theoretical foundation of medical diagnosis on disease, therapeutic process.
The complementary definition of epilepsy: main reason outside intracranial or cranium, cause cerebrovascular change in organization, blood flow rate is unusual, the cerebral tissue blood supply insufficiency, cause sexual centre neurocyte exaltation, popularity, synchronicity high-frequency discharge take place, and sensation, the symptom of behavior, consciousness or disturbance of consciousness occur.Clinical symptoms is the mechanical property that is ictal, short-time characteristic, symptom.
The prescription of " preparation " of the present invention is formed, and comprises two parts: promoting blood circulation to remove obstruction in the collateral medicine and medicinal for tranquilizing mind.It is reliable that said preparation has curative effect, do not have any toxicity again, but can be from the conclusion this is to certify that of following two laboratory reports.
(1) main pharmacodynamics of " preparation " experiment: conclusion shows, " preparation " has obvious antagonism to electrofit, the anti-frightened rate of basic, normal, high dosage is respectively 20%, 55%, 100%, can prolong drug cause the latent time and the death time of mice convulsion, and can make 60% convulsions Mus avoid death.
Laboratory report two: the long term toxicity test result of " preparation " shows:
1, irritated " preparation " of stomach various dose in continuous 90 days, to feed, drinking-water, the activity of experimental rat, produced harmful effect (T check) by Mao Junwei.
2, hematological indices is observed: compare no difference of science of statistics (T check) between RWC, BWC, Hb, reticulocyte count, each dosage group of leukocyte differential count and with the blank group.
3. the Radix Et Rhizoma Nardostachyos antiepilepsirine Rats Organs and Tissues coefficient value mensuration of irritating the stomach various dose in continuous 90 days shows that poisoning symptom does not appear in this medicine, and the result of histopathologic examination also shows liver, kidney, the heart, spleen, lung main organs free of toxic effects.
Epileptics is a chronic disease, and treatment is longer medicine time, and is higher to the standard-required of medicine for treatment, both required curative effect to get well, and any toxicity of unlikely again generation is fit to take for a long time, and drug price is also moderate, and the most epilepsy patient can both be born,
These are basic goals of our upright topic development novel formulation, and above-mentioned experimental result shows that its prescription combination has reached the purpose requirement substantially.
Clinical case is to the explanation of not invention curative effect:
For many years, cure various types of epileptics totally 1080 people altogether.Now select two routine intractable epileptics' of acquisition healing treatment process to be set forth in down again:
Case 1:
Old XX man, 26 years old, Kunming county cadre of the trade union.The first visit time: on December 13rd, 1993.Main suit: suffer from intermittent the tic 2 years.
Medical history: readme nineteen ninety was once eaten twice the live pig sliced meat when going to the countryside work in the Baoshan Prefecture, Yunnan.The epileptics grand mal appearred for the first time on July 16th, 1991.The same year, JIUYUE 18 days was done head CT to Kunming hospital functional compartments: brain abscess.Through hospital's neurosurgery treatment.The postoperative pathological replacement is " brain abscess " due to the cerebral cysticercosis.
Perioperatively occurs intermittent stupor always, twitches.Each outbreak continues about 2 minutes, is mainly in daytime, and show effect 1～2 average every day.Obeyed carbamazepine once and natrium valericum, phenytoin Sodium, XIBILING JIAONANG etc., all can not control of seizures.Spirit is normal, still adheres at working unit.Blood pressure: 130/80mmHg
Hospital's functional compartments is checked: 1, EEG (1991,9): light-moderate is unusual.2, CT (1992,8,10) hospital scanning consultation of doctors report: head enhanced ct scans.The right parietal lobe sheet closes the about 4 * 2.5cm of low-density kitchen range
2, do not see the enhancing kitchen range in it.3TCD (transcranial doppler scanning): right side anterior cerebral artery blood flow rate slows down, blood supply insufficiency; Left side brain vertebral artery blood flow rate is accelerated arteriospasm (1992.12.8).
Diagnosis: right parietal lobe small pieces cerebral malacia kitchen range, do not see the abscess recurrence.The secondary epilepsy grand mal.
The treatment process: December came my clinic out-patient treatment on the 13rd in 1993, changed the following medicine of clothes:
(1), 10 bottles of 5#Tid of the present invention " preparation "
(2), the carbamazepine of the former clothes clothes that reduce by half.
Nineteen ninety-five further consultation on April 18: still have outbreak, but prolong blanking time.
In 1 year after taking medicine, show effect altogether 5 times, outbreak in average two months once continues clothes " preparation ".(1), these " preparation " 30 bottles of 5#Tid.
Nineteen ninety-five 10 is used further consultation: reaccess eight the end of month at interval.Continue clothes " preparation ".(1), " preparation " 20 bottles of 5#Bid.
Further consultation in August, 1997: two-and-a-half years do not show effect at interval.Arrive hospital's functional compartments check once more: result: EEG: normal.CT: no abnormality seen.TCD: see the slight blood supply insufficiency of right side top.Advise its progressively decrement continuation clothes this " preparation ".
Case 2:
Woods * * man, 10 years old, the student.The first visit time: on February 8th, 1997.Home address: Dali.
Main suit: suffered from the big petit mal of epilepsy 3 years.Medical history: occur ictal stupor in January, 1994 for the first time, whole body is twitched.Spit out white foams, urinary incontinence, 3 minutes of asking when lasting.April in the same year, May successively show effect 2 times again, and symptom is similar when showing effect to the first time.Once arrived certain hospital neruosurgery diagnosis and treatment, tentative diagnosis is an epilepsy grand mal.After hospital's functional compartments is done following inspection, the result:
EEG (in May, 1994): children's's abnormal electroencephalogram (central authorities' forehead pillow sees that single high-amplitude sharp wave, spike are to show with the right side).Brain mapping (in May, 1994): unusual (the brain electrical activity mapping change meets clinical " epilepsy, " diagnosis).CT (in June, 1994): no abnormality seen.TCD (in June, 1994): left and right side posterior cerebral artery, right side anterior cerebral artery vasospasm.
Once obeyed sodium valproate, can prolong the blanking time of showing effect, annual big outbreak 1～2 time.Absence petit mal appears once in a while.
Be first tire, stages of labor is long, once uses the obstetric forceps practise midwifery, and head is not seen hematoma.(1989) are once because of hyperpyrexia convulsion (tonsillitis) in the time of two years old.Head when one-year-old (right side) is got injured by a fall, and a lump occurs, not stupor.Intelligence is medium.The houselessness same clan is like sick
Diagnosis: the large and small outbreak of secondary epilepsy.
Treatment process: clothes this " preparation ", obey 3, day clothes 3 times, third the eleventh of the twelve Earthly Branches acid sodium of the former clothes clothes that reduce by half at every turn.Further consultation on November 10 in 1997: behind the clothes this " preparation ", grand mal does not appear again certainly, but still have inattentive, nod, the petit mal of frequently blinking.Continue this " preparation ", obey 3 at every turn, day clothes 3 times, and advise it below hospital's functional compartments is done, to check: 1, EEG (on August 10th, 2000): no abnormality seen.CT: no abnormality seen.2, TCD (on August 15th, 2000): former vasospasm still exists, but compares with checking report in February, 1997, obviously alleviates.Further consultation in May in 2001 month: not outbreak in 2 years 03 months at interval.Intelligence development is medium.Arrive other hospitals again and do following the inspection.1, EEG (May 24 calendar year 2001): left and right side posterior cerebral artery, right side anterior cerebral artery do not have the performance of blood vessel spasm.2002, according to its father's introduction, withdrew this " preparation " nearly five months, do not see uncomfortable reaction.
Claims (2)
1, a kind of Chinese and western medical of epilepsy for the treatment of is in conjunction with preparation, the mass ratio that it is characterized in that formulation of drug is: Radix Et Rhizoma Nardostachyos 14～18, Fructus Piperis 0.4～0.6, Rhizoma valerianae latifoliae 11～13, Radix Salviae Miltiorrhizae 18～22, rhizoma sparganic 14～18, Rhizoma Curcumae 14～18, Semen Pharbitidis 4.8～5.4, Scorpio 14～16, Hirudo 15～16, Bombyx Batryticatus 4～6, phenobarbital 0.4～0.6; According to above-mentioned prescription, according to the conventional dose production method, produce tablet, or capsule, or granule, or the oral administration solution conventional formulation.
2, a kind of Chinese and western medical for the treatment of epilepsy according to claim 1 is characterized in that the mass ratio of formulation of drug is: Radix Et Rhizoma Nardostachyos 16, Fructus Piperis 0.5, Rhizoma valerianae latifoliae 12 in conjunction with preparation, Radix Salviae Miltiorrhizae 20, rhizoma sparganic 16, Rhizoma Curcumae 16, Semen Pharbitidis 5.2, Scorpio 15, Hirudo 15, Bombyx Batryticatus 5, phenobarbital 0.5.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008100686631A CN101249236B (en) | 2008-03-17 | 2008-03-17 | Chinese and western medicine combined preparations for curing epileptic |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008100686631A CN101249236B (en) | 2008-03-17 | 2008-03-17 | Chinese and western medicine combined preparations for curing epileptic |
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| CN101249236A true CN101249236A (en) | 2008-08-27 |
| CN101249236B CN101249236B (en) | 2010-07-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008100686631A Expired - Fee Related CN101249236B (en) | 2008-03-17 | 2008-03-17 | Chinese and western medicine combined preparations for curing epileptic |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579989A (en) * | 2012-03-13 | 2012-07-18 | 山东仁和堂药业有限公司 | Flunarizine hydrochloride and preparation process thereof |
| CN105582052A (en) * | 2015-09-18 | 2016-05-18 | 丽水学院 | Preparation for preventing and treating gingival atrophy |
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2008
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579989A (en) * | 2012-03-13 | 2012-07-18 | 山东仁和堂药业有限公司 | Flunarizine hydrochloride and preparation process thereof |
| CN105582052A (en) * | 2015-09-18 | 2016-05-18 | 丽水学院 | Preparation for preventing and treating gingival atrophy |
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| Publication number | Publication date |
|---|---|
| CN101249236B (en) | 2010-07-07 |
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