CN105560696A - 一种用于治疗脂肪肝的药物 - Google Patents
一种用于治疗脂肪肝的药物 Download PDFInfo
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Abstract
本发明涉及一种用于治疗脂肪肝的药物，它是由以下重量配比的原料药材制备而成：分心木9份、腐婢根12份、老虎耳10份、合萌15份、发痧藤6份、王瓜子9份、无漏子15份、岩谷伞6份、七爪风9份。本发明运用：分心木，健脾益气，补肾涩精；腐婢根，清热解毒；老虎耳，利尿消肿；合萌，清热去风，利湿消肿解毒；发痧藤，祛风解表，舒筋活血；王瓜子，清热利湿，凉血止血；无漏子，益气补虚，消食除痰，主气虚赢弱；岩谷伞，镇静安神，清心明目；七爪风，祛风除湿，活血通络。诸药合用，共奏疏肝健脾，化湿消积祛痰之功。临床实验证明，本发明能够安全有效治疗脂肪肝。
Description
技术领域
本发明涉及一种中药，具体涉及一种用于治疗脂肪肝的药物。
背景技术
由于疾病或药物等因素导致肝细胞内脂质积聚超过肝湿重的5％，称之为脂肪肝，肝内积聚的脂质依病因不同可以是三酰甘油、脂肪酸、磷脂或胆固醇酯等，其中以三酰甘油为多。根据脂肪含量，可将脂肪肝分为轻型(含脂肪5％～10％)、中型(含脂肪10％～25％)、重型(含脂肪25％～50％或>30％)三型，脂肪肝是一个常见的临床现象，而不是一个独立的疾病。
脂肪肝的临床表现与其病因，病理类型及其伴随疾病状态密切相关，临床上，根据起病缓急可将脂肪肝分为急性和慢性两大类，前者相对少见，病理上多表现为典型的小泡性肝细胞脂肪变，后者主要指由肥胖，糖尿病和酗酒等引起的大泡性肝细胞脂肪变。祖国医学无“脂肪肝”的病名，可归属于“胁痛”、“积聚”等的范畴。多数学者认为其病因与过食肥甘厚味、饮酒过度、久卧久坐、体丰痰盈、感受湿热毒邪、情志失调、久病体虚等有关。祖国医学认为，脂肪肝最常见原因为饮食不节，过食肥甘厚味，肆意饮酒，慢性刺激，过度安逸少动，形体肥胖等。这些因素极易导致肝脾受损，肝失疏泄，脾失健运。
临床表现
脂肪肝形成后，大部分表现食欲不振，恶心，呕吐，体重下降，乏力，腹胀，肝区不适或隐痛。
体格检查：可触及肿大的肝脏(一般在右肋下2-3厘米以内)，表面光滑，边缘圆钝，质地软或中等硬度，可有轻度压痛，部分病人有叩击痛，重症病人可出现肝硬化表现。
诊断上主要依靠实验室B超检查，因为查弥漫性脂肪肝的超声波图像主要表现为回声波衰减，因此按其衰减的程度，脂肪肝分为3种：
(1)轻度脂肪肝：表现为近场回声增强，远场回声衰减不明显，肝内管状结构仍可见。
(2)中度脂肪肝：前场回声增强，后场回声衰减，管状结构模糊。
(3)重度脂肪肝：近场回声显著增强，远场回声明显衰减，管状结构不清，无法辨认，超声对重度脂肪肝的灵敏度达95％。
药物治疗①祛脂保肝药物主要用于伴有肝功能损害和(或)症状明显的非酒精性脂肪性肝炎和酒精性肝病患者的辅助治疗。如胆碱、蛋氨酸、部分B族维生素。②中药治疗脂肪肝可用中医中药治疗，效果比较理想。同时应注意饮食：适宜的热量摄取，合理分配三大营养要素并兼顾其质量，适当补充维生素，矿物质及膳食纤维，戒酒和改变不良饮食习惯，调整饮食是治疗大多数慢性脂肪肝的基本方法；以及生活习惯：运动每次持续10～30min，每周3次以上，对肥胖者运动疗法比单纯节食减肥更重要，其原因为运动减肥祛除的主要是腹部内脏脂肪，常可引起三酰甘油，低密度脂蛋白(LDL)下降及高密度脂蛋白(HDL)升高，葡萄糖耐量改善以及血压下降。
本发明所涉及药材均可见记载于《中华本草》。
发明内容
本发明旨在提供一种用于治疗脂肪肝的药物，通过选择合适的药材及其配比，达到安全有效治愈脂肪肝的目的。
为了达到上述目的，本发明采用以下技术方案：
一种用于治疗脂肪肝的药物，其特征在于，它是由以下重量配比的原料药材制备而成：分心木9份、腐婢根12份、老虎耳10份、合萌15份、发痧藤6份、王瓜子9份、无漏子15份、岩谷伞6份、七爪风9份。
下面结合中药学理论说明本发明有益效果：
发明人认为，脂肪肝的基本病机为饮食不节，过食肥甘厚味，肆意饮酒，慢性刺激，过度安逸少动，形体肥胖等。这些因素极易导致肝脾受损，肝失疏泄，脾失健运。从而致痰浊内生，气滞血瘀，肝络瘀阻。故临床治疗常以疏肝健脾，化湿消积祛痰为主。水湿、痰浊、瘀血在脂肪肝的发生发展过程中起关键作用。
本发明运用：分心木，健脾益气，补肾涩精；腐婢根，清热解毒；老虎耳，利尿消肿；合萌，清热去风，利湿消肿解毒；发痧藤，祛风解表，舒筋活血；王瓜子，清热利湿，凉血止血；无漏子，益气补虚，消食除痰，主气虚赢弱；岩谷伞，镇静安神，清心明目；七爪风，祛风除湿，活血通络。诸药合用，共奏疏肝健脾，化湿消积祛痰之功。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2012年6月-2014年6月间共收集80例脂肪肝患者。随机分为：治疗组40例，对照组40例。其中治疗组男22例，女18例，年龄20～67岁，平均年龄(49.46±10.16)岁；对照组男23例，女17例，年龄19～65岁，平均年龄(49.46±10.83)岁。两组性别、年龄、病程等资料无显著性差异，具有可比性。
诊断标准
脂肪肝形成后，大部分表现食欲不振，恶心，呕吐，体重下降，乏力，腹胀，肝区不适或隐痛。
实验室检查主要表现：①BMI＝体重(kg)/身高(m)2。对于亚洲成人而言，BMI≥23kg/m2提示体重超重，BMI≥25kg/m2提示轻度肥胖，BMI≥30kg/m2提示重度肥胖。②血浆脂类TG，FA，胆固醇，磷脂常升高，其中胆固醇升高显著，常>13mmol/L；③ALT，AST：一般为轻度升高，达正常上限的2～3倍，酒精性脂肪肝的AST升高明显，AST/ALT>2有诊断意义，非酒精性脂肪肝时则ALT/AST>1，ALT>130U，提示肝小叶脂肪浸润明显，ALT持续增高提示有脂肪性肉芽肿。
B超检查主要表现为①肝区近场弥漫性点状高回声，回声强度高于脾脏和肾脏，少数表现为灶性高回声。②远场回声衰减，光点稀疏。③肝内管道结构显示不清。④肝脏轻度或中度肿大，肝前缘变钝。
纳入标准①符合诊断标准；②年龄18～70岁；③依从性好；④自愿签署知情同意书。
排除标准①肝炎病毒感染(HAV，HBV，HCV，HDV，HEV)酒精性、药物性、自身免疫性或代谢性肝病；②患有严重心、肺、肝、肾脏疾病患者；③有精神系统疾病，不能配合治疗者；④发病后经其他药物治疗的患者。
2、治疗方法
治疗组口服本发明按照具体实施例3制得的胶囊，每日3次。治疗1个月。
对照组口服氧化胆碱，每次0.6mg，3次/d，维生素B，维生素C，维生素E，2片/次，3次/日，治疗1个月。
3、疗效标准与治疗结果
3.1疗效标准
①痊愈：BMI下降大于10％，TG下降大于20％，ALT、AST正常或下降大于50％，彩超显示肝内回声明显好转，肝内血管清晰；
②有效：BMI下降范围在5％～9％，TG下降范围在10％～19％，ALT、AST下降范围在20％～49％，彩超显示肝内回声有好转，肝内血管模糊；
③无效：BMI下降小于4％，TG下降小于9％，ALT、AST下降小于19％，彩超显示肝内回声无改变，肝内血管模糊。
3.2治疗统计结果见表1。
表1两组疗效比较
可见，本发明制得的药物能够安全有效治疗脂肪肝，治愈率高。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
实施例1
称取：分心木9克、腐婢根12克、老虎耳10克、合萌15克、发痧藤6克、王瓜子9克、无漏子15克、岩谷伞6克、七爪风9克；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩至120克，即得符合正常成人一天用量的煎剂。
用于治疗脂肪肝。口服，每日服用一次。
实施例2
称取：分心木9克、腐婢根12克、老虎耳10克、合萌15克、发痧藤6克、王瓜子9克、无漏子15克、岩谷伞6克、七爪风9克；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得符合正常成人一天用量的散剂。
用于治疗脂肪肝。口服，每日分早晚两次服用。
实施例3
称取：分心木9克、腐婢根12克、老虎耳10克、合萌15克、发痧藤6克、王瓜子9克、无漏子15克、岩谷伞6克、七爪风9克；加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，干燥，装入胶囊壳，即得符合正常成人一天用量的胶囊剂。
用于治疗脂肪肝。口服，每日分早中晚三次服用。
Claims (4)
1.一种用于治疗脂肪肝的药物，其特征在于，它是由以下重量配比的原料药材制备而成：分心木9份、腐婢根12份、老虎耳10份、合萌15份、发痧藤6份、王瓜子9份、无漏子15份、岩谷伞6份、七爪风9份。
2.如权利要求1所述的用于治疗脂肪肝的药物，其特征在于，其制备方法为：称取：分心木9份、腐婢根12份、老虎耳10份、合萌15份、发痧藤6份、王瓜子9份、无漏子15份、岩谷伞6份、七爪风9份；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩至120份，即得煎剂；上述份均是指重量份。
3.如权利要求1所述的用于治疗脂肪肝的药物，其特征在于，其制备方法为：称取：分心木9份、腐婢根12份、老虎耳10份、合萌15份、发痧藤6份、王瓜子9份、无漏子15份、岩谷伞6份、七爪风9份；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得散剂；上述份均是指重量份。
4.如权利要求1所述的用于治疗溃疡性结肠炎的药物，其特征在于，其制备方法为：称取：分心木9份、腐婢根12份、老虎耳10份、合萌15份、发痧藤6份、王瓜子9份、无漏子15份、岩谷伞6份、七爪风9份；加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，干燥，装入胶囊壳，即得胶囊剂；上述份均是指重量份。
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104027468A (zh) * | 2014-06-24 | 2014-09-10 | 俞天阳 | 一种用于治疗头皮脂溢性皮炎的中药 |
| CN104815299A (zh) * | 2015-06-01 | 2015-08-05 | 路云香 | 一种用于治疗脂肪肝的中药 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104815299A (zh) * | 2015-06-01 | 2015-08-05 | 路云香 | 一种用于治疗脂肪肝的中药 |
Cited By (2)
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|---|---|---|---|---|
| CN113599414A (zh) * | 2021-09-16 | 2021-11-05 | 中国人民解放军海军特色医学中心 | 分心木水提物在制备治疗溃疡性结肠炎药物中的应用 |
| CN113599414B (zh) * | 2021-09-16 | 2022-03-04 | 中国人民解放军海军特色医学中心 | 分心木水提物在制备治疗溃疡性结肠炎药物中的应用 |
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