CN106177651A - 一种小儿疳积药 - Google Patents
一种小儿疳积药 Download PDFInfo
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- CN106177651A CN106177651A CN201610750238.5A CN201610750238A CN106177651A CN 106177651 A CN106177651 A CN 106177651A CN 201610750238 A CN201610750238 A CN 201610750238A CN 106177651 A CN106177651 A CN 106177651A
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Abstract
本发明公开了一种小儿疳积药，按质量克由以下组分组成：使君子72～89g，鸡矢藤43～57g，榧子22～35g，芜荑2～7g，骨碎补60～78g，鸡内金24～36g，山药22～38g，刺五加5～10g，青皮3～8g，银柴胡3～10g，枳实3～7g，山楂74～86g，麦芽72～86g，玉竹24～36g，神曲26～36g，五谷虫16～24g，核桃24～37g。本发明诸药合用具杀虫消积，健脾补肾，补充大脑营养效果，可驱除蛔虫后补充体内所需各种营养，安全无毒副作用，疗效好、见效快、治疗周期短、安全无毒。
Description
技术领域
本发明涉及小儿疳积药物技术领域，具体涉及一种小儿疳积药。
背景技术
疳积多因饮食不节，乳食喂养不当，损伤脾胃，运化失职，营养不足，气血精微不能濡养脏腑，或因慢性腹泻、慢性痢疾、肠道寄生虫等病，经久不愈，损伤脾胃等而逐渐形成的一种慢性病证。临床上常以神萎、面黄肌瘦、毛发焦枯、肚大筋露、纳呆便溏、爱喝水，爱掐人，爱扑地睡，大便腥臭为主要病证。目前，市场上虽已有治疗疳积的药物，但其大多治疗效果有限，且治疗周期较长。
本发明研究配制出了一种中药组合物，由使君子，鸡矢藤，榧子，骨碎补，鸡内金，山药，山楂，麦芽，玉竹，神曲，五谷虫，核桃共12味中药组成；同时，还可以再添加芜荑，剌五加，青皮，银柴胡，枳实等5味中药，效果更佳。该中药组合物兼有驱除蛔虫和补充体内所需各种营养的双向作用，安全有效，目前，尚未见相关报道。
(1)使君子，为使君子科植物使君子Quisqualis indica L.的干燥成熟果实。收载于《中国药典》2010版【性味与归经】甘，温。归脾、胃经。【功能与主治】杀虫消积。用于蛔虫病，蛲虫病，虫积腹痛，小儿疳积。
(2)鸡矢藤，为茜草科植物鸡矢藤Paederia scandens(Lour.)Merr.的全草。收藏于《中药大辞典》【性味】性平，味甘、微苦。【功能主治】祛风利湿，止痛解毒，消食化积，活血消肿。用于风湿筋骨痛、跌打损伤、外伤性疼痛、肝胆及胃肠绞痛、消化不良、小儿疳积、支气管火、放射反应引起的白血球减少症；外用皮炎、湿疹及疮疡肿毒。
(3)榧子，为红豆杉科植物榧TorreyagrandisFort.的干燥成熟种子。收载于《中国药典》2010版【性味与归经】甘，平。归肺、胃、大肠经。【功能与主治】杀虫消积，润肺止咳，润燥通便。用于钩虫病，蛔虫病，绦虫病，虫积腹痛，小儿疳积，肺燥咳嗽，大便秘结。
(4)芜荑，为榆科榆属植物大果榆Ulmus macrocarpa Hance的种子经加工后的成品。收载于《全国中草药汇编》【性味】辛苦平。归脾胃经。【功能主治】消积杀虫。用于小儿疳积，蛔虫病，蛲虫病。
(5)骨碎补，为水龙骨科植物槲蕨Drynariafortunei(Kunze)J.Sm.的干燥根茎。收载于《中国药典》2010版【性味与归经】苦，温。归肝、肾经。【功能与主治】疗伤止痛，补肾强骨.外用消风祛斑。用于跌扑闪挫，筋骨折伤，肾虚腰痛，筋骨痿软，耳鸣耳聋，牙齿松动；外治斑秃，白癜风。
(6)鸡内金，为雉科动物家鸡GallusgallusdomesticusBrisson的干燥沙囊内壁。收载于《中国药典》2010版【性味与归经】甘，平。归脾、胃、小肠、膀胱经。【功能与主治】健胃消食，涩精止遗，通淋化石。用于食积不消，呕吐泻痢，小儿疳积，遗尿，遗精，石淋涩痛，胆胀胁痛。
(7)山药，为薯蓣科植物薯蓣DioscoreaoppositaThunb.的干燥根茎。收载于《中国药典》2010版【性味与归经】甘，平。归脾、肺、肾经。【功能与主治】补脾养胃，生津益肺，补肾涩精。用于脾虚食少，久泻不止，肺虚喘咳，肾虚遗精，带下，尿频，虚热消渴。麸炒山药补脾健胃。用于脾虚食少，泄泻便溏，白带过多。
(8)剌五加，为五加科植物刺五加Acanthopanax Senticosus(Ruper.et Maxim.)Harms的干燥根茎。收载于《药典》2010版【性味与归经】辛微苦温，归脾肾心经。【功能与主治】益气健脾，补肾安神。用于脾肺气虚，体虚乏力，食欲不振，肺肾两虚，久咳虚喘，肾虚腰膝酸痛，心脾不足，失眠多梦。
(9)青皮，为芸香科植物橘Citrus reticulata Blanco及其栽培变种的干燥幼果或未成熟果实的果皮。收载于《药典》2010版【性味与归经】苦、辛，温。归肝、胆、胃经。【功能与主治】疏肝破气，消积化滞。用于胸胁胀痛，疝气疼痛，乳癖，乳痈，食积气滞，脘腹胀痛。
(10)银柴胡，为石竹科植物银柴胡StellariadichotomaL.var.lanceolataBge.的干燥根。收载于《中国药典》2010版【性味与归经】甘，微寒。归肝、胃经。【功能与主治】清虚热，除疳热。用于阴虚发热，骨蒸劳热，小儿疳热。
(11)枳实，为芸香科植物酸橙CitrusaurantiumL.及其栽培变种或甜橙CitrussinensisOsbeck的干燥幼果。收载于《中国药典》2010版【性味与归经】苦、辛、酸，微寒。归脾、胃经。【功能与主治】破气消积，化痰散痞。用于积滞内停，痞满胀痛，泻痢后重，大便不通，痰滞气阻，胸痹，结胸，脏器下垂。
(12)山楂，为蔷薇科植物山里红CrataeguspinnatifidaBge.var.majorN.E.Br.或山楂CrataeguspinnatifidaBge.的干燥成熟果实。收载于《中国药典》2010版【性味与归经】酸、甘，微温。归脾、胃、肝经。【功能与主治】消食健胃，行气散瘀，化浊降脂。用于肉食积滞，胃脘胀满，泻痢腹痛，瘀血经闭，产后瘀阻，心腹刺痛，胸痹心痛，疝气疼痛，高脂血症。焦山楂消食导滞作用增强。用于肉食积滞，泻痢不爽。
(13)麦芽，为禾本科植物大麦HordeumvulgareL.的成熟果实经发芽干燥的炮制加工品。收载于《中国药典》2010版【性味与归经】甘，平。归脾、胃经。【功能与主治】行气消食，健脾开胃，回乳消胀。用于食积不消，脘腹胀痛，脾虚食少，乳汁郁积，乳房胀痛，妇女断乳，肝郁胁痛，肝胃气痛。
(14)玉竹，为百合科植物玉竹Polygonatumodoratum(Mill.)Druce的干燥根茎。收载于《中国药典》2010版【性味与归经】甘，微寒。归肺、胃经。【功能与主治】养阴润燥，生津止渴。用于肺胃阴伤，燥热咳嗽，咽干口渴，内热消渴。
(15)神曲，为辣蓼、青蒿、杏仁泥、赤小豆、鲜苍耳子加入面粉或麸皮后发酵而成的曲剂。收载于《中药大辞典》【性味与归经】甘辛，温。入脾、胃经。【功能与主治】健脾和胃，消食调中。治饮食停滞，胸痞腹胀，呕吐泻痢，产后瘀血腹痛，小儿腹大坚积。
(16)五谷虫，为丽蝇科昆虫大头金蝇或其它近缘昆虫的干燥幼虫。收载于《中药大辞典》【性味与归经】咸，寒。归脾、胃经。【功能与主治】健脾消积，清热除疳。主疳积发热，食积泻痢，疳疮，疳眼，走马牙疳。
(17)核桃，为胡桃科植物胡桃JuglansregiaL.的干燥成熟种子。收载于《中国药典》2010版【性味与归经】甘，温。归肾、肺、大肠经。【功能与主治】补肾，温肺，润肠。用于肾阳不足，腰膝酸软，阳痿遗精，虚寒喘嗽，肠燥便秘。
发明内容
本发明目的在于提供一种疗效好、见效快、治疗周期短、安全无毒的小儿疳积药。
为达到上述目的，本发明采用如下技术方案：
一种小儿疳积药，按质量克由以下组分组成：使君子72～89g，鸡矢藤43～57g，榧子22～35g，骨碎补60～78g，鸡内金24～36g，山药22～38g，山楂74～86g，麦芽72～86g，玉竹24～36g，神曲26～36g，五谷虫16～24g，核桃24～37g。
以上所述一种小儿疳积药，优选的按质量克还包括以下组分：芜荑2～7g，剌五加5～10g，青皮3～8g，银柴胡3～10g，枳实3～7g。
以上所述一种小儿疳积药，优选的按质量克由以下组分组成：使君子76～84g，鸡矢藤46～54g，榧子26～33g，芜荑3～6g，骨碎补67～73g，鸡内金27～32g，山药27～32g，剌五加6～8g，青皮4～6g，银柴胡5～8g，枳实4～6g，山楂76～83g，麦芽77～83g，玉竹26～32g，神曲27～33g，五谷虫17～22g，核桃28～33g。
以上所述一种小儿疳积药，优选的按质量克由以下组分组成：使君子80g，鸡矢藤50g，榧子30g，芜荑5g，骨碎补70g，鸡内金30g，山药30g，剌五加7g，青皮5g，银柴胡6g，枳实5g，山楂80g，麦芽80g，玉竹30g，神曲30g，五谷虫20g，核桃30g。
本发明根据传统中医药理论，结合现代中医的辩证疗法，以“药食同源”品种为原料，组方严谨科学，由使君子，鸡矢藤，榧子，芜荑，骨碎补，鸡内金，山药，剌五加，青皮，银柴胡，枳实，山楂，麦芽，玉竹，神曲，五谷虫，核桃共17味中药组成：使君子、鸡矢藤，榧子、芜荑、枳实、五谷虫和鸡内金杀虫消积，银柴胡、剌五加、骨碎补补肾强骨，山药、麦芽，玉竹、神曲，核桃养脾健胃，补充身体营养；青皮、山楂润肠通便，消食。诸药合用具显著的杀虫消积，健脾补肾，补充大脑营养效果，可驱除蛔虫等后补充体内所需各种营养，安全无毒副作用。
本发明的有益效果是：
1.组分均取自“药食同源”品种，含有丰富的营养物质及改善小孩健康和的治疗疳积的有效成分，使用安全。
2、组方严谨，药少力专，通过驱除体内蛔虫，健脾胃，补充大脑营养，达到消积目的，治疗小儿爱喝水，爱掐人，爱扑地睡，不吃饭，头发竖天，大便腥臭等小儿疳积疾病。
3、本发明将诸药混合一起打磨成粉末，纯中药纯中药无添加剂，安全，适合1-6岁小孩服用。
具体实施方式
下面结合具体实施例对本发明作进一步描述，但不限制本发明的保护范围和应用范围：
实施例1
一种小儿疳积药，按质量克由以下组分组成：使君子72g，鸡矢藤43g，榧子22g，骨碎补60g，鸡内金24g，山药22g，山楂74g，麦芽72g，玉竹24g，神曲26g，五谷虫16g，核桃24g。
实施例2
一种小儿疳积药，按质量克由以下组分组成：使君子80g，鸡矢藤50g，榧子30g，骨碎补70g，鸡内金30g，山药30g，山楂80g，麦芽80g，玉竹30g，神曲30g，五谷虫20g，核桃20g。
实施例3
一种小儿疳积药，按质量克由以下组分组成：使君子89g，鸡矢藤57g，榧子35g，骨碎补78g，鸡内金36g，山药38g，山楂86g，麦芽86g，玉竹36g，神曲36g，五谷虫24g，核桃37g。
实施例4
一种小儿疳积药，按质量克由以下组分组成：使君子72g，鸡矢藤43g，榧子22g，芜荑2g，骨碎补60g，鸡内金24g，山药22g，剌五加5g，青皮3g，银柴胡3g，枳实3g，山楂74g，麦芽72g，玉竹24g，神曲26g，五谷虫16g，核桃24g。
实施例5
一种小儿疳积药，按质量克由以下组分组成：使君子76g，鸡矢藤46g，榧子26g，芜荑3g，骨碎补67g，鸡内金27g，山药27g，剌五加6g，青皮4g，银柴胡5g，枳实4g，山楂76g，麦芽77g，玉竹26g，神曲27g，五谷虫17g，核桃28g。
实施例6
一种小儿疳积药，按质量克由以下组分组成：使君子80g，鸡矢藤50g，榧子30g，芜荑5g，骨碎补70g，鸡内金30g，山药30g，剌五加7g，青皮5g，银柴胡6g，枳实5g，山楂80g，麦芽80g，玉竹30g，神曲30g，五谷虫20g，核桃30g。
实施例7
一种小儿疳积药，按质量克由以下组分组成：使君子84g，鸡矢藤54g，榧子33g，芜荑6g，骨碎补73g，鸡内金32g，山药32g，剌五加8g，青皮6g，银柴胡8g，枳实6g，山楂83g，麦芽83g，玉竹32g，神曲33g，五谷虫22g，核桃33g。
实施例8
一种小儿疳积药，按质量克由以下组分组成：使君子89g，鸡矢藤57g，榧子35g，芜荑7g，骨碎补78g，鸡内金36g，山药38g，剌五加10g，青皮8g，银柴胡10g，枳实7g，山楂86g，麦芽86g，玉竹36g，神曲36g，五谷虫24g，核桃37g。
二、临床试验
1.病例选择标准
参照国家中医药管理局颁布的《中医病证诊断疗效标准》中的小儿疳积诊断标准。饮食异常，大便干稀不调或脘腹胀满等明显脾胃功能失调；形体消瘦体重低于正常平均值的15％～40％，伴面色不华，毛发稀疏枯黄；兼有精神不振，或烦躁易怒，或喜揉眉擦眼，或吮指磨牙等症；有喂养不当或病后饮食失调及长期消瘦史；大便镜检可查见蛔虫卵；血清总蛋白(TP)大多在45g/L以下，血清白蛋白(HSA)约在20g/L以下。
1.1纳入标准
(1)符合小儿疳积的诊断标准；(2)年龄1～6岁患儿；(3)粪检蛔虫卵阳性者，驱虫后纳入观察。
1.2排除标准
(1)患有先天性、器质性、发育缺陷性疾病；(2)依从性差，不予配合者。
2.治疗方案
将符合上述标准的90例疳积患儿按就诊顺序随机分为实施例2、6组和对照组，每组30例。
(1)实施例2组：将上述实施例2的诸药混合一起打磨成粉末，用于临床试验。口服，1～2岁每天服1/2包；2岁以上每天服1包/次，一日3次。疗程：用药4周。
(2)实施例6组：将上述制备好的实施例6的诸药混合一起打磨成粉末，用于临床试验。口服，1～2岁每天服1/2包；2岁以上每天服1包/次，一日3次。疗程：用药4周。
(3)对照组：化积口服液(江西地威药业有限公司，批准文号：国药准字Z10890005)。1～5岁每次10mL，每日2次；大于5岁每次10mL，每日3次；用药4周。
3、观察指标
治疗前分别对两组病例进行肝功能、血、粪常规化验。逐项记录体质量、皮下脂肪、肌肉松弛、皮肤弹性、精神、食欲及伴随症状。治疗期间观察体质量、食欲、精神及伴随症状。4周后复查治疗前各项指标，观察症状改善和体质量变化等情况。
4、疗效判定标准
参照《中医病证诊断疗效标准》拟定。(1)治愈：体质量增加，接近正常健康小儿体质量，各种症状消失，实验室检查指标恢复正常；(2)好转：体质量有所增加，精神、食欲及其他症状改善；(3)未愈：症状及体征均无变化。
5.治疗结果
实施例2组：显效23例(76.7％)、有效5例(16.7％)，无效2例(6.7％)，总有效率93.3％。
实施例6组：显效20例(66.7％)、有效9例(30.0％)，无效1例(3.3％)，总有效率96.7％。
对照组：显效18例(60.0％)，有效9例(30.0％)，无效3例(10.0％)，总有效率90.0％。
用药4周后，分别测定患者自身服药前后体重、血清总蛋白、血清白蛋白，详见下表：
表1治疗前后体重变化
实施例2、6组与对照组比较，P＜0.05。
表2治疗前后血清总蛋白、血清白蛋白变化
实施例2、6组与对照组比较，P＜0.05。
试验结果表明：本发明实施例2、6组，患者自身治疗前后体重、血清总蛋白、血清白蛋白的改变，差异均有高度显著性，说明本发明小儿疳积药对治疗小儿疳积具有显著的疗效。对照组治疗后，也具有较好的疗效，但实施例2、6组效果优于对照组。且本发明小儿疳积药临床用药期间，均无不良反应，用药后2天左右，患儿食欲均有所改善，3天左右，精神状况可见明显好转，用药四周后各项指标均慢慢恢复至正常水平。
Claims (4)
1.一种小儿疳积药，其特征在于，按质量克包括以下组分：使君子72～89g，鸡矢藤43～57g，榧子22～35g，骨碎补60～78g，鸡内金24～36g，山药22～38g，山楂74～86g，麦芽72～86g，玉竹24～36g，神曲26～36g，五谷虫16～24g，核桃24～37g。
2.根据权利要求1所述的一种小儿疳积药，其特征在于，按质量克还包括以下组分：芜荑2～7g，剌五加5～10g，青皮3～8g，银柴胡3～10g，枳实3～7g。
3.根据权利要求2所述的一种小儿疳积药，其特征在于，按质量克由以下组分组成：使君子76～84g，鸡矢藤46～54g，榧子26～33g，芜荑3～6g，骨碎补67～73g，鸡内金27～32g，山药27～32g，剌五加6～8g，青皮4～6g，银柴胡5～8g，枳实4～6g，山楂76～83g，麦芽77～83g，玉竹26～32g，神曲27～33g，五谷虫17～22g，核桃28～33g。
4.根据权利要求2或3所述的一种小儿疳积药，其特征在于，按质量克由以下组分组成：使君子80g，鸡矢藤50g，榧子30g，芜荑5g，骨碎补70g，鸡内金30g，山药30g，剌五加7g，青皮5g，银柴胡6g，枳实5g，山楂80g，麦芽80g，玉竹30g，神曲30g，五谷虫20g，核桃30g。
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| CN113521213A (zh) * | 2021-07-30 | 2021-10-22 | 余建社 | 一种疳积散的生产方法 |
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