CN105560584A - Traditional Chinese medicine for treating CT scanning contrast medium exosmosis in image department and preparation method - Google Patents
Traditional Chinese medicine for treating CT scanning contrast medium exosmosis in image department and preparation method Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine for treating CT scanning contrast medium exosmosis in an image department and a preparation method. The traditional Chinese medicine is prepared from solanum indicum, Amaranthus tricolor L., dragonflies, lindera fragrans, cottonrose hibiscus leaves, Lysimachia circaeoides Hemsl., cyathocline purpurea, cyathocline purpurea, malvastrum coromandelianum, all grass of crinite uraria, rhynchosia volubilis, litmus, scutellaria indica and field mustard. The traditional Chinese medicine has the advantages that the traditional Chinese medicine is good in treatment effect on treating contrast medium exosmosis, effect taking is rapid, no toxic or side effect or allergic or adverse reaction is generated, and pain can be rapidly eliminated or obviously relieved within 1-3 days.
Description
Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to Chinese medicine and the preparation method of a kind of image department treatment CT scan extravasation of contrast media.
Background technology
Along with spiral CT is generally applied clinically, strengthen the first-selected inspection method checking and become many clinicians, owing to needing intravenous injection contrast agent, we often only pay attention to the adverse effectes such as the allergy of contrast agent at ordinary times, pay close attention to not to the outer harm to patient of blood vessel extravasation of contrast media.Contrast agent vascular exosmosis refers to the superficial vein angiorrhexis be injected when CT enhanced ct scans, cause contrast agent to spill and infiltrate adjacent tissue gap, comparatively strong stimulation is produced to subcutaneous tissue, causes the local swelling of respective organization, pain, even cause local organization cell dehydration, cutaneous necrosis.The surrounding tissue generally showing as point of puncture is full, swelling, pain, severe patient can involve the soft tissue of whole puncture limbs, occasionally has blister to occur, and with serious suffering limb limitation of activity.
Extravasation of contrast media with the elastic quality of patient's blood vessel, whether repeatedly puncture, injection pressure, puncture technique, scanning bed mobile time nervous, the mobile site of puncture of patient limbs time syringe needle accidentally to puncture the factors such as blood vessel relevant.In order to avoid extravasation of contrast media, the preparation before radiography should be carried out, the selection of puncture vessel, generally select thick, straight, resilient superficial vein, site of puncture is easy to fixing, avoid joint, vein blood vessel crotch as far as possible, generally commonly use the positions such as hand back vein, forearm superficial vein and median cubital vein.Striving " hitting the nail on the head " when puncturing, avoiding in same position repeated localised puncture.The medical adhesive tape that wide 2.5cm can be applied in site of puncture is pasted centered by needle plate, and then fixing flexible pipe, the last locking pin wing, swings to prevent the vasopressing injection hour hands wing.According to our working experience, puncture the most handy large size " Y " type remaining needle, and reduce extravasation of contrast media occurrence probability, be also convenient in emergency circumstances to the first aid process of patient simultaneously.Before scanning during injection of contrast medium, our nurse and doctor preferably look on patient the situation of examining, pre-note 3 milliliters, during observation, forefinger is put down gently patient injection site, injection site is without swelling and can feel and confirm the flowing of liquid that liquid flows into blood vessel, can leave scanning room before exposure.In addition, CT high pressure injector rate of administration is fast, greatly also be cause the main cause of extravasation of contrast media to the impulsive force of blood vessel wall, to high-risk group as the patients such as long-term chemotherapy, old sclerosis of blood vessels, obesity carry out enhanced ct scans time, should slow down injection speed, between injection, the many inquiries of close observation patient have why not fit phenomenon.
If once generation extravasation of contrast media, should stop immediately injecting and pull out pin, the outer sepage of resorption of trying one's best before pulling out pin, presses site of puncture with disinfecting cotton swab, avoids blood extravasation to increase the weight of local swelling; Can ice bag local cold compress in 48 hours, reduce contrast agent to the degree of dermal tissue insult; Extravasation of contrast media edema compressing local venous return is obstructed, lifting affected limb as far as possible, to promote venous return, is conducive to local medicinal liquid and absorbs, alleviate edema.Drug treating can comprise: dexamethasone 5mg adds 2% procaine 2ml partial closure, with reduction of patient pain; 50% magnesium sulfate or 20% mannitol local wet dressing, can have detumescence effect to local organization; Hirudiod is coated with outward, has the effect of local anti-inflammatory, detumescence; Vitamin B12 analgesic effect is also good; Said method all has certain effect to tools such as the swelling that elimination extravasation of contrast media causes, but effect is still not ideal enough.
Summary of the invention
Technical problem to be solved by this invention is, provides a kind of and can eliminate the pain and swelling that extravasation of contrast media causes fast, therapeutic effect good and the Chinese medicine of the image department had no side effect treatment CT scan extravasation of contrast media and preparation method.
In order to solve the problems of the technologies described above, the invention provides the Chinese medicine of a kind of image department treatment CT scan extravasation of contrast media, each raw medicinal material of described Chinese medicine comprises: bitter sky eggplant, Semen Amaranthi tricoloris, Aeschna melanictera, Cortex Linderae Fragrantis, Folium Hibisci Mutabilis, Herba Lysimachiae Circaeoidis, cup chrysanthemum, Calyx Seu Fructus Physalis, Herba Malvastri Coromandeliani, Herba Urariae crinitae, Herba rhynchosiae volubilis, Herba Cladoniae rangiferinae, Herba Scutellariae indicae and Caulis et Folium Brassicae campestris.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: bitter sky eggplant 5 ~ 15 parts, Semen Amaranthi tricoloris 10 ~ 20 parts, Aeschna melanictera 15 ~ 25 parts, Cortex Linderae Fragrantis 10 ~ 20 parts, Folium Hibisci Mutabilis 10 ~ 20 parts, Herba Lysimachiae Circaeoidis 20 ~ 30 part, glass chrysanthemum 20 ~ 30 parts, Calyx Seu Fructus Physalis 10 ~ 20 parts, Herba Malvastri Coromandeliani 20 ~ 30 parts, Herba Urariae crinitae 15 ~ 25 parts, Herba rhynchosiae volubilis 20 ~ 30 parts, Herba Cladoniae rangiferinae 10 ~ 20 parts, Herba Scutellariae indicae 8 ~ 18 parts and Caulis et Folium Brassicae campestris 5 ~ 15 parts.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: bitter sky eggplant 7 ~ 12 parts, Semen Amaranthi tricoloris 10 ~ 15 parts, Aeschna melanictera 18 ~ 23 parts, Cortex Linderae Fragrantis 12 ~ 17 parts, Folium Hibisci Mutabilis 13 ~ 18 parts, Herba Lysimachiae Circaeoidis 22 ~ 27 part, glass chrysanthemum 20 ~ 25 parts, Calyx Seu Fructus Physalis 13 ~ 18 parts, Herba Malvastri Coromandeliani 25 ~ 30 parts, Herba Urariae crinitae 17 ~ 22 parts, Herba rhynchosiae volubilis 22 ~ 27 parts, Herba Cladoniae rangiferinae 10 ~ 15 parts, Herba Scutellariae indicae 11 ~ 16 parts and Caulis et Folium Brassicae campestris 8 ~ 13 parts.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: bitter sky eggplant 12 parts, Semen Amaranthi tricoloris 10 parts, Aeschna melanictera 22 parts, Cortex Linderae Fragrantis 13 parts, Folium Hibisci Mutabilis 16 parts, Herba Lysimachiae Circaeoidis 24 part, glass chrysanthemum 24 parts, Calyx Seu Fructus Physalis 14 parts, Herba Malvastri Coromandeliani 28 parts, Herba Urariae crinitae 18 parts, Herba rhynchosiae volubilis 26 parts, Herba Cladoniae rangiferinae 12 parts, Herba Scutellariae indicae 15 parts and Caulis et Folium Brassicae campestris 9 parts.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: bitter sky eggplant 8 parts, Semen Amaranthi tricoloris 14 parts, Aeschna melanictera 20 parts, Cortex Linderae Fragrantis 15 parts, Folium Hibisci Mutabilis 15 parts, Herba Lysimachiae Circaeoidis 26 part, glass chrysanthemum 20 parts, Calyx Seu Fructus Physalis 16 parts, Herba Malvastri Coromandeliani 25 parts, Herba Urariae crinitae 20 parts, Herba rhynchosiae volubilis 24 parts, Herba Cladoniae rangiferinae 14 parts, Herba Scutellariae indicae 12 parts and Caulis et Folium Brassicae campestris 12 parts.
When the dosage form of described Chinese medicine is unguentum, its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, decocts with water 2 ~ 4 times, each 1 ~ 3 hour, add the water of 6 ~ 10 times amount, decoction liquor is filtered at every turn, merge the filtrate of each time, add determining alcohol be 90% ~ 95% ethanol to alcohol content be 40% ~ 50%, leave standstill 3 ~ 5 hours, filter, filtrate concentrates, and drying is also pulverized, and obtains mixed-powder, cross 200 mesh sieves, adopt ultra violet lamp sterilizing in 1 ~ 2 hour;
Second step, relative to mixed-powder described in 100 weight portions that the first step obtains, 1 weight portion ~ 3 weight portion stearic acid, 0.5 weight portion ~ 1.5 weight portion stearyl alcohol, 0.5 weight portion ~ 1.5 weight portion glyceryl monostearate, 3 weight portion ~ 5 weight portion liquid Paraffin, 8 weight portion ~ 10 weight portion dimethicones are mixed and heated to 75 DEG C ~ 85 DEG C, under constantly stirring, add 1 weight portion ~ 3 part by weight of vitamin E dissolve, obtain oil phase;
3rd step, relative to mixed-powder described in 100 weight portions that the first step obtains, 0.5 weight portion ~ 1.5 weight portion sodium lauryl sulphate, 0.5 weight portion ~ 1.5 weight portion triethanolamine, 1 weight portion ~ 2 weight portion ethyl hydroxybenzoate, 1000 weight portion ~ 1500 weight portion distilled water are mixed and heated to 75 DEG C ~ 85 DEG C, obtain aqueous phase;
4th step, the oil phase obtained by second step slowly adds in the aqueous phase of the 3rd step acquisition under constantly stirring, and fully stirs 30 minutes ~ 1 hour, makes emulsifying, add the mixed-powder that the first step obtains, stir, subpackage at the temperature of 60 DEG C ~ 70 DEG C.
When above-mentioned the dosage form of Chinese medicine is injectable powder described in any one time, its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
Beneficial effect of the present invention: Chinese medicine of the present invention, to treatment extravasation of contrast media, therapeutic effect is good, instant effect, has no side effect, irritated and untoward reaction, can eliminate fast in 1-3 or obviously ease the pain.
Detailed description of the invention
The invention provides the Chinese medicine of a kind of image department treatment CT scan extravasation of contrast media, its raw medicinal material comprises: bitter sky eggplant, Semen Amaranthi tricoloris, Aeschna melanictera, Cortex Linderae Fragrantis, Folium Hibisci Mutabilis, Herba Lysimachiae Circaeoidis, cup chrysanthemum, Calyx Seu Fructus Physalis, Herba Malvastri Coromandeliani, Herba Urariae crinitae, Herba rhynchosiae volubilis, Herba Cladoniae rangiferinae, Herba Scutellariae indicae and Caulis et Folium Brassicae campestris.
In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:
Bitter sky eggplant: [another name] bitter Semen daturae, yellow Fructus Gleditsia acupuncture, Fructus Solani Khasiani, Solanum aculeatissimum Jacq., Herba Solani Surattensis, paddy finch egg, Herba seu Fructus Physalis Minimae, add money fruit, Canis familiaris L. Fructus Solani melongenae, really angle eggplant, large bitter Pueraria lobota, golden pellet.[source] medical material Ji Yuan: be the fruit of the western eggplant of plant of Solanaceae noise made in coughing or vomiting.[nature and flavor] mildly bitter flavor; Cold in nature; Mild toxicity.[function cures mainly] wind-expelling pain-stopping; Heat-clearing and toxic substances removing.Main air pain of dampness syndrome; Headache; Toothache; Acute mastitis; Mumps; Traumatic injury pain.[extracts] " China's book on Chinese herbal medicine "
Semen Amaranthi tricoloris: [another name] not reality, Herba Amaranthi tricoloris, Amaranthus mangostanus L. is sub.[source] medical material Ji Yuan: be amaranthaceous plant Herba Amaranthi tricoloris seed.[nature and flavor] are sweet; Cold in nature.[return through] liver; Large intestine; Urinary bladder channel.[function cures mainly] liver heat removing and eyesight improving; Smoothening secretion.Main optic atrohic blindness cataracta; Poor vision; Nebulousurine hematuria; Difficulty in urination and defecation.[extracts] " China's book on Chinese herbal medicine "
Aeschna melanictera: [another name] bears labor, damselfly, Radix Mori, storehouse, butterfly, Vulpes pears, Zhu Cheng, recklessly clam, horse major part, yarn sheep, Lytta caragana Pallas.[source] medical material Ji Yuan: be the entirety of the green tail dragonfly of dragonfly section animal and dragonfly section animal Crocothemis servillia (Drury), Xia Chizu, Sympetrum infuscatum (Selys), Planta La flavescens (Fabricius)． etc.[nature and flavor] salty in the mouth; Warm in nature.[return through] kidney channel.[function cures mainly] kidney-reinforcing Yang-strengthening; The secret essence of reinforcing YIN-essence.Main impotence of suffering from a deficiency of the kidney; Seminal emission; Breath with cough.[extracts] " China's book on Chinese herbal medicine "
Cortex Linderae Fragrantis: [source] medical material Ji Yuan: be bark or the leaf of canella Cortex Linderae Fragrantis.[nature and flavor] are pungent; Temperature.[return through] stomach warp.[function cures mainly] warming middle-JIAO to promote flow of QI; Expelling wind and cold.Main anemofrigid cold; Gastralgia; Dyspepsia; Rheumatic arthralgia.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "
Folium Hibisci Mutabilis: [another name] refuses red leaves, Hibisci Mutabilis floral leaf, Cortex cynoglossi zeylanici radicis.[source] medical material Ji Yuan: be the leaf of Malvaceae plant Hibisci Mutabilis.[nature and flavor] are pungent; Bitter; Cool.[return through] lung; Liver Channel.[function cures mainly] Qingfei Liangxue; Removing toxic substances and promoting subsidence of swelling.Main cough due to lung-heat; Conjunctival congestion and swelling pain; Swollen ulcer drug; Malignant boil; Be burdened with herpes zoster; Impetigo; Pyelonephritis; Burn due to hot liquid or fire; Venom; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "
Herba Lysimachiae Circaeoidis: [another name] to leaf red line grass, see that stitchings, gold building, loose greatly blood, Amaranthus mangostanus L. Radix Notoginseng, Sha Hong seven, blood are careless.[source] medical material Ji Yuan: be the whole herb with root of Ofthe Primulaceae dewdrop Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis).[nature and flavor] are pungent; Bitter; Cold in nature.[return through] lung; Liver Channel.[function cures mainly] heat-clearing and toxic substances removing, dissipating blood stasis stops blooding.Main laryngopharynx swelling and pain; Spitting of blood; Carbuncle furuncle; Traumatic injury; Fracture; Traumatic hemorrhage; Burn and scald; Venom; Corneal nebula.[extracts] " China's book on Chinese herbal medicine "
Cup chrysanthemum: [another name] little red Artemisia, Herba Cyathoclines purpureae.[source] Compositae cup chrysanthemum, with all herbal medicine.[nature and flavor] are bitter, cool.[function cures mainly] heat-clearing and toxic substances removing, anti-inflammation hemostasia, dehumidifying diuresis, parasite killing.Cure mainly acute gastroenteritis, heatstroke, cystitis, urethritis, pharyngolaryngitis, stomatitis, spit blood, epistaxis.[extracts] " national Chinese herbal medicine compilation "
Calyx Seu Fructus Physalis: [another name] Calyx seu Fructus physalis, golden lamp, Radix Ribis manschurici, Calyx Seu Fructus Physalis, bubble.[source] this product is the dry Constellation calyx of plant of Solanaceae Calyx seu fructus physalis or the Constellation calyx of band fruit.Autumn fruit maturation, Constellation calyx take on a red color or orange red time gather, dry.[nature and flavor] are bitter, cold.[return through] returns lung meridian.[function cures mainly] heat-clearing and toxic substances removing, sore-throat relieving, reduces phlegm, diuresis.For pharyngalgia hoarseness, phlegm-heat cough, dysuria; External treatment pemphigus, eczema.[extracts] " Chinese Pharmacopoeia "
Herba Malvastri Coromandeliani: [another name] Coromadel Coast Falsemallow Herb, mountain Corchorus olitorius L., fiery leaf Hemerocallis citrina Baroni is violent, Prunus davidiana is young, bitter numb Herba Malvastri Coromandeliani, bitter fiber crops, Hemerocallis citrina Baroni are complied with one's wishes, mountain rope blood, the Flos Camelliae Japonicae heart, Herba Malvastri Coromandeliani, Hemerocallis citrina Baroni louse fiber crops head.[source] medical material Ji Yuan: be the herb of Malvaceae plant Herba Malvastri Coromandeliani.[nature and flavor] are micro-sweet; Cool.[return through] lung; Liver; Large intestine channel.[function cures mainly] clearing away heat-damp and promoting diuresis; Removing toxic substances and promoting subsidence of swelling.Main damp-heat dysentery; Jaundice; Cough due to lung-heat; Laryngopharynx swelling and pain; Hemorrhoid; Carbuncle sore tumefacting virus; Traumatic injury; Before split adenitis.[extracts] " China's book on Chinese herbal medicine "
Herba Urariae crinitae: [another name] Herba Urariae Lagopodioidis, timothy grass, tiger tail, system sky grass, university degree mountain green grass or young crops, ancient coin window grass, the golden mace of ferrum, Canis familiaris L. tail are penetrated.[source] medical material Ji Yuan: the herb penetrated for leguminous plant cat tail.[nature and flavor] are sweet; Micro-hardship; Flat.[return through] heart; Lung; Liver Channel.[function cures mainly] clearing away lung-heat to relieve cough; Dissipating blood stasis stops blooding.Main cough due to lung-heat; Lung abscess; Gather; Acute mastitis; Proctoptosis; Uterine prolapse; Spit blood; Hematuria; Traumatic hemorrhage.[extracts] " China's book on Chinese herbal medicine "
Herba rhynchosiae volubilis: [another name] Crafts-Co., deer bean, Beans bean, wild Semen phaseoli radiati, wild Semen Glycines, mouse eye, mouse bean, wild green soyabeans, door are thin, wine pot rattan, black eyes bean, the wild Semen phaseoli radiati of great Ye, terrible Radix Sophorae Tonkinensis, Resina garciniae bean, black eyeball pearl, light eye bell bell rattan, mountain Semen sojae atricolor, terrible eyes, Glycine tomentella.[source] medical material Ji Yuan: be the stem and leaf of leguminous plant Herba rhynchosiae volubilis.[nature and flavor] bitter in the mouth; Acid; Property is put down.[return through] stomach; Spleen; Liver Channel.[function cures mainly] expelling wind and removing dampness; Invigorate blood circulation; Removing toxic substances.Main air pain of dampness syndrome; Headache; Toothache; Lumbar vertebrae pain; Abdominal pain due to blood stasis; Lochiopyra; Scrofula; Carbuncle sore tumefacting virus; Traumatic injury; Burn and scald.[extracts] " China's book on Chinese herbal medicine "
Herba Cladoniae rangiferinae: [another name] litmus, stone mustard, cloud tea, illiteracy top tea, Herba Cladoniae rangiferinae flower, Shi Yuncha, Coriolous Dersicolor (Fr.) Quel tea, monsanto tea, Mengyin tea, enzyme tongue, Parmelia saxatilis Ach., drug for incised wound.[source] medical material Ji Yuan: be the dendrimer of Cladoniaceae plant deer stamen.[nature and flavor] are sweet; Puckery, cool in nature.[return through] heart, Liver Channel.[function cures mainly] heat clearing away, moisturizes, and cool liver, reduces phlegm, dampness removing.Main dysphoria with smothery sensation is uneasy, and parched throat expectorant is tied, blurred vision cataracta, pyretic stranguria, jaundice.[extracts] " China's book on Chinese herbal medicine "
Herba Scutellariae indicae: [another name] energetically grass, scutllaria indica, golden teaspoon, large Herba Scutellariae indicae, along, red autumnal leaves Rhizoma typhonii divaricati, India Radix Scutellariae, great Ye Herba Scutellariae Barbatae careless through grass, spoon, laugh at medicinal herbs, Glinus lotoides, India skullcap, Herba Scutellariae Barbatae, conjunction ear flower, dragon trip Rhizoma et radix valerianae, gib head line.[source] medical material Ji Yuan: be the herb of labiate Herba Scutellariae indicae.[nature and flavor] acrid in the mouth; Bitter; Bosom is cold.[return through] GUIXIN; Liver; Lung meridian.[function cures mainly] heat-clearing and toxic substances removing; Promoting blood circulation and stopping pain; Hemostasia and detumescence.Main carbuncle furunculosis; Lung abscess; Intestinal carbuncle; Scrofula; Venom; Lung-heat cough with asthma; Toothache; Sore throat; Pharyngalgia; Bones and muscles pain; Spit blood; Spitting of blood; Have blood in stool; Traumatic injury; Wound hemorrhage; Skin pruritus.[extracts] " China's book on Chinese herbal medicine "
Caulis et Folium Brassicae campestris: [another name] Caulis et Folium Brassicae campestris, cold dish, a kind of sedge dish, Caulis et Folium Brassicae campestris dish, a kind of sedge mustard, green vegetable, chilli oil dish.[source] medical material Ji Yuan: be the root of crucifer Brassica campestris L, stem and leaf.[nature and flavor] are pungent; Sweet; Property is put down.[return through] lung; Liver; Spleen channel.[function cures mainly] removing pathogenic heat from blood and dissipating blood stasis; Removing toxic substances and promoting subsidence of swelling.Main dysentery; Erysipelas; Hot carbuncle toxin; Acute mastitis; Rubella; Spit blood.[extracts] " China's book on Chinese herbal medicine "
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: bitter sky eggplant 5 ~ 15 parts, Semen Amaranthi tricoloris 10 ~ 20 parts, Aeschna melanictera 15 ~ 25 parts, Cortex Linderae Fragrantis 10 ~ 20 parts, Folium Hibisci Mutabilis 10 ~ 20 parts, Herba Lysimachiae Circaeoidis 20 ~ 30 part, glass chrysanthemum 20 ~ 30 parts, Calyx Seu Fructus Physalis 10 ~ 20 parts, Herba Malvastri Coromandeliani 20 ~ 30 parts, Herba Urariae crinitae 15 ~ 25 parts, Herba rhynchosiae volubilis 20 ~ 30 parts, Herba Cladoniae rangiferinae 10 ~ 20 parts, Herba Scutellariae indicae 8 ~ 18 parts and Caulis et Folium Brassicae campestris 5 ~ 15 parts.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: bitter sky eggplant 7 ~ 12 parts, Semen Amaranthi tricoloris 10 ~ 15 parts, Aeschna melanictera 18 ~ 23 parts, Cortex Linderae Fragrantis 12 ~ 17 parts, Folium Hibisci Mutabilis 13 ~ 18 parts, Herba Lysimachiae Circaeoidis 22 ~ 27 part, glass chrysanthemum 20 ~ 25 parts, Calyx Seu Fructus Physalis 13 ~ 18 parts, Herba Malvastri Coromandeliani 25 ~ 30 parts, Herba Urariae crinitae 17 ~ 22 parts, Herba rhynchosiae volubilis 22 ~ 27 parts, Herba Cladoniae rangiferinae 10 ~ 15 parts, Herba Scutellariae indicae 11 ~ 16 parts and Caulis et Folium Brassicae campestris 8 ~ 13 parts.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: bitter sky eggplant 12 parts, Semen Amaranthi tricoloris 10 parts, Aeschna melanictera 22 parts, Cortex Linderae Fragrantis 13 parts, Folium Hibisci Mutabilis 16 parts, Herba Lysimachiae Circaeoidis 24 part, glass chrysanthemum 24 parts, Calyx Seu Fructus Physalis 14 parts, Herba Malvastri Coromandeliani 28 parts, Herba Urariae crinitae 18 parts, Herba rhynchosiae volubilis 26 parts, Herba Cladoniae rangiferinae 12 parts, Herba Scutellariae indicae 15 parts and Caulis et Folium Brassicae campestris 9 parts.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: bitter sky eggplant 8 parts, Semen Amaranthi tricoloris 14 parts, Aeschna melanictera 20 parts, Cortex Linderae Fragrantis 15 parts, Folium Hibisci Mutabilis 15 parts, Herba Lysimachiae Circaeoidis 26 part, glass chrysanthemum 20 parts, Calyx Seu Fructus Physalis 16 parts, Herba Malvastri Coromandeliani 25 parts, Herba Urariae crinitae 20 parts, Herba rhynchosiae volubilis 24 parts, Herba Cladoniae rangiferinae 14 parts, Herba Scutellariae indicae 12 parts and Caulis et Folium Brassicae campestris 12 parts.
When the dosage form of described Chinese medicine is unguentum, its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, decocts with water 2 ~ 4 times, each 1 ~ 3 hour, add the water of 6 ~ 10 times amount, decoction liquor is filtered at every turn, merge the filtrate of each time, add determining alcohol be 90% ~ 95% ethanol to alcohol content be 40% ~ 50%, leave standstill 3 ~ 5 hours, filter, filtrate concentrates, and drying is also pulverized, and obtains mixed-powder, cross 200 mesh sieves, adopt ultra violet lamp sterilizing in 1 ~ 2 hour;
Second step, relative to mixed-powder described in 100 weight portions that the first step obtains, 1 weight portion ~ 3 weight portion stearic acid, 0.5 weight portion ~ 1.5 weight portion stearyl alcohol, 0.5 weight portion ~ 1.5 weight portion glyceryl monostearate, 3 weight portion ~ 5 weight portion liquid Paraffin, 8 weight portion ~ 10 weight portion dimethicones are mixed and heated to 75 DEG C ~ 85 DEG C, under constantly stirring, add 1 weight portion ~ 3 part by weight of vitamin E dissolve, obtain oil phase;
3rd step, relative to mixed-powder described in 100 weight portions that the first step obtains, 0.5 weight portion ~ 1.5 weight portion sodium lauryl sulphate, 0.5 weight portion ~ 1.5 weight portion triethanolamine, 1 weight portion ~ 2 weight portion ethyl hydroxybenzoate, 1000 weight portion ~ 1500 weight portion distilled water are mixed and heated to 75 DEG C ~ 85 DEG C, obtain aqueous phase;
4th step, the oil phase obtained by second step slowly adds in the aqueous phase of the 3rd step acquisition under constantly stirring, and fully stirs 30 minutes ~ 1 hour, makes emulsifying, add the mixed-powder that the first step obtains, stir, subpackage at the temperature of 60 DEG C ~ 70 DEG C.
When above-mentioned the dosage form of Chinese medicine is injectable powder described in any one time, its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.
Embodiment 1: unguentum
Get bitter sky eggplant 120g, Semen Amaranthi tricoloris 100g, Aeschna melanictera 220g, Cortex Linderae Fragrantis 130g, Folium Hibisci Mutabilis 160g, Herba Lysimachiae Circaeoidis 240g, cup chrysanthemum 240g, Calyx Seu Fructus Physalis 140g, Herba Malvastri Coromandeliani 280g, Herba Urariae crinitae 180g, Herba rhynchosiae volubilis 260g, Herba Cladoniae rangiferinae 120g, Herba Scutellariae indicae 150g and Caulis et Folium Brassicae campestris 90g.
Its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, decocts with water 3 times, each 3 hours, add the water of 7 times amount, decoction liquor is filtered at every turn, merge the filtrate of each time, add determining alcohol be 95% ethanol to alcohol content be 50%, leave standstill 5 hours, filter, filtrate concentrates, and drying is also pulverized, and obtains mixed-powder, cross 200 mesh sieves, adopt ultra violet lamp sterilizing in 2 hours;
Second step, relative to mixed-powder described in 100 weight portions that the first step obtains, 2 weight portion stearic acid, 1.2 weight portion stearyl alcohol, 0.9 weight portion glyceryl monostearate, 4.5 weight portion liquid Paraffin, 9 weight portion dimethicones are mixed and heated to 85 DEG C, under constantly stirring, add 3 part by weight of vitamin E dissolve, obtain oil phase;
1.5 weight portion sodium lauryl sulphates, 1 weight portion triethanolamine, 1.6 weight portion ethyl hydroxybenzoates, 1200 weight portion distilled water relative to mixed-powder described in 100 weight portions that the first step obtains, are mixed and heated to 80 DEG C, obtain aqueous phase by the 3rd step;
4th step, the oil phase obtained by second step slowly adds in the aqueous phase of the 3rd step acquisition under constantly stirring, and fully stirs 1 hour, makes emulsifying, add the mixed-powder that the first step obtains, stir, subpackage at the temperature of 65 DEG C.
Embodiment 2: injectable powder
Get bitter sky eggplant 80g, Semen Amaranthi tricoloris 140g, Aeschna melanictera 200g, Cortex Linderae Fragrantis 150g, Folium Hibisci Mutabilis 150g, Herba Lysimachiae Circaeoidis 260g, cup chrysanthemum 200g, Calyx Seu Fructus Physalis 160g, Herba Malvastri Coromandeliani 250g, Herba Urariae crinitae 200g, Herba rhynchosiae volubilis 240g, Herba Cladoniae rangiferinae 140g, Herba Scutellariae indicae 120g and Caulis et Folium Brassicae campestris 120g;
Its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 5 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 25 hours under the condition of 7 DEG C, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 50 minutes at this, the micron particles of acquisition 2 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets the mixed powder 15g that second step obtains, adds propylene glycol 40g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g needle-use activated carbon, fully stirs 35 minutes; Decarbonization filtering; With 0.23 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
Medicine for external use toxicity test:
1, experimental technique: depilatory is evenly coated by 4 groups of Cavia porcelluss (often organizing 15) spinal column both sides, back, makes unhairing scope about 40 square centimeters.Clean depilatory returns cage to observe 24 hours, wherein three groups, often organize Cavia porcellus and be coated with Chinese medicine preparation externally used paste 0.3,0.5 of the present invention and 0.8ml respectively, respectively containing crude drug 90mg, 150mg and 240mg, another group is coated with solvent 0.8ml, every twice-daily, continuous one week, after experiment terminates, Cavia porcellus is put to death, the heart, liver, kidney and depilation skin do pathological examination.
2, result: above-mentioned three groups of medication Cavia porcellus trunks depilation district, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group Cavia porcellus chroma of hair, ingest, matched group no significant difference, histopathologic examination, the medication group heart, liver, kidney and depilation skin and the matched group more also no significant difference such as extremity are movable.
Result is pointed out, and Chinese medicine for external application of the present invention, without local irritant effect, also has no general toxicity performance.Show Chinese medicine for external application use safety of the present invention.
Clinical data:
Case selection: whole 82 routine cases are my Out-patient Department or the extravasation of contrast media patient that is in hospital, wherein, male 40 example, women 42 example, 28 ~ 68 years old age.Be divided into treatment group and matched group at random, wherein, treatment group 41 people, wherein, male 22 example, women 19 example, 28 ~ 58 years old age; Slight 38 examples, severe 4 example; Exosmose area < 3cm
2person 12 example, exosmose area 3 ~ 6cm
2person 22 example, exosmose area>=7cm
2person 7 example.Matched group 41 people, wherein, male 18 example, women 23 example, 31 ~ 69 years old age; Slight 39 examples, severe 3 example; Exosmose swelling area < 3cm
2person 13 example, exosmose swelling area 3 ~ 6cm
2person 22 example, exosmose swelling area>=7cm
2person 6 example.Two groups of patients equal not statistically significant of comparing difference (p>0.05) in sex, age, clinical manifestation etc.
Clinical manifestation: patients with mild, shows as surrounding or the antetheca swelling of point of puncture, and the pain touched or mild pain, can stand.Severe patient, point of puncture local obvious tumefaction or upper limb Severe edema, skin tension is strong, and pain heavier being difficult to stands, limb activity dysfunction, and surface, swelling portion can occur blister.
Therapeutic Method:
Treatment group: give the external application of the embodiment of the present invention 1 unguentum, to exceed extent of disease 1 ~ 2cm, thickness about 1 ~ 2mm is advisable, and available preservative film covers, two ends immobilization with adhesive tape, volatilizees and pollution clothes or bedding to prevent liniment, every day 2 times; It within 5 days, is 1 course for the treatment of; And enjoin patient's lifting affected limb, be beneficial to venous return.
Matched group: get sterile gauze and dip in 50% Adlerika local wet dressing, soak area exceeds diseased region 1 ~ 2cm, available preservative film covers, two ends immobilization with adhesive tape, and volatilizing to prevent liniment and pollution clothes or bedding, 5 days is 1 course for the treatment of; And enjoin patient's lifting affected limb, be beneficial to venous return.
Curative effect judging standard: cure: local pain disappears, swelling disappears, and skin elasticity recovers normal.Effective: local pain obviously alleviates, the wound surface area of swelling reduces more than 60%.Invalid: local skin swelling, pain are not alleviated, even there is phlebitis, tissue necrosis or form ulcer.
Therapeutic outcome: two groups treat 5 days respectively after, statistical result is see table 1.
A table 1 liang group treats two groups of comparitive study (example) after 5 days respectively:
| Group | n | Cure | Effectively | Invalid | Effectively total |
| Treatment group | 41 | 36 | 5 | 0 | 41(100％) |
| Matched group | 41 | 29 | 9 | 3 | 38(92.68％) |
As can be seen from Table 1, adopt treatment by Chinese herbs extravasation of contrast media of the present invention, relative to matched group on therapeutic effect, there is significant improvement.
A table 2 liang group treats 5 days healing numbers afterwards and time comparative example (%) respectively
| Group | n | Medication 2 days | Medication 3 days | Medication 4 days | Medication 5 days |
| Treatment group | 35 | 20(48.8％) | 27(65.9％) | 32(78.0％) | 36(87.8％) |
| Matched group | 29 | 13(31.7％) | 18(43.9％) | 23(56.1％) | 29(70.7％) |
As can be seen from Table 2, adopt treatment by Chinese herbs extravasation of contrast media of the present invention, relative to matched group, not only better efficacy, takes effect also faster.
Untoward reaction: anaphylaxis or other untoward reaction all do not appear in two groups of patients.
Concrete case: Lee, women, 59 years old, suffers from hepatocarcinoma, need to carry out CT enhanced ct scans, in injection of contrast medium process, surrounding's discovery swelling of point of puncture, mild pain, the pain touched increases the weight of, but can stand, be judged as extravasation of contrast media, may be relevant with long-term chemotherapy blood vessel elasticity difference, stop immediately injecting and pulling out pin, pull out the outer sepage of the front resorption as far as possible of pin, site of puncture is pressed with disinfecting cotton swab, blood extravasation is avoided to increase the weight of local swelling, after conventional treatment, give the external application of the embodiment of the present invention 1 unguentum, external application scope exceeds extent of disease 1 ~ 2cm, thickness is 1 ~ 2mm about, cover with preservative film, two ends immobilization with adhesive tape, volatilize and pollution clothes or bedding to prevent liniment, every day 2 times, and enjoin patient's lifting affected limb, be beneficial to venous return.Medication 2 days, local pain disappears, and swelling disappears, and skin elasticity recovers normal, cures.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (9)
1. the Chinese medicine of an image department treatment CT scan extravasation of contrast media, it is characterized in that, each raw medicinal material of described Chinese medicine comprises: bitter sky eggplant, Semen Amaranthi tricoloris, Aeschna melanictera, Cortex Linderae Fragrantis, Folium Hibisci Mutabilis, Herba Lysimachiae Circaeoidis, cup chrysanthemum, Calyx Seu Fructus Physalis, Herba Malvastri Coromandeliani, Herba Urariae crinitae, Herba rhynchosiae volubilis, Herba Cladoniae rangiferinae, Herba Scutellariae indicae and Caulis et Folium Brassicae campestris.
2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: bitter sky eggplant 5 ~ 15 parts, Semen Amaranthi tricoloris 10 ~ 20 parts, Aeschna melanictera 15 ~ 25 parts, Cortex Linderae Fragrantis 10 ~ 20 parts, Folium Hibisci Mutabilis 10 ~ 20 parts, Herba Lysimachiae Circaeoidis 20 ~ 30 part, glass chrysanthemum 20 ~ 30 parts, Calyx Seu Fructus Physalis 10 ~ 20 parts, Herba Malvastri Coromandeliani 20 ~ 30 parts, Herba Urariae crinitae 15 ~ 25 parts, Herba rhynchosiae volubilis 20 ~ 30 parts, Herba Cladoniae rangiferinae 10 ~ 20 parts, Herba Scutellariae indicae 8 ~ 18 parts and Caulis et Folium Brassicae campestris 5 ~ 15 parts.
3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: bitter sky eggplant 7 ~ 12 parts, Semen Amaranthi tricoloris 10 ~ 15 parts, Aeschna melanictera 18 ~ 23 parts, Cortex Linderae Fragrantis 12 ~ 17 parts, Folium Hibisci Mutabilis 13 ~ 18 parts, Herba Lysimachiae Circaeoidis 22 ~ 27 part, glass chrysanthemum 20 ~ 25 parts, Calyx Seu Fructus Physalis 13 ~ 18 parts, Herba Malvastri Coromandeliani 25 ~ 30 parts, Herba Urariae crinitae 17 ~ 22 parts, Herba rhynchosiae volubilis 22 ~ 27 parts, Herba Cladoniae rangiferinae 10 ~ 15 parts, Herba Scutellariae indicae 11 ~ 16 parts and Caulis et Folium Brassicae campestris 8 ~ 13 parts.
4. the Chinese medicine as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: bitter sky eggplant 12 parts, Semen Amaranthi tricoloris 10 parts, Aeschna melanictera 22 parts, Cortex Linderae Fragrantis 13 parts, Folium Hibisci Mutabilis 16 parts, Herba Lysimachiae Circaeoidis 24 part, glass chrysanthemum 24 parts, Calyx Seu Fructus Physalis 14 parts, Herba Malvastri Coromandeliani 28 parts, Herba Urariae crinitae 18 parts, Herba rhynchosiae volubilis 26 parts, Herba Cladoniae rangiferinae 12 parts, Herba Scutellariae indicae 15 parts and Caulis et Folium Brassicae campestris 9 parts.
5. the Chinese medicine as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: bitter sky eggplant 8 parts, Semen Amaranthi tricoloris 14 parts, Aeschna melanictera 20 parts, Cortex Linderae Fragrantis 15 parts, Folium Hibisci Mutabilis 15 parts, Herba Lysimachiae Circaeoidis 26 part, glass chrysanthemum 20 parts, Calyx Seu Fructus Physalis 16 parts, Herba Malvastri Coromandeliani 25 parts, Herba Urariae crinitae 20 parts, Herba rhynchosiae volubilis 24 parts, Herba Cladoniae rangiferinae 14 parts, Herba Scutellariae indicae 12 parts and Caulis et Folium Brassicae campestris 12 parts.
6. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is unguentum, and its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, decocts with water 2 ~ 4 times, each 1 ~ 3 hour, add the water of 6 ~ 10 times amount, decoction liquor is filtered at every turn, merge the filtrate of each time, add determining alcohol be 90% ~ 95% ethanol to alcohol content be 40% ~ 50%, leave standstill 3 ~ 5 hours, filter, filtrate concentrates, and drying is also pulverized, and obtains mixed-powder, cross 200 mesh sieves, adopt ultra violet lamp sterilizing in 1 ~ 2 hour;
Second step, relative to mixed-powder described in 100 weight portions that the first step obtains, 1 weight portion ~ 3 weight portion stearic acid, 0.5 weight portion ~ 1.5 weight portion stearyl alcohol, 0.5 weight portion ~ 1.5 weight portion glyceryl monostearate, 3 weight portion ~ 5 weight portion liquid Paraffin, 8 weight portion ~ 10 weight portion dimethicones are mixed and heated to 75 DEG C ~ 85 DEG C, under constantly stirring, add 1 weight portion ~ 3 part by weight of vitamin E dissolve, obtain oil phase;
3rd step, relative to mixed-powder described in 100 weight portions that the first step obtains, 0.5 weight portion ~ 1.5 weight portion sodium lauryl sulphate, 0.5 weight portion ~ 1.5 weight portion triethanolamine, 1 weight portion ~ 2 weight portion ethyl hydroxybenzoate, 1000 weight portion ~ 1500 weight portion distilled water are mixed and heated to 75 DEG C ~ 85 DEG C, obtain aqueous phase;
4th step, the oil phase obtained by second step slowly adds in the aqueous phase of the 3rd step acquisition under constantly stirring, and fully stirs 30 minutes ~ 1 hour, makes emulsifying, add the mixed-powder that the first step obtains, stir, subpackage at the temperature of 60 DEG C ~ 70 DEG C.
7. the Chinese medicine as described in claim 1 to 5, is characterized in that, when the dosage form of described Chinese medicine is injectable powder, its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
8. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is unguentum, and its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, decocts with water 2 ~ 4 times, each 1 ~ 3 hour, add the water of 6 ~ 10 times amount, decoction liquor is filtered at every turn, merge the filtrate of each time, add determining alcohol be 90% ~ 95% ethanol to alcohol content be 40% ~ 50%, leave standstill 3 ~ 5 hours, filter, filtrate concentrates, and drying is also pulverized, and obtains mixed-powder, cross 200 mesh sieves, adopt ultra violet lamp sterilizing in 1 ~ 2 hour;
Second step, relative to mixed-powder described in 100 weight portions that the first step obtains, 1 weight portion ~ 3 weight portion stearic acid, 0.5 weight portion ~ 1.5 weight portion stearyl alcohol, 0.5 weight portion ~ 1.5 weight portion glyceryl monostearate, 3 weight portion ~ 5 weight portion liquid Paraffin, 8 weight portion ~ 10 weight portion dimethicones are mixed and heated to 75 DEG C ~ 85 DEG C, under constantly stirring, add 1 weight portion ~ 3 part by weight of vitamin E dissolve, obtain oil phase;
3rd step, relative to mixed-powder described in 100 weight portions that the first step obtains, 0.5 weight portion ~ 1.5 weight portion sodium lauryl sulphate, 0.5 weight portion ~ 1.5 weight portion triethanolamine, 1 weight portion ~ 2 weight portion ethyl hydroxybenzoate, 1000 weight portion ~ 1500 weight portion distilled water are mixed and heated to 75 DEG C ~ 85 DEG C, obtain aqueous phase;
4th step, the oil phase obtained by second step slowly adds in the aqueous phase of the 3rd step acquisition under constantly stirring, and fully stirs 30 minutes ~ 1 hour, makes emulsifying, add the mixed-powder that the first step obtains, stir, subpackage at the temperature of 60 DEG C ~ 70 DEG C.
9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is injectable powder, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106074956A (en) * | 2016-08-25 | 2016-11-09 | 丁长青 | A kind of Chinese medicine composition for the treatment of CT enhanced ct scans contrast agent seepage |
| CN106138522A (en) * | 2016-07-22 | 2016-11-23 | 张文军 | A kind of liniment treating CT enhanced ct scans extravasation of contrast media and preparation method |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520427A (en) * | 2013-10-22 | 2014-01-22 | 姜永杰 | Traditional Chinese medicine for treating body-resistance-weak and pathogen-strong type chronic osteomyelitis and preparation method thereof |
| CN103655854A (en) * | 2012-09-18 | 2014-03-26 | 韩立丽 | External application medicine for treating phlebitis caused by intravenous infusion and using method thereof |
| CN104147367A (en) * | 2014-08-19 | 2014-11-19 | 李有花 | Sponginum for eliminating swelling caused by magnetic resonance contrast agent extravasation, and preparation method thereof |
| CN104840629A (en) * | 2015-05-18 | 2015-08-19 | 新希望六和饲料股份有限公司 | Drug composition for treating cat jaundice and preparation method thereof |
-
2016
- 2016-01-20 CN CN201610037802.9A patent/CN105560584A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103655854A (en) * | 2012-09-18 | 2014-03-26 | 韩立丽 | External application medicine for treating phlebitis caused by intravenous infusion and using method thereof |
| CN103520427A (en) * | 2013-10-22 | 2014-01-22 | 姜永杰 | Traditional Chinese medicine for treating body-resistance-weak and pathogen-strong type chronic osteomyelitis and preparation method thereof |
| CN104147367A (en) * | 2014-08-19 | 2014-11-19 | 李有花 | Sponginum for eliminating swelling caused by magnetic resonance contrast agent extravasation, and preparation method thereof |
| CN104840629A (en) * | 2015-05-18 | 2015-08-19 | 新希望六和饲料股份有限公司 | Drug composition for treating cat jaundice and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106138522A (en) * | 2016-07-22 | 2016-11-23 | 张文军 | A kind of liniment treating CT enhanced ct scans extravasation of contrast media and preparation method |
| CN106074956A (en) * | 2016-08-25 | 2016-11-09 | 丁长青 | A kind of Chinese medicine composition for the treatment of CT enhanced ct scans contrast agent seepage |
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