CN105535370A - Liniment for underarm odor patient and preparation method - Google Patents

Liniment for underarm odor patient and preparation method Download PDF

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CN105535370A
CN105535370A CN201610062572.1A CN201610062572A CN105535370A CN 105535370 A CN105535370 A CN 105535370A CN 201610062572 A CN201610062572 A CN 201610062572A CN 105535370 A CN105535370 A CN 105535370A
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parts
liniment
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bromhidrosis
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不公告发明人
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535—Perilla (beefsteak plant)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/58—Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
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    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/86—Violaceae (Violet family)
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    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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Abstract

The invention discloses liniment for an underarm odor patient. The liniment is prepared from the following active pharmaceutical ingredients in parts by weight: 8 to 12 parts of common perilla leaves, 6 to 11 parts of ficus carica, 7 to 12 parts of petasites folium, 4 to 9 parts of hog brake, 6 to 12 parts of yam, 9 to 13 parts of aglaia odorata flower, 7 to 14 parts of common perilla stems, 5 to 13 parts of Chinese violet, 3 to 9 parts of aster subulatus michx, 4 to 6 parts of buerger raspberry roots, 7 to 11 parts of lithargite, 3 to 8 parts of feather cockscomb seeds and 6 to 13 parts of moellendorf spikemoss herb. The liniment has the excellent effects that the theory of traditional Chinese medicine is used for analyzing the recipe composition; according to the research result of the pharmacological action and the physicochemical property of ingredients contained by each medicine, a preparation method of reasonable and stable active ingredients is obtained through research; the composition has the effects of sterilization, convergence, hidroschesis, deodorization, wind dispel and dampness removal; the underarm odor can be effectively removed; the curative effect is stable; the property is mild; no toxic or side effect exits.

Description

The liniment that bromhidrosis patient uses and preparation method
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to liniment and the preparation method of a kind of bromhidrosis patient use.
Background technology
Bromhidrosis is because the apocrine gland of patient is more flourishing, and while it secretes antiperspirant, collaborative secretion Organic substance is many, is degraded to the products such as short-chain fatty acid sulfide and ammonia and produces stink under skin surface bacterial action.Because apocrine gland is vigorous in adolescence secretion, therefore secondary disease is more common in person between twenty and fifty.Primary disease is disease that is a kind of and genetic correlation, and most of patients has obvious family history.The abnormal flavour of bromhidrosis patient adolescence and the hyperhidrosis phase in summer serious all the more, bring great misery to patients ' psychological, have a strong impact on the life of patient, work and social activity, have influence on the image of self, to the life direction of patient, career prospect brings huge loss, affects greatly human psychological.Bromhidrosis patient easily have a depression, and severe patient can threat to life.
At present, treating bromhidrosis simple effective method is the apocrine gland being surgically removed axillary region.Although the abnormal flavour of postoperative patients can obviously alleviate, but patient not only will bear larger misery, but also the series of problems such as the cicatricial contracture of post-operative complication, higher relapse rate and skin can be produced, also must bear high Operation Fee in addition, thus Drug therapy is still the Therapeutic Method of current most of patients first-selection.Current, the medicine for the treatment of bromhidrosis is numerous, but the chemosynthesis of most employing Western medicine, there is certain effect to elimination bromhidrosis, but can not effect a radical cure, easily recur.
Application publication number CN104906193A(application number 201510340084.8) Chinese invention patent document disclose one dispel bromhidrosis spraying and preparation method thereof, be made up of the raw material of following weight portion: lavandula angustifolia 5-15 part, Poria 10-20 part, Magnolia denudata Desr. 5-15 part, Moschus 15-25 part, Folium Artemisiae Argyi 5-15 part, rice vinegar 15-25 part, Flos Caryophylli 10-20 part, Herba Menthae 15-25 part.Application publication number CN104027776A(application number 201410288134.8) Chinese invention patent document disclose a kind of Chinese medicine for the treatment of bromhidrosis, be made up of the raw material of following weight portion: Fructus Perillae 4-10 part, Rhizoma Pinelliae 3-9 part, Rhizoma Zingiberis Recens 3-9 part, Calx 1-3 part, Radix Angelicae Dahuricae 3-9 part, Herba Menthae 2-6 part, Rhizoma Corydalis 3-9 part, MEIHUA BINGPIAN 0.1-0.3 part, Lithargyrum 0.1-0.5 part, Rhizoma Solani tuber osi 10-20 part, Folium Aleuritis Fordii 10-20 part, Radix Et Rhizoma Rhei 3-9 part, Radix Aristolochiae 1-2 part, Fructus Anisi Stellati 2-6 part, Aranea 0.3-1 part.Application publication number CN103638216A(application number 201310531261.1) Chinese invention patent document disclose a kind of Chinese medicine composition for the treatment of bromhidrosis, be made up of the raw material of following weight portion: dried Alumen 3-5, Calomelas 8-10, Fructus Cnidii 2-4, Nidus Vespae 4-6, Fructus Psoraleae 2-4, Herba Asari 1-2, Concha Ostreae 5-7, Rhizoma Chuanxiong 3-5, Herba Menthae 10-15, Flos Albiziae 7-9, Herba Taraxaci 3-5, Pollen Typhae 1-3, Herba Plantaginis 7-8, Herba Hyperici Japonici 2-4, french spinach 8-10, Radix Rhapontici 2-4, Herba Typhonii gigantei 1-3, Caulis et Folium cayratiae trifoliae 1-2 and tetrastigma hemsleyanum 1-2.
The Chinese medicine of current treatment bromhidrosis, not only treatment is longer for the course for the treatment of, somewhat expensive, and therapeutic effect is also not obvious, and cure routine low, relapse rate is high, is difficult to the needs meeting patient.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide that one is prepared simply, the property of medicine is gentle, the liniment that effective fast bromhidrosis patient uses and preparation method.
Technical scheme of the present invention is:
The liniment that bromhidrosis patient uses, is prepared from by following bulk drugs, is weight portion: Folium Perillae Frutescentis 8-12; Fructus Fici 6-11; Petasites japonicus 7-12; Rhizoma Osmundae Japonicae 4-9; Rhizoma Dioscoreae 6-12; Flos Aglaiae Odoratae flower 9-13; Caulis Perillae Frutescentis 7-14; Herba Violae 5-13; The careless 3-9 of auspicious company; Radix rubi buergeri 4-6; Lithargyrum 7-11; Semen Celosiae 3-8; Herba Selaginellae Moellendorfii 6-13.
In preferred scheme, Folium Perillae Frutescentis 9-11; Fructus Fici 8-9; Petasites japonicus 9-10; Rhizoma Osmundae Japonicae 6-7; Rhizoma Dioscoreae 8-10; Flos Aglaiae Odoratae flower 10-12; Caulis Perillae Frutescentis 9-12; Herba Violae 7-11; The careless 5-7 of auspicious company; Radix rubi buergeri 4.5-5.5; Lithargyrum 8-10; Semen Celosiae 4.5-6.5; Herba Selaginellae Moellendorfii 8-11.
Be more preferably, Folium Perillae Frutescentis 10; Fructus Fici 8.5; Petasites japonicus 9.5; Rhizoma Osmundae Japonicae 6.5; Rhizoma Dioscoreae 9; Flos Aglaiae Odoratae spends 11; Caulis Perillae Frutescentis 10.5; Herba Violae 9; Auspicious even grass 6; Radix rubi buergeri 5; Lithargyrum 9; Semen Celosiae 5.5; Herba Selaginellae Moellendorfii 9.5.
The preparation method of the liniment that bromhidrosis patient uses, step is as follows:
(1) by broken for Flos Aglaiae Odoratae pollen, sieve, be placed in round-bottomed flask, add distilled water immersion 2-5 hour the distilled water immersion of 20 times amount (preferably add 3.5 hours) of 15-25 times amount, then according to extraction by steam distillation volatile oil, for subsequent use;
(2) Rhizoma Osmundae Japonicae is placed in non iron container, add concentration be the saline solution of 10%-30% mix thoroughly (preferably add concentration be 20% saline solution mix thoroughly), vexed 30-50 minute (preferably vexed 40 minutes), taking-up, intense fire stir-fry to surface is coke black, inside is sepia, takes out, cool, for subsequent use;
(3) Rhizoma Osmundae Japonicae after step (2) being processed mixes with Lithargyrum, Semen Celosiae and Herba Selaginellae Moellendorfii, smash into coarse powder to pieces, be placed in Chinese medicament extracting device, take ethanol as solvent, heating and refluxing extraction twice, each respectively extraction 30-56 minute (preferably each each extraction 43 minutes), merge twice alcohol extract, filter, reclaim ethanol, filtrate is for subsequent use;
(4) surplus stock medicine is placed in medicine pot, adds pure water and soak, then slow fire boiling 55-75 minute (preferred slow fire boiling 65 minutes), filter, filtrate reduced in volume, to 1/4 of original volume, is cooled to room temperature, merge with step (3) gained filtrate, obtain mixed solution, for subsequent use;
(5) in step (1) gained volatile oil, add the dehydrated alcohol (preferably adding the dehydrated alcohol of 1.3 times amount) of 1-1.6 times amount, obtain shallow yellow transparent solution, mix with step (4) gained mixed solution, sterilizing encapsulates, and to obtain final product.
The preparation method of the liniment that above-mentioned bromhidrosis patient uses, preferred scheme is, the middle 40-90 mesh sieve excessively of step (1) (preferred 55-75 mesh sieve excessively, mistake 65 mesh sieve be more preferably).
The preparation method of the liniment that above-mentioned bromhidrosis patient uses, preferred scheme is, in step (2), the amount of saline solution is the 0.65-1.05 of described raw material dose doubly (amount of preferred saline solution is 0.75-0.95 times of described raw material dose, and the amount of the saline solution be more preferably is 0.85 times of described raw material dose).
The preparation method of the liniment that above-mentioned bromhidrosis patient uses, preferred scheme is, in step (3), the concentration of ethanol is the concentration of the preferred ethanol of 45%-75%(is 55%-65%, and the concentration of the ethanol be more preferably is 60%).
The preparation method of the liniment that above-mentioned bromhidrosis patient uses, preferred scheme is, in step (3), the amount of solvent is the 10-15 of described raw material dose doubly (amount of preferred solvent is 11-14 times of described raw material dose, and the amount of the solvent be more preferably is 12.5 times of described raw material dose).
The preparation method of the liniment that above-mentioned bromhidrosis patient uses, preferred scheme is, in step (4), the amount of pure water is the 14-17 of described raw material dose doubly (amount of preferred pure water is 15-16 times of described raw material dose, and the amount of the pure water be more preferably is 15.5 times of described raw material dose).
The preparation method of the liniment that above-mentioned bromhidrosis patient uses, preferred scheme is, the time of soaking in step (4) is 3-5 hour (the preferred time of soaking is 3.5-4.5 hour, and the time of the immersion be more preferably is 4 hours).
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Folium Perillae Frutescentis: base is former: be the leaf of labiate common perilla.Chemical analysis: containing perillaldehyde, perilla ketone, perfume (or spice) needs ketone, left-handed limonene, pinene, myristicin, dill-apiol, stigmasterol.Nature and flavor: acrid in the mouth; Warm in nature.Gui Jing: return lung; Spleen channel.Function cures mainly: dispelling wind and ventilating the lung; Regulate the flow of vital energy and help digestion, solving toxin of fish and crab.Main cold; Cough and asthma; Gastral cavity abdominal distention is vexed; Accumulation of food in the stomach and intes tine due to indigestion; Vomit and diarrhoea; Cold-dysentery; Middle fish Eriocheir sinensis poison; Man's swelling of the vulva; Limb edema due to disorder of QI poison; Snake bite and insect sting.
Fructus Fici: base is former: be the dry holder of moraceae plants Fructus Fici.Pharmacological action: 1.Fructus Fici is containing abundant nutritional labeling, edible.When constipation, can be used as food aperient.2。The material of water extract gained after active carbon, acetone treatment of dry fruit has the effect of anti-Emhorn sarcoma.3。In immature fruit, the milk of gained can suppress rat implantation sarcoma, mice spontaneous mammary carcinoma, causes neoplasm necrosis; The development of transplantability adenocarcinoma, myelomatosis, lymphosarcoma can be delayed again, make it degenerate.Nature and flavor: sweet; Cool in nature.Gui Jing: lung; Stomach; Large intestine channel.Function cures mainly: clearing away heat and promoting production of body fluid; Spleen benefiting and stimulating the appetite; Removing toxic substances and promoting subsidence of swelling.Main laryngopharynx swelling and pain; Cough caused by dryness hoarseness; Milk is rare; The hot constipation of intestinal; Inappetence; Dyspepsia, dysentery; Carbuncle; Tinea disease.
Petasites japonicus: base is former: be rhizome and the herb of feverfew Petasites japonicus.Chemical analysis: root is containing petasin 50 ~ 55%; also containing carene-3, eremophilene, α-Lignum Santali Albi terpenes, thymol methyl ether, furan eremophilane, ligularone, petasalbin and its angelate, 6-hydroxyeremophilenolide, petasalbin methyl ether, furanofukinol, 6-acetyl furan Petasites japonicus alcohol, 6-angeloyl groups furanofukinol, furanopetasitin, furanojaponin, and choline, protocatechuic acid, angelic acid, caproic acid, sad, cupreol, flavone compound etc.Nature and flavor: " Jiangxi medical herbs ": " toil, cool." function cures mainly: 1. " Jiangxi medical herbs ": " detoxification and removing stasis.Treating tonsillitis, carbuncle furunculosis, venom." 2. " Zhejiang conventional medical herbs among the people ": " reducing swelling and alleviating pain, detoxification and removing stasis.Control traumatic injury, venom.”
Rhizoma Osmundae Japonicae: base is former: be rhizome and the petiole residual base of Osmundaceae plant osmund.Chemical analysis: Rhizoma Osmundae Japonicae rhizome is containing dryocrassin and multiple Ginkgolide Component: osmundalactone, 5-hydroxyl-2-hexenoic acid-4-lactone, 5-hydroxycaproic acid-4-lactone, 3-hydroxycaproic acid-5-lactone, glucosyl group osmundalactone, the different glucosyl group osmundalactone of dihydro, 2-deoxidation-2-ribopyranose lactone.Also containing class sorbic acid glycoside, 5-hydroxyl-3-(β-D-glucopyra glycosyloxy base) methyl caproate, maltol-β-D-glucopyanoside, 5 hydroxymethyl 2 furaldehyde, glycerol, succinic acid, sharp leaf soil China fir sterone A, ecdysterone, ecdysone and polysaccharide.Pharmacological action: 1. anthelmintic action: when the rhizome of Rhizoma Osmundae Japonicae and the decoct of petiole base are diluted to 16% concentration, external have suppression in various degree and relexation to ascaris suum head section, the decoct of 50%-60% is to overall ascaris suum effect after 2-6 hour, and the activity of ascaris suum is in suppression in various degree.Osmund extract has good therapeutic effect to expeling human body intestinal anthelmintic.2. can resist the attack of adenovirus type III (Ad3) to the HeLa cell monolayer cultivated after the Rhizoma Osmundae Japonicae aqueous extract of antivirus action: 1g/ml dilutes 320 times, have stronger anti-Ad3 active; The attack of herpes simplex virus I-type to hepatoma carcinoma cell (Hep-2 cell) can be resisted.3., on the impact of blood clotting: to rabbit oral osmund aqueous extract 11.1g/kg, every day 1 time, totally 4 times, rabbit prothrombin time can be shortened.100% osmund decoct can obviously shorten the clotting time of exempting from.Osmund extract has the effect showing and suppress blood clotting.Nature and flavor: bitter; Be slightly cold; Slightly poisonous.Gui Jing: spleen; Stomach warp.Function cures mainly: heat-clearing and toxic substances removing; Hemostasis by removing blood stasis; Parasite killing.Main flow sense; Epidemic encephalitis; Encephalitis b; Parotitis; Carbuncle pyogenic infections from tumour or sore; Measles; Chickenpox; Dysentery; Spit blood; Epistaxis; Have blood in stool; Metrorrhagia; Leukorrhagia; Pinworm; Cestode; The intestinal parasitical diseases such as ancylostome.
Rhizoma Dioscoreae: base is former: this product is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae.Nature and flavor: sweet are flat.Gui Jing: return spleen, lung, kidney channel.Effect: spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.Cure mainly: for insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.
Flos Aglaiae Odoratae flower: base is former: be the flower of Meliaceae plant Flos Aglaiae Odoratae.Chemical analysis: flower is containing volatile oil, and the main component in volatile oil has: a-Humuleno, the a-flaw in a piece of jade (king's bar) alkene, β-Flos Caryophylli alkene, β-cubebene, β-gurjunene and cubebene etc.Nature and flavor: pungent; Sweet; Flat.Function cures mainly: promoting the circulation of QI to alleviate the stagnation in middle-JIAO; Lung qi dispersing cough-relieving.Main chest and diaphragm is full vexed; Dysphagic from the beginning of; Cold cough.
Caulis Perillae Frutescentis: base is former: be the stem of labiate common perilla.Nature and flavor: " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " acrid in the mouth, warm in nature, nontoxic." return through " Traditional Chinese Medicine in Sichuan will ": " enter lung, spleen two warp." function cures mainly: pleasant, help digestion, pain relieving, antiabortive.Control the stagnation of QI, dyspepsia, chest and diaphragm painful abdominal mass is vexed, epigastric pain, and nausea is got along well.
Herba Violae: base is former: this product is the dry herb of Violaceae Chinese violet.Nature and flavor: bitter, acrid, cold.Gui Jing: GUIXIN, Liver Channel.Function with cure mainly: heat-clearing and toxic substances removing, removing heat from blood subside a swelling.For furuncle swelling toxin, carbuncle carbuncle on the back, erysipelas, venom.
Auspicious even grass: base is former: be the herb that feverfew bores leaf Radix Asteris.Chemical analysis: herb is containing apigenin-7-O-beta-D glycoside, apigenin-7-O-beta-D-galactoside, Kaempferol-O-β-D glycoside 3-O-β-D-galactoside-O-α-L-rhamanopyranosyl nimbecetin, Quercetin-3-O-β-D-glucopyranoside and apigenin, nimbecetin, luteolin, Quercetin and chlorogenic acid.Nature and flavor: bitter in the mouth; Acid; Cool in nature.Function cures mainly: heat-clearing and toxic substances removing.Main carbuncle; Eczema.
Radix rubi buergeri: base is former: for rosaceous plant is trembled with fear the root of the certain kind of berries.Nature and flavor: bitter; Acid; Cold.Gui Jing: liver; Kidney channel.Function cures mainly: heat-clearing and toxic substances removing; Promoting blood circulation and stopping pain.Main jaundice due to damp-heat; Puerperal fever; Infantile hyperpyrexia; Menoxenia; Leukorrhagia; Stomachache folic acid; Swelling and pain of hemorrhoid; Anus fistulae.
Lithargyrum: base is former: for crude oxidation is plumbous.Chemical analysis: mainly containing lead oxide; Still containing field trashes such as a small amount of sandstone, metallic lead, Lead oxide brown.And micro lead, antimony, ferrum, calcium, magnesium etc.Pharmacological action: be inhibitory action to the little sporeformer of homocentricity trichophyton, trichophyton, trichophyton and rust in test tube during Lithargyrum's cream 2% concentration; When 4% concentration, to acrothesium floccosum, trichophyton gypseum, sufficient sole of the foot trichophyton, trichophyton interdigitale, oidium schoenleinii and Mongolian mutation thereof etc. all in inhibitory action.Water logging agent (1: 3) also has inhibitory action in various degree to various skin fungus in vitro.Can reduce inflammation as medicine for external use.The preserved material of 1:3 has inhibitory action to dermatophytess such as trichophyton, the little full daughter bacterias of rust in vitro.Nature and flavor: salty; Pungent; Flat; Poisonous.Gui Jing: liver; Spleen channel.Function cures mainly: dampness; Parasite killing; Convergence; Anticorrosion; Removing toxic substances; .Main skin infection festers for a long time not convergence; Aphtha; Scabies; Bromhidrosis; Tinea versicolor; (black dry) is dim; Wine Zha nose; Burn and scald; Eczema.
Semen Celosiae: base is former: be the seed of amaranthaceous plant Herba Celosiae argenteae.Chemical analysis: the fatty oil of Semen Celosiae about 15%, starch 30.8%, nicotinic acid about 14 μ g/g and abundant potassium nitrate.Contained fatty oil is called Semen Celosiae oils and fats.Pharmacological action: 1. antibacterial action savors decoct has comparatively high inhibition effect to bacillus pyocyaneus, and infected wound is through using 10% decoct, and bacillus pyocyaneus not regrowth, to wound without obvious stimulation.2. dry powder can shorten plasma in rabbit recalcification time.3. have reducing iop Semen Celosiae decocting liquid (every 1ml is equivalent to 1g crude drug) to have no significant effect normal rabbits pupil, continuous use is after 6 days, and intraocular pressure has slight decline, and matched group comparing difference shows, but the intraocular pressure after Water l oad can not be stoped to raise.Nature and flavor: bitter; Cold in nature.Gui Jing: Liver Channel.Function cures mainly: people's heat of dispelling; Clearing away liver-fire; Improving acuity of vision and removing nebula.Main conjunctival congestion and swelling pain; Nebula of looking unfamiliar film; Blurring of vision; Hypertension; Epistaxis; Skin wind heat pruritus; Skin ulcer tinea.
Herba Selaginellae Moellendorfii: base is former: be the herb of Spikemoss plant Herba Selaginellae Involventis.Chemical analysis: containing different beans flavored with aniseed essence, cupreol, Palmic acid, stearic acid.Pharmacological action: 1, anastalsis: extract (may for aldehydes composition) in vitro and whole animal all have and accelerate blood clotting and anastalsis, can postpone fibrinous dissolving, can increase total number of blood platelet in rabbit peripheral blood, leukocyte count also has rising.Nature and flavor: sweet; Pungent; Flat; Nontoxic.Gui Jing: liver; Gallbladder; Lung meridian.Function cures mainly: clearing away heat-damp and promoting diuresis; Hemostasis.Main lung-heat spitting of blood; Spit blood; Epistaxis; Have blood in stool; Bleeding hemorrhoids; Traumatic hemorrhage; Heating; Infantile convulsion; Jaundice due to damp-heat; Gonorrhea; Edema; Burn due to hot liquid or fire.
The liniment that bromhidrosis patient provided by the invention uses, scientific formula, preparation method is simple, taking convenience.In addition, excellent results of the present invention also shows:
1, the present invention uses theory of Chinese medical science to analyze prescription composition, and according to each physicochemical property of flavour of a drug ingredient and the result of study of pharmacological action, research obtains the preparation method of reasonable, stable active component;
2, this prescription has sterilization, convergence, antiperspirant deodorant, effect of loose wind dehumidifying, and effectively can remove bromhidrosis, stable curative effect, performance is gentle, has no side effect;
3, medicine source is easy to get, and medical material is with low cost, can relieve patient ' s burden.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
The liniment that embodiment 1 bromhidrosis patient uses, is prepared from by following bulk drugs, is weight portion (300g/ part): Folium Perillae Frutescentis 8 parts; Fructus Fici 6 parts; Petasites japonicus 7 parts; Rhizoma Osmundae Japonicae 4 parts; Rhizoma Dioscoreae 6 parts; Flos Aglaiae Odoratae spends 9 parts; Caulis Perillae Frutescentis 7 parts; Herba Violae 5 parts; Auspicious even grass 3 parts; Radix rubi buergeri 4 parts; Lithargyrum 7 parts; Semen Celosiae 3 parts; Herba Selaginellae Moellendorfii 6 parts.
The preparation method of the liniment that bromhidrosis patient uses is:
(1) by broken for Flos Aglaiae Odoratae pollen, cross 40 mesh sieves, be placed in round-bottomed flask, add the distilled water immersion 2 hours of 15 times amount, then according to extraction by steam distillation volatile oil, for subsequent use;
(2) Rhizoma Osmundae Japonicae is placed in non iron container, the concentration adding 0.65 times of raw material dose be 10% saline solution mix thoroughly, vexed 30 minutes, take out, intense fire to be fried to surface in coke black, inner in sepia, take out, cool, for subsequent use;
(3) Rhizoma Osmundae Japonicae after step (2) being processed mixes with Lithargyrum, Semen Celosiae and Herba Selaginellae Moellendorfii, smash into coarse powder to pieces, being placed in Chinese medicament extracting device, take concentration as the ethanol of 45% is solvent, and wherein the amount of solvent is 10 times of described raw material dose, heating and refluxing extraction twice, each each extraction 30 minutes, merges twice alcohol extract, filters, reclaim ethanol, filtrate is for subsequent use;
(4) be placed in medicine pot by surplus stock medicine, the pure water adding 14 times of described raw material doses soaks 3 hours, then slow fire boiling 55 minutes, filter, filtrate reduced in volume, to 1/4 of original volume, is cooled to room temperature, merge with step (3) gained filtrate, obtain mixed solution, for subsequent use;
(5) in step (1) gained volatile oil, add the dehydrated alcohol of 1 times amount, obtain shallow yellow transparent solution, mix with step (4) gained mixed solution, sterilizing encapsulates, and to obtain final product.
The using method of gained liniment of the present invention is: after being cleaned up at axillary fossa position, gets the even wiping affected part of appropriate this product, every day 2-3 time, within 20 days, is a course for the treatment of.
The liniment that embodiment 2 bromhidrosis patient uses, is prepared from by following bulk drugs, is weight portion (100g/ part): Folium Perillae Frutescentis 12 parts; Fructus Fici 11 parts; Petasites japonicus 12 parts; Rhizoma Osmundae Japonicae 9 parts; Rhizoma Dioscoreae 12 parts; Flos Aglaiae Odoratae spends 13 parts; Caulis Perillae Frutescentis 14 parts; Herba Violae 13 parts; Auspicious even grass 9 parts; Radix rubi buergeri 6 parts; Lithargyrum 11 parts; Semen Celosiae 8 parts; Herba Selaginellae Moellendorfii 13 parts.
The preparation method of the liniment that bromhidrosis patient uses is:
(1) by broken for Flos Aglaiae Odoratae pollen, cross 90 mesh sieves, be placed in round-bottomed flask, add the distilled water immersion 5 hours of 25 times amount, then extract volatile oil according to vapor extraction method, for subsequent use;
(2) Rhizoma Osmundae Japonicae is placed in non iron container, add 1.05 times of raw material doses, concentration be 30% saline solution mix thoroughly, vexed 50 minutes, take out, intense fire to be fried to surface in coke black, inner in sepia, take out, cool, for subsequent use;
(3) Rhizoma Osmundae Japonicae after step (2) being processed mixes with Lithargyrum, Semen Celosiae and Herba Selaginellae Moellendorfii, smash into coarse powder to pieces, being placed in Chinese medicament extracting device, take concentration as the ethanol of 75% is solvent, and wherein the amount of solvent is 15 times of described raw material dose, heating and refluxing extraction twice, each each extraction 56 minutes, merges twice alcohol extract, filters, reclaim ethanol, filtrate is for subsequent use;
(4) be placed in medicine pot by surplus stock medicine, the pure water adding 17 times of described raw material doses soaks 5 hours, then slow fire boiling 75 minutes, filter, filtrate reduced in volume, to 1/4 of original volume, is cooled to room temperature, merge with step (3) gained filtrate, obtain mixed solution, for subsequent use;
(5) in step (1) gained volatile oil, add the dehydrated alcohol of 1.6 times amount, obtain shallow yellow transparent solution, mix with step (4) gained mixed solution, sterilizing encapsulates, and to obtain final product.
The using method of gained liniment of the present invention is: after being cleaned up at axillary fossa position, gets the even wiping affected part of appropriate this product, every day 2-3 time, within 20 days, is a course for the treatment of.
Model case: old XX, man, 21 years old, people from Zaozhuang.Patient is a student enrollment, has a bright and cheerful disposition, vivaciously active, fine in school popularity, Shi Jiao basketball team a member.Patient, because Inheritance reason, has suffered from bromhidrosis, though it is pretty good therefore to acquire university patient popularity from childhood, often custom is come and gone all alone, and often worries that the reason friend of self bromhidrosis can away from oneself.Patient once attempted the medicine using various treatment bromhidrosis, but mostly can only respite, can not thoroughly effect a radical cure.Afterwards household Drug therapy bromhidrosis of the present invention is evident in efficacy upon somebody's introduction, cure rate is high, then to come together my institute's treatment on August 11st, 2012 with patient.Use the liniment that the present embodiment gained bromhidrosis patient uses, using method: after being cleaned up at axillary fossa position, gets the even wiping affected part of appropriate this product, every day 2-3 time, within 20 days, is a course for the treatment of.After treating a course for the treatment of, obviously reduce before the conscious perspire of patient comparatively, abnormal smells from the patient significantly alleviates, and use the present invention stopped using after four courses for the treatment of continuously, and private prosecution amount of sweat is normal, and body odour is normal, follows up a case by regular visits to half a year, nothing recurrence.
The liniment that embodiment 3 bromhidrosis patient uses, is prepared from by following bulk drugs, is weight portion (250g/ part): Folium Perillae Frutescentis 9 parts; Fructus Fici 8 parts; Petasites japonicus 9 parts; Rhizoma Osmundae Japonicae 6 parts; Rhizoma Dioscoreae 8 parts; Flos Aglaiae Odoratae spends 10 parts; Caulis Perillae Frutescentis 9 parts; Herba Violae 7 parts; Auspicious even grass 5 parts; Radix rubi buergeri 4.5 parts; Lithargyrum 8 parts; Semen Celosiae 4.5 parts; Herba Selaginellae Moellendorfii 8 parts.
The preparation method of the liniment that bromhidrosis patient uses is:
(1) by broken for Flos Aglaiae Odoratae pollen, cross 55 mesh sieves, be placed in round-bottomed flask, add the distilled water immersion 3 hours of 18 times amount, then extract volatile oil according to vapor extraction method, for subsequent use;
(2) Rhizoma Osmundae Japonicae is placed in non iron container, add 0.75 times of raw material dose, concentration be 15% saline solution mix thoroughly, vexed 35 minutes, take out, intense fire to be fried to surface in coke black, inner in sepia, take out, cool, for subsequent use;
(3) Rhizoma Osmundae Japonicae after step (2) being processed mixes with Lithargyrum, Semen Celosiae and Herba Selaginellae Moellendorfii, smash into coarse powder to pieces, being placed in Chinese medicament extracting device, take concentration as the ethanol of 55% is solvent, and wherein the amount of solvent is 11 times of described raw material dose, heating and refluxing extraction twice, each each extraction 38 minutes, merges twice alcohol extract, filters, reclaim ethanol, filtrate is for subsequent use;
(4) be placed in medicine pot by surplus stock medicine, the pure water adding 15 times of described raw material doses soaks 3.5 hours, then slow fire boiling 60 minutes, filter, filtrate reduced in volume, to 1/4 of original volume, is cooled to room temperature, merge with step (3) gained filtrate, obtain mixed solution, for subsequent use;
(5) in step (1) gained volatile oil, add the dehydrated alcohol of 1.2 times amount, obtain shallow yellow transparent solution, mix with step (4) gained mixed solution, sterilizing encapsulates, and to obtain final product.
The using method of gained liniment of the present invention is: after being cleaned up at axillary fossa position, gets the even wiping affected part of appropriate this product, every day 2-3 time, within 20 days, is a course for the treatment of.
The liniment that embodiment 4 bromhidrosis patient uses, is prepared from by following bulk drugs, is weight portion (150g/ part): Folium Perillae Frutescentis 11 parts; Fructus Fici 9 parts; Petasites japonicus 10 parts; Rhizoma Osmundae Japonicae 7 parts; Rhizoma Dioscoreae 10 parts; Flos Aglaiae Odoratae spends 12 parts; Caulis Perillae Frutescentis 12 parts; Herba Violae 11 parts; Auspicious even grass 7 parts; Radix rubi buergeri 5.5 parts; Lithargyrum 10 parts; Semen Celosiae 6.5 parts; Herba Selaginellae Moellendorfii 11 parts.
The preparation method of the liniment that bromhidrosis patient uses is:
(1) by broken for Flos Aglaiae Odoratae pollen, cross 75 mesh sieves, be placed in round-bottomed flask, add the distilled water immersion 4 hours of 22 times amount, then extract volatile oil according to vapor extraction method, for subsequent use;
(2) Rhizoma Osmundae Japonicae is placed in non iron container, add 0.95 times of described raw material dose, concentration be 25% saline solution mix thoroughly, vexed 45 minutes, take out, intense fire to be fried to surface in coke black, inner in sepia, take out, cool, for subsequent use;
(3) Rhizoma Osmundae Japonicae after step (2) being processed mixes with Lithargyrum, Semen Celosiae and Herba Selaginellae Moellendorfii, smash into coarse powder to pieces, being placed in Chinese medicament extracting device, take concentration as the ethanol of 65% is solvent, and wherein the amount of solvent is 14 times of described raw material dose, heating and refluxing extraction twice, each each extraction 48 minutes, merges twice alcohol extract, filters, reclaim ethanol, filtrate is for subsequent use;
(4) be placed in medicine pot by surplus stock medicine, the pure water adding 16 times of described raw material doses soaks 4.5 hours, then slow fire boiling 70 minutes, filter, filtrate reduced in volume, to 1/4 of original volume, is cooled to room temperature, merge with step (3) gained filtrate, obtain mixed solution, for subsequent use;
(5) in step (1) gained volatile oil, add the dehydrated alcohol of 1.4 times amount, obtain shallow yellow transparent solution, mix with step (4) gained mixed solution, sterilizing encapsulates, and to obtain final product.
The using method of gained liniment of the present invention is: after being cleaned up at axillary fossa position, gets the even wiping affected part of appropriate this product, every day 2-3 time, within 20 days, is a course for the treatment of.
Model case: cattle XX, female, 18 years old, people from Jinan.Patient's readme suffers from bromhidrosis and has a surplus for 5 years, and always there is a strand abnormal flavour in every summer with it, does not also have too much to take notice of this part thing, still every day normal studying and living, diligent laundry; Until there is one day, the house friend together with living together with her is to its candid that strand of bromhidrosis taste because of can't stand hers with it, and wish that patient exchanges dormitory, face awkward situation like this, patient recognizes that own idea is thoroughly treated, and could remove this embarrassment.Patient successively attempts the medicine using various treatment bromhidrosis, and effect is not very desirable, and again because surgery cost is expensive, be difficult to burden, patient loses the confidence gradually.Surprisingly learnt that Drug therapy bromhidrosis of the present invention was evident in efficacy afterwards, cure rate is high, then carrys out my institute's treatment on July 20th, 2014.Use the liniment that the present embodiment gained bromhidrosis patient uses, using method: after being cleaned up at axillary fossa position, gets the even wiping affected part of appropriate this product, every day 2-3 time, within 20 days, is a course for the treatment of.After treating a course for the treatment of, obviously reduce before the conscious perspire of patient comparatively, abnormal smells from the patient significantly alleviates, and use the present invention stopped using after four courses for the treatment of continuously, and private prosecution amount of sweat is normal, and body odour is normal, follows up a case by regular visits to half a year, nothing recurrence.
The liniment that embodiment 5 bromhidrosis patient uses, is prepared from by following bulk drugs, is weight portion (200g/ part): Folium Perillae Frutescentis 10 parts; Fructus Fici 8.5 parts; Petasites japonicus 9.5 parts; Rhizoma Osmundae Japonicae 6.5 parts; Rhizoma Dioscoreae 9 parts; Flos Aglaiae Odoratae spends 11 parts; Caulis Perillae Frutescentis 10.5 parts; Herba Violae 9 parts; Auspicious even grass 6 parts; Radix rubi buergeri 5 parts; Lithargyrum 9 parts; Semen Celosiae 5.5 parts; Herba Selaginellae Moellendorfii 9.5 parts.
The preparation method of the liniment that bromhidrosis patient uses is:
(1) by broken for Flos Aglaiae Odoratae pollen, cross 65 mesh sieves, be placed in round-bottomed flask, add the distilled water immersion 3.5 hours of 20 times amount, then according to extraction by steam distillation volatile oil, for subsequent use;
(2) Rhizoma Osmundae Japonicae is placed in non iron container, add 0.85 times of described raw material dose, concentration be 20% saline solution mix thoroughly, vexed 40 minutes, take out, intense fire to be fried to surface in coke black, inner in sepia, take out, cool, for subsequent use;
(3) Rhizoma Osmundae Japonicae after step (2) being processed mixes with Lithargyrum, Semen Celosiae and Herba Selaginellae Moellendorfii, smash into coarse powder to pieces, being placed in Chinese medicament extracting device, take concentration as the ethanol of 60% is solvent, and wherein the amount of solvent is 12.5 times of described raw material dose, heating and refluxing extraction twice, each each extraction 43 minutes, merges twice alcohol extract, filters, reclaim ethanol, filtrate is for subsequent use;
(4) be placed in medicine pot by surplus stock medicine, the pure water adding 15.5 times of described raw material doses soaks 4 hours, then slow fire boiling 65 minutes, filter, filtrate reduced in volume, to 1/4 of original volume, is cooled to room temperature, merge with step (3) gained filtrate, obtain mixed solution, for subsequent use;
(5) in step (1) gained volatile oil, add the dehydrated alcohol of 1.3 times amount, obtain shallow yellow transparent solution, mix with step (4) gained mixed solution, sterilizing encapsulates, and to obtain final product.
The using method of gained liniment of the present invention is: after being cleaned up at axillary fossa position, gets the even wiping affected part of appropriate this product, every day 2-3 time, within 20 days, is a course for the treatment of.
The applied research of the liniment (embodiment 5) that test example gained bromhidrosis of the present invention patient uses:
1, physical data
Choose 366 routine bromhidrosis patients of my institute treatment in October ,-2013 in June, 2011, wherein male patient's totally 192 examples, female patient is totally 174 examples, the age 17-33 year, the mean age is 25 years old, and the course of disease, at 7 months-3 years, is bilateral morbidity.All patients are divided into experimental group and matched group at random, and two groups of patients comparing difference not statistically significant (P > 0.05) in age, sex, the state of an illness etc., has comparability.
2, diagnostic criteria
(1) fox is had to urinate stink, movable heating postemphasis; (2) armpit hair has yellow-white fine crystalline granule or with the liquid adhesion thing more sticky than perspiration; (3) observing ear Ding (cerumen) is sugared ear, the similar otitis media of oily ear, moist sticky property ear Ding; (4) observe underwear axillary fossa position of wearing and have jaundice metachromatism.
3, Therapeutic Method
The liniment that experimental group uses gained bromhidrosis patient of the present invention to use, using method: after being cleaned up at axillary fossa position, gets the even wiping affected part of appropriate this product, every day 2-3 time, within 20 days, is a course for the treatment of.Matched group uses other medicine conventional medication such as (as clean in bromhidrosis powder, bromhidrosis) axil Bao Kang.Treat four courses for the treatment of altogether.
4, efficacy assessment standard
Cure: after treatment, bromhidrosis symptom and sign disappear completely, drug withdrawal is nothing recurrence after three months;
Effective: after treatment, armpit only can smell less malodor;
Invalid: after treatment, bromhidrosis symptom is comparatively treated front unchanged.
Total effective rate=(curing number of cases+effective number of cases)/total inspection case load × 100%.
5, therapeutic effect
Result is as shown in table 1.
Table 1: the therapeutic outcome of experimental group and matched group patient
Therapeutic effect: experimental group cures 161 examples (77.4%), effective 45 examples (21.6%), invalid 2 examples (1%), total effective rate is 99%.And matched group total effective rate is 82.9%.From table 1 data, experimental group therapeutic effect is obviously better than matched group.
The present invention select Folium Perillae Frutescentis, Fructus Fici, Petasites japonicus, Rhizoma Osmundae Japonicae, Rhizoma Dioscoreae and Flos Aglaiae Odoratae flower etc. totally 13 taste primary raw material medicines be prepared from.Fructus Fici removing toxic substances and promoting subsidence of swelling in side; Rhizoma Osmundae Japonicae heat-clearing and toxic substances removing, antibacterial, worm-expelling; Flos Aglaiae Odoratae flower promoting the circulation of QI to alleviate the stagnation in middle-JIAO; The pleasant resolving depression of Caulis Perillae Frutescentis; Herba Violae heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling; Lithargyrum also has inhibitory action in various degree to various skin fungus; Semen Celosiae anti-inflammation; Herba Selaginellae Moellendorfii convergence, astringent or styptic treatment for spontaneous sweating.Full side's compatibility, plays the merit of convergence, antibacterial, dehumidifying altogether.Treat four courses for the treatment of in experimental group, total effective rate is 99%, evident in efficacy.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.

Claims (10)

1. the liniment of bromhidrosis patient use, is characterized in that, be prepared from by following bulk drugs, be weight portion: Folium Perillae Frutescentis 8-12; Fructus Fici 6-11; Petasites japonicus 7-12; Rhizoma Osmundae Japonicae 4-9; Rhizoma Dioscoreae 6-12; Flos Aglaiae Odoratae flower 9-13; Caulis Perillae Frutescentis 7-14; Herba Violae 5-13; The careless 3-9 of auspicious company; Radix rubi buergeri 4-6; Lithargyrum 7-11; Semen Celosiae 3-8; Herba Selaginellae Moellendorfii 6-13.
2. the liniment of bromhidrosis patient use as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Folium Perillae Frutescentis 9-11; Fructus Fici 8-9; Petasites japonicus 9-10; Rhizoma Osmundae Japonicae 6-7; Rhizoma Dioscoreae 8-10; Flos Aglaiae Odoratae flower 10-12; Caulis Perillae Frutescentis 9-12; Herba Violae 7-11; The careless 5-7 of auspicious company; Radix rubi buergeri 4.5-5.5; Lithargyrum 8-10; Semen Celosiae 4.5-6.5; Herba Selaginellae Moellendorfii 8-11.
3. the liniment of bromhidrosis patient use as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Folium Perillae Frutescentis 10; Fructus Fici 8.5; Petasites japonicus 9.5; Rhizoma Osmundae Japonicae 6.5; Rhizoma Dioscoreae 9; Flos Aglaiae Odoratae spends 11; Caulis Perillae Frutescentis 10.5; Herba Violae 9; Auspicious even grass 6; Radix rubi buergeri 5; Lithargyrum 9; Semen Celosiae 5.5; Herba Selaginellae Moellendorfii 9.5.
4. the preparation method of the liniment that the bromhidrosis patient as described in as arbitrary in claim 1-3 uses, it is characterized in that, step is as follows:
(1) by broken for Flos Aglaiae Odoratae pollen, sieve, be placed in round-bottomed flask, add distilled water immersion 2-5 hour the distilled water immersion of 20 times amount (preferably add 3.5 hours) of 15-25 times amount, then according to extraction by steam distillation volatile oil, for subsequent use;
(2) Rhizoma Osmundae Japonicae is placed in non iron container, add concentration be the saline solution of 10%-30% mix thoroughly (preferably add concentration be 20% saline solution mix thoroughly), vexed 30-50 minute (preferably vexed 40 minutes), taking-up, intense fire stir-fry to surface is coke black, inside is sepia, takes out, cool, for subsequent use;
(3) Rhizoma Osmundae Japonicae after step (2) being processed mixes with Lithargyrum, Semen Celosiae and Herba Selaginellae Moellendorfii, smash into coarse powder to pieces, be placed in Chinese medicament extracting device, take ethanol as solvent, heating and refluxing extraction twice, each respectively extraction 30-56 minute (preferably each each extraction 43 minutes), merge twice alcohol extract, filter, reclaim ethanol, filtrate is for subsequent use;
(4) surplus stock medicine is placed in medicine pot, adds pure water and soak, then slow fire boiling 55-75 minute (preferred slow fire boiling 65 minutes), filter, filtrate reduced in volume, to 1/4 of original volume, is cooled to room temperature, merge with step (3) gained filtrate, obtain mixed solution, for subsequent use;
(5) in step (1) gained volatile oil, add the dehydrated alcohol (preferably adding the dehydrated alcohol of 1.3 times amount) of 1-1.6 times amount, obtain shallow yellow transparent solution, mix with step (4) gained mixed solution, sterilizing encapsulates, and to obtain final product.
5. the preparation method of the liniment of bromhidrosis patient use according to claim 4, is characterized in that, the middle 40-90 mesh sieve excessively of step (1) (preferred 55-75 mesh sieve excessively, mistake 65 mesh sieve be more preferably).
6. the preparation method of the liniment of bromhidrosis patient use according to claim 4, it is characterized in that, in step (2), the amount of saline solution is the 0.65-1.05 of described raw material dose doubly (amount of preferred saline solution is 0.75-0.95 times of described raw material dose, and the amount of the saline solution be more preferably is 0.85 times of described raw material dose).
7. the preparation method of the liniment of bromhidrosis patient use according to claim 4, is characterized in that, in step (3), the concentration of ethanol is the concentration of the preferred ethanol of 45%-75%(is 55%-65%, and the concentration of the ethanol be more preferably is 60%).
8. the preparation method of the liniment of bromhidrosis patient use according to claim 4, it is characterized in that, in step (3), the amount of solvent is the 10-15 of described raw material dose doubly (amount of preferred solvent is 11-14 times of described raw material dose, and the amount of the solvent be more preferably is 12.5 times of described raw material dose).
9. the preparation method of the liniment of bromhidrosis patient use according to claim 4, it is characterized in that, in step (4), the amount of pure water is the 14-17 of described raw material dose doubly (amount of preferred pure water is 15-16 times of described raw material dose, and the amount of the pure water be more preferably is 15.5 times of described raw material dose).
10. the preparation method of the liniment of bromhidrosis patient use according to claim 4, is characterized in that, the time of soaking in step (4) is 3-5 hour (the preferred time of soaking is 3.5-4.5 hour, and the time of the immersion be more preferably is 4 hours).
CN201610062572.1A 2016-01-29 2016-01-29 Liniment for underarm odor patient and preparation method Pending CN105535370A (en)

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Application publication date: 20160504