Summary of the invention
The purpose of this invention is to provide a kind of medicine for the treatment of cancer, extract the active ingredient that contains anticancerization tumor from Chinese medicine, have the effect of anticancerization tumor, anti-inflammatory analgetic, reparation body injury, and toxic and side effects is little, cost hangs down good effect.
For this reason, the present invention is the medicine of being made by the following weight proportion raw material:
8~12 parts of 8~12 portions of Semen Hydnocarpis of 1~3 portion of Hirudo of Mylabris
8~12 parts of 2~10 parts of Herba Thermopsis Lanceolataes of 1~5 part of Periostracum Serpentis of Scolopendra
8~12 parts of 8~12 parts of Fructus Quisqualis of 1.5~5 portions of Rhizoma Coptidis of Calculus Bovis
8~15 parts of 8~15 parts of Pericarpium Papaveriss of 6~12 parts of Radixs Astragali of Scorpio
1~3 part of 8~15 parts of Semen Strychni of 1.5~5 parts of Fructus Cnidiis of Moschus.
The weight proportion of preferred each raw material of the present invention is:
9~11 parts of 9~11 portions of Semen Hydnocarpis of 1~2 portion of Hirudo of Mylabris
9~11 parts of 4~9 parts of Herba Thermopsis Lanceolataes of 2~4 parts of Periostracum Serpentiss of Scolopendra
9~11 parts of 9~11 parts of Fructus Quisqualis of 2~4 portions of Rhizoma Coptidis of Calculus Bovis
9~12 parts of 9~12 parts of Pericarpium Papaveriss of 7~11 parts of Radixs Astragali of Scorpio
1~2 part of 9~11 parts of Semen Strychni of 2~4 parts of Fructus Cnidiis of Moschus.
The weight proportion of best each raw material of prescription of the present invention is:
10 parts of 10 portions of Semen Hydnocarpis of 1.5 portions of Hirudos of Mylabris
10 parts of 8 parts of Herba Thermopsis Lanceolataes of 3 parts of Periostracum Serpentiss of Scolopendra
10 parts of 10 parts of Fructus Quisqualis of 2.5 portions of Rhizoma Coptidis of Calculus Bovis
10 parts of 10 parts of Pericarpium Papaveriss of 10 parts of Radixs Astragali of Scorpio
1 part of 10 parts of Semen Strychni of 2.5 parts of Fructus Cnidiis of Moschus.
Medicine of the present invention can be made injection or capsule as required.
Solution of the present invention is according to the rule of the traditional Chinese medical science to the carcinoma disease, i.e. enriching yin and nourishing kidney, and blood circulation promoting and blood stasis dispelling, eliminating stasis to stop pain, the collateral dredging of enriching blood, bactericidal antiphlogistic, clearing away damp-heat rushes down the poison fire, counteracting toxic substances, eliminating stagnation.The present invention forms according to above-mentioned rule, can blood circulation promoting and blood stasis dispelling, and eliminating stasis to stop pain, clearing away damp-heat rushes down the poison fire, and counteracting toxic substances, eliminating stagnation again can eliminating stasis to stop pain, the collateral dredging of enriching blood.Moschus of the present invention, property and flavor of peppery and warm has and has one's ideas straightened out, ward off dirty, collateral dredging, the effect of dissipating blood stasis and anti-inflammatory, antibacterial can be controlled apoplexy, syncope due to accumulation of phlegm, attacked by pestiferous factors unhappiness, trusted subordinate's sudden pain, traumatic injury, swollen ulcer drug.The cancerous cell that the muscone that contains in the Moschus blood stasis that division forms to the intravital virus of people and virokine causes has the effect of inhibition.Muscone contains multiple androstane derivatives and cholesterol compounds outward, gal4 amino acid, and fatty carbamide ammonium money salt etc. also stop leukoplania, are liver YANG hyperactivity suppressing medicines.To central nervous system and the effect that has two-phase to regulate, the anti-inflammatory, antibacterial effect is arranged.Discover that now muscone has inhibitory action to the carcinoma cell of intravital virus of people and the formation of virokine division formation blood stasis knot.Mylabris, property and flavor of peppery and cold, poisonous has counteracting toxic substances, and malignant boil is controlled in the effect of removing blood stasis, stubborn dermatitis, throat moth, lyssodexis, scrofula, the eliminating mass of stimulating the menstrual flow can be used for treating various cancers.Hirudo, nature and flavor are salty, bitter, flat, poisonous, contain protein in the Hirudo, and a kind of anticoagulant material is arranged, be called hirudin, form, also contain heparin, antithrombotic element etc. by carbon, hydrogen, nitrogen element sulphur, the internal resistance of energy congestion, lump in the abdomen have preventing tumor, the effect of promoting blood circulation.Semen Hydnocarpi, nature and flavor suffering, heat, poisonous, the energy dispeiling pathogenic wind and removing dampness, detoxicating and killing parasites has antitumor, the effect of cancer.Scolopendra, nature and flavor suffering, temperature, poisonous, have dispel the wind, the effect of arresting convulsion, counteracting toxic substances, eliminating stagnation, can play protective effect on cancer risk.Periostracum Serpentis, property sweet-salty, flat, poisonous, have dispel the wind, arresting convulsion, nebula removing, detumescence, parasiticidal effect, can change congestion detoxification heat, the detumescence tumor.Herba Thermopsis Lanceolatae, nature and flavor are sweet, tepor, poisonous, have subduing swelling and detoxicating, heat clearing away blood stasis removing, swollen ulcer drug, sterilization antitumaous effect.Calculus Bovis, property bitter but sweet flavor, cold have heat-clearing and toxic substances removing, and endogenous wind stopping ends warp, the effect that blood stasis dispelling is had one's ideas straightened out, Calculus Bovis has antineoplastic component, can make tumor tissues extensively downright bad.Rhizoma Coptidis, nature and flavor hardship, cold has pathogenic fire purging, dampness, detoxifcation, parasite killing, the effect of anticancer cell.Fructus Quisqualis, nature and flavor are sweet, warm, have parasite killing, removing food stagnancy, spleen invigorating, the effect of cancer-resisting.Scorpio, the salty suffering of nature and flavor, flat, poisonous, have dispel the wind, relieving convulsion, collateral dredging, detoxifcation, anticancer antineoplastic action is arranged.The Radix Astragali, sweet, the tepor of nature and flavor has invigorating QI to consolidate the body surface resistance, and promoting pus discharge and tissue regeneration strengthening has the effect of killing cancerous cell.Pericarpium Papaveris, nature and flavor acid, puckery, be slightly cold, have and astringe the lung, cough-relieving, astringing intestine to stop diarrhea, pain relieving, the anti-cancer cellular invasion effect.Fructus Cnidii, nature and flavor are arduous, warm, have to dispel the wind, dampness, parasite killing, kill the effect of cancerous cell.Semen Strychni, nature and flavor hardship, cold, very toxic has curing rheumatism, strengthening bone and muscle, reducing swelling and alleviating pain, kills the effect of cancerous cell.Of the present invention one the course of treatment cost only be 20% of the traditional identical cancer cost course of treatment, can save patient's expense expenditure greatly.
The present invention has eliminating evil just the wound, and set upright and do not stay heresy, the kidney invigorating collateral dredging, warm network blood stasis dispelling, intelligence promoting and the mind tranquilizing, a surname's air to open key, the strongly fragrant eliminating phlegm that looses, subduing swelling and detoxicating, bactericidal antiphlogistic, the collateral dredging of enriching blood has good anticancerization tumor effect.The poison of drug that medical institutions did, pharmacology, effect experiments such as medicine of the present invention Heilongjiang Prov. Tumour Hospital prove that it is 97% that animal presses down cancer test effective percentage, and tumour inhibiting rate is 72%, and remission rate is more than 73%.For showing therapeutic effect of the present invention, select body weight 18~20g Switzerland male mice for use, random packet, 10 every group, every group of average body method of double differences is less than 0.5g.Be divided into experimental group and matched group, the experimental group administration once a day, 55mg/kg, successive administration 7 days, control group administered physiological saline 0.4ml will grow color Pu EAC tumor pearl under aseptic condition on the 8th day, with 1:3 times of dilution of normal saline (about 2,500 ten thousand cancerous cell), at mice right fore subcutaneous abdomen inoculation 0.2ml, inoculation back is normal raised 7 days, put to death mice on the 8th day, weighed respectively and got tumor and weigh, experimental group and matched group relatively have significant inhibitory effect, average tumour inhibiting rate 60%.
Medicine of the present invention is tested through allergy, and hemolytic test, abnormal toxicity test show that injection is nontoxic, have no side effect drug safety.The present invention is 55% to hepatocarcinoma and patients with lung cancer cure rate, to other cancer patient cure and effective percentage about 45%.In clinical hundreds of cancer patients, in being, terminal cancer shifts the patient, except that cure rate, coefficient of stabilization reaches that survival rate reaches more than 95% more than 60%, one year.
The specific embodiment
Embodiment 1: take by weighing raw material by following proportioning: Mylabris 150g, Hirudo 1000g, Semen Hydnocarpi 1000g; Scolopendra 300g, Periostracum Serpentis 800g, Herba Thermopsis Lanceolatae 1000g; Calculus Bovis 250g, Rhizoma Coptidis 1000g, Fructus Quisqualis 1000g; Scorpio 1000g; Radix Astragali 1000g, Pericarpium Papaveris 1000g, Moschus 250g; Fructus Cnidii 1000g, Semen Strychni 100g.
Preparation method is: Rhizoma Coptidis, Semen Hydnocarpi, Pericarpium Papaveris, Herba Thermopsis Lanceolatae, Semen Strychni and Fructus Cnidii are concocted or handle the back pulverize by the Pharmacopoeia of the People's Republic of China.The close parch of the Radix Astragali, chopping is used as medicine.Moschus is put into 100 ℃ of water and is stirred and make paste, places in 0.5 liter the hot water again, and 100 ℃ of water temperatures are soaked and got supernatant in 3 hours, and twice filtration repeatedly merges 2 times supernatant, and be standby.Calculus Bovis, levigation, getting supernatant in 8 hours with 80 ℃ of water loggings bubble of 0.5 liter, to fry in shallow oil into paste three times standby.Periostracum Serpentis Testa Tritici parching to brown is pulverized.Hirudo vinegar system 30 minutes, reuse Chinese liquor are boiled taking-up in 10 minutes, chopping is used as medicine.Behind the little Huang of Scolopendra fire preparing, parched with bran vinegar boils, shreds and be used as medicine.Scorpio fire preparing salt is fried, chopping is used as medicine.Reuse Chinese liquor boils half an hour after the Mylabris fire preparing, and chopping is used as medicine.Fructus Quisqualis parching to brown, chopping are used as medicine.
The above-mentioned Chinese medicine for preparing and extract inserted add 2.6 premium on currency in the container, water temperature was boiled 40 minutes for 100 ℃, filtered, and took out clear liquid, and spice adds 2.6 premium on currency again and boils after 40 minutes and take out clear liquid, repeats once again.3 decocting liquids are merged, and freezing precipitation was got the Chinese herbal medicine extractum that supernatant concentration becomes water content 45-50% after 20 hours, by every 50g extractum adding distil water 1000ml, heat 100 ℃, fried in shallow oil plate-and-frame filtration 45 minutes, filtrate adding, account for the active carbon and 0 of volume ratio 0.05-0.08%, the tween 80 of 03-0.05% volume ratio, and transfer pH to 7 with 1.2% NaOH, add 1000 ml distilled waters after the filtration again, use the G filter stick, outsourcing filter paper and thick cloth C3 filter bulb 0.45 μ filtering with microporous membrane.Filtrate is through fill, sealing by fusing sterilization, and packing 2ml pacifies the bottle injection.
Medication every day once, 21 days is a course of treatment, a 2ml adopts intramuscular injection or acupoint injection therapy.Treatment, short treating period, fast, the medication handy and safe of curative effect are convenient to treat, are made things convenient for to injection of the present invention, can be used for treating various cancers and tumor.
Embodiment 2: take by weighing raw material by following proportioning: Mylabris 100g, Hirudo 1200g, Semen Hydnocarpi 800g; Scolopendra 500g, Periostracum Serpentis 200g, Herba Thermopsis Lanceolatae 800g; Calculus Bovis 400g, Rhizoma Coptidis 1200g, Fructus Quisqualis 1200g; Scorpio 600g; Radix Astragali 1500g, Pericarpium Papaveris 800g, Moschus 150g; Fructus Cnidii 1500g, Semen Strychni 300g.
Preparation method is: Rhizoma Coptidis, Scorpio, Semen Hydnocarpi and Fructus Cnidii are pulverized, crossed 200 mesh sieves.Moschus is put into 100 ℃ of water and is stirred and make paste, places in 0.5 liter the hot water again, and 100 ℃ of water temperatures are soaked and got supernatant in 3 hours, and twice filtration repeatedly merges 2 times supernatant, and be standby.Calculus Bovis, levigation, it is standby to get supernatant three times in 8 hours with 80 ℃ of water loggings bubble of 0.5 liter.After the Radix Astragali, Periostracum Serpentis, Hirudo, Scolopendra, Mylabris, Pericarpium Papaveris, Herba Thermopsis Lanceolatae, Fructus Quisqualis, Semen Strychni concocted or handle by the Pharmacopoeia of the People's Republic of China, pulverize, add the conventional water yield and decoct 3-4 time; get decoction liquor and merge Moschus supernatant and Calculus Bovis supernatant, concentrate, be prepared into extract powder by the pharmacopeia standard; add; cross all the other raw material powders of 200 mesh sieves, be mixed, oven dry; pulverize; add the starch that accounts for medicated powder total amount 5~15%, be mixed, incapsulate.
Capsule of the present invention, oral usually, the twice-daily of being grown up, one time two, adorn 5 grams for every, the child reduces by half, with warm boiled water (taking medicine before meal with).Can be used for treating various cancers and tumor.
Embodiment 3: take by weighing raw material by following proportioning: Mylabris 300g, Hirudo 800g, Semen Hydnocarpi 1100g; Scolopendra 100g, Periostracum Serpentis 1000g, Herba Thermopsis Lanceolatae 1200g; Calculus Bovis 180g, Rhizoma Coptidis 800g, Fructus Quisqualis 900g; Scorpio 1200g; Radix Astragali 800g, Pericarpium Papaveris 1500g, Moschus 500g; Fructus Cnidii 800g, Semen Strychni 150g.Method for making and usage are with embodiment 2.After also the above-mentioned raw materials medicine can being concocted or handled by the Pharmacopoeia of the People's Republic of China, pack adds constant water, connects and to fry in shallow oil 3 times, and collecting decoction is made decoct, the clothes decocting liquid, every day secondary, each 150 grams are so be not repeated.
In a word, the effect with anticancerization tumor, anti-inflammatory analgetic, reparation body injury of the present invention, and toxic and side effects is little, and cost hangs down good effect.