CN105878877A - Composition for treating pruritus caused by allergy and preparation method of composition - Google Patents

Composition for treating pruritus caused by allergy and preparation method of composition Download PDF

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CN105878877A
CN105878877A CN201510413570.8A CN201510413570A CN105878877A CN 105878877 A CN105878877 A CN 105878877A CN 201510413570 A CN201510413570 A CN 201510413570A CN 105878877 A CN105878877 A CN 105878877A
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parts
propolis
compositions
pericarpium zanthoxyli
preparation
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胡蓉
于海涛
朱磊
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Abstract

The invention discloses a composition for treating pruritus caused by allergy. The composition is prepared from the following main medicinal materials in parts by weight: 3-8 parts of semen brassicae, 6-12 parts of propolis, 10-15 parts of radix stemonae, 5-10 parts of common baphicacanthus rhizome and root, 6-12 parts of honeysuckle flowers, 15-60 parts of lalang grass rhizome, 5-15 parts of radix sophorae flavescentis, 4.5-9 parts of Chinese prickly ash, 5-15 parts of semen impatientis, 2-5 parts of hairy flower wasp larva, 5-15 parts of tropic ageratum herb, and 105-125 parts of vinegar. The composition has the advantages that the preparation operation is easy, the curative effects are significant, and the pain born by the patient is small; the composition is prepared from the local common traditional Chinese medicinal materials which are low in cost.

Description

A kind of treat compositions of pruritus that allergy causes and preparation method thereof
Technical field
The invention belongs to traditional Chinese medicine field, especially relate to a kind of treat compositions of pruritus that allergy causes and preparation method thereof.
Background technology
Allergy, the phenomenon increased abnormally that the impression of some drugs or environmental stimuli is caused by organism, drug allergy.Allergy is exactly briefly to certain material tetchiness.When you eat, touch or suck certain material when, health can produce excessive reaction;The material causing this reaction is exactly so-called " anaphylactogen ".Under normal conditions, health can manufacture antibody for protecting health not encroached on by disease;But the most harmless material can be mistakenly considered harmful thing by the health of allergy sufferers, producing antibody, this material just becomes a kind of " anaphylactogen ".
Skin peptide allergy: skin allergy is more common in what female caused, what man caused be also easier to occurs, and shows as face, erythema that cervical region is slight, edema, protuberance or the little pimple caused with the red edema that the minority grain of rice is big;Have shows as near the eyes or cervical region erythema, and edema is inconspicuous;The similar eczema having, surface is slightly thick thick, has thin thin desquamation, is often accompanied by pruritus.Spring, the main cause of the easy allergy of skin was pollen, next to that the stimulation of daylight.Winter, sunlight intensity was weak, and people are seldom in outdoor activity, to spring, accepted that sun-exposed intensity is big, the time is long, and skin does not adapts to, and is susceptible to inflammation.It addition, the change that the cosmetics that face is smeared raise through Exposure to Sunlight and temperature, the most easily make skin allergy.Once skin generation allergy, not only pruritus is unbearably, and affect attractive in appearance, then many people accept other people suggestion, find out the ointment containing hormone from the medicine-chest of family, it is coated in face, pruritus typically can disappear at once, erythra also prompt resolution, but the most also can recur, reuse the ointment of these hormoness, the most effectively.After repeated multiple times, easily there is flushing, telangiectasis, dry, coarse etc. in face, and is changed into " dermatitis that hormone dependant causes ", and patient feels that face is terribly hot, and is difficult to see.At this moment treatment is got up the most thorny, takes long enough, has people the most forever can not recover normal.The friend having the female of allergies to cause should avoid long-time outdoor activities, and once erythra occurs in face, the most a lot of in indoor, and disables all cosmetics.
In existing traditional Chinese medicine field treats the technology of the pruritus that allergy causes, the patent document of Authorization Notice No. CN 103356890 B (application number 201310325093.0) discloses a kind of Chinese medicine for outer use treating allergic skin itching, it is characterized in that being made up by ratio of weight and the number of copies of following medicine: Rhizoma Coptidis 80-85, Cortex Phellodendri 60-65, Radix Sophorae Flavescentis 50-53, Cortex Dictamni 40-45, Fructus Kochiae 40-43, Rhizoma Polygonati 55-58, Camphora 52-55, Borax 20-23, Indigo Naturalis 28-33, Borneolum Syntheticum 25-28, Flos Lonicerae 66-70, Fructus Forsythiae 53-58, Mentholum 60-65, Oleum Caryophylli 35-38, Oleum Camphora 45-50, vaseline 50.The patent of Authorization Notice No. CN 103100016B (application number 201310042803.9) discloses a kind of Chinese medicine treating skin peptide pruritus, it is characterized by, the raw material of following parts by weight make unguentum: Fructus Xanthii 3~9 parts, Herba Spirodelae 3~9 parts, Flos Sophorae 4~10 parts, Fructus Viticis 6~10 parts, Herba Menthae 2~6 parts, Periostracum Cicadae 2~6 parts, Herba Portulacae 9~15 parts, Radix Stemonae (processed) 3~9 parts, Radix Sophorae Flavescentis 3~9 parts, Radix Saposhnikoviae 4~10 parts, Fructus Cnidii 3~9 parts, Pericarpium Zanthoxyli 2~6 parts, Flos Caryophylli 1~5 parts, Folium Persicae 2~6 parts, Cortex Myricae Rubrae 9~15 parts, Ramulus et Folium Tamaricis 9~15 parts.
As can be seen here, Chinese medicine occupies an important position in terms for the treatment of skin pruritus and the pruritus that caused by allergy, but in existing patent, preparation method is complicated, and drug regimen is complicated, and DeGrain, have plenty of ointment and be easy to medicated clothing of making dirty, it has not been convenient to use.
Summary of the invention
For existing current treatment status, an object of the present invention is to provide a kind of compositions treating the pruritus that allergy causes, have easily operation, evident in efficacy, sufferer bears painful little feature, and it use the most relatively conventional Chinese crude drug as raw material, with low cost.
Another object of the present invention is just to provide the preparation method of the pruritus compositions that above-mentioned treatment allergy causes.
The above-mentioned purpose of the present invention is achieved through the following technical solutions:
A kind of compositions treating the pruritus that allergy causes, takes off and states the primary raw material of weight proportion and be prepared from: Semen Sinapis Albae 3-8 part, propolis 6-12 part, Radix Stemonae 10-15 part, Indigo Naturalis 5-10 part, Flos Lonicerae 6-12 part, Rhizoma Imperatae 15-60 part, Radix Sophorae Flavescentis 5-15 part, Pericarpium Zanthoxyli 4.5-9 part, Semen Impatientis 5-15 part, Discolia vittifrons Sch. 2-5 part, Herba Agerati Conyzoidis 5-15 part, vinegar 105-125 part.
The compositions of the pruritus that above-mentioned treatment allergy causes, takes off and states the primary raw material of weight proportion and be prepared from: Semen Sinapis Albae 4-7 part, propolis 7-10 part, Radix Stemonae 11-14 part, Indigo Naturalis 6-9 part, Flos Lonicerae 9-11 part, Rhizoma Imperatae 25-40 part, Radix Sophorae Flavescentis 8-11 part, Pericarpium Zanthoxyli 5-8 part, Semen Impatientis 7-12 part, Discolia vittifrons Sch. 3-4 part, Herba Agerati Conyzoidis 7-12 part, vinegar 110-120 part.
The compositions of the pruritus that above-mentioned treatment allergy causes, takes off and states the primary raw material of weight proportion and be prepared from: Semen Sinapis Albae 5.5 parts, propolis 8 parts, the Radix Stemonae 12 parts, Indigo Naturalis 8 parts, Flos Lonicerae 10 parts, Rhizoma Imperatae 30 parts, Radix Sophorae Flavescentis 10 parts, 6.5 parts of Pericarpium Zanthoxyli, Semen Impatientis 10 parts, Discolia vittifrons Sch. 3.5 parts, Herba Agerati Conyzoidis 10 parts, vinegar 115 parts.
The preparation method of a kind of compositions treating the pruritus that allergy causes, specifically has following steps to be prepared from:
1. taking Pericarpium Zanthoxyli to be placed in husky pot, add the clear water of Pericarpium Zanthoxyli weight 10-15 times, big fire decocts to boiling, ceases fire after Pericarpium Zanthoxyli expands completely, filters, and filtrate is standby, takes out stand-by by well-done Pericarpium Zanthoxyli;
2. Semen Sinapis Albae, the Radix Stemonae, Flos Lonicerae, Rhizoma Imperatae, Radix Sophorae Flavescentis, Semen Impatientis, Discolia vittifrons Sch., Herba Agerati Conyzoidis and step (1) gained Pericarpium Zanthoxyli rice vinegar are mixed thoroughly, agglomerating with preservative film parcel, sealing and standing 5-10 hour, above-mentioned raw materials medicine is placed on tile, little fire is even with rice vinegar spray after drying slowly 5-15 minute, drying 2-6 minute slow, dry in the air to room temperature, grinding to form smalls, to cross 80-120 mesh sieve stand-by;
3. vinegar is placed in iron pan; little fire decocts and puts into propolis and Indigo Naturalis when bubbling to surrounding and hiss, and stirs to decoct and melts completely to propolis, and after propolis melts completely, big fire decocts the boiling 50-70 second; putting into step 2. gained smalls before truce, stewing 20-40 minute stand-by;
4. being poured in step 1. gained filtrate by step 3. gains, stir with big ferrum spoon, little fire decocts 3-8 minute, turns big fire and decocts to boiling, stands 2-4 hour, obtain supernatant, supernatant is crossed 200-240 mesh drainage screen, and filtrate is bottled and i.e. obtained compositions.
The preparation method of above-mentioned composition, 1. preparation process adds the clear water (preferably, adding the clear water of Pericarpium Zanthoxyli weight 12.5 times) of Pericarpium Zanthoxyli weight 11-14 times.
The preparation method of above-mentioned composition, preparation process is 2. agglomerating with preservative film parcel, sealing and standing 6-9 hour (preferably agglomerating with preservative film parcel, sealing and standing 7.5 hours).
The preparation method of above-mentioned composition, the least fire of preparation process is even with rice vinegar spray after drying slowly 8-13 minute, dries 3-5 minute (the least fire sprays even with rice vinegar after drying 10 minutes slowly, dries 4 minutes) slow slow.
The preparation method of above-mentioned composition, preparation process 3. big fire decoction boiling 55-65 second (preferably big fire decocts boiling 60 seconds after propolis melts completely) after propolis melts completely.
The preparation method of above-mentioned composition, preparation process is put into step 2. gained smalls, is boiled in a covered pot over a slow fire 25-35 minute stand-by (putting into step 2. gained smalls before preferably ceasing fire, stewing 30 minutes stand-by) before 3. ceasing fire.
The preparation method of above-mentioned composition, the least fire of preparation process decocts 4-7 minute, turns big fire and decocts to boiling, stands 2.5-3.5 hour, obtains supernatant (preferably, little fire decocts 5 minutes, turns big fire and decocts to boiling, stands 3 hours, obtain supernatant).
The pruritus effect that allergy is caused by said composition is notable, there is antibacterial, antipruritic, effect of antiinflammatory, Pericarpium Zanthoxyli in side has obtained pepper water after processing, Pericarpium Zanthoxyli has good removing dampness to relieve itching effect, the crude drug such as Semen Sinapis Albae, the Radix Stemonae and Radix Sophorae Flavescentis all have antipruritic, and effect of damp eliminating can be at the pruritis of medication initial stage rapid recovery patient, make patient have the confidence adhering to treatment, alleviate physical pain and the burden of patient.
The pharmacological effect of each crude drug is respectively as follows:
Semen Sinapis Albae: another name hot food, Latin literary fame 1 year or the dry mature seed of biennial plant Caulis et Folium Sinapis albee.Cruciferae, spherical in shape, surface canescence is to faint yellow, and seed coat is thin and crisp, has oil to cause.Odorless, acrid in the mouth is peppery.Can be used as medicine.Warming the lung eliminating phlegm promoting the circulation of QI, resolving mass and removing the obstruction of the collateral pain relieving, reduce phlegm by drink;Mass dissipating and swelling eliminating.Main cough with asthma abundant expectoration;Fullness in the chest and hypochondriac pain;Numb limbs and tense tendons;Arthralgia;Multiple abscess caused by damp-phlegm;Carbuncle of yin nature toxic swelling.Controlling acute mastitis, breast carcinoma, mammary gland pain, tuberculosis, phlegm retention cough with asthma, fullness and distention in the chest and hypochondrium pain, regurgitation is vomitted, aphasia due to apoplexy, and limbs arthralgia pain is numb, tinea pedis, carbuncle of yin nature, toxic swelling, treating swelling and pain by traumatic injury.
Propolis: antibacterial, looks improving and the skin nourishing that propolis has, the effect of promotion cell regeneration, this has just been doomed the propolis critical role in skin care item industry, it not only can eliminate fungal infection, pigment can also be decomposed, calm down wrinkle, delaying senility, accelerating the healing of histiocytic regeneration and wound, pox scar pox left to small pox print also has good curative effect.Recent studies proves, enriching and the bioactive substance of uniqueness contained by propolis, make it have the several functions such as antibacterial, antiinflammatory, antipruritic, antioxidation, enhancing immunity, blood sugar lowering, blood fat reducing, antitumor, human body is had medical treatment, health-care effect widely, become the focus of various countries' scientific research, and become emerging health product and extremely praise highly.Antibacterial action.Propolis energy sterilizing, sterilize, sterilize, antibacterial, mildew-resistant, anticorrosion, solve the defect that single microorganism is only worked by antibiotic, and be free from side effects.In daily life dermatosis is had good therapeutic effect.Antivirus action.Propolis is natural antiviral substance, and multiple virus is had the strongest suppression and killing action.Antioxidation.Propolis is referred to as antioxidant and free radical scavenger, it is possible to effectively remove the refuses such as the excess activated oxygen produced because of the bad life habits such as fat, overworked, environmental pollution, smoking and extraneous factor and free radical.Enhancing immunity effect.The immune system of human body is easily infracting by virus, and propolis can strengthen body immunity, strengthens the ability of human body opposing virus infraction.Antitumaous effect.Domestic and international substantial amounts of research shows, propolis has good effect pressing down cancer anticancer aspect.Promote cell regeneration effect.Propolis can accelerate the healing of tissue regeneration and wound.Effects of beautification and nourishing face.Propolis can decompose pigment, calm down wrinkle, delaying senility etc., is women cosmetic good merchantable brand.Analgesic activity.Propolis also has good effect in terms of analgesia.Prophylaxis of tumours.Containing abundant cancer-resisting substance in propolis, research proves, cancer patient after taking propolis, can reduce cancerous cell and chemotherapy can be alleviated, side effect that radiotherapy causes.Resisting hypertension.Much more very the patient suffering from hypertension takes the Flavonoid substances contained continuously and has the propolis of very strong anti-oxidation ability, it is possible not only to reduce the harm of lipid peroxidation confrontation blood vessel, prevent sclerosis of blood vessels, and the content of triglyceride can also be effectively reduced, reduce platelet aggregation, improve microcirculation, too high blood pressure can be reduced, prevent the generation of unexpected thing.Thus, middle-aged and elderly people, particularly hypertension, heart disease, arteriosclerosis patient, usually take propolis, good health and a long life are quite had benifit.
The Radix Stemonae: the Radix Stemonae (Classification system: Stemona japonica) is also known as mother-in-law woman grass, and medicine louse medicine, is the plant of Stemonaceae.The Radix Stemonae is perennial herb, the raw fusiform meat tuber in underground bunch, and stem top is climbed up by holding on to its thing and risen.Root is used as medicine, outward for parasite killing, antipruritic, delousing;For oral administration have lung moistening, cough-relieving, the effect eliminated the phlegm.
Indigo Naturalis: have another name called Concha Meretricis Seu Cyclinae powder, indigo-blue flower, for Acanthaceae Acanthaceous indigo platymiscium Acanthaceous indigo, Polygonaceae arsesmart polygonum tinctorium ait., pulse family anil Folium et Caulis Indigoferae Tinctoriae, the leaf of Cruciferae Isatis indigotica Fort. platymiscium Isatis indigotica Fort. or the processed prepared dried powder of stem and leaf or agglomerate.The property of medicine: this product is navy blue powder, body is light, easily flies upward, and micro-have careless stink smell, and taste becomes, cold in nature.Composition: its main component has indirubin, indigo.The symptoms such as finding according to modern pharmacological research, this medical instrument has antitumor, anti-inflammatory and antalgic, antiulcer, antibacterial, clearing away heat and cooling blood, effect of removing toxic substances, for temperature poison macule, laryngopharynx swelling and pain, spits blood, epistaxis, spitting of blood.
Flos Lonicerae: Flos Lonicerae the most just medical value with it is extensive and famous.Its effect is mainly heat-clearing and toxic substances removing, cures mainly epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle furunculosis etc..nullModern study proves,Flos Lonicerae contains chlorogenic acid、The pharmacological components such as luteolin glycosides,To Hemolytic streptococcus、The various pathogens such as staphylococcus aureus and upper respiratory tract infection Causative virus etc. have stronger restraint,The most also can enhancing immunity、Antiearly pregnancy、Hepatoprotective、Antitumor、Antiinflammatory、Antipyretic、Hemostasis (blood coagulation)、Suppression intestinal absorption cholesterol etc.,Its clinical application is widely,Can be used for treating respiratory tract infection with other medicines compatibility、Bacillary dysentery、Acute urinary、Hypertension etc. more than 40 plant disease,After vine of Flos Lonicerae pot water, the skin pruritus such as infant eczema there is certain therapeutical effect,Multiple to sick pathogenic bacteria to poultry、Virus has inhibitory action,If vine of Flos Lonicerae leaf (Caulis Lonicerae) powder or pot water of doses can be added during animal feeding,Epidemic febrile disease heating to prevention and treatment animal、Anemopyretic cold、Laryngopharyngitis、Pneumonia、Dysentery、Swollen ulcer、Erysipelas、The diseases such as cellulitis all have goodish effect.
Rhizoma Imperatae: the taste caused: sweet, cold.Gui Jing: return lung, stomach, bladder warp.Effect: cooling blood for hemostasis, clearing away heat and promoting diuresis.Cure mainly: spit blood for heat in blood. epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria;The oedema due to nephritis suddenly caused.
Radix Sophorae Flavescentis: GUIXIN, liver, stomach, large intestine, bladder warp.Effect heat clearing and damp drying, parasite killing, diuresis.Cure mainly for hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy, external treatment trichomonal vaginitis.
Pericarpium Zanthoxyli: the traditional Chinese medical science is thought, Pericarpium Zanthoxyli is warm in nature, acrid in the mouth, have warming spleen and stomach for dispelling cold, stomach invigorating dehumidifying, pain relieving parasite killing, removing toxic substances regulate the flow of vital energy, effect of antipruritic raw meat of dispelling;Can be used for treating food stagnation, stop the pain of joint muscle caused by drink, singultus, vomiting, wind-cold damp pathogen, coldness and pain in the epigastrium, have loose bowels, dysentery, ascarid, the disease such as pudendal pruritus.Function cures mainly: warming spleen and stomach for dispelling cold, dehumidifying, pain relieving, parasite killing, solves fish raw meat poison.Controlling food stagnation and stop drink, trusted subordinate's cold type of pain, vomiting, oh, cough gas Pericarpium Zanthoxyli is inverse, and anemofrigid-damp arthralgia is had loose bowels, dysentery, colic, toothache, ascariasis, enterobiasis, pudendal pruritus, skin ulcer scabies.
Semen Impatientis: for the seed of Balsaminaceae impatiens Flos Impatientis.Pharmacology: have the effect of antifertility, also have antianaphylactic effect, uterus spinosity is swashed effect by antibacterial action.The property of medicine: pungent, micro-hardship, temperature, mild toxicity.Return liver, spleen channel.Function cures mainly: blood stasis expelling sending down the abnormal ascending QI, hard masses softening and resolving.
Discolia vittifrons Sch.: for Scoliidae Scolia animal red stricture of vagina Discolia Vittifrons Sch. and the immaturity larva of Vespidae Vespa animal ring yellow wasp.The property of medicine: sweet, cool, poisonous.Function cures mainly: dispel the wind, spasmolytic, removing toxic substances and promoting subsidence of swelling.Cure mainly infantile convulsion, rubella pruritus, laryngopharynx swelling and pain, carbuncle, erysipelas, puerpera's agalactia.
Herba Agerati Conyzoidis: for the herb of Compositae Ageratum plant Ageratum conyzoides.Composition: herb is containing flavonoid: Herba Agerati Conyzoidis flavone A, B, C, Nobiletin, senensetin, lindera pyrite B, etc..Alkaloid: Lycopodium clavatum amine, Echinatin.Triterpenoid compound: freidelin.Sterols: stigmasterol etc..Volatile oil: Herba Agerati Conyzoidis chromene, coumarin etc..Aerial parts contains chromene class: 7 methoxyl group-2,2-dimethyl chromogen alkene, 7,8-dimethoxys-2 etc..The property of medicine: micro-hardship, pungent, cool.Function cures mainly: heat-clearing and toxic substances removing, hemostasis, pain relieving.Cure mainly cold, fever, laryngopharynx swelling and pain, aphtha of the mouth and tongue, spitting of blood, epistaxis, metrorrhagia, epigastric pain, rheumatic arthralgia, traumatic injury, traumatic hemorrhage, thrush, carbuncle furuncle, eczema pruritus.
Vinegar: rice vinegar is that numerous kinds vinegar Middle nutrition is worth higher one, the aminoacid that causes containing abundant alkali, glucide, organic acid, vitamin B1, vitamin B2, vitamin C, inorganic salt, mineral etc., there is lipoid and reducing blood pressure of dispelling, reduce cholesterol, removing toxic substances, relieve the effect of alcohol, help digestion, fat-reducing, relieving restlessness of calming the nerves, useful cardiovascular.
The present composition debates the principle of disease treatment based on Chinese medicine.The medical material selected has antibacterial for table disease, antipruritic, antiinflammatory, also has and adjusts kidney for inner disease heat extraction, belong to inside and outside take into account and safely and effectively medicine, the pruritus causing allergy has fabulous therapeutical effect.
Detailed description of the invention
Describe technical scheme in detail below in conjunction with embodiment and experimental example, but protection domain is not limited by this.
Embodiment 1 one kinds treats the compositions of the pruritus that allergy causes, and takes off and states the primary raw material of weight proportion and be prepared from (every part takes 10g): Semen Sinapis Albae 3 parts, propolis 6 parts, the Radix Stemonae 10 parts, Indigo Naturalis 5 parts, Flos Lonicerae 6 parts, Rhizoma Imperatae 15 parts, Radix Sophorae Flavescentis 5 parts, 4.5 parts of Pericarpium Zanthoxyli, Semen Impatientis 5 parts, Discolia vittifrons Sch. 2 parts, Herba Agerati Conyzoidis 5 parts, vinegar 105 parts.
The preparation method of the compositions of the pruritus that above-mentioned treatment allergy causes, step is as follows:
1. taking Pericarpium Zanthoxyli to be placed in husky pot, add the clear water of Pericarpium Zanthoxyli weight 10 times, big fire decocts to boiling, ceases fire after Pericarpium Zanthoxyli expands completely, filters, and filtrate is standby, takes out stand-by by well-done Pericarpium Zanthoxyli;
2. Semen Sinapis Albae, the Radix Stemonae, Flos Lonicerae, Rhizoma Imperatae, Radix Sophorae Flavescentis, Semen Impatientis, Discolia vittifrons Sch., Herba Agerati Conyzoidis and step (1) gained Pericarpium Zanthoxyli rice vinegar are mixed thoroughly, agglomerating with preservative film parcel, sealing and standing 5 hours, to be placed on tile by crude drug according to claim 4, little fire is even with rice vinegar spray after drying slowly 5 minutes, drying 2 minutes slow, dry in the air to room temperature, grinding to form smalls, to cross 80 mesh sieves stand-by;
3. vinegar is placed in iron pan; little fire decocts and puts into propolis and Indigo Naturalis when bubbling to surrounding and hiss, and stirs to decoct and melts completely to propolis, and after propolis melts completely, big fire decocts boiling 50 seconds; putting into step 2. gained smalls before truce, stewing 20 minutes stand-by;
4. being poured in step 1. gained filtrate by step 3. gains, stir with big ferrum spoon, little fire decocts 3 minutes, turns big fire and decocts to boiling, stands 2 hours, obtain supernatant, supernatant is crossed 200 mesh drainage screens, and filtrate is bottled and i.e. obtained compositions.
Model case one Zhu XX, man, 13 years old, Dezhou, Shandong Province personage, the student in certain middle school, patient is from little to Stigma Maydis allergy, and at a touch Stigma Maydis will play erythema by whole body, and pruritus is hard to bear, the when that allergy being serious, whole body pruritus is incomparable, all can not continue to attend class, owing to patient wants to continue to attending class, adhering to again expectant treatment, doctor is it has been suggested that use the present composition.
Using the compositions of embodiment 1 gained, each allergy is, takes present composition 2ml, is sprayed on the place of pruritus allergy, take present composition 3ml after adhering to going home, be put in bathtub, soak whole body, after spraying, pruritus 1-3 minute disappears immediately, and after soak whole body in the evening, erythema disappears.
Embodiment 2 one kinds treats the compositions of the pruritus that allergy causes, and takes off and states the primary raw material of weight proportion and be prepared from (every part takes 10g): Semen Sinapis Albae 8 parts, propolis 12 parts, the Radix Stemonae 15 parts, Indigo Naturalis 10 parts, Flos Lonicerae 12 parts, Rhizoma Imperatae 60 parts, Radix Sophorae Flavescentis 15 parts, 9 parts of Pericarpium Zanthoxyli, Semen Impatientis 15 parts, Discolia vittifrons Sch. 5 parts, Herba Agerati Conyzoidis 15 parts, vinegar 125 parts.
The preparation method of the compositions of the pruritus that above-mentioned treatment allergy causes, step is as follows:
1. taking Pericarpium Zanthoxyli to be placed in husky pot, add the clear water of Pericarpium Zanthoxyli weight 15 times, big fire decocts to boiling, ceases fire after Pericarpium Zanthoxyli expands completely, filters, and filtrate is standby, takes out stand-by by well-done Pericarpium Zanthoxyli;
2. Semen Sinapis Albae, the Radix Stemonae, Flos Lonicerae, Rhizoma Imperatae, Radix Sophorae Flavescentis, Semen Impatientis, Discolia vittifrons Sch., Herba Agerati Conyzoidis and step (1) gained Pericarpium Zanthoxyli rice vinegar are mixed thoroughly, agglomerating with preservative film parcel, sealing and standing 10 hours, to be placed on tile by crude drug according to claim 4, little fire is even with rice vinegar spray after drying slowly 15 minutes, drying 6 minutes slow, dry in the air to room temperature, grinding to form smalls, to cross 120 mesh sieves stand-by;
3. vinegar is placed in iron pan; little fire decocts and puts into propolis and Indigo Naturalis when bubbling to surrounding and hiss, and stirs to decoct and melts completely to propolis, and after propolis melts completely, big fire decocts boiling 70 seconds; putting into step 2. gained smalls before truce, stewing 40 minutes stand-by;
4. being poured in step 1. gained filtrate by step 3. gains, stir with big ferrum spoon, little fire decocts 8 minutes, turns big fire and decocts to boiling, stands 4 hours, obtain supernatant, supernatant is crossed 240 mesh drainage screens, and filtrate is bottled and i.e. obtained compositions.
Embodiment 3 one kinds treats the compositions of the pruritus that allergy causes, and takes off and states the primary raw material of weight proportion and be prepared from (every part takes 10g): Semen Sinapis Albae 4 parts, propolis 7 parts, the Radix Stemonae 11 parts, Indigo Naturalis 6 parts, Flos Lonicerae 9 parts, Rhizoma Imperatae 25 parts, Radix Sophorae Flavescentis 8 parts, 5 parts of Pericarpium Zanthoxyli, Semen Impatientis 7 parts, Discolia vittifrons Sch. 3 parts, Herba Agerati Conyzoidis 7 parts, vinegar 110 parts.
The preparation method of the compositions of the pruritus that above-mentioned treatment allergy causes, step is as follows:
1. taking Pericarpium Zanthoxyli to be placed in husky pot, add the clear water of Pericarpium Zanthoxyli weight 11 times, big fire decocts to boiling, ceases fire after Pericarpium Zanthoxyli expands completely, filters, and filtrate is standby, takes out stand-by by well-done Pericarpium Zanthoxyli;
2. Semen Sinapis Albae, the Radix Stemonae, Flos Lonicerae, Rhizoma Imperatae, Radix Sophorae Flavescentis, Semen Impatientis, upper honeybee, Herba Agerati Conyzoidis and step (1) gained Pericarpium Zanthoxyli rice vinegar are mixed thoroughly, agglomerating with preservative film parcel, sealing and standing 6 hours, to be placed on tile by crude drug according to claim 4, little fire is even with rice vinegar spray after drying slowly 8 minutes, drying 3 minutes slow, dry in the air to room temperature, grinding to form smalls, to cross 90 mesh sieves stand-by;
3. vinegar is placed in iron pan; little fire decocts and puts into propolis and Indigo Naturalis when bubbling to surrounding and hiss, and stirs to decoct and melts completely to propolis, and after propolis melts completely, big fire decocts boiling 55 seconds; putting into step 2. gained smalls before truce, stewing 25 minutes stand-by;
4. being poured in step 1. gained filtrate by step 3. gains, stir with big ferrum spoon, little fire decocts 4 minutes, turns big fire and decocts to boiling, stands 2.5 hours, obtain supernatant, supernatant is crossed 210 mesh drainage screens, and filtrate is bottled and i.e. obtained compositions.
Embodiment 4 one kinds treats the compositions of the pruritus that allergy causes, and takes off and states the primary raw material of weight proportion and be prepared from (every part takes 10g): Semen Sinapis Albae 7 parts, propolis 10 parts, the Radix Stemonae 14 parts, Indigo Naturalis 9 parts, Flos Lonicerae 11 parts, Rhizoma Imperatae 40 parts, Radix Sophorae Flavescentis 11 parts, 8 parts of Pericarpium Zanthoxyli, Semen Impatientis 12 parts, Discolia vittifrons Sch. 4 parts, Herba Agerati Conyzoidis 12 parts, vinegar 120 parts.
The preparation method of the compositions of the pruritus that above-mentioned treatment allergy causes, step is as follows:
1. taking Pericarpium Zanthoxyli to be placed in husky pot, add the clear water of Pericarpium Zanthoxyli weight 14 times, big fire decocts to boiling, ceases fire after Pericarpium Zanthoxyli expands completely, filters, and filtrate is standby, takes out stand-by by well-done Pericarpium Zanthoxyli;
2. Semen Sinapis Albae, the Radix Stemonae, Flos Lonicerae, Rhizoma Imperatae, Radix Sophorae Flavescentis, Semen Impatientis, Discolia vittifrons Sch., Herba Agerati Conyzoidis and step (1) gained Pericarpium Zanthoxyli rice vinegar are mixed thoroughly, agglomerating with preservative film parcel, sealing and standing 9 hours, to be placed on tile by crude drug according to claim 4, little fire is even with rice vinegar spray after drying slowly 13 minutes, drying 5 minutes slow, dry in the air to room temperature, grinding to form smalls, to cross 110 mesh sieves stand-by;
3. vinegar is placed in iron pan; little fire decocts and puts into propolis and Indigo Naturalis when bubbling to surrounding and hiss, and stirs to decoct and melts completely to propolis, and after propolis melts completely, big fire decocts boiling 65 seconds; putting into step 2. gained smalls before truce, stewing 35 minutes stand-by;
4. being poured in step 1. gained filtrate by step 3. gains, stir with big ferrum spoon, little fire decocts 7 minutes, turns big fire and decocts to boiling, stands 3.5 hours, obtain supernatant, supernatant is crossed 230 mesh drainage screens, and filtrate is bottled and i.e. obtained compositions.
Model case two: Liu XX, man, 20 years old, Jinan, Shandong Province personage, there is the pruritus that allergy causes before 2 years, carry out infusing and Drug therapy in hospital, leaving hospital latter 1 year and allergy pruritis occur again, repeatedly occurred the symptom of allergy pruritus since May, patient is to pollen hypersensitivity to go to hospital to find after having done comprehensive inspection, often there is pruritus in just cause, so its use resulting composition of the present invention of doctor advised.
Use the compositions of embodiment 4 gained, allergy is every time; takes present composition 1ml, is sprayed on the place of pruritus allergy, take present composition 3ml after adhering to going home; is put in bathtub; soaking whole body, after spraying, pruritus 1-3 minute disappears immediately; after soak whole body in the evening, and malaise symptoms disappears.
Embodiment 5 one kinds treats the compositions of the pruritus that allergy causes, and takes off and states the primary raw material of weight proportion and be prepared from (every part takes 10g): Semen Sinapis Albae 5.5 parts, propolis 8 parts, the Radix Stemonae 12 parts, Indigo Naturalis 8 parts, Flos Lonicerae 10 parts, Rhizoma Imperatae 30 parts, Radix Sophorae Flavescentis 10 parts, 6.5 parts of Pericarpium Zanthoxyli, Semen Impatientis 10 parts, Discolia vittifrons Sch. 3.5 parts, Herba Agerati Conyzoidis 10 parts, vinegar 115 parts.
The preparation method of the compositions of the pruritus that above-mentioned treatment allergy causes, step is as follows:
1. taking Pericarpium Zanthoxyli to be placed in husky pot, add the clear water of Pericarpium Zanthoxyli weight 12.5 times, big fire decocts to boiling, ceases fire after Pericarpium Zanthoxyli expands completely, filters, and filtrate is standby, takes out stand-by by well-done Pericarpium Zanthoxyli;
2. Semen Sinapis Albae, the Radix Stemonae, Flos Lonicerae, Rhizoma Imperatae, Radix Sophorae Flavescentis, Semen Impatientis, Discolia vittifrons Sch., Herba Agerati Conyzoidis and step (1) gained Pericarpium Zanthoxyli rice vinegar are mixed thoroughly, agglomerating with preservative film parcel, sealing and standing 7.5 hours, to be placed on tile by crude drug according to claim 4, little fire is even with rice vinegar spray after drying slowly 10 minutes, drying 4 minutes slow, dry in the air to room temperature, grinding to form smalls, to cross 100 mesh sieves stand-by;
3. vinegar is placed in iron pan; little fire decocts and puts into propolis and Indigo Naturalis when bubbling to surrounding and hiss, and stirs to decoct and melts completely to propolis, and after propolis melts completely, big fire decocts boiling 60 seconds; putting into step 2. gained smalls before truce, stewing 30 minutes stand-by;
4. being poured in step 1. gained filtrate by step 3. gains, stir with big ferrum spoon, little fire decocts 5 minutes, turns big fire and decocts to boiling, stands 3 hours, obtain supernatant, supernatant is crossed 220 mesh drainage screens, and filtrate is bottled and i.e. obtained compositions.
Test example: the clinical practice of the compositions of pruritus that embodiment 5 gained treatment allergy causes: in June, 2010 in December ,-2014,200 example patients are screened in 4 hospitals, before test, this crowd is carried out Continuous Observation, record symptom and change, be randomly divided into two groups, experimental group and matched group, experimental group takes embodiment 5 products obtained therefrom, and matched group takes other medicine.
Using method: for making the present invention reach optimum therapeuticing effect, one is for several times, takes present composition 2-4ml every time, is sprayed on the place of pruritus allergy, if running into the patient of systemic anaphylaxis, desirable present composition 3ml, it is put in bathtub, soaks whole body.
Curative effect situation criterion: cure: after using this product, pruritus was stopped in 1-5 minute immediately;Effective: after using this product, pruritus substantially alleviated in 1-5 minute;Invalid: using one course for the treatment of of this product, malaise symptoms is unchanged.
Result is as shown in table 1.
Table 1:
During use, self-induction symptom variation is as shown in table 2.
Table 2:
Efficacy analysis: when administration group (present composition) uses 1 minute, most patient sensory symptoms substantially alleviates, substantially feel to take a favorable turn in affected part, patient's pruritus alleviates, during medication 2 minutes, patient's malaise symptoms is substantially achieved improvement, during medication 3 minutes, the malaise symptoms major part of patient disappears, and the state of an illness is preferably controlled, matched group is evident in efficacy after taking medicine, but after drug withdrawal, relapse rate is high.
Clinical tests prove that, the present composition is in the pruritus that treatment allergy causes, and total effective rate is 99%, exceeds 31% than the effective percentage of matched group, makes the state of an illness of patient be stablized;And the health of patient will not be caused any burden.Present composition instant effect, it is possible to reach to alleviate rapidly the purpose that patient is painful, is the compositions of the pruritus that a kind of safely and effectively treatment allergy causes.

Claims (10)

1. the compositions treating the pruritus that allergy causes, it is characterised in that: take off the primary raw material system stating weight proportion For forming: Semen Sinapis Albae 3-8 part, propolis 6-12 part, Radix Stemonae 10-15 part, Indigo Naturalis 5-10 part, Flos Lonicerae 6-12 part, in vain Rhizoma Imperatae 15-60 part, Radix Sophorae Flavescentis 5-15 part, Pericarpium Zanthoxyli 4.5-9 part, Semen Impatientis 5-15 part, Discolia vittifrons Sch. 2-5 part, Herba Agerati Conyzoidis 5-15 Part, vinegar 105-125 part.
The compositions of the pruritus that treatment allergy causes the most according to claim 1, it is characterised in that: take following weight and join The primary raw material of ratio is prepared from: Semen Sinapis Albae 4-7 part, propolis 7-10 part, Radix Stemonae 11-14 part, Indigo Naturalis 6-9 part, gold silver Flower 9-11 part, Rhizoma Imperatae 25-40 part, Radix Sophorae Flavescentis 8-11 part, Pericarpium Zanthoxyli 5-8 part, Semen Impatientis 7-12 part, Discolia vittifrons Sch. 3-4 part, Herba Agerati Conyzoidis 7-12 part, vinegar 110-120 part.
The compositions of the pruritus that treatment allergy causes the most according to claim 1, it is characterised in that: take following weight and join The primary raw material of ratio is prepared from: Semen Sinapis Albae 5.5 parts, propolis 8 parts, the Radix Stemonae 12 parts, Indigo Naturalis 8 parts, Flos Lonicerae 10 parts, Rhizoma Imperatae 30 parts, Radix Sophorae Flavescentis 10 parts, 6.5 parts of Pericarpium Zanthoxyli, Semen Impatientis 10 parts, Discolia vittifrons Sch. 3.5 parts, Herba Agerati Conyzoidis 10 parts, vinegar 115 parts.
4. according to the preparation method of the compositions treating the pruritus that allergy causes described in any one of claim 1-3, its feature It is: step is as follows:
1. taking Pericarpium Zanthoxyli to be placed in husky pot, add the clear water of Pericarpium Zanthoxyli weight 10-15 times, big fire decocts to boiling, treats that Pericarpium Zanthoxyli is complete Ceasing fire after expansion, filter, filtrate is standby, takes out stand-by by well-done Pericarpium Zanthoxyli;
2. by Semen Sinapis Albae, the Radix Stemonae, Flos Lonicerae, Rhizoma Imperatae, Radix Sophorae Flavescentis, Semen Impatientis, Discolia vittifrons Sch., Herba Agerati Conyzoidis and step (1) Gained Pericarpium Zanthoxyli rice vinegar is mixed thoroughly, and agglomerating with preservative film parcel, sealing and standing 5-10 hour, will be the most former Material medicine is placed on tile, and little fire is even with rice vinegar spray after drying slowly 5-15 minute, dries 2-6 minute slow, dries in the air to room temperature, grind to form It is stand-by that smalls crosses 80-120 mesh sieve;
3. being placed in iron pan by vinegar, little fire decocts and puts into propolis and Indigo Naturalis when bubbling to surrounding and hiss, stirring Melting completely while decocting to propolis, after propolis melts completely, big fire decocts the boiling 50-70 second, puts into step 2. before truce Gained smalls, stewing 20-40 minute stand-by;
4. being poured in step 1. gained filtrate by step 3. gains, stir with big ferrum spoon, little fire decocts 3-8 minute, Turning big fire to decoct to boiling, stand 2-4 hour, obtain supernatant, supernatant is crossed 200-240 mesh drainage screen, filtrate is bottled Obtain compositions.
The preparation method of compositions the most according to claim 4, it is characterised in that: 1. preparation process adds Pericarpium Zanthoxyli weight The clear water (preferably, adding the clear water of Pericarpium Zanthoxyli weight 12.5 times) of 11-14 times.
The preparation method of compositions the most according to claim 4, it is characterised in that: 2. preparation process wraps up with preservative film Agglomerating, sealing and standing 6-9 hour (preferably agglomerating with preservative film parcel, sealing and standing 7.5 hours).
The preparation method of compositions the most according to claim 4, it is characterised in that: the least fire of preparation process dries 8-13 slowly Spray even with rice vinegar after minute, dry 3-5 minute (the least fire sprayed even with rice vinegar after drying 10 minutes slowly, slow baking 4 minutes) slow.
The preparation method of compositions the most according to claim 4, it is characterised in that: 3. preparation process treats that propolis melts completely After change, big fire decocts the boiling 55-65 second (preferably big fire decocts boiling 60 seconds after propolis melts completely).
The preparation method of compositions the most according to claim 4, it is characterised in that: preparation process puts into step before 3. ceasing fire Rapid 2. gained smalls, stewing 2535 minutes stand-by (putting into step 2. gained smalls before preferably ceasing fire, stewing 30 minutes are stand-by).
The preparation method of compositions the most according to claim 4, it is characterised in that: the least fire of preparation process decocts 4-7 Minute, turn big fire and decoct to boiling, stand 2.5-3.5 hour, (preferably, little fire decocts 5 minutes, turns to obtain supernatant Big fire decocts to boiling, stands 3 hours, obtains supernatant).
CN201510413570.8A 2015-07-15 2015-07-15 Composition for treating pruritus caused by allergy and preparation method of composition Pending CN105878877A (en)

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