CN105517554B - 使用甲基巴多索隆或其类似物治疗和预防内皮功能障碍的方法 - Google Patents

使用甲基巴多索隆或其类似物治疗和预防内皮功能障碍的方法 Download PDF

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CN105517554B
CN105517554B CN201480049377.4A CN201480049377A CN105517554B CN 105517554 B CN105517554 B CN 105517554B CN 201480049377 A CN201480049377 A CN 201480049377A CN 105517554 B CN105517554 B CN 105517554B
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CN105517554A (zh
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钱珮珩
柯林·J·米尔
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Riata Pharmaceutical Holding Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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CN201480049377.4A 2013-08-23 2014-08-22 使用甲基巴多索隆或其类似物治疗和预防内皮功能障碍的方法 Active CN105517554B (zh)

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US201361869527P 2013-08-23 2013-08-23
US61/869,527 2013-08-23
PCT/US2014/052382 WO2015027206A1 (en) 2013-08-23 2014-08-22 Methods of treating and preventing endothelial dysfunction using bardoxololone methyl or analogs thereof

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CN202110101573.3A Pending CN112870202A (zh) 2013-08-23 2014-08-22 使用甲基巴多索隆或其类似物治疗和预防肾病的方法

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AU (2) AU2014308600B2 (https=)
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IL272242A (en) 2020-02-27
JP6701407B2 (ja) 2020-05-27
PH12016500358B1 (en) 2023-08-16
BR112016003454A2 (pt) 2017-08-01
IL285832B1 (en) 2023-09-01
NZ744036A (en) 2020-09-25
IL272242B (en) 2021-09-30
EA201690456A1 (ru) 2016-06-30
AU2014308600B2 (en) 2020-03-05
PH12016500358A1 (en) 2016-05-16
CA2921386A1 (en) 2015-02-26
MX380589B (es) 2025-03-12
WO2015027206A1 (en) 2015-02-26
WO2015027206A8 (en) 2015-06-11
KR102322057B1 (ko) 2021-11-05
MX2021002897A (es) 2021-06-08
TW202026003A (zh) 2020-07-16
NZ756256A (en) 2021-07-30
BR112016003454B1 (pt) 2023-02-14
TWI717026B (zh) 2021-01-21
AU2020203510B2 (en) 2023-05-11
EP3035937B1 (en) 2025-12-31
MY198522A (en) 2023-09-04
IL285832B2 (en) 2024-01-01
MY205497A (en) 2024-10-23
JP6526306B2 (ja) 2019-06-05
JP2019131599A (ja) 2019-08-08
IL244171B (en) 2020-02-27
CN112870202A (zh) 2021-06-01
NZ630951A (en) 2018-09-28
AU2020203510A1 (en) 2020-06-18
SG10201906113RA (en) 2019-08-27
JP2016528300A (ja) 2016-09-15
US20240115542A1 (en) 2024-04-11
CL2016000405A1 (es) 2017-02-24
AU2014308600A1 (en) 2016-03-03
CN105517554A (zh) 2016-04-20
JP6564372B2 (ja) 2019-08-21
KR20160061994A (ko) 2016-06-01
JP2019048873A (ja) 2019-03-28
SG11201601202WA (en) 2016-03-30
TWI716341B (zh) 2021-01-21
EP3035937A1 (en) 2016-06-29
US20190091194A1 (en) 2019-03-28
NZ774222A (en) 2023-01-27
TW201542211A (zh) 2015-11-16
US20150080465A1 (en) 2015-03-19
HK1223015A1 (zh) 2017-07-21
MX2016002375A (es) 2016-12-20
IL244171A0 (en) 2016-04-21
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