CN105497538A - Preparing method for Chinese herba preparation sugar-free granules for treating tubercular meningitis - Google Patents

Preparing method for Chinese herba preparation sugar-free granules for treating tubercular meningitis Download PDF

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CN105497538A
CN105497538A CN201511001580.7A CN201511001580A CN105497538A CN 105497538 A CN105497538 A CN 105497538A CN 201511001580 A CN201511001580 A CN 201511001580A CN 105497538 A CN105497538 A CN 105497538A
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Abstract

The invention relates to a preparing method for Chinese herba preparation sugar-free granules for treating tubercular meningitis. The Chinese herba preparation sugar-free granules are mainly prepared from, by weight, 5-15 parts of Chinese holly leaves, 6-14 parts of scorpions, 10-20 parts of radix ranunculi ternati, 8-16 parts of stiff silkworms, 3-6 parts of semen strychni, 2-8 parts of house lizards, 5-15 parts of sinense knotweed rhizome, 2-8 parts of blumea balsamifera and 4-12 parts of elsholtzia cillata hyland. The proper medicinal materials are selected, and treated and prepared properly, efficacy of the Chinese herba preparation sugar-free granules can be given into full play, and the purposes of treating both symptoms and root causes and curing tubercular meningitis efficiently and rapidly are achieved.

Description

The preparation method of the Chinese medicine preparation sugar free granule for the treatment of tuberculous meningitis
Divisional application, original applying number 201410157077X, applying date 2014.04.19, a kind of Chinese medicine preparation for the treatment of tuberculous meningitis of title and preparation method thereof.
Technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of tuberculous meningitis and preparation method thereof, belonged to traditional Chinese medicine field, be mainly used in treating tuberculous meningitis.
Background technology
Tuberculous meningitis is that tubercule bacillus causes meninges and membrane of spinal cord (brain essence) nonsuppurative inflammation, is modal nervous system tuberculosis, is often the brain performance of the disseminated tuberculosis of whole body blood group.Be a kind of cerebrovascular characteristic of disease disease having tubercule bacillus to cause, the cerebral vasculitis of secondary can cause ischemia, infarction.Tubercle can develop into large tuberculoma, occurs occupation time process.Inflammatory exudate blocks Basement geology can cause hydrocephalus and cranial nerve paralysis.General many infection in latter 3 months ~ 1 year in primary tuberculosis is fallen ill, and is more common in the children's of 1 ~ 5 years old.The course of disease of tuberculous meningitis from onset to death about 3 ~ 6 weeks is the most important reason of tuberculosis in children death.
Pathogeny: when the sick pathological changes of primary tuberculosis is formed, the tubercule bacillus of intralesional can rest in meninges, brain essence, spinal cord through blood, form the tuberculose focus of concealment, comprises tubercle knot, tuberculoma.When above-mentioned focus is once ulceration.Tulase directly enters subarachnoid space, causes tuberculous inflammation.In addition, tissue is as tuberculose focus such as middle ear, mastoid process, cervical vertebra, skulls near brain, also can direct extension, invade meninges, but comparatively rare, from etiopathogenesis, tuberculous meningitis system secondary tuberculosis, also has minority case, and primary lesion has been healed or can not find.
In the invention of the Chinese medicine preparation of existing treatment tuberculous meningitis, application publication number CN103494967A(application number 201310428985.3) disclose a kind of Chinese medicine preparation for the treatment of tuberculous meningitis in children, selection has replenishing YIN and removing heat, easing the affected liver relieves dizziness, high fever, infantile convulsions, epilepsy, etc., warming YANG is rescued inverse, the Chinese medicine Rhizoma Stachydis of causing resuscitation with aromatic drugs, Radix Campanumoeae, Rhizoma Fagopyri Cymosi, Herba Zephyranthis Candidae, Herba Swertiae heteranthae, Fructus Litseae pungentis, Folium Linderae strychnifoliae, Lignum seu Radix Acronychiae, Rhizoma Anemones Altaicae, Rhizoma Lycopi Lucidi, decocting becomes decoction.Application publication number CN102847035A(application number 201110175672.2) disclose a kind of prescription for the treatment of tuberculous meningitis, make for raw material with Os Draconis, Concha Ostreae, Radix Bupleuri, Radix Paeoniae Rubra, the Radix Paeoniae Alba, the Cortex Eucommiae, Radix Dipsaci, Radix Paeoniae Alba, Semen Cassiae, Concha Haliotidis, Folium Mori, Herba Taxilli, Fructus Amomi, Herba Asari, the Radix Rehmanniae, Radix Rehmanniae Preparata, Colla cornus cervi, Semen Astragali Complanati, Fructus Tribuli, Poria, Radix Ophiopogonis, double hook, Radix Cynanchi Atrati.Application publication number CN102824429A(application number 201210356851.0) disclose a kind of Chinese medicine formula specially controlling tuberculous meningitis external application Chinese medicine and preparation method; it is a kind of Chinese fuming drugss; use the medical material of following component, Calculus Bovis 1-5 gram, Moschus 0.2-3 gram, Margarita 3-6 gram, Hydrargyri Oxydum Rubrum 2-6 gram, Mentholum 9-15 gram, Vermilion 3-9 gram, Calomelas 4-6 gram, Borneolum Syntheticum 3-8 gram, Plumbum preparatium 2-8 gram, black small arms propellant 28-40 gram.
Summary of the invention
For the present situation of tuberculous meningitis, the object of the present invention is to provide Chinese medicine preparation of a kind of tuberculous meningitis and preparation method thereof, by selecting suitable medical material, through appropriate process and preparation, it is made to play maximum drug effect, reach treating both the principal and secondary aspects of a disease, cure the object of tuberculous meningitis efficiently, rapidly.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
The Chinese medicine preparation for the treatment of tuberculous meningitis, takes off the primary raw material stating weight proportion and is prepared from: Folium Mahoniae 5-15 part Scorpio 6-14 part Radix Ranunculi Ternati 10-20 part, Bombyx Batryticatus 8-16 part, Semen Strychni 3-6 part, Gekko Swinhonis 2-8 part, Rhizoma cypripedii macranthi 5-15 part, Herba Blumeae Balsamiferae 2-8 part, Herba Elsholtziae Ciliatae 4-12 part.
The Chinese medicine preparation of above-mentioned treatment tuberculous meningitis, preferred scheme, take off the primary raw material stating weight proportion to be prepared from: Folium Mahoniae 8-12 part, Scorpio 9-11 part, Radix Ranunculi Ternati 14-16 part, Bombyx Batryticatus 10-14 part, Semen Strychni 4-5 part, Gekko Swinhonis 4-6 part, Rhizoma cypripedii macranthi 8-12 part, Herba Blumeae Balsamiferae 4-6 part, Herba Elsholtziae Ciliatae 7-9 part.
The Chinese medicine preparation of the above treatment tuberculous meningitis, better preferred scheme, takes off the primary raw material stating weight proportion and is prepared from: Folium Mahoniae 10 parts, Scorpio 10 parts, Radix Ranunculi Ternati 15 parts, Bombyx Batryticatus 12 parts, Semen Strychni 5 parts, Gekko Swinhonis 5 parts, Rhizoma cypripedii macranthi 10 parts, Herba Blumeae Balsamiferae 5 parts, Herba Elsholtziae Ciliatae 8 parts.
According to the Chinese medicine preparation of arbitrary described treatment tuberculous meningitis above, be prepared into pharmaceutically acceptable unguentum, granules of sugar agent or sugar free granule.
According to the Chinese medicine preparation of described treatment tuberculous meningitis above, the preparation method of unguentum, step is as follows:
1. Folium Mahoniae, Radix Ranunculi Ternati, Herba Blumeae Balsamiferae, Herba Elsholtziae Ciliatae are cleaned, cut and pulverize, cross 120-150 mesh sieve (preferably 135 mesh sieves);
2. by Scorpio, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi removing impurity, clean, in 50-90 DEG C of water, soak 3-6 hour;
3. the Scorpio after immersion, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi are decocted with water 2 times, add 3-7 times of water gaging (preferred amount of water to 5 times) at every turn, respectively decoct 4-8 hour (preferably 6 hours), then medicinal liquid is merged, filter, filtrate and step 1. middle gained medicated powder mix, and are then concentrated into relative density and are about 1.0-1.3(60 DEG C) clear paste, be cooled to room temperature, sterile packaged obtains unguentum.
According to preparation method recited above, preferred scheme is, 2. step uses the water (preferably 75 DEG C) of 60-80 DEG C.
According to preparation method recited above, preferred scheme is, 2. step soaks 4-5 hour (preferably 4.5 hours).
According to preparation method recited above, preferred scheme is, 3. step is concentrated into the preferred relative density to 1.15 of relative density 1.1-1.2().
According to the Chinese medicine preparation of described treatment tuberculous meningitis above, the preparation method of granules of sugar agent, step is as follows:
folium Mahoniae, Radix Ranunculi Ternati, Herba Blumeae Balsamiferae, Herba Elsholtziae Ciliatae are cleaned, cuts and pulverize, cross 120-150 mesh sieve (preferably 135 mesh sieves);
by Scorpio, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi removing impurity, clean, soak in 50-90 DEG C of (preferably 70 DEG C) water 3-6 hour (preferably 4.5 hours);
3. the Scorpio after immersion, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi are decocted with water 2 times, add 3-7 times of water gaging (preferred amount of water to 5 times) at every turn, respectively decoct 4-8 hour (preferably 6 hours), then medicinal liquid is merged, filter, filtrate and step 1. in gained medicated powder mix, be then concentrated into relative density and be about 1.0-1.3(60 DEG C) clear paste of (preferred relative density to 1.15), be cooled to room temperature;
in step 3. gained clear paste, add ethanol makes alcohol content reach 60%, leave standstill, getting supernatant concentration to relative density is 1.2-1.8(60 DEG C) thick paste of (preferred relative density to 1.5), add cane sugar powder, dextrin and ethanol in proper amount soft material, cross 10-24 mesh sieve granule (preferably 17 mesh sieves), wet granular is dry in 50-90 DEG C (preferably 70 DEG C), and dry granule crosses 17 mesh sieve granulate, screens out fine powder after No. five, subpackage, check, packaging, get product medicament.
According to the Chinese medicine preparation of described treatment tuberculous meningitis above, the preparation method of sugar free granule, step is as follows:
folium Mahoniae, Radix Ranunculi Ternati, Herba Blumeae Balsamiferae, Herba Elsholtziae Ciliatae are cleaned, cuts and pulverize, cross 120-150 mesh sieve (preferably 135 mesh sieves);
by Scorpio, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi removing impurity, clean, soak in 50-90 DEG C of (preferably 70 DEG C) water 3-6 hour (preferably 4.5 hours);
3. the Scorpio after immersion, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi are decocted with water 2 times, add 3-7 times of water gaging (preferred amount of water to 5 times) at every turn, respectively decoct 4-8 hour (preferably 6 hours), then medicinal liquid is merged, filter, filtrate and step 1. in gained medicated powder mix, be then concentrated into relative density and be about 1.0-1.3(60 DEG C) clear paste of (preferred relative density to 1.15), be cooled to room temperature;
in step 3. gained clear paste, add ethanol makes alcohol content reach 60%, leaves standstill, gets supernatant concentration and become relative density 1.6-1.8(60 DEG C) clear paste of (preferred relative density to 1.7), add dextrin, steviosin is appropriate, mixing, spraying dry, with a sieve, No. five screening grains, obtain sugar-free granule.
The Chinese medicine preparation for the treatment of tuberculous meningitis, the pharmacological effect of each raw material is respectively:
Folium Mahoniae: be the leaf of Aquifoliaceae Holly Ilex cornuta Lindl..The property of medicine: bitter, cool.Return liver, kidney channel.Effect: clearind deficient heat, liver and kidney tonifying, wind-damp dispelling.Cure mainly hectic fever due to deficiency of YIN, cough spitting of blood, has a dizzy spell, soreness of the waist and knees, rheumatic arthralgia, vitiligo.
Scorpio: be the entirety of Buthidae Buthus animal Scorpio.The property of medicine: salty, pungent, flat, poisonous.Return Liver Channel.Effect: relieving spasm by subduing liver-wind, removing obstruction in the collateral to relieve pain, dispersing pathogen accumulation.Cure mainly child convulsion to twitch epilepsy, apoplexy and hemiplegia, Kou Yan wai is oblique, migraine and general headache, rheumatoid arthritis stubborn, lockjaw, scrofula subcutaneous nodule, rubella pyogenic infections.
Radix Ranunculi Ternati: be tuber or the herb of Ranunculaceae ranunculus Seynuns Kugelann.The property of medicine: acrid, sweet, warm.Return liver, lung meridian.Effect: reduce phlegm, eliminating stagnation, removing toxic substances.Cure mainly scrofula, tuberculosis, furuncle, migraine, malaria, toothache, snake bite and insect sting.
Bombyx Batryticatus: the larva belonging to animal bombyx mori for Bombycidae silkworm infects muscardine and ossified Scorpio.The property of medicine: pungent, salty, flat.Return liver, lung, stomach warp.Effect: expelling wind and relieving convulsion, dissipating phlegm and resolving masses, resolving toxin and disinhibiting the throat.Cure mainly infantile convulsion, twitch, middle wind-eye mouth is crooked, migraine and general headache, laryngopharynx swelling and pain, scrofula, mumps, rubella, sore.
Semen Strychni: be the seed of Loganiaceae Poisonnut plant Semen Strychni.The property of medicine: bitter, cold, poison greatly.Return liver, spleen channel.Effect: removing obstruction in the collateral to relieve pain, powder detoxifcation.Cure mainly rheumatic arthralgia, numbness of the skin, quadriplegia, traumatic injury, skin sore, sore throat, toothache, leprosy, stubborn dermatitis, malignant tumor.
Gekko Swinhonis: salty, cold.Mild toxicity.Return Liver Channel.Effect: expelling wind for relieving convulsion, detoxicating and resolving stagnation of pathogens.Cure mainly apoplexy infantile convulsion, severe and migratory arthralgia pain, tetanus, carbuncle skin ulcer, scrofula, leprosy, tinea corporis, dysphagic.
Rhizoma cypripedii macranthi: be the root and rhizome of the orchid family Cypripedium vegetable hair lady's slipper or great Ye lady's slipper.The property of medicine: bitter, pungent, temperature.Effect: diuretic swells, curing rheumatism, pain relieving.Cure mainly edema, rheumatic arthralgia, leukorrhagia, stranguria, traumatic injury, impairment caused by overstrain.
Herba Blumeae Balsamiferae: be the herb of Compositae Herba Blumeae Balsamiferae platymiscium Herba Blumeae Balsamiferae.The property of medicine: pungent, bitter, temperature.Effect: ward off dirty, warming middle-JIAO, parasite killing, expelling wind and removing dampness.Cure mainly pestilence, dysentery, flu, taeniasis, venom, tinea skin ulcer, cold-damp dysentery, wind syndrome of head is had a headache, rheumatic arthralgia, traumatic pain.
Herba Elsholtziae Ciliatae: be the herb of platymiscium brocade fringe Soviet Union of Labiatae brocade fringe Soviet Union.The property of medicine: " Guizhou folk medicine ": " warm in nature, acrid in the mouth, micro-hardship." effect: dispel the wind and deliver, hemostasia and detumescence.Cure mainly headache due to common cold, paralysis, over-strained hemoptysis, metrorrhagia, menoxenia, dysmenorrhea, sore and toxic.
The invention provides Chinese medicine preparation scientific formula, selected medical material has synergism, can play detoxicating and resolving stagnation of pathogens, the effect of reducing swelling and alleviating pain.Effectively can treat tuberculous meningitis.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
Embodiment 1 treats the Chinese medicine preparation of tuberculous meningitis, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Folium Mahoniae 8 parts, Scorpio 9 parts, Radix Ranunculi Ternati 14 parts, Bombyx Batryticatus 10 parts, Semen Strychni 4 parts, Gekko Swinhonis 4 parts, Rhizoma cypripedii macranthi 8 parts, Herba Blumeae Balsamiferae 4 parts, Herba Elsholtziae Ciliatae 7 parts.
The preparation method of the unguentum of above-mentioned treatment tuberculous meningitis, step is as follows:
1. Folium Mahoniae, Radix Ranunculi Ternati, Herba Blumeae Balsamiferae, Herba Elsholtziae Ciliatae are cleaned, cut and pulverize, cross 120 mesh sieves;
2. by Scorpio, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi removing impurity, clean, soak 3 hours in 60 DEG C of water;
3. the Scorpio after immersion, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi are decocted with water 2 times, add 4 times of water gagings at every turn, respectively decoct 4 hours, then medicinal liquid is merged, filter, filtrate and step 1. middle gained medicated powder mix, and are then concentrated into relative density and are about 1.1(60 DEG C) clear paste, be cooled to room temperature, sterile packaged obtains unguentum.
Typical case one week XX, female, 18 years old.The year before because having a headache and being hospitalized for treatment with heating, check result is cerebrospinal fluid total white blood cells 30/mm 3, lymphocyte 70%, protein content 150mg%, blood sugar content 50%, there is hydrocephalus and edema phenomenon in skull CT scanning, is diagnosed as tuberculous meningitis.After hospitalize is invalid, bring into use Chinese medicinal ointment of the present invention.
Embodiment 1 gained unguentum, warm water is taken after mixing it with water, every day 4 times, a 10ml, within 10 days, is a course for the treatment of, and use 20 days, cerebrospinal fluid indices recovers normal substantially.Use 40 days, headache and heating paresthesia disappear, and tuberculous meningitis is fully recovered, follows up a case by regular visits to and no longer recurs.
Embodiment 2 treats the Chinese medicine preparation of tuberculous meningitis, takes off the primary raw material stating weight proportion and is prepared from (getting 5g for every part): Folium Mahoniae 12 parts, Scorpio 11 parts, Radix Ranunculi Ternati 16 parts, Bombyx Batryticatus 14 parts, Semen Strychni 5 parts, Gekko Swinhonis 6 parts, Rhizoma cypripedii macranthi 12 parts, Herba Blumeae Balsamiferae 6 parts, Herba Elsholtziae Ciliatae 9 parts.
The preparation method of the unguentum of above-mentioned tuberculous meningitis, step is as follows:
1. Folium Mahoniae, Radix Ranunculi Ternati, Herba Blumeae Balsamiferae, Herba Elsholtziae Ciliatae are cleaned, cut and pulverize, cross 150 mesh sieves;
2. by Scorpio, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi removing impurity, clean, soak 5 hours in 80 DEG C of water;
3. the Scorpio after immersion, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi are decocted with water 2 times, add 7 times of water gagings at every turn, respectively decoct 8 hours, then medicinal liquid is merged, filter, filtrate and step 1. middle gained medicated powder mix, and are then concentrated into relative density and are about 1.2(60 DEG C) clear paste, be cooled to room temperature, sterile packaged obtains unguentum.
Typical case two Korea Spro XX, man, 4 years old.Because hectic is hospitalized for treatment, occur tired mind because nursing inconsiderate initiation tuberculous meningitis afterwards, two dull, sleep disorder, inappetence, the Recurrent Vomiting of unknown cause.Bregma bulge, abdominal reflex disappear, tendon hyperreflexia, and progress into comatose state, with convulsive attack, the state of an illness increases the weight of further.
Embodiment 2 gained unguentum, warm water is taken after mixing it with water, every day 4 times, a 5ml, within 10 days, is a course for the treatment of, and use 25 days, the state of an illness no longer worsens, and stupor symptom alleviates gradually.Take 50 days, sleep and feed recover normal, transference cure.
Embodiment 3 treats the Chinese medicine preparation of tuberculous meningitis, takes off the primary raw material stating weight proportion and is prepared from (getting 15g for every part): Folium Mahoniae 10 parts, Scorpio 10 parts, Radix Ranunculi Ternati 15 parts, Bombyx Batryticatus 12 parts, Semen Strychni 5 parts, Gekko Swinhonis 5 parts, Rhizoma cypripedii macranthi 10 parts, Herba Blumeae Balsamiferae 5 parts, Herba Elsholtziae Ciliatae 8 parts.
The preparation method of the unguentum of above-mentioned treatment tuberculous meningitis, step is as follows:
folium Mahoniae, Radix Ranunculi Ternati, Herba Blumeae Balsamiferae, Herba Elsholtziae Ciliatae are cleaned, cuts and pulverize, cross 135 mesh sieves;
by Scorpio, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi removing impurity, clean, soak 4.5 hours in 70 DEG C of water;
3. the Scorpio after immersion, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi are decocted with water 2 times, add 5 times of water gagings at every turn, respectively decoct 6 hours, then medicinal liquid is merged, filter, filtrate and step 1. middle gained medicated powder mix, and are then concentrated into relative density and are about 1.15(60 DEG C) clear paste, be cooled to room temperature, sterile packaged obtains unguentum.
Typical case three king XX, man, 2 years old.Often occur that cranial nerve is got involved condition of illness, left side facial hemiparalysis, limb muscle relaxes, and disapperance of nasolabial sulcus, blepharoptosis, eye are crooked, diplopia and platycoria, and the visible optic neuritis of examination of ocular fundus, depending on mastoid process edema, choroid can accidental tubercle knot.Change after hospitalize is invalid and take Chinese medicinal ointment of the present invention.
Embodiment 3 gained unguentum, warm water is taken after mixing it with water, every day 4 times, a 18ml, within 10 days, is a course for the treatment of, and use after 30 days, all symptoms obviously alleviate.Take 60 days, cure, follow up a case by regular visits to without recurrence.
Embodiment 4 treats the Chinese medicine preparation of tuberculous meningitis, takes off the primary raw material stating weight proportion and is prepared from (getting 20g for every part): Folium Mahoniae 10 parts, Scorpio 10 parts, Radix Ranunculi Ternati 15 parts, Bombyx Batryticatus 12 parts, Semen Strychni 5 parts, Gekko Swinhonis 5 parts, Rhizoma cypripedii macranthi 10 parts, Herba Blumeae Balsamiferae 5 parts, Herba Elsholtziae Ciliatae 8 parts.
The preparation method of the granules of sugar agent of above-mentioned treatment tuberculous meningitis, step is:
folium Mahoniae, Radix Ranunculi Ternati, Herba Blumeae Balsamiferae, Herba Elsholtziae Ciliatae are cleaned, cuts and pulverize, cross 135 mesh sieves;
by Scorpio, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi removing impurity, clean, soak 4.5 hours in 70 DEG C of water;
3. the Scorpio after immersion, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi are decocted with water 2 times, add 5 times of water gagings at every turn, respectively decoct 6 hours, then merge medicinal liquid, filter, filtrate and step 1. middle gained medicated powder mix, then be concentrated into relative density and be about 1.15(60 DEG C) clear paste, be cooled to room temperature;
in step 3. gained clear paste, add ethanol makes alcohol content reach 60%, leave standstill, getting supernatant concentration to relative density is 1.5(60 DEG C) thick paste, add cane sugar powder, dextrin and ethanol in proper amount soft material, cross 17 mesh sieve granules, wet granular is in 70 DEG C of dryings, and dry granule crosses 17 mesh sieve granulate, screens out fine powder after No. five, subpackage, check, packaging, get product medicament.
Typical case four Lee XX, female, 3 years old.Irritated after hectic, cry well, low grade fever, persistent headache, and repeatedly fainting from fear, platycoria, disappears to luminous reflectance, respiratory rhythm is not whole.Find that metabolic acidosis, brain mistake ferrum sodium syndrome, low potassium overstock the water and electrolyte metabolism disorders such as disease.Be start after tuberculous meningitis to take granules of sugar agent of the present invention through hospital diagnosis.
Gained granules of sugar agent in embodiment 4, warm water is taken after mixing it with water, every day 4 times, one time 5 bag, within 10 days, be a course for the treatment of, use after 30 days, breathe and pupil normal, convulsive attack minimizing; After taking 30 days, recovery from illness, follows up a case by regular visits to 1 year, does not recur.
Embodiment 5 treats the Chinese medicine preparation of tuberculous meningitis, takes off the primary raw material stating weight proportion and is prepared from (getting 30g for every part): Folium Mahoniae 10 parts, Scorpio 10 parts, Radix Ranunculi Ternati 15 parts, Bombyx Batryticatus 12 parts, Semen Strychni 5 parts, Gekko Swinhonis 5 parts, Rhizoma cypripedii macranthi 10 parts, Herba Blumeae Balsamiferae 5 parts, Herba Elsholtziae Ciliatae 8 parts.
The preparation method of the sugar free granule of above-mentioned treatment tuberculous meningitis, step is as follows:
folium Mahoniae, Radix Ranunculi Ternati, Herba Blumeae Balsamiferae, Herba Elsholtziae Ciliatae are cleaned, cuts and pulverize, cross 135 mesh sieves;
by Scorpio, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi removing impurity, clean, soak 4.5 hours in 70 DEG C of water;
3. the Scorpio after immersion, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi are decocted with water 2 times, add 5 times of water gagings at every turn, respectively decoct 6 hours, then merge medicinal liquid, filter, filtrate and step 1. middle gained medicated powder mix, then be concentrated into relative density and be about 1.15(60 DEG C) clear paste, be cooled to room temperature;
in step 3. gained clear paste, add ethanol makes alcohol content reach 60%, leaves standstill, gets supernatant concentration and become relative density 1.7(60 DEG C) clear paste, add dextrin, steviosin be appropriate, mixing, spraying dry, with a sieve, No. five screen grains, obtain sugar-free granule.
Experimental example, in order to verify that Chinese medicine preparation of the present invention has definite curative effect to treatment tuberculous meningitis, carries out clinical experiment.
One, physical data:
Randomly drawed the diabetics that 180 are suffered from tuberculous meningitis, the mean age is 10 years old, minimum 1 years old, maximum 18 years old.Be divided into administration group and matched group according to the state of an illness and pathology, often organize each 90 people, guarantee administration group and matched group situation basically identical.
Two, Therapeutic Method:
Administration group uses the embodiment of the present invention 5 gained sugar free granule every day, and for making Chinese medicine preparation of the present invention reach optimum therapeuticing effect, in embodiment 5, gained sugar free granule warm water is taken after mixing it with water, and warm water is taken after mixing it with water, every day 4 times, and a 3-5 bag 10 days is a course for the treatment of.Matched group uses the medicine (medicine as conventional therapy tuberculous meningitis such as isoniazid, rifampicin, pyrazinamide) of other treatment tuberculous meningitis.
Three, criterion:
1. fully recover: symptom disappears completely;
2. effective: symptom obviously alleviates;
invalid: after above-mentioned treatment, symptom is not improved, and increases the weight of even to some extent.
Four, observational technique and result:
Observe 45 days time limits, observed once every 9 days, record the number that disease is obviously alleviated;
Matched group takes the medicine of other treatment tuberculous meningitis and experimental group takes Chinese medicine preparation Comparison of therapeutic of the present invention, and result is as shown in table 1:
Table 1
Analyze: as can be seen from Table 1, take Chinese medicine preparation effective percentage of the present invention up to 97.8%, cure rate is up to 96%, and successful is better than the medicine taking other treatment tuberculous meningitis.
Administration group (sugar free granule of the present invention) and matched group all can reach the object making remission in 45 days of the observation period, but there will be headache, dizzy in matched group after part patient on medication, the untoward reaction such as meropresthesia.Chinese medicine preparation of the present invention selects medicine reasonable, evident in efficacy, without any side effects, effectively can treat tuberculous meningitis.

Claims (2)

1. treat the Chinese medicine preparation of tuberculous meningitis, it is characterized in that, take off the primary raw material stating weight proportion and be prepared from: Folium Mahoniae 5 parts, Scorpio 6 parts, Radix Ranunculi Ternati 10 parts, Bombyx Batryticatus 8 parts, Semen Strychni 3 parts, Gekko Swinhonis 2 parts, Rhizoma cypripedii macranthi 5 parts, Herba Blumeae Balsamiferae 2 parts, Herba Elsholtziae Ciliatae 4 parts.
2. treat the preparation method of the Chinese medicine preparation sugar free granule of tuberculous meningitis, it is characterized in that, step is as follows:
1. Folium Mahoniae, Radix Ranunculi Ternati, Herba Blumeae Balsamiferae, Herba Elsholtziae Ciliatae are cleaned, cut and pulverize, cross 120-150 mesh sieve (preferably 135 mesh sieves);
2. by Scorpio, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi removing impurity, clean, soak in 50-90 DEG C of (preferably 70 DEG C) water 3-6 hour (preferably 4.5 hours);
3. the Scorpio after immersion, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi are decocted with water 2 times, add 3-7 times of water gaging (preferred amount of water to 5 times) at every turn, respectively decoct 4-8 hour (preferably 6 hours), then medicinal liquid is merged, filter, filtrate and step 1. in gained medicated powder mix, be then concentrated into relative density and be about the preferred relative density to 1.15 of 1.0-1.3() clear paste, be cooled to room temperature;
in step 3. gained clear paste, add ethanol makes alcohol content reach 60%, leave standstill, get supernatant concentration and become the preferred relative density to 1.7 of relative density 1.6-1.8() clear paste, add dextrin, steviosin is appropriate, mixing, spraying dry, with a sieve, No. five screening grains, obtain sugar-free granule.
CN201511001580.7A 2014-04-19 2014-04-19 Preparing method for Chinese herba preparation sugar-free granules for treating tubercular meningitis Pending CN105497538A (en)

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