CN103933352A - Traditional Chinese medicinal preparation for treating tubercular meningitis and preparation method thereof - Google Patents

Traditional Chinese medicinal preparation for treating tubercular meningitis and preparation method thereof Download PDF

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CN103933352A
CN103933352A CN201410157077.XA CN201410157077A CN103933352A CN 103933352 A CN103933352 A CN 103933352A CN 201410157077 A CN201410157077 A CN 201410157077A CN 103933352 A CN103933352 A CN 103933352A
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闫超
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Priority to CN201511001592.XA priority Critical patent/CN105497540A/en
Priority to CN201511001579.4A priority patent/CN105456721A/en
Priority to CN201511001595.3A priority patent/CN105477345A/en
Priority to CN201511001593.4A priority patent/CN105521294A/en
Priority to CN201511001580.7A priority patent/CN105497538A/en
Priority to CN201511001594.9A priority patent/CN105535478A/en
Priority to CN201410157077.XA priority patent/CN103933352A/en
Priority to CN201511001591.5A priority patent/CN105497539A/en
Priority to CN201511001578.XA priority patent/CN105456720A/en
Publication of CN103933352A publication Critical patent/CN103933352A/en
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Abstract

The invention relates to a traditional Chinese medicinal preparation for treating tubercular meningitis and a preparation method thereof. The traditional Chinese medicinal preparation is mainly prepared from the following raw materials in parts by weight: 5-15 parts of Chinese holly leaf, 6-14 parts of scorpion, 10-20 parts of ternate buttercup root, 8-16 parts of stiff silkworm, 3-6 parts of nux vomica, 2-8 parts of gecko, 5-15 parts of sinense knotweed rhizome, 2-8 parts of blumea balsamifera and 4-12 parts of common elsholtzia herb. The medicament can play the highest drug effect by selecting proper medicinal materials and adopting proper treatment and preparation, and can achieve the aims of treating both symptoms and root causes, and effectively and quickly healing tubercular meningitis.

Description

A kind of Chinese medicine preparation for the treatment of tuberculous meningitis and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of tuberculous meningitis and preparation method thereof, belonged to Chinese medicine field, be mainly used in treating tuberculous meningitis.
Background technology
Tuberculous meningitis is that tubercule bacillus causes meninges and membrane of spinal cord (brain essence) nonsuppurative inflammation, is modal nervous system tuberculosis, is often the brain performance of the disseminated tuberculosis of whole body blood group.Be a kind of cerebrovascular characteristic of disease disease that has tubercule bacillus to cause, the cerebral vasculitis of secondary can cause ischemia, infarction.Tubercle can develop into large tuberculoma, occurs occupy-place effect.Inflammatory exudate blocks substrate pond can cause hydrocephalus and cranial nerve paralysis.Generally how to infect morbidity in latter 3 months～1 year in primary tuberculosis, be more common in the children's of 1～5 years old.Tuberculous meningitis, from onset to the dead course of disease approximately 3～6 weeks, is the most important reason of tuberculosis in children death.
Pathogeny: when the sick pathological changes of primary tuberculosis forms, the tubercule bacillus of intralesional can rest in meninges, brain essence, spinal cord through blood, forms the tuberculose focus of concealment, comprises tubercle knot, tuberculoma.Once when above-mentioned focus ulceration.Tulase directly enters subarachnoid space, causes tuberculous inflammation.In addition, tissue, also can direct extension as tuberculose focus such as middle ear, mastoid process, cervical vertebra, skulls near brain, invade meninges, but comparatively rare, from etiopathogenesis, tuberculous meningitis is secondary tuberculosis, also has minority case, and primary lesion has been healed or can not find.
In the invention of the Chinese medicine preparation of existing treatment tuberculous meningitis, application publication number CN 103494967 A(application numbers 201310428985.3) a kind of Chinese medicine preparation for the treatment of tuberculous meningitis in children disclosed, selection has replenishing YIN and removing heat, easing the affected liver relieves dizziness, high fever, infantile convulsions, epilepsy, etc., warming YANG is rescued contrary, the Chinese medicine Rhizoma Stachydis of causing resuscitation with aromatic drugs, Radix Campanumoeae, Rhizoma Fagopyri Cymosi, Herba Zephyranthis Candidae, Herba Swertiae heteranthae, Fructus Litseae pungentis, Folium Linderae strychnifoliae, Lignum seu Radix Acronychiae, Rhizoma Anemones Altaicae, Rhizoma Lycopi Lucidi, decocting becomes decoction.Application publication number CN 102847035 A(application numbers 201110175672.2) a kind of prescription for the treatment of tuberculous meningitis disclosed, make taking Os Draconis, Concha Ostreae, Radix Bupleuri, Radix Paeoniae Rubra, the Radix Paeoniae Alba, the Cortex Eucommiae, Radix Dipsaci, Radix Paeoniae Alba, Semen Cassiae, Concha Haliotidis, Folium Mori, Herba Taxilli, Fructus Amomi, Herba Asari, the Radix Rehmanniae, Radix Rehmanniae Preparata, Colla cornus cervi, Semen Astragali Complanati, Fructus Tribuli, Poria, Radix Ophiopogonis, double hook, Radix Cynanchi Atrati as raw material.Application publication number CN 102824429 A(application numbers 201210356851.0) a kind of Chinese medicine formula of specially controlling tuberculous meningitis external application Chinese medicine and preparation method disclosed; it is a kind of Chinese fuming drugss; use the medical material of following component, Calculus Bovis 1-5 gram, Moschus 0.2-3 gram, Margarita 3-6 gram, Hydrargyri Oxydum Rubrum 2-6 gram, Mentholum 9-15 gram, Vermilion 3-9 gram, Calomelas 4-6 gram, Borneolum Syntheticum 3-8 gram, Plumbum preparatium 2-8 gram, black small arms propellant 28-40 gram.
Summary of the invention
For the present situation of tuberculous meningitis, the object of the present invention is to provide Chinese medicine preparation of a kind of tuberculous meningitis and preparation method thereof, by selecting suitable medical material, through appropriate processing and preparation, make it bring into play maximum drug effect, reach treating both the principal and secondary aspects of a disease, cure efficiently, rapidly the object of tuberculous meningitis.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
The Chinese medicine preparation for the treatment of tuberculous meningitis, takes off the primary raw material of stating weight proportion and is prepared from: Folium Mahoniae 5-15 part Scorpio 6-14 part Radix Ranunculi Ternati 10-20 part, Bombyx Batryticatus 8-16 part, Semen Strychni 3-6 part, Gekko Swinhonis 2-8 part, Rhizoma cypripedii macranthi 5-15 part, Herba Blumeae Balsamiferae 2-8 part, Herba Elsholtziae Ciliatae 4-12 part.
The Chinese medicine preparation of above-mentioned treatment tuberculous meningitis, preferred scheme, taking off the primary raw material of stating weight proportion is prepared from: Folium Mahoniae 8-12 part, Scorpio 9-11 part, Radix Ranunculi Ternati 14-16 part, Bombyx Batryticatus 10-14 part, Semen Strychni 4-5 part, Gekko Swinhonis 4-6 part, Rhizoma cypripedii macranthi 8-12 part, Herba Blumeae Balsamiferae 4-6 part, Herba Elsholtziae Ciliatae 7-9 part.
The Chinese medicine preparation of the above treatment tuberculous meningitis, better preferred scheme, takes off the primary raw material of stating weight proportion and is prepared from: 10 parts of Folium Mahoniaves, 10 parts of Scorpios, 15 parts of Radix Ranunculi Ternatis, 12 parts of Bombyx Batryticatus, 5 parts of Semen Strychni, 5 parts of Gekko Swinhonis, 10 parts of Rhizoma cypripedii macranthis, 5 parts of Herba Blumeae Balsamiferaes, 8 parts of Herba Elsholtziae Ciliataes.
According to the Chinese medicine preparation of arbitrary described treatment tuberculous meningitis above, be prepared into pharmaceutically acceptable unguentum, granules of sugar agent or sugar free granule.
According to the Chinese medicine preparation of described treatment tuberculous meningitis above, the preparation method of unguentum, step is as follows:
1. Folium Mahoniae, Radix Ranunculi Ternati, Herba Blumeae Balsamiferae, Herba Elsholtziae Ciliatae are cleaned, cut and pulverize, cross 120-150 mesh sieve (preferably 135 mesh sieves);
2. Scorpio, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi are removed to impurity, clean, in 50-90 DEG C of water, soak 3-6 hour;
3. Scorpio, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi after soaking are decocted with water 2 times, add 3-7 times of water gaging (preferably amount of water to 5 times) at every turn, respectively decoct 4-8 hour (preferably 6 hours), then merge medicinal liquid, filter, filtrate and step 1. middle gained medicated powder are mixed, and are then concentrated into relative density and are about 1.0-1.3(60 DEG C) clear paste, be cooled to room temperature, sterile packaged obtains unguentum.
According to preparation method recited above, preferred scheme is that 2. step uses the water (preferably 75 DEG C) of 60-80 DEG C.
According to preparation method recited above, preferred scheme is that 2. step soaks 4-5 hour (preferably 4.5 hours).
According to preparation method recited above, preferred scheme is that 3. step is concentrated into the preferred relative density to 1.15 of relative density 1.1-1.2().
According to the Chinese medicine preparation of described treatment tuberculous meningitis above, the preparation method of granules of sugar agent, step is as follows:
folium Mahoniae, Radix Ranunculi Ternati, Herba Blumeae Balsamiferae, Herba Elsholtziae Ciliatae are cleaned, cut and pulverize, cross 120-150 mesh sieve (preferably 135 mesh sieves);
scorpio, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi are removed to impurity, clean, in 50-90 DEG C of (preferably 70 DEG C) water, soak 3-6 hour (preferably 4.5 hours);
3. Scorpio, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi after soaking are decocted with water 2 times, add 3-7 times of water gaging (preferably amount of water to 5 times) at every turn, respectively decoct 4-8 hour (preferably 6 hours), then merge medicinal liquid, filter, filtrate and step 1. in gained medicated powder mixes, be then concentrated into relative density and be about 1.0-1.3(60 DEG C) clear paste of (preferred relative density to 1.15), be cooled to room temperature;
3. adding ethanol in gained clear paste to step makes to reach 60% containing alcohol amount, leave standstill, getting supernatant concentration to relative density is 1.2-1.8(60 DEG C) thick paste of (preferably relative density to 1.5), add cane sugar powder, dextrin and appropriate ethanol soft material processed, cross 10-24 mesh sieve granule processed (preferably 17 mesh sieves), wet granular is dry in 50-90 DEG C (preferably 70 DEG C), and dry granule is crossed 17 mesh sieve granulate, screens out fine powder after No. five, subpackage, check, packaging, medicament gets product.
According to the Chinese medicine preparation of described treatment tuberculous meningitis above, the preparation method of sugar free granule, step is as follows:
folium Mahoniae, Radix Ranunculi Ternati, Herba Blumeae Balsamiferae, Herba Elsholtziae Ciliatae are cleaned, cut and pulverize, cross 120-150 mesh sieve (preferably 135 mesh sieves);
scorpio, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi are removed to impurity, clean, in 50-90 DEG C of (preferably 70 DEG C) water, soak 3-6 hour (preferably 4.5 hours);
3. Scorpio, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi after soaking are decocted with water 2 times, add 3-7 times of water gaging (preferably amount of water to 5 times) at every turn, respectively decoct 4-8 hour (preferably 6 hours), then merge medicinal liquid, filter, filtrate and step 1. in gained medicated powder mixes, be then concentrated into relative density and be about 1.0-1.3(60 DEG C) clear paste of (preferred relative density to 1.15), be cooled to room temperature;
3. add ethanol in gained clear paste to step and make to reach 60% containing alcohol amount, leave standstill, get supernatant concentration and become relative density 1.6-1.8(60 DEG C) clear paste of (preferably relative density to 1.7), add dextrin, steviosin is appropriate, mixes, spraying is dry, with a sieve, No. five screening grains, obtain sugar-free granule.
The Chinese medicine preparation for the treatment of tuberculous meningitis, the pharmacological effect of each raw material is respectively:
Folium Mahoniae: be the leaf of Aquifoliaceae Holly Ilex cornuta Lindl..The property of medicine: hardship, cool.Return liver, kidney channel.Effect: clearind deficient heat, liver and kidney tonifying, wind-damp dispelling.Cure mainly hectic fever due to deficiency of YIN, cough spitting of blood, has a dizzy spell, soreness of the waist and knees, rheumatic arthralgia, vitiligo.
Scorpio: all for Buthidae Buthus animal Scorpio.The property of medicine: salty, pungent, flat, poisonous.Return Liver Channel.Effect: relieving spasm by subduing liver-wind, removing obstruction in the collateral to relieve pain, dispersing pathogen accumulation.Cure mainly child convulsion and twitch, epilepsy, apoplexy and hemiplegia, Kou Yan is oblique, migraine and general headache, rheumatoid arthritis stubborn, lockjaw, scrofula subcutaneous nodule, rubella pyogenic infections.
Radix Ranunculi Ternati: be tuber or the herb of the little Herba Ranunculi Japonici of Ranunculaceae ranunculus.The property of medicine: acrid, sweet, warm.Return liver, lung meridian.Effect: reduce phlegm, eliminating stagnation, removing toxic substances.Cure mainly scrofula, tuberculosis, furuncle, migraine, malaria, toothache, snake bite and insect sting.
Bombyx Batryticatus: the larva that belongs to animal bombyx mori for Bombycidae silkworm infects the ossified Scorpio of muscardine.The property of medicine: pungent, salty, flat.Return liver, lung, stomach warp.Effect: expelling wind and relieving convulsion, dissipating phlegm and resolving masses, resolving toxin and disinhibiting the throat.Cure mainly infantile convulsion, twitch, middle wind-eye mouth is crooked, migraine and general headache, laryngopharynx swelling and pain, scrofula, mumps, rubella, sore.
Semen Strychni: be the seed of Loganiaceae Poisonnut plant Semen Strychni.The property of medicine: hardship, cold, poison greatly.Return liver, spleen channel.Effect: removing obstruction in the collateral to relieve pain, powder detoxifcation.Cure mainly rheumatic arthralgia, numbness of the skin, quadriplegia, traumatic injury, skin sore, sore throat, toothache, leprosy, stubborn dermatitis, malignant tumor.
Gekko Swinhonis: salty, cold.Mild toxicity.Return Liver Channel.Effect: expelling wind for relieving convulsion, detoxicating and resolving stagnation of pathogens.Cure mainly apoplexy infantile convulsion, severe and migratory arthralgia pain, tetanus, carbuncle skin ulcer, scrofula, leprosy, tinea corporis, dysphagic.
Rhizoma cypripedii macranthi: be the root and rhizome of the orchid family Cypripedium vegetable hair lady's slipper or great Ye lady's slipper.The property of medicine: bitter, pungent, temperature.Effect: diuretic is swollen, curing rheumatism, pain relieving.Cure mainly edema, rheumatic arthralgia, leukorrhagia, stranguria, traumatic injury, impairment caused by overstrain.
Herba Blumeae Balsamiferae: be the herb of Compositae Herba Blumeae Balsamiferae platymiscium Herba Blumeae Balsamiferae.The property of medicine: pungent, bitter, temperature.Effect: ward off dirty, warming middle-JIAO, parasite killing, expelling wind and removing dampness.Cure mainly pestilence, dysentery, flu, taeniasis, venom, tinea skin ulcer, cold-damp dysentery, wind syndrome of head headache, rheumatic arthralgia, traumatic pain.
Herba Elsholtziae Ciliatae: be the herb of platymiscium brocade fringe Soviet Union of Labiatae brocade fringe Soviet Union.The property of medicine: " Guizhou folk medicine ": " warm in nature, acrid in the mouth, micro-hardship." effect: dispel the wind and deliver, hemostasia and detumescence.Cure mainly headache due to common cold, paralysis, over-strained hemoptysis, metrorrhagia, menoxenia, dysmenorrhea, sore and toxic.
The invention provides Chinese medicine preparation prescription science, selected medical material has synergism, can bring into play detoxicating and resolving stagnation of pathogens, the effect of reducing swelling and alleviating pain.Can effectively treat tuberculous meningitis.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1the Chinese medicine preparation for the treatment of tuberculous meningitis, takes off the primary raw material of stating weight proportion and is prepared from (getting 10g for every part): 8 parts of Folium Mahoniaves, 9 parts of Scorpios, 14 parts of Radix Ranunculi Ternatis, 10 parts of Bombyx Batryticatus, 4 parts of Semen Strychni, 4 parts of Gekko Swinhonis, 8 parts of Rhizoma cypripedii macranthis, 4 parts of Herba Blumeae Balsamiferaes, 7 parts of Herba Elsholtziae Ciliataes.
The preparation method of the unguentum of above-mentioned treatment tuberculous meningitis, step is as follows:
1. Folium Mahoniae, Radix Ranunculi Ternati, Herba Blumeae Balsamiferae, Herba Elsholtziae Ciliatae are cleaned, cut and pulverize, cross 120 mesh sieves;
2. Scorpio, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi are removed to impurity, clean, in 60 DEG C of water, soak 3 hours;
3. Scorpio, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi after soaking are decocted with water 2 times, add 4 times of water gagings at every turn, respectively decoct 4 hours, then merge medicinal liquid, filter, filtrate and step 1. middle gained medicated powder are mixed, and are then concentrated into relative density and are about 1.1(60 DEG C) clear paste, be cooled to room temperature, sterile packaged obtains unguentum.
typical case oneweek XX, female, 18 years old.Because having a headache and being hospitalized for treatment with heating, check result is 30/mm of cerebrospinal fluid total white blood cells the year before 3, lymphocyte 70%, protein content 150 mg%, blood sugar content 50%, there is hydrocephalus and edema phenomenon in skull CT scanning, is diagnosed as tuberculous meningitis.After hospitalize is invalid, bring into use Chinese medicinal ointment of the present invention.
Embodiment 1 gained unguentum, warm water is taken after mixing it with water, and every day 4 times, a 10ml, 10 days is a course for the treatment of, uses 20 days, and it is normal that cerebrospinal fluid indices recovers substantially.Use 40 days, headache and heating paresthesia disappear, and tuberculous meningitis is fully recovered, follow up a case by regular visits to no longer recurrence.
embodiment 2the Chinese medicine preparation for the treatment of tuberculous meningitis, takes off the primary raw material of stating weight proportion and is prepared from (getting 5g for every part): 12 parts of Folium Mahoniaves, 11 parts of Scorpios, 16 parts of Radix Ranunculi Ternatis, 14 parts of Bombyx Batryticatus, 5 parts of Semen Strychni, 6 parts of Gekko Swinhonis, 12 parts of Rhizoma cypripedii macranthis, 6 parts of Herba Blumeae Balsamiferaes, 9 parts of Herba Elsholtziae Ciliataes.
The preparation method of the unguentum of above-mentioned tuberculous meningitis, step is as follows:
1. Folium Mahoniae, Radix Ranunculi Ternati, Herba Blumeae Balsamiferae, Herba Elsholtziae Ciliatae are cleaned, cut and pulverize, cross 150 mesh sieves;
2. Scorpio, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi are removed to impurity, clean, in 80 DEG C of water, soak 5 hours;
3. Scorpio, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi after soaking are decocted with water 2 times, add 7 times of water gagings at every turn, respectively decoct 8 hours, then merge medicinal liquid, filter, filtrate and step 1. middle gained medicated powder are mixed, and are then concentrated into relative density and are about 1.2(60 DEG C) clear paste, be cooled to room temperature, sterile packaged obtains unguentum.
typical case twokorea Spro XX, man, 4 years old.Because hectic is hospitalized for treatment, there is tired mind because nursing inconsiderate initiation tuberculous meningitis afterwards, two are dull, sleep disorder, inappetence, the Recurrent Vomiting of unknown cause.Bregma bulge, abdominal reflex disappear, tendon hyperreflexia, progress into comatose state, and with convulsive attack, the state of an illness further increases the weight of.
Embodiment 2 gained unguentum, warm water is taken after mixing it with water, and every day 4 times, a 5ml, 10 days is a course for the treatment of, uses 25 days, and the state of an illness no longer worsens, and stupor symptom alleviates gradually.Take 50 days, sleep and feed recover normal, transference cure.
embodiment 3the Chinese medicine preparation for the treatment of tuberculous meningitis, takes off the primary raw material of stating weight proportion and is prepared from (getting 15g for every part): 10 parts of Folium Mahoniaves, 10 parts of Scorpios, 15 parts of Radix Ranunculi Ternatis, 12 parts of Bombyx Batryticatus, 5 parts of Semen Strychni, 5 parts of Gekko Swinhonis, 10 parts of Rhizoma cypripedii macranthis, 5 parts of Herba Blumeae Balsamiferaes, 8 parts of Herba Elsholtziae Ciliataes.
The preparation method of the unguentum of above-mentioned treatment tuberculous meningitis, step is as follows:
folium Mahoniae, Radix Ranunculi Ternati, Herba Blumeae Balsamiferae, Herba Elsholtziae Ciliatae are cleaned, cut and pulverize, cross 135 mesh sieves;
scorpio, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi are removed to impurity, clean, in 70 DEG C of water, soak 4.5 hours;
3. Scorpio, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi after soaking are decocted with water 2 times, add 5 times of water gagings at every turn, respectively decoct 6 hours, then merge medicinal liquid, filter, filtrate and step 1. middle gained medicated powder are mixed, and are then concentrated into relative density and are about 1.15(60 DEG C) clear paste, be cooled to room temperature, sterile packaged obtains unguentum.
typical case threeking XX, man, 2 years old.Often there is the cranial nerve condition of illness of getting involved, left side facial hemiparalysis, limb muscle is lax, and disapperance of nasolabial sulcus, blepharoptosis, eye are crooked, diplopia and platycoria, the visible optic neuritis of examination of ocular fundus, depending on mastoid process edema, choroid can accidental tubercle knot.After hospitalize is invalid, change and take Chinese medicinal ointment of the present invention.
Embodiment 3 gained unguentum, warm water is taken after mixing it with water, and every day 4 times, a 18ml, 10 days is a course for the treatment of, uses after 30 days, and all symptoms obviously alleviate.Take 60 days, cure, follow up a case by regular visits to without recurrence.
embodiment 4the Chinese medicine preparation for the treatment of tuberculous meningitis, takes off the primary raw material of stating weight proportion and is prepared from (getting 20g for every part): 10 parts of Folium Mahoniaves, 10 parts of Scorpios, 15 parts of Radix Ranunculi Ternatis, 12 parts of Bombyx Batryticatus, 5 parts of Semen Strychni, 5 parts of Gekko Swinhonis, 10 parts of Rhizoma cypripedii macranthis, 5 parts of Herba Blumeae Balsamiferaes, 8 parts of Herba Elsholtziae Ciliataes.
The preparation method of the granules of sugar agent of above-mentioned treatment tuberculous meningitis, step is:
folium Mahoniae, Radix Ranunculi Ternati, Herba Blumeae Balsamiferae, Herba Elsholtziae Ciliatae are cleaned, cut and pulverize, cross 135 mesh sieves;
scorpio, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi are removed to impurity, clean, in 70 DEG C of water, soak 4.5 hours;
3. Scorpio, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi after soaking are decocted with water 2 times, add 5 times of water gagings at every turn, respectively decoct 6 hours, then merge medicinal liquid, filter, filtrate and step 1. middle gained medicated powder are mixed, then be concentrated into relative density and be about 1.15(60 DEG C) clear paste, be cooled to room temperature;
3. adding ethanol in gained clear paste to step makes to reach 60% containing alcohol amount, leave standstill, getting supernatant concentration to relative density is 1.5(60 DEG C) thick paste, add cane sugar powder, dextrin and appropriate ethanol soft material processed, cross 17 mesh sieve granule processed, wet granular in 70 DEG C dry, dry granule is crossed 17 mesh sieve granulate, screens out fine powder after No. five, subpackage, check, packaging, medicament gets product.
typical case fourlee XX, female, 3 years old.Irritated after hectic, cry well, low grade fever, persistence headache, and repeatedly fainting from fear, platycoria, to luminous reflectance disappear, respiratory rhythm is not whole.Find that metabolic acidosis, brain lose ferrum sodium syndrome, low potassium overstocks water, the metabolic disturbance of electrolyte such as disease.After being tuberculous meningitis, hospital diagnosis starts to take granules of sugar agent of the present invention.
Gained granules of sugar agent in embodiment 4, warm water is taken after mixing it with water, and every day 4 times, one time 5 bag, 10 days is a course for the treatment of, uses after 30 days, breathes and pupil normal, and convulsive attack reduces; Take after 30 days, recovery from illness, follows up a case by regular visits to 1 year, not recurrence.
embodiment 5the Chinese medicine preparation for the treatment of tuberculous meningitis, takes off the primary raw material of stating weight proportion and is prepared from (getting 30g for every part): 10 parts of Folium Mahoniaves, 10 parts of Scorpios, 15 parts of Radix Ranunculi Ternatis, 12 parts of Bombyx Batryticatus, 5 parts of Semen Strychni, 5 parts of Gekko Swinhonis, 10 parts of Rhizoma cypripedii macranthis, 5 parts of Herba Blumeae Balsamiferaes, 8 parts of Herba Elsholtziae Ciliataes.
The preparation method of the sugar free granule of above-mentioned treatment tuberculous meningitis, step is as follows:
folium Mahoniae, Radix Ranunculi Ternati, Herba Blumeae Balsamiferae, Herba Elsholtziae Ciliatae are cleaned, cut and pulverize, cross 135 mesh sieves;
scorpio, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi are removed to impurity, clean, in 70 DEG C of water, soak 4.5 hours;
3. Scorpio, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi after soaking are decocted with water 2 times, add 5 times of water gagings at every turn, respectively decoct 6 hours, then merge medicinal liquid, filter, filtrate and step 1. middle gained medicated powder are mixed, then be concentrated into relative density and be about 1.15(60 DEG C) clear paste, be cooled to room temperature;
3. add ethanol in gained clear paste to step and make to reach 60% containing alcohol amount, leave standstill, get supernatant concentration and become relative density 1.7(60 DEG C) clear paste, add dextrin, steviosin is appropriate, mixes, spraying is dry, with a sieve, No. five screenings, obtains sugar-free granule.
experimental examplein order to verify that Chinese medicine preparation of the present invention has definite curative effect to treatment tuberculous meningitis, carries out clinical experiment.
One, physical data:
Randomly drawed 180 diabeticss of suffering from tuberculous meningitis, the mean age is 10 years old, minimum 1 years old, and maximum 18 years old.Be divided into administration group and matched group according to the state of an illness and pathology, every group of each 90 people, guarantee that administration group and matched group situation are basically identical.
Two, Therapeutic Method:
Administration group is used the embodiment of the present invention 5 gained sugar free granule every day, and for making Chinese medicine preparation of the present invention reach optimum therapeuticing effect, in embodiment 5, gained sugar free granule warm water is taken after mixing it with water, and warm water is taken after mixing it with water, and every day 4 times, a 3-5 bag, 10 days is a course for the treatment of.Matched group uses the medicine (as the medicine of the conventional therapy tuberculous meningitis such as isoniazid, rifampicin, pyrazinamide) of other treatment tuberculous meningitis.
Three, criterion:
1. recovery from illness: symptom disappears completely;
2. effective: symptom obviously alleviates;
invalid: after above-mentioned treatment, symptom is not improved, and increases the weight of even to some extent.
Four, observational technique and result:
Observe 45 days time limits, observed once every 9 days, record the number that disease is obviously alleviated;
Matched group is taken medicine and the experimental group of other treatment tuberculous meningitis and is taken Chinese medicine preparation Comparison of therapeutic of the present invention, and result is as shown in table 1:
Table 1
Analyze: as can be seen from Table 1, take Chinese medicine preparation effective percentage of the present invention up to 97.8%, cure rate is up to 96%, and successful is better than the medicine of taking other treatment tuberculous meningitis.
Administration group (sugar free granule of the present invention) and matched group all can reach the object that makes remission in 45 days of the observation period, but in matched group, after some patients were drug administration, there will be headache, dizzy, the untoward reaction such as meropresthesia.Chinese medicine preparation of the present invention selects medicine reasonable, evident in efficacy, without any side effects, can effectively treat tuberculous meningitis.

Claims (10)

1. the Chinese medicine preparation for the treatment of tuberculous meningitis, it is characterized in that, taking off the primary raw material of stating weight proportion is prepared from: Folium Mahoniae 5-15 part, Scorpio 6-14 part, Radix Ranunculi Ternati 10-20 part, Bombyx Batryticatus 8-16 part, Semen Strychni 3-6 part, Gekko Swinhonis 2-8 part, Rhizoma cypripedii macranthi 5-15 part, Herba Blumeae Balsamiferae 2-8 part, Herba Elsholtziae Ciliatae 4-12 part.
2. treat according to claim 1 the Chinese medicine preparation of tuberculous meningitis, it is characterized in that, taking off the primary raw material of stating weight proportion is prepared from: Folium Mahoniae 8-12 part, Scorpio 9-11 part, Radix Ranunculi Ternati 14-16 part, Bombyx Batryticatus 10-14 part, Semen Strychni 4-5 part, Gekko Swinhonis 4-6 part, Rhizoma cypripedii macranthi 8-12 part, Herba Blumeae Balsamiferae 4-6 part, Herba Elsholtziae Ciliatae 7-9 part.
3. treat according to claim 1 the Chinese medicine preparation of tuberculous meningitis, it is characterized in that, taking off the primary raw material of stating weight proportion is prepared from: 10 parts of Folium Mahoniaves, 10 parts of Scorpios, 15 parts of Radix Ranunculi Ternatis, 12 parts of Bombyx Batryticatus, 5 parts of Semen Strychni, 5 parts of Gekko Swinhonis, 10 parts of Rhizoma cypripedii macranthis, 5 parts of Herba Blumeae Balsamiferaes, 8 parts of Herba Elsholtziae Ciliataes.
4. the Chinese medicine preparation for the treatment of according to claim 1 tuberculous meningitis, is characterized in that, is prepared into pharmaceutically acceptable unguentum, granules of sugar agent or sugar free granule.
5. Chinese medicine preparation according to claim 4, is characterized in that, the preparation method of described unguentum is as follows:
Folium Mahoniae, Radix Ranunculi Ternati, Herba Blumeae Balsamiferae, Herba Elsholtziae Ciliatae are cleaned, cut and pulverize, cross 120-150 mesh sieve (preferably 135 mesh sieves);
Scorpio, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi are removed to impurity, clean, in 50-90 DEG C of water, soak 3-6 hour;
Scorpio, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi after soaking are decocted with water 2 times, add 3-7 times of water gaging (preferably amount of water to 5 times) at every turn, respectively decoct 4-8 hour (preferably 6 hours), then merge medicinal liquid, filter, filtrate and step 1. middle gained medicated powder are mixed, and are then concentrated into the clear paste that relative density is about 1.0-1.3, be cooled to room temperature, sterile packaged obtains unguentum.
6. preparation method according to claim 5, is characterized in that, 2. step uses the water (preferably 75 DEG C) of 60-80 DEG C.
7. preparation method according to claim 5, is characterized in that, 2. step soaks 4-5 hour (preferably 4.5 hours).
8. preparation method according to claim 5, is characterized in that, 3. step is concentrated into the preferred relative density to 1.15 of relative density 1.1-1.2().
9. Chinese medicine preparation according to claim 4, is characterized in that, the preparation method of described granules of sugar agent is as follows:
folium Mahoniae, Radix Ranunculi Ternati, Herba Blumeae Balsamiferae, Herba Elsholtziae Ciliatae are cleaned, cut and pulverize, cross 120-150 mesh sieve (preferably 135 mesh sieves);
scorpio, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi are removed to impurity, clean, in 50-90 DEG C of (preferably 70 DEG C) water, soak 3-6 hour (preferably 4.5 hours);
3. Scorpio, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi after soaking are decocted with water 2 times, add 3-7 times of water gaging (preferably amount of water to 5 times) at every turn, respectively decoct 4-8 hour (preferably 6 hours), then merge medicinal liquid, filter, filtrate and step 1. in gained medicated powder mix, be then concentrated into relative density and be about the preferred relative density to 1.15 of 1.0-1.3() clear paste, be cooled to room temperature;
3. adding ethanol in gained clear paste to step makes to reach 60% containing alcohol amount, leave standstill, getting supernatant concentration to relative density is the preferred relative density to 1.5 of 1.2-1.8() thick paste, add cane sugar powder, dextrin and appropriate ethanol soft material processed, cross 10-24 mesh sieve granule processed (preferably 17 mesh sieves), wet granular is dry in 50-90 DEG C (preferably 70 DEG C), and dry granule is crossed 17 mesh sieve granulate, screens out fine powder after No. five, subpackage, check, packaging, medicament gets product.
10. Chinese medicine preparation according to claim 4, is characterized in that, the preparation method of described sugar free granule is as follows:
folium Mahoniae, Radix Ranunculi Ternati, Herba Blumeae Balsamiferae, Herba Elsholtziae Ciliatae are cleaned, cut and pulverize, cross 120-150 mesh sieve (preferably 135 mesh sieves);
scorpio, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi are removed to impurity, clean, in 50-90 DEG C of (preferably 70 DEG C) water, soak 3-6 hour (preferably 4.5 hours);
3. Scorpio, Bombyx Batryticatus, Semen Strychni, Gekko Swinhonis, Rhizoma cypripedii macranthi after soaking are decocted with water 2 times, add 3-7 times of water gaging (preferably amount of water to 5 times) at every turn, respectively decoct 4-8 hour (preferably 6 hours), then merge medicinal liquid, filter, filtrate and step 1. in gained medicated powder mix, be then concentrated into relative density and be about the preferred relative density to 1.15 of 1.0-1.3() clear paste, be cooled to room temperature;
3. add ethanol in gained clear paste to step and make to reach 60% containing alcohol amount, leave standstill, get supernatant concentration and become the preferred relative density to 1.7 of relative density 1.6-1.8() clear paste, add dextrin, steviosin is appropriate, mixes, spraying is dry, with a sieve, No. five screening grains, obtain sugar-free granule.
CN201410157077.XA 2014-04-19 2014-04-19 Traditional Chinese medicinal preparation for treating tubercular meningitis and preparation method thereof Pending CN103933352A (en)

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CN201511001595.3A CN105477345A (en) 2014-04-19 2014-04-19 Method for preparing ointment for treating tubercular meningitis
CN201511001593.4A CN105521294A (en) 2014-04-19 2014-04-19 Traditional Chinese medicinal preparation ointment for treating tubercular meningitis
CN201511001580.7A CN105497538A (en) 2014-04-19 2014-04-19 Preparing method for Chinese herba preparation sugar-free granules for treating tubercular meningitis
CN201511001594.9A CN105535478A (en) 2014-04-19 2014-04-19 Preparation for treating tubercular meningitis
CN201410157077.XA CN103933352A (en) 2014-04-19 2014-04-19 Traditional Chinese medicinal preparation for treating tubercular meningitis and preparation method thereof
CN201511001591.5A CN105497539A (en) 2014-04-19 2014-04-19 Medicinal preparation for treating tubercular meningitis
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