CN104840669A - Chinese medicinal preparation for treating vascular headache - Google Patents

Abstract

The invention discloses a Chinese medicinal preparation for treating vascular headache. The Chinese medicinal preparation is consistent with the traditional Chinese medical theory. Marigold inflorescence, tribulus terrestris, black sesame, Chinese ligusticum rhizome, raw pinellia and root of red-rooted salvia having the effects of sending up the lucid yang, removing blood stasis, tranquilizing mind and relieving spasm and pain are taken as monarch drugs; longleaf luckyweed flower, philadelphus root bark, triflorous ainsliaea leaf, umbellate rockjasmine herb, frankincense and nutgrass galingale rhizome are taken as ministerial drugs for soothing the liver and relieving depression, suppressing hyperactive liver and subsiding yang, calming wind and relieving convulsion, and activating meridians to stop pain; solidago virgaurea, linaria vulgaris, nandina root, serrate glory-bower and globe amaranth flower are taken as adjuvant drugs for coordinating and enhancing the treatment functions of the monarch drugs and the ministerial drugs and limiting the toxic and side effects of other medicaments; larva of silkworm with batrytis, alangium leaf, grossedentate clematis root and dunn antiotrema root are taken as conductant drugs for relaxing bowel, clearing away heat and drying dampness, activating collaterals, relieving pain, blending the medicaments and guiding the medicaments to reach the focus. The Chinese medicinal preparation is simple and convenient in preparation process, has small toxic and side effects, is convenient for administration, is convenient to prepare, is low in cost, can reach the focus directly, is short in curing time, and is free from relapse after curing.

Description

A kind of Chinese medicine preparation for the treatment of vascular headache

Technical field

The present invention relates to the field of Chinese medicines, specifically a kind of Chinese medicine preparation for the treatment of vascular headache.

Background technology

Vascular headache is also called vascular headache, is a type the most common in outpatient service headache patient, and vascular headache is divided into constitutional and the large class of Secondary cases two.Because of the headache that head vasomotor dysfunction causes, be called constitutional vascular headache; There is the clear and definite headache caused by cerebrovascular disease (as apoplexy, intracranial hematoma, cerebral vasculitis etc.), be called secondary headache.Its headache many in mild to moderate full headache, distending pain, also can show as occipitalia, forehead, two temples pain, require mental skill, exert oneself, movable punch head and change position time have a headache and increase the weight of, often with similar neurasthenia symptom.Also normal outbreak presents obvious blood vessel jumping pain, nausea and vomiting, has blurred vision before typical patient episode, and eye grows dim performance.Domestic typical migraine is exactly the one of vascular headache.

The traditional Chinese medical science claims " migraine ", disease name.The relatively side person of headache.Have another name called migraine, severe headache with tonsillitis." danxi's experiential therapy wind syndrome of head ": " migraine, the left and person that belongs to wind." " Zhang Shi doctor logical all pain doors ": " and migraine person, its people first has damp-phlegm usually, and in addition pathogenic wind attacks it, migraine of a specified duration and hot and suffocating be fire, always belong to few positive, cloudy two warps of fainting." with the gas of the exciting phlegm-damp of wind-fire, visible left pain is moved suddenly in the right side, and right pain is moved suddenly in a left side.Pain for a long time endlessly, makes us losing order.Controlling should dispelling wind and removing obstruction in the collateral, soothing liver-QI eliminating phlegm, and tonifying liver nourishes blood all blood, with emptying cream, loose inclined soup, adding the sides such as taste SIWU TANG.It is generally acknowledged, have a headache person to the left, belongs to wind and belong to blood deficiency or blood deficiency fire Sheng; Have a headache person to the right, belongs to expectorant and belong to heat, or deficiency of vital energy folder expectorant.

Have another name called severe headache with tonsillitis, migraine.Its pain is many in temples or the brilliance, or left or right, or left and right is moved and changed, and has to connect ophthalmalgia or pain damages order person for a long time, the person that has nausea and vomiting, and double disease is differed.How because ailment said due to cold or exposure is attacked in few sun, or caused by the pent-up of deficiency of the liver phlegm-fire.Controlling should dispelling wind and removing obstruction in the collateral, soothing liver-QI eliminating phlegm, and tonifying liver nourishes blood all methods.Availablely empty the side such as cream, loose inclined soup, all beam ball.There is person's migraine to the left of having a headache ancient times, belong to wind and belong to blood deficiency, or belong to blood deficiency fire Sheng; Have a headache person to the right, belongs to expectorant and belong to heat, or belong to the discussion of deficiency of vital energy folder expectorant.

The non-drug therapy of current headache is mainly divided into two kinds, and one is " naturopathy ", comprises acupuncture and moxibustion treatment, massage therapy, neuromuscular electrical stimulation, electroexcitation therapy, meridians lead and bring treatment etc. under control; Another kind is " relaxation therapy ", and it is as the complementary therapy of Drug therapy, mainly through controlling consciously or regulating the psychology physiological of self movable, reduces body arousal level, make people's ataraxy of flaccid muscles, thus alleviate the Therapeutic Method of headache to reach.

Summary of the invention

Technical problem to be solved by this invention is, provides that a kind of formula is simple, processing technology is easy, and the little and convenient drug administration of toxic and side effects, medicament is easy to manufacture, new drug with low cost.The present invention is Chinese medicine preparation, can reach suppressing the hyperactive liver and subsiding YANG, dredge the meridian passage, blood-activating and qi-promoting, effect of resolving depression pain relieving.The present invention is under the guidance of Basic Theories of Chinese Medicine, and determining the pathogenesis of ZANG-FU disease based on the differentiation of symptoms and signs combines with differentiation of syndromes of meridian, adopts the Chinese crude drug of different properties, carry out scientific compatibility, the side of being combined into, we have safe and effective, and side effect is little, preparation is simple, through focus, healing time is short, the not easily feature such as recurrence after healing, by a large amount of clinical practice case, achieve satisfied effect.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of vascular headache, in described Chinese medicine preparation, the ratio of weight and number of various crude drug is:

Flos Tagetis Erectae inflorescence 15-30 part, Fructus Atriplicis Sibiricae 15-30 part, Semen Sesami Nigrum 15-20 part, Rhizoma Ligustici 10-20 part, Rhizoma Pinelliae 10-20 part, Radix Salviae Miltiorrhizae 10-20 part, Flos Spatholirionis longifolii 10-20 part, Cortex Philadephi Sericanthi Radicis 10-20 part, Folium Ainslaea Triflorae 5-10 part, Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 5-10 part, Olibanum 10-15 part, Rhizoma Cyperi 10-15 part, Herba Solidaginis 10-15 part, Herba Linariae Vulgaris 10-15 part, Radix Nandinae Domesticae 1-15 part, Herba Clerodendri Serrati 1-15 part, Flos Gomphrenae 1-15 part, Bombyx Batryticatus 1-15 part, Folium Alangii 5-10 part, Radix Clematidis Argentilucidae 15-30 part, Radix Antiotrematis dunniani 10-15 part.

The Chinese medicine preparation of described treatment headache, the ratio of weight and number of various crude drug can also be: Flos Tagetis Erectae inflorescence 16-28 part, Fructus Atriplicis Sibiricae 16-28 part, Semen Sesami Nigrum 16-18 part, Rhizoma Ligustici 12-18 part, Rhizoma Pinelliae 12-18 part, Radix Salviae Miltiorrhizae 12-18 part, Flos Spatholirionis longifolii 12-18 part, Cortex Philadephi Sericanthi Radicis 15-18 part, Folium Ainslaea Triflorae 6-8 part, Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 6-8 part, Olibanum 12-14 part, Rhizoma Cyperi 12-14 part, Herba Solidaginis 12-14 part, Herba Linariae Vulgaris 12-14 part, Radix Nandinae Domesticae 2-12 part, Herba Clerodendri Serrati 2-12 part, Flos Gomphrenae 2-12 part, Bombyx Batryticatus 2-12 part, Folium Alangii 2-8 part, Radix Clematidis Argentilucidae 16-28 part, Radix Antiotrematis dunniani 12-14 part.

The Chinese medicine preparation of described treatment headache, the ratio of weight and number of various crude drug can also be: Flos Tagetis Erectae inflorescence 19 parts, Fructus Atriplicis Sibiricae 19 parts, Semen Sesami Nigrum 17 parts, Rhizoma Ligustici 15 parts, Rhizoma Pinelliae 15 parts, Radix Salviae Miltiorrhizae 15 parts, Flos Spatholirionis longifolii 15 parts, Cortex Philadephi Sericanthi Radicis 17 parts, Folium Ainslaea Triflorae 7 parts, Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 7 parts, Olibanum 13 parts, Rhizoma Cyperi 13 parts, Herba Solidaginis 13 parts, Herba Linariae Vulgaris 13 parts, Radix Nandinae Domesticae 8 parts, Herba Clerodendri Serrati 8 parts, Flos Gomphrenae 8 parts, Bombyx Batryticatus 8 parts, Folium Alangii 6 parts, Radix Clematidis Argentilucidae 18 parts, Radix Antiotrematis dunniani 13 parts.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine preparation of vascular headache, and the dosage form of described Chinese medicine preparation is that the preparation method of capsule comprises:

A, get crude drug and add alcohol reflux 1 time, reclaiming ethanol concentrating under reduced pressure and become extractum shape, is component 1;

B, medicinal residues decoct with water 2 times, and merge decoction liquor, filtering and concentrating is extractum shape, is component 2;

C, above-mentioned two kinds of extractum concentrate dryings are become dry cream, co-grinding, add dextrin, fill capsule.

In described step a, weighting raw materials material can add the 60-80% soak with ethanol 1-4 hour of 5-8 times amount, and reflux, extract, 1 time is above got clear liquid decompression recycling ethanol and is concentrated into extractum shape, as component 1.

In described step b, medicinal residues can soak 0.5-2.5 hour, decoct 2 times, each 1-3 hour, merges decoction liquor, and 80-200 order filters, 5000-10000 rev/min centrifugal after supernatant, through the ultrafiltration post ultrafiltration that the molecular weight that dams is 5000-10000, ultrafiltrate concentrating under reduced pressure relative density is 1.30(60 DEG C) extractum, as component 2.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine preparation of vascular headache, and described Chinese medicine preparation dosage form is that the preparation method of tablet comprises:

A, Flos Carthami, Flos Chrysanthemi and Herba Menthae are added reflux, extract, in ethanol;

B, get surplus stock in above-mentioned side again, decoct with water;

C, above-mentioned two kinds of extracting solution to be merged, decompression recycling ethanol concentrated sucking filtration absorption, obtain crude drug; Add dextrin or starch tabletting.

In described step a, Flos Carthami, Flos Chrysanthemi and Herba Menthae can be put into 10 times amount ethanol, reflux, extract, 2 times, each 1 ~ 2 hour, merge extractive liquid, leave standstill, filter;

In described step b, surplus stock is put into 10 times of water gagings, decoct 2 times, each 0.5 ~ 2 hour, merge decoction liquor, leave standstill, filter;

In described step c, above-mentioned two kinds of filtrates can be merged, decompression recycling ethanol to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, the relative density of filtrate is about 1.08 (20 DEG C); Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first use deionized water or the distilled water eluting of 10 times of resin column volumes, discard, use 95% ethanol elution of 5 times of resin column volumes again, collect ethanol elution, decompression recycling ethanol, and be condensed into thick paste, add starch or dextrin wet method granule, drying under reduced pressure, tabletting.

For solving the problems of the technologies described above, the present invention also provides a kind of pharmaceutical dosage form for the treatment of the Chinese medicine preparation of vascular headache, and its pharmaceutical dosage form comprises: capsule, tablet, granule, honey pill agent, powder, sublimed preparation, injection, suppository, plaster, syrup, powder, pin powder or patch.

The Chinese medicine preparation that the present invention treats headache meets Chinese medical theory, with Flos Tagetis Erectae inflorescence, Fructus Atriplicis Sibiricae, Semen Sesami Nigrum, Rhizoma Ligustici, Rhizoma Pinelliae, Radix Salviae Miltiorrhizae sending up the lucid YANG, and blood circulation promoting and blood stasis dispelling, tranquilizing the mind, relieving spasm to stop pain is monarch drug; With Flos Spatholirionis longifolii, Cortex Philadephi Sericanthi Radicis, Folium Ainslaea Triflorae, Herba Androsaces Umbellatae (Herba Androsaces Coccineae), Olibanum, Rhizoma Cyperi for ministerial drug, dispersing the stagnated live-QI to relieve the stagnation of QI, suppressing the hyperactive liver and subsiding YANG, endogenous wind stopping relieving convulsion, removing obstruction in the collateral to relieve pain; With Herba Solidaginis, Herba Linariae Vulgaris, Radix Nandinae Domesticae, Herba Clerodendri Serrati, Flos Gomphrenae for adjuvant drug, play coordination, strengthen the treatment function of monarch drug and ministerial drug, and restrict effect of the toxic and side effects of other drug; With Bombyx Batryticatus, Folium Alangii, Radix Clematidis Argentilucidae, Radix Antiotrematis dunniani for making medicine, loosening bowel to relieve constipation, heat clearing and damp drying, activating collaterals to relieve pain, coordinating the actions of various ingredients in a prescription, and guide all medicines to go directly disease institute.Processing technology of the present invention is easy, and toxic and side effects is little, and convenient drug administration, medicament is easy to manufacture, with low cost, and focus of going directly, healing time is short, non-relapse after healing.

the present invention relates to Chinese medicine pharmacology and the property of medicine as follows:

Flos Tagetis Erectae inflorescence: bitter, cool.Suppressing the hyperactive liver is antipyretic, dispelling pathogenic wind and eliminating phlegm.For having a dizzy spell, wind syndrome of head ophthalmalgia, infantile convulsion, cold cough, pertussis, mastalgia, mumps.

Radix Clematidis Argentilucidae:

[nature and flavor] acrid in the mouth, warm in nature.

[function cures mainly-Radix Clematidis Argentilucidae effect] promoting flow of QI and blood, wind-damp dispelling, pain relieving.

Herba Clerodendri Serrati:

[meridian distribution of property and flavor]: Xin Gan, temperature.Return spleen; Kidney channel

[function cures mainly] synthetism, pain relieving, preventing the attack (or recurrence) of malaria.Control fracture, traumatic injury, rheumatalgia, malaria.Clearing away heat-damp and promoting diuresis; Eliminating stasis to stop pain; Removing toxic substances and promoting subsidence of swelling.Main hygropyretic dysentery; Stranguria; Beriberoid pyretic arthralgia; Dysmenorrhea due to blood stasis; Traumatic injury; Laryngopharynx swelling and pain; Swollen ulcer drug; Urticaria; Malaria

1. " register planted by Guangxi medicine ": refute bone, parasite killing, stomach invigorating, clearing away heart-fire, strengthening bone and muscle.Treating malaria disease, dysentery, headache, ophthalmia, traumatic injury.

2. " Guizhou medical herbs ": invigorating spleen to remove dampness, tonify deficiency benefit is damaged.Control weak edema, impairment caused by overstrain.

3. " mountain of papers Chinese herbal medicine ": bone-setting pain stopping, heat-clearing and toxic substances removing.Control fracture, traumatic injury, rheumatalgia, innominate toxic swelling.

Fructus Atriplicis Sibiricae:

[meridian distribution of property and flavor] is bitter, pungent; Enter Liver Channel.

[function] suppressing the hyperactive liver resolving depression, dispelling pathogenic wind for improving eyesight, for dizziness due to hyperactivity of liver-YANG headache, hypochondriac pain due to stagnation of liverQI, headache due to pathogenic wind-heat, conjunctival congestion and swelling pain, the diseases such as skin pruritus.

Semen Sesami Nigrum:

[nature and flavor] are flat, sweet in the mouth.

[effect] invigorating the liver and kidney, benefiting essence-blood, intestine moistening is dry; For dizziness and blurred vision, Hiccough and deaf, early whitening of beard and hair, post disease alopecia, dryness of the intestine constipation.

Rhizoma Ligustici:

[nature and flavor] are pungent, temperature; Return urinary bladder channel.

[function cures mainly] cures mainly headche due to wind-cold, wind syndrome of head hemialgia, and blurred vision is had a stuffy nose, toothache gingival atrophy, rheumatic arthralgia, and cold-damp stomachache is had loose bowels, pruritus due to wind pathogen scabies, married woman's YIN-cold hernia abdominal mass." Japan hanako materia medica ": " disease of curing the disease, and skin defect Shao-, Jiu Zha, acne." there is expelling wind and cold, effect of removing damp and stopping pain.

Rhizoma Pinelliae:

[nature and flavor] are pungent, temperature, poisonous.1. " herbal classic ": pungent, flat.2. " not Lu ": to be rawly slightly cold, ripe temperature, poisonous.3. " property of medicine opinion ": very toxic.4. " Japan hanako materia medica ": acrid in the mouth.5. (medicine origin ": " curing mainly secret wanting " cloud, warm in nature, acrid in the mouth is bitter.

[return through] enters spleen, stomach warp.1. Materia Medica of Decoction: enter bright, lunar, the shaoyang channel of foot sun.2. " Thunder God concocts property of medicine solution ": enter lung, spleen, stomach three warp.3. " Bencao Jingshu ": enter foot too bright, the few sun of yin, yang, meridian of Hand-SHAO YIN.4. " book on Chinese herbal medicine converges and says ": bright, lunar, few cloudy three warps of sun of starting with.5. " book on Chinese herbal medicine is new again ": enter liver, spleen, lung three warp.

[function cures mainly-Rhizoma Pinelliae effect] drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.Control damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm is had a headache, dizzy sleeplessness.Outer subduing inflammation., vomiting regurgitation dizzy for abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, interior expectorant, breast gastral cavity painful abdominal mass are vexed, globus hystericus disease; Raw with external treatment carbuncle sucutaneous nodule.

Radix Salviae Miltiorrhizae:

[meridian distribution of property and flavor] is bitter, is slightly cold.GUIXIN, Liver Channel.

[function cures mainly] stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris." book on Chinese herbal medicine justice ": Radix Salviae Miltiorrhizae, being slightly cold of " herbal classic " meaning, TAO Hong-Jing has doubted it by mistake, and Miao's secondary alcohol also doubts it, and stupid to a stone is transform tepor into." herbal classic ": main trusted subordinate's pathogen, borborygmus are faint as leaked water, and cold and heat gather; Broken disease, except abdominal mass, stops stuffy sensation with restlessness, QI invigorating." WU Pu Bencao ": control cardiac and abdominal pain." not Lu ": nourish blood, remove trusted subordinate's obstinate disease stagnation of QI, stiffness along the spinal column, foot numbness; Except wind, Xing stays heat, takes sharp people for a long time.TAO Hong-Jing: stain beverage it, treat migratory arthralgia." property of medicine opinion ": control flaccidity of the lower limbs, pain numbness, main attacked by pestiferous factors; Control stomachache, gas is done sound ring and is shouted." Japan hanako materia medica ": sedate of reposing, tonneau GUAN-pulse.Control cold and hot labor, arthralgia, extremity are unsuccessful; Evacuation of pus pain relieving, granulation promoting is put on flesh; Broken stagnated blood, mends new hemopoietic; Peaceful tire, fall stillborn fetus; Under hemostasis metrorrhagia and leukorrhagia, adjust married woman's passages through which vital energy circulates irregular, blood evil thought is tired of; Malignant boil scabies, wart is gone to live in the household of one's in-laws on getting married toxic swelling, erysipelas; Headache, acute conjunctivitis, hot temperature is mad vexed." the southern regions of the Yunnan Province book on Chinese herbal medicine ": reinforcing the heart sedate, calming heart and tranquilizing mind.Control forgetful palpitation with a distress feeling, palpitation with fear is insomnia." detailed outline ": invigorate blood circulation, logical percardium.Control colic." choosing of Yunnan Chinese herbal medicine ": promoting blood circulation to remove blood stasis, sedation-analgesia.Control menoxenia, dysmenorrhea, rheumatic arthralgia, metrorrhagia, spit blood, mastitis, carbuncle.

Olibanum: regulating QI, invigorates blood circulation, and pain relieving chases after poison.Antibacterial, restrain, flatulence of dispelling, promote wound scab, promote cytoactive, profit digestion, diuresis, calmness, benefit body, sharp uterus, control wound.

Rhizoma Cyperi:

[nature and flavor] pungent micro-hardship is sweet, flat.

[function cures mainly] regulates the flow of vital energy resolving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, menoxenia, amenorrhea dysmenorrhea, colic of cold type is suffered from abdominal pain, distending pain of the breast.

Flos Spatholirionis longifolii:

[nature and flavor] are puckery, cool.

Effect of [function cures mainly] Flos Spatholirionis longifolii is QI and blood regulating, pain relieving, and treatment menoxenia, nervous headache and constipation, have toxin expelling effect.

Cortex Philadephi Sericanthi Radicis:

[meridian distribution of property and flavor] is bitter, micro-pungent, flat.Enter spleen, stomach, bladder three warp.

[function cures mainly] treating malaria disease, headache, dampens, waist hypochondriac pain, stomach qi ache.

Folium Ainslaea Triflorae:

[effect] anti-inflammatory analgesic, expelling pathogenic wind from the body surface, dispersing lung-QI and dissipating phlegm, dispel the wind spasmolytic.

[curing mainly] is for pain in chest and hypochondrium, headache person, diseases caused by exogenous pathogenic factor card, infantile cough, infantile convulsion.

[meridian distribution of property and flavor] pungent, micro-hardship, flat.Enter liver, lung, spleen three warp.

Herba Androsaces Umbellatae (Herba Androsaces Coccineae): medicine name: Herba Androsaces umbellatae

Nature and flavor: bitter; Pungent; Cold nature

Gui Jing: lung meridian; Liver Channel; Spleen channel.

Function: heat-clearing and toxic substances removing; Reducing swelling and alleviating pain.

Cure mainly: laryngopharynx swelling and pain; Aphtha; Toothache; Headache; Acute conjunctivitis; Rheumatic arthralgia; Asthma; Stranguria with turbid discharge; Treat pyogenic infections from tumour or sore; Burn and scald; Venom; Traumatic injury.

Herba Solidaginis:

[meridian distribution of property and flavor] is pungent, bitter, flat.Enter liver, gallbladder two warp.

[function] wind and heat dispersing, anti-inflammation.For anemopyretic cold headache, (wind and cold is avoided) heat-clearing and toxic substances removing, detumescence is except pain.Upper respiratory tract infection, tonsillitis, laryngopharynx swelling and pain, bronchitis, pneumonia, pulmonary tuberculosis hemoptysis, anxious, chronic nephritis, infantile malnutrition, traumatic injury is controlled in external, venom, sore swollen toxin, mastitis, 1, antibacterial action: decoct (causes inflammation of suppurating to staphylococcus aureus in vitro, skin scabies carbuncle, infantile bronchitis), bacillus pyocyaneus (pneumonia), dysentery (acute bacillary dysentery), (intestinal injures Bacillus typhi, avoid and be cautious use of for a long time, easily hemorrhage), Diplococcus pneumoniae (lobar pneumonia), α-hemolytic streptococcus (tonsillitis) and red moss bacterium, Candida albicans (belongs to fungus and causes fungal infection of hand and foot, tinea unguium, tinea pedis, women's colpitis mycotica) all there is inhibitory action.

Herba Linariae Vulgaris:

[nature and flavor]: sweet, micro-hardship, cold.

[function]: heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, diuresis.For jaundice, headache, dizzy, constipation due to hemorrhoids, dermatosis, scalds.[function cures mainly]: heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.Control headache, dizzy, jaundice, constipation due to hemorrhoids, dermatosis, burn.

Radix Nandinae Domesticae:

[nature and flavor] are bitter, cold.

1. " Chongqing medical herbs ": " bitter in the mouth, cold in nature, nontoxic."

2. " Fujian Chinese herbal medicine ": " bitter, flat."

Function cures mainly: dispel the wind, heat clearing away, and dehumidifying, reduces phlegm.Control headache due to pathogenic wind-heat, cough due to lung-heat, jaundice due to damp-heat, rheumatic arthralgia, acute catarrhal conjunctivitis, skin infection, scrofula.

1. " conventional glossary of Herbs and Drugs among the people ": " control back food sick."

2. " Chinese soil pesticide will ": " control neck scrofula, productive cough."

3. " wild medicine is planted figure and said ": " control skin ulcer tinea mange."

4. " Chongqing medical herbs ": " removing damp-heat.Control heat symptom-complex acute catarrhal conjunctivitis, spit blood, headache due to pathogenic wind-heat, rheumatism skelalgia or work low back lower limb distending pain."

5. " Fujian Chinese herbal medicine ": " heat clearing away, dampness, removing toxic substances.Control cough due to lung-heat, jaundice due to damp-heat, damp-heat arthralgia, sciatica."

Flos Gomphrenae:

[nature and flavor] are sweet, flat.

[function cures mainly] controls wind syndrome of head, ophthalmalgia, asthma and cough, dysentery, pertussis, infantile convulsion, and scrofula is stolen, skin infection.For chronic or asthmatic bronchitis, pertussis.

Bombyx Batryticatus:

[meridian distribution of property and flavor] is pungent salty, flat.1. " herbal classic ": salty in the mouth, flat.2. " not Lu ": pungent, flat, nontoxic.3. " property of medicine opinion ": tepor, slightly poisonous.Enter liver, lung, stomach warp.1. " detailed outline ": yin, yang of fainting is bright.2. " Thunder God concocts property of medicine solution ": enter the heart, liver, spleen, lung four warp.

Expelling wind to relieve convulsion, dissipating phlegm and resolving masses.

[function cures mainly] controls apoplectic aphasia, infantile convulsion, wind syndrome of head, acute throat trouble.Sore throat, scrofula tuberculosis.Wind skin ulcer urticaria, erysipelas, mastitis.1. " herbal classic ": main pediatric epilepsy scared night cry, go three worms, Mie Hei über, the cloudy infections of man is sick.2. " not Lu ": woman's metrorrhagia is in vain red, puerperal remaining pain, all skin ulcer cicatrixs of going out.Not it, envelope furuncle swell, root ought go out certainly.3. " property of medicine opinion ": control locked mouth, diaphoresis, housewife people's metrorrhagia hematochezia is more than.4. " Japan hanako materia medica ": control apoplectic aphasia, and a wind cutting disease, convulsive seizure induced by terror in children, man's pudendal pruritus pain, woman's leukorrhagia.5. " Bencao Tujing ": control apoplexy, acute inflammation of the throat, sieve smalls is smash, the filling of Rhizoma Zingiberis Recens nature juice tune.6. " medicine origin ": all wind between peeling skin.7. " detailed outline ": loose wind-phlegm tuberculosis, scrofula, wind syndrome of head, wind worm toothache, skin wind skin ulcer, erysipelas is had an itch, intermittent fever due to phlegm crux, married woman's galactostasis, metrorrhagia hematochezia, children's's infantile malnutrition erosion squama body, all incised wounds, and furuncle swells wind hemorrhoid.8. " book on Chinese herbal medicine just ": control the erosion of children's's infantile malnutrition, ulcer of gums, congenital deformity of the tongue, swollen and rigid tongue.9. " beautiful Chinese catalpa medicine solution ": actively to stimulate the menstrual flow, wind dispelling opens numbness.Control the headache thoracic obstruction, locked mouth is had a toothache, urticaria wind scabies; Burning grinds wine clothes, and the broken top of carbuncle of bursting, controls again stranguria with blood metrorrhagia.

Folium Alangii:

[meridian distribution of property and flavor] is pungent bitter flat return liver kidney channel

[function cures mainly] removing toxic substances and promoting subsidence of swelling blood-activating analgetic traumatic injury congestive edema fracture skin ulcer swells acute mastitis cracked nipple dermatitis rhus scabies the arthroncus of knee traumatic hemorrhage

Radix Antiotrematis dunniani:

[meridian distribution of property and flavor]

Bitter, micro-sweet, the lung that is slightly cold, stomach two warp.

[effect]

Heat-clearing and toxic substances removing, yin nourishing tonify deficiency.Control the heating of empty tumor, dizzy, pyretic stranguria, carbuncle, aphtha, ulcerative gingivitis." Japan hanako materia medica ": control wind syndrome of head pyretic toxicity urticaria, tonify deficiency strains, and the heart is frightened irritated, and bad weary hectic fever due to YIN-deficiency passes corpse pathogen, only forgetful, detumescence poison." detailed outline ": nourishing YIN to lower pathogenic fire, separates speckle poison, throat, diuresis stasis.

detailed description of the invention:

The headache that this Chinese medicine preparation is treated mainly refers to the functional headache such as tension headache and angioneurotic headache, risk factor mostly is psychentonia, suffers from cold and anger, cardinal symptom is cephalic pain, constriction, the sense of heaviness of persistence, and some patient's private prosecutions are head " lock ring " sense.Major part patient pain position is many at two temporo sides, rear pillow part and head or full head.The character of headache is dull pain, distending pain, constriction, feeling of numbness or the sense of band sample lock ring.

The headache degree that this Chinese medicine preparation is treated mostly is slight to moderate, and only a few patient be unable to leave the bed because of headache, has a strong impact on daily life.Can be there is persistent headache year in year out in most of patients, the even sustainable 10-20 of symptom of some patients.The factors such as excited, angry, insomnia, anxiety can cause that the pain increased.Tension headache and angioneurotic headache merge simultaneously outbreak patient also comparatively common clinically, we be also called mixed type headache.Its main manifestations is both sides temples throbbing pains, how with dizziness, irritable, anxious, have palpitation, breathe hard, fear, the symptom such as tinnitus insomnia and dreamful sleep, Wry Neck.Obvious pressure pain point is there is in some patients in neckpillow both sides or two temporo sides.

This Chinese medicine preparation treatment functional headache was undertaken by the course for the treatment of, and general case one month is a course for the treatment of, can at outpatient service medication treatment.The chronic cases in year more than course of disease 10-20, then need to carry out Comprehensive Treatment in hospital, generally need 2-3 the course for the treatment of.Be in hospital Comprehensive Treatment except adopting this Chinese medicine preparation, also need to coordinate psychological counseling, so just can obtain better effect.

embodiment 1, formula:flos Tagetis Erectae inflorescence 15g, Fructus Atriplicis Sibiricae 15g, Semen Sesami Nigrum 15g, Rhizoma Ligustici 10g, Rhizoma Pinelliae 10g, Radix Salviae Miltiorrhizae 10g, Flos Spatholirionis longifolii 10g, Cortex Philadephi Sericanthi Radicis 10g, Folium Ainslaea Triflorae 5g, Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 5g, Olibanum 10g, Rhizoma Cyperi 10g, Herba Solidaginis 10g, Herba Linariae Vulgaris 10g, Radix Nandinae Domesticae 1g, Herba Clerodendri Serrati 1g, Flos Gomphrenae 1g, Bombyx Batryticatus 1g, Folium Alangii 5g, Radix Clematidis Argentilucidae 15g, Radix Antiotrematis dunniani 10g.

The dosage form of Chinese medicine preparation of the present invention is capsule, and its preparation method is as follows:

By formula proportion, above-mentioned raw materials medicine is added the 50-90% soak with ethanol 1-3 hour of 6-12 times amount, reflux, extract, is extracted 1-3 time, and each 1-3 hour, gets supernatant, is evaporated to extractum shape, as component 1; Medicinal residues are soaked 0.5-1.5 hour, decoct 2 times, each 1-2 hour, merge decoction liquor, filter, concentrated, 80-160 order filters, 6000-10000 rev/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure relative density is 1.30(60 DEG C) extractum; Above-mentioned two kinds of extractum concentrate dryings are become dry cream, co-grinding, fill capsule.

Case: fourth, female.Have a headache 4 years.There is volume top pulsation dull pain after anger before 4 years, time and left side, time and right side.Si dol urg is with Nausea and vomiting.After taking diazepam rest, pain can disappear.Row cerebral CT shows no obvious abnormalities.Take Chinese medicinal tablet of the present invention after 7 days, headache is alleviated substantially, changes pill and deals with problems arising from an accident, take medicine January again, and the state of an illness is fully recovered, and follows up a case by regular visits to without recurrence.

embodiment 2, formula:flos Tagetis Erectae inflorescence 16g, Fructus Atriplicis Sibiricae 16g, Semen Sesami Nigrum 16g, Rhizoma Ligustici 12g, Rhizoma Pinelliae 12g, Radix Salviae Miltiorrhizae 12g, Flos Spatholirionis longifolii 12g, Cortex Philadephi Sericanthi Radicis 15g, Folium Ainslaea Triflorae 6g, Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 6g, Olibanum 12g, Rhizoma Cyperi 12g, Herba Solidaginis 12g, Herba Linariae Vulgaris 12g, Radix Nandinae Domesticae 2g, Herba Clerodendri Serrati 2g, Flos Gomphrenae 2g, Bombyx Batryticatus 2g, Folium Alangii 2g, Radix Clematidis Argentilucidae 16g, Radix Antiotrematis dunniani 12g.

The dosage form of Chinese medicine preparation of the present invention is tablet, and its preparation method is as follows:

By formula proportion, Flos Carthami, Flos Chrysanthemi and Herba Menthae are put into 10 times amount ethanol, heating and refluxing extraction 2 times, each 1-2 hour, extract active ingredient, 2 extracting solution are merged and leaves standstill; Surplus stock is put into 10 times of water gagings again, heating and refluxing extraction 3 times, each 30 minutes-1 hour, 3 extracting solution are merged and leaves standstill; Finally by the merging of above-mentioned two kinds of filtrates, decompression recycling ethanol to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, the relative density of filtrate is about 1.08 (20 DEG C); Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains crude drug; Add starch or dextrin tabletting.

Case: Liu.Female, has a headache more than 5 years, or forehead or back or top, mountain peak, and painful area is not fixed, and in pulsation jumping pain, with nausea and vomiting, doublely sees dizzy, insomnia, irritated.Through inspections such as CT, electroencephalogram, rheoencephalograms, all there is not obvious change.Take Chinese medicinal tablet more than 20 sky of the present invention, sick announcement is fully recovered.

embodiment 3, formula:flos Tagetis Erectae inflorescence 19g, Fructus Atriplicis Sibiricae 19g, Semen Sesami Nigrum 17g, Rhizoma Ligustici 15g, Rhizoma Pinelliae 15g, Radix Salviae Miltiorrhizae 15g, Flos Spatholirionis longifolii 15g, Cortex Philadephi Sericanthi Radicis 17g, Folium Ainslaea Triflorae 7g, Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 7g, Olibanum 13g, Rhizoma Cyperi 13g, Herba Solidaginis 13g, Herba Linariae Vulgaris 13g, Radix Nandinae Domesticae 8g, Herba Clerodendri Serrati 8g, Flos Gomphrenae 8g, Bombyx Batryticatus 8g, Folium Alangii 6g, Radix Clematidis Argentilucidae 18g, Radix Antiotrematis dunniani 13g.

The dosage form of Chinese medicine preparation of the present invention is honey refining pill, and its preparation method is as follows:

By formula proportion, medical material is soaked 30 minutes to 1 hour, heated and boiled 30 minutes, filter, filtrate is for subsequent use; Filtering residue adds water, second time heating, and boil 30 minutes, refilter, filtrate is for subsequent use; Filtering residue adds water again, for the third time heated and boiled 30 minutes, filters; Three filtrates are combined, heating be concentrated into pasty state, put into baking oven, control at 75 DEG C, be cooled to after oven dry Powdered be mixed in right amount with Mel together be twisted into slice; With every 5g be a ball wax seal be packaged into honey refining pill.

Case: Zhao, female.Without obvious inducement, patient occurs that head tightens sample pain at the beginning of 2010, during bad, psychentonia, the Changes in weather of sleeping, pain increases the weight of, and originally pain still can be stood, and the state of an illness increases the weight of gradually, and night causes patient's insomnia because of pain, and appetite is poor.In the row acupuncture and moxibustion therapy of our province Duo Jia hospital, symptom is without being clearly better.Once arrived Beijing Grade A hospital to go to a doctor, diagnosis " vascular headache ", give Chinese and western drugs Comprehensive Treatment, symptom is not improved.Take the present invention's honey refining pill after 15 days, headache is alleviated substantially, and adhere to February of taking medicine, headache syndromes disappears completely, follows up a case by regular visits to without recurrence.

embodiment 4, formula:flos Tagetis Erectae inflorescence 28g, Fructus Atriplicis Sibiricae 28g, Semen Sesami Nigrum 18g, Rhizoma Ligustici 18g, Rhizoma Pinelliae 18g, Radix Salviae Miltiorrhizae 18g, Flos Spatholirionis longifolii 18g, Cortex Philadephi Sericanthi Radicis 18g, Folium Ainslaea Triflorae 8g, Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 8g, Olibanum 14g, Rhizoma Cyperi 14g, Herba Solidaginis 14g, Herba Linariae Vulgaris 14g, Radix Nandinae Domesticae 12g, Herba Clerodendri Serrati 12g, Flos Gomphrenae 12g, Bombyx Batryticatus 12g, Folium Alangii 8g, Radix Clematidis Argentilucidae 28g, Radix Antiotrematis dunniani 14g.

Preparation method is identical with embodiment 1.

Case: Liu, female.Patient has a headache more than 6 years, recurrent exerbation, and during outbreak, headache unbearably, often with Nausea and vomiting, maintains by taking analgesic drug product.When just starting effectively, effect weakened gradually afterwards.Once went to a doctor many large hospitals in provincial capital, the inspections such as row eye, head, cervical vertebra, are showed no exception.Fatigue, cold or emotional distress is often had to bring out.Western medicine diagnose is " angioneurotic headache ".Because of work strain since nearly February, brain overwork and suffering from cold brings out, and takes tablet for alleviating pain without any effect.Chinese medicine preparation 2 weeks rear headache syndromes that patient takes in the embodiment of the present invention disappear substantially, advise patient to take a good rest, suitably movable, mind at rest as far as possible, and note warming.Follow the tracks of and have no repeatedly for 3 months.

embodiment 5, formula:flos Tagetis Erectae inflorescence 30g, Fructus Atriplicis Sibiricae 30g, Semen Sesami Nigrum 20g, Rhizoma Ligustici 20g, Rhizoma Pinelliae 20g, Radix Salviae Miltiorrhizae 20g, Flos Spatholirionis longifolii 20g, Cortex Philadephi Sericanthi Radicis 20g, Folium Ainslaea Triflorae 10g, Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 10g, Olibanum 15g, Rhizoma Cyperi 15g, Herba Solidaginis 15g, Herba Linariae Vulgaris 15g, Radix Nandinae Domesticae 15g, Herba Clerodendri Serrati 15g, Flos Gomphrenae 15g, Bombyx Batryticatus 15g, Folium Alangii 10g, Radix Clematidis Argentilucidae 30g, Radix Antiotrematis dunniani 15g.

Preparation method is identical with embodiment 1.

Case: Zhao, man.Right side migraine more than 10 years, increases the weight of half a year.Patient goes out to suffer from cold after having a bath before 10 years and causes cephalic pain, takes a turn for the better after hospital treatment.After this namely often feel cephalic pain, based on right side pain, symptom increases the weight of gradually.Toss about in bed Ge Jia hospital over more than ten years, clinic among the people treatment, is diagnosed as the pathological changes such as " migraine ", " angioneurotic headache ", " temporal arteritis ", once accepts Chinese and western drugs and acupuncture and moxibustion therapy all without obviously imitating.Near headache is over the past half year increased the weight of gradually, and take " tablet for alleviating pain 2, Naoqing tablets 2 " day twice, headache can alleviate.But take with the passing of time, often there is discomfort in gastral cavilty portion.Patient suffering can't bear.Carry out my Office visits, after taking 1 month, the state of an illness is fully recovered.

pharmacology pharmacodynamic is tested:

1, acute toxicity test

Application mice carries out acute toxicity testing and shows: the Traditional Chinese medicine preparation capsule agent of the present invention of Mouse oral gavage, under 485.7g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 2 hours recover normal, Continuous Observation 7 days after administration, without animal dead, its overall health of patients, take the photograph water, diet, urine and body weight increase all normal, experimental result shows: the maximum dosage-feeding of Mouse oral gavage Traditional Chinese medicine preparation capsule agent of the present invention is 485.7g crude drug/kg/d (LD 50 > 485.7g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.5g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 971.4 times of clinical patient.Point out this medicine acute toxicity low, clinical drug safety.

2, long term toxicity test

Select rat, give the Chinese medicine preparation pill of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, BUN, Crea, Glu, TP, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: invention formulation is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.

1 clinical data

The all cases of 1.1 physical data are I Out-patient Department and inpatient, are vascular headache, migrainous patient

, get rid of the patient that the diseases such as liver, gallbladder, the heart, lung need accept Drug therapy for a long time simultaneously.

Treatment group 102 example, man 66 example, female 36 example; 19 ~ 68 years old age;

Matched group 40 example, man 27 example, female 13 example; 18 ~ 67 years old age;

2 groups of ages, sexes, there are no significant difference, have comparability.

1.2 Therapeutic Method

Matched group adopts western medicine therapy merely: ibuprofen bufferin plus, each a slice of being grown up, if symptom is not alleviated, interval 4-6 hour can repeated drug taking once; Loose profit pain, each 1-2 sheet, every day treats for 3 times.

Treatment group gives treatment by Chinese herbs of the present invention,

Each 2 of capsule, every day 3 times, warm water takes, and serve on January;

Or each 4 of tablet, every day 3 times, warm water takes, and serve on January;

Or each 9 grams of pill, every day 3 times, warm water takes, and serve on January.

1.3 observational technique

1. short term effect: check after taking medicine 1 month, 2 months; The cure rate of symptom, improvement rate.

2. late result: follow up a case by regular visits to check rehabilitation, as there is symptom person repeatedly, row checks again, the record state of an illness.

2 observation of curative effect

2.1 efficacy assessment standard evaluation criterias are with reference to Ministry of Public Health clinical drug research guideline.

1. symptom: main detection cephalic pain, divides 0,1,2,3 grades.Be 0 grade without pain symptom, have pain symptom, do not affect work or do not need pill taker to be 1 grade; Have pain symptom, some effects work or normal pill taker are 2 grades; Have pain symptom, must rest completely, the medicine does no good to, and person is 3 grades.After treatment, symptom obviously improves >2 level is effective; It is effective that symptom obviously improves >1 level; Symptom is without improvement or increase the weight of as invalid.

2.2 2 groups of check results compare

Treatment group cures 94 examples, and take a turn for the better 6 examples, invalid 2 examples, cure rate >=92%, effective percentage >=98%.

Matched group cures 35 examples, and take a turn for the better 2 examples, invalid 3 examples, cure rate >=87%, effective percentage >=92%.Through statistical procedures, 2 groups of there was no significant differences (P>0.05).

2.3 2 groups of Long term follow up results

Treatment group obtains visit 90 example, recurrence 6 example in 1 a, relapse rate < 7%; Recurrence 13 example in 3 a, relapse rate < 15%.

Matched group obtains visit 32 example, recurrence 15 example in 1 a, and recurrence 19 example in relapse rate > 46%, 3 a, relapse rate is greater than 59%.

2 groups are compared and have significant difference (P<0.01).

Claims (6)

1. treat the Chinese medicine preparation of vascular headache for one kind, it is characterized in that the ratio of weight and number of various crude drug in this Chinese medicine preparation is: Flos Tagetis Erectae inflorescence 15-30 part, Fructus Atriplicis Sibiricae 15-30 part, Semen Sesami Nigrum 15-20 part, Rhizoma Ligustici 10-20 part, Rhizoma Pinelliae 10-20 part, Radix Salviae Miltiorrhizae 10-20 part, Flos Spatholirionis longifolii 10-20 part, Cortex Philadephi Sericanthi Radicis 10-20 part, Folium Ainslaea Triflorae 5-10 part, Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 5-10 part, Olibanum 10-15 part, Rhizoma Cyperi 10-15 part, Herba Solidaginis 10-15 part, Herba Linariae Vulgaris 10-15 part, Radix Nandinae Domesticae 1-15 part, Herba Clerodendri Serrati 1-15 part, Flos Gomphrenae 1-15 part, Bombyx Batryticatus 1-15 part, Folium Alangii 5-10 part, Radix Clematidis Argentilucidae 15-30 part, Radix Antiotrematis dunniani 10-15 part.

2. Chinese medicine preparation according to claim 1, it is characterized in that: the ratio of weight and number of various crude drug is: Flos Tagetis Erectae inflorescence 16-28 part, Fructus Atriplicis Sibiricae 16-28 part, Semen Sesami Nigrum 16-18 part, Rhizoma Ligustici 12-18 part, Rhizoma Pinelliae 12-18 part, Radix Salviae Miltiorrhizae 12-18 part, Flos Spatholirionis longifolii 12-18 part, Cortex Philadephi Sericanthi Radicis 15-18 part, Folium Ainslaea Triflorae 6-8 part, Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 6-8 part, Olibanum 12-14 part, Rhizoma Cyperi 12-14 part, Herba Solidaginis 12-14 part, Herba Linariae Vulgaris 12-14 part, Radix Nandinae Domesticae 2-12 part, Herba Clerodendri Serrati 2-12 part, Flos Gomphrenae 2-12 part, Bombyx Batryticatus 2-12 part, Folium Alangii 2-8 part, Radix Clematidis Argentilucidae 16-28 part, Radix Antiotrematis dunniani 12-14 part.

3. Chinese medicine preparation according to claim 1, is characterized in that: the ratio of weight and number of various crude drug is: Flos Tagetis Erectae inflorescence 19 parts, Fructus Atriplicis Sibiricae 19 parts, Semen Sesami Nigrum 17 parts, Rhizoma Ligustici 15 parts, Rhizoma Pinelliae 15 parts, Radix Salviae Miltiorrhizae 15 parts, Flos Spatholirionis longifolii 15 parts, Cortex Philadephi Sericanthi Radicis 17 parts, Folium Ainslaea Triflorae 7 parts, Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 7 parts, Olibanum 13 parts, Rhizoma Cyperi 13 parts, Herba Solidaginis 13 parts, Herba Linariae Vulgaris 13 parts, Radix Nandinae Domesticae 8 parts, Herba Clerodendri Serrati 8 parts, Flos Gomphrenae 8 parts, Bombyx Batryticatus 8 parts, Folium Alangii 6 parts, Radix Clematidis Argentilucidae 18 parts, Radix Antiotrematis dunniani 13 parts.

4. the Chinese medicine preparation described in claims 1-3 any one, body characteristics is: the pharmaceutical dosage form of Chinese medicine preparation comprises capsule, tablet, granule, honey pill agent, powder, sublimed preparation, injection, suppository, plaster, syrup, powder, pin powder or patch.

5. Chinese medicine preparation according to claim 4, is characterized in that: the dosage form of this Chinese medicine preparation is that the preparation method of capsule comprises:

A, get crude drug and add ethanol extraction 1 time, becoming extractum shape, is component 1;

B, medicinal residues extracting in water 2 times, thickening filtration is extractum shape, is component 2;

C, above-mentioned two kinds of extractum concentrate dryings are become dry cream, co-grinding, load capsule;

In described a, can get the 60-90% soak with ethanol 1-2 hour that crude drug adds 5-8 times amount, heating extraction 1-2 hour, removes supernatant, and mass is concentrated into extractum shape, becomes component 1;

In described b, 0.5-1.5 hour can be soaked by medicinal residues, extract twice, each 1-2 hour, merge extractive liquid, filters, concentrated, 80-160 order filters, 6000-10000 rev/min centrifugal after supernatant, through the ultrafiltration post ultrafiltration that the molecular weight that dams is 5000-10000, when ultrafiltrate concentrating under reduced pressure relative density is 60 DEG C 1.35 extractum, heating and refluxing extraction 2 times, each 30 minutes ~ 45 minutes, extract active ingredient, 2 extracting solution are merged and is settled into extractum shape, as component 2.

6. Chinese medicine preparation according to claim 4, is characterized in that: described Chinese medicine preparation dosage form is that the preparation method of tablet comprises:

A, Flos Carthami, Flos Chrysanthemi and Herba Menthae are put into ethanol heating and refluxing extraction;

B, get surplus stock in above-mentioned side again, add water heating and refluxing extraction;

C, above-mentioned two kinds of extracting solution to be merged, decompression recycling ethanol concentrated sucking filtration absorption, obtain crude drug; Add dextrin or starch tabletting;

In described a, Flos Carthami, Flos Chrysanthemi and Herba Menthae can be put into 10 times amount ethanol, heating and refluxing extraction 2 times, each 1 ~ 2 hour, extract active ingredient, 2 extracting solution be merged and leaves standstill;

In described b, surplus stock is put into 10 times of water gagings, heating and refluxing extraction 3 times, each 30 minutes ~ 1 hour, 3 extracting solution are merged and leaves standstill;

In described c, can by the merging of above-mentioned two kinds of filtrates, decompression recycling ethanol to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, the relative density of filtrate is about 1.08 (20 DEG C); Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains crude drug; Add starch or dextrin tabletting.