CN108671050A - Treat the drug and preparation method thereof of apoplexy - Google Patents
Treat the drug and preparation method thereof of apoplexy Download PDFInfo
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- CN108671050A CN108671050A CN201810746855.7A CN201810746855A CN108671050A CN 108671050 A CN108671050 A CN 108671050A CN 201810746855 A CN201810746855 A CN 201810746855A CN 108671050 A CN108671050 A CN 108671050A
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Abstract
The invention discloses a kind of drugs for treating apoplexy, and as unit of parts by weight, the bulk pharmaceutical chemicals that its active ingredient is made are：15~25 parts of uncaria, 10~20 parts of pyrrosia lingua, 20~30 parts of pueraria lobata is 10~20 parts parasitic, 5~15 parts of antelope's horn, 5~10 parts of stiff silkworm, 20~30 parts of the shell of seaear, 15~25 parts of chrysanthemum, 20~30 parts of Prunella vulgaris, 10~20 parts of the root of bidentate achyranthes, 5 ~ 10 parts of bark of ash, 10~20 parts of Radix Salviae Miltiorrhizae.Inventive formulation science is exquisite,, dysphonia, hemiplegia oblique to the mouth eye hair in apoplexy have good therapeutic effect, achieve the purpose that effect a radical cure apoplexy by clearing heat and detoxicating, dispelling wind and removing obstruction in the meridians, promoting blood circulation, dispelling wind and relieving convulsion, the case where avoiding dependence and drug resistance that patient occurs with western medicine apoplexy, it is good to provide a kind of therapeutic effect, have no toxic side effect, can more effective, more speed treatment apoplexy drug.
Description
One, technical field：
The present invention relates to a kind of preparation sides for the Chinese medicine and the Chinese medicinal soft capsule that can effectively treat curing apoplexy apoplexy
Method belongs to Chinese medicine and its preparing technical field.
Two, background technology：
Recently, with the improvement of the quality of life with the change of operating mode, apoplexy has become a kind of sick higher illness of hair rate.
Apoplexy, names of disease of tcm are divided into exogenous wind and interior wind, and exogenous wind is because of being invaded by exogenous pathogen,invasion of exogenous pathogen（Ailment said due to cold or exposure）It is caused,《The Treatise on Fevrile Diseases》Name says apoplexy（Also
Claim syndrome of decoction GUI ZHI）；Interior wind category diseases caused by internal damage, also known as cerebral apoplexy, palsy etc..Modern times are commonly referred to as apoplexy, refer to the class of diseases caused by internal damage more
Apoplexy, mostly because qi and blood is inverse disorderly, the resistance of brain vessle-Bi symptom-complex or blood are overflow caused by brain.It is not smoothgoing not with unexpected confused servant, hemiplegia, extremity numbness, tongue
Language, dispute is crooked, and hemianesthesia etc. is the brain disease mainly showed.And, variation anxious with onset is soon, as ailment said due to cold or exposure benefaction number becomes
Feature disease.
Currently, being protected frequently with thrombolysis, antiplatelet, anti-agglutinant, hypotensor, nerve for the present medicine of apoplexia disease
The treatment means such as shield.These medicines are mostly Western medicine, and there is certain side effect, long-time service patient can be allowed to develop immunity to drugs and rely medicine
Property.
Invention content：
The technical problem to be solved by the present invention is to：A kind of Chinese medicine for treating apoplexy is provided, scientific formulation is exquisite, therapeutic effect
It is good, have no toxic side effect, avoid and develop immunity to drugs in patient's western medicine and drug dependence.
The present invention is for the technical solution adopted for solving the technical problem：
A kind of drug for treating apoplexy, as unit of parts by weight, the bulk pharmaceutical chemicals that its active ingredient is made are：Uncaria 15~25
Part, 10~20 parts of pyrrosia lingua, 20~30 parts of pueraria lobata is 10~20 parts parasitic, 5~15 parts of antelope's horn, 5~10 parts of stiff silkworm, the shell of seaear 20
~30 parts, 15~25 parts of chrysanthemum, 20~30 parts of Prunella vulgaris, 10~20 parts of the root of bidentate achyranthes, 5 ~ 10 parts of bark of ash, 10~20 parts of Radix Salviae Miltiorrhizae.
The drug of the treatment apoplexy, as unit of parts by weight, the bulk pharmaceutical chemicals that its active ingredient is made are：Uncaria 20
Part, 15 parts of pyrrosia lingua, 25 parts of pueraria lobata is 15 parts parasitic, 10 parts of antelope's horn, 7 parts of stiff silkworm, 25 parts of the shell of seaear, 20 parts of chrysanthemum, Prunella vulgaris 25
Part, 15 parts of the root of bidentate achyranthes, 7 parts of bark of ash, 15 parts of Radix Salviae Miltiorrhizae.
The dosage form of the drug for the treatment of apoplexy described above is Chinese medicinal soft capsule.
A, claim each raw material of its parts by weight to mix, add the water of 6 times of amounts to impregnate 40 minutes, then heating decocts
2 hours, obtain decoction liquor A and dregs of a decoction A；
B, the water of 4 times of amounts is added into dregs of a decoction A, heating decocts 1.5 hours, obtains decoction liquor B and dregs of a decoction B；
C, the water of 2 times of amounts is added into dregs of a decoction B, heating decocts 50 minutes, obtains dregs of a decoction C and decoction liquor C；
D, merge 3 decoction liquors, after static 12 hours, supernatant is crossed into 200 mesh sieve, it is for use to obtain filtrate A；
E, filtrate A is concentrated by evaporation to paste, stops heating, 75% ethanol of 2 times of amounts is added into thick paste, it is quiet after uniform
It sets overnight, liquor B is obtained after supernatant liquid filtering；
F, edible vegetable oil dissolving is added in liquor B, and it is 80% or more expression amount containing traditional Chinese medicine ingredients to adjust concentration to every ball, is made
It is for use for liquid A；
G, another that qs glycerin is taken to be heated to 80 degrees Celsius, the gelatin of amounts of glycerol 20% is added, stirring call keeps the temperature 1.5h, filtering
Obtain liquor C；
H, liquid A and liquor C are added in pill and carry out dripping, the capsule and pill of condensation is collected after cooling, is removed photoresist with gauze
The coolant liquid adhered on ball, cold wind are dried after blowing 3 hours, with petroleum ether 3 times, remove the liquid stone of capsule and pill outer layer
Wax, screening, quality inspection, packaging.
The positive beneficial effect of the present invention is as follows：
1, the drug of present invention treatment apoplexy is based on motherland's traditional Chinese medicine and pharmacy theory, in conjunction with clinical practice for many years, from doing
It crosses in medical treasure-house and filters out with clearing heat and detoxicating, dispelling wind and removing obstruction in the meridians, promoting blood circulation, dispelling wind and relieving convulsion and other effects, in the drug component：
Uncaria：Sweet in flavor, cool in nature, Return liver, pericardium channel have the effect of dispelling wind and relieving convulsion, The flat liver of heat-clearing；Hypertension is controlled, is had a dizzy spell, nerve
Property headache；Pyrrosia lingua：Bitter, it is cool in nature, enter lung, bladder warp, there is the effects that promoting diuresis for stranguria, clearing lung-heat expel the heat-evil.Energy clearing away damp-heat, diuresis are logical
It drenches, to control knife wound, scald, de- power deficient；Pueraria lobata：It is sweet in flavor, pungent, it is cool in nature, it attaches to the lung and stomach meridians, brings down a fever with expelling pathogenic factors from muscles and skin, promoting eruption is promoted the production of body fluid only
Yearningly, the effect of Shengyang Zhixie；It is parasitic：Bitter, it is mild-natured, return liver and kidney channel；With control filling liver kidney, strengthening the bones and muscles, wind-damp dispelling, tocolysis it
Effect；Antelope's horn：Taste is salty, cold in nature, Return liver, the heart channel of Hang-Shaoyin, has suppressing hyperactive liver for calming endogenous wind, clears liver and improve vision, and dissipates the effect of blood detoxifies；Stiff silkworm：
Taste is salty, pungent, mild-natured, Return liver, lung, stomach；With Inflammation Zhijing, the effect of wind-expelling pain-stopping, reducing phlegm and resolving masses；The shell of seaear：Taste is salty, property
It is flat, return liver and kidney channel, have it is calming the liver, except heat, the effect of tomorrow；Wind-yang and up-boring, dizziness of having a headache are controlled, frightened to jerk, hectic fever due to yin virtue heat,
Optic atrophy；Chrysanthemum：Bitter, sweet, cold nature, return lung, Liver Channel；With relieve heat heat-clearing, flat liver improving eyesight, it is clearing heat and detoxicating the effect of；
Prunella vulgaris：Acrid flavour, hardship, cold in nature, Return liver, gallbladder channel have the effect of clearing heat-fire, improving eyesight, mass dissipating and swelling eliminating；The root of bidentate achyranthes：Bitter, it is sweet,
Acid, it is mild-natured；Return liver and kidney channel；With dispelling stasis of blood and stimulating the menstrual flow, filling liver kidney, strengthening the bones and muscles, inducing diuresis for treating strangurtia ensurings proper downward flow of the blood；Bark of ash：Acrid flavour, hardship,
It is mild-natured；Return stomach, liver, gallbladder channel；With wind-damp dispelling, clearing away damp-heat, stopping numbness pain.For muscle arteries and veins contraction, skeletal pain, afternoon tidal fever is small
The effect of youngster's infantile malnutrition due to digestive disturbances or intestinalparasites is generated heat；Radix Salviae Miltiorrhizae：Bitter is slightly cold, converge to heart and liver channels；It is inducing meastruation to relieve menalgia with promoting blood circulation, relieving restlessness that clears away heart-fire, cool blood
The effect of carbuncle that disappears.
2, inventive formulation science is exquisite, by clinical practice, wherein：Pyrrosia lingua, parasitism, uncaria, pueraria lobata are in apoplexy
Mouth eye hair tiltedly, dysphonia, hemiplegia there are good therapeutic effect and other Chinese herbal medicines to combine, play
The effect of significant collaboration enhancing, the mesh for the treatment of apoplexy is reached by clearing heat and detoxicating, dispelling wind and removing obstruction in the meridians, promoting blood circulation, dispelling wind and relieving convulsion
's.
3, the case where dependence and drug resistance for occurring with western medicine apoplexy the invention avoids patient, one kind is provided
Therapeutic effect is good, has no toxic side effect, can more effective, more speed treatment apoplexy drug.
The present invention provides a kind of preparation method of drug that treating apoplexy, and method is easy, easy to operate, during drug is made
Medicine soft capsule preparation, it is easy to carry, pharmacological property can be performed to maximum, convenient for promoting.
Clinical typical case：
Case 1：
Zhang, female 58 years old, when carrying out diagnosis and treatment symptoms include burst mouth eye hair is oblique, and one's ears rang and spots danced before one's eyes, dysphonia, hemiplegia, after diagnosing for
Apoplexy（The deficiency of liver-yin and kidney-yin, wind-yang and up-boring type）, take this drug after a week, mouth eye restores normal, language, one's ears rang and spots danced before one's eyes, half body not
Then it is improved, then takes one week and can simply walk, continuing to take later 2 weeks can be recovered at present with independent ambulation
Normally, and no sequel.
Case 2：
Lee, man 45 years old, getting up early suddenly sensuously, numbness of lower limbs, be tied to one's bed, come to go to a doctor in that afternoon and household, take
After this drug 2 days, you can voluntarily get up, restore freely after 3 days, and take this drug and consolidate 4 days, until currently, the state of an illness
Without recurrence, without any sequelae.
Case 3：
Zhang, man, 47 years old, retired professor was fallen in a swoon suddenly when go out to buy vegetables in the morning in cell doorway, facial paralysis, tinnitus mesh
It is dizzy, numbness of lower limbs；That afternoon takes this drug, can be fully recovered after 3 days with independent ambulation, medication second day afternoon, no sequel.
Case 4：
Lin, man, 39 years old, be in the peasant being engaged in agriculture, and getting up early is gone to work in the fields, and sense of dashing forward is dizzy, numb in every limb, skin numbness, the same day
It takes this drug afternoon, restores freely, later to have consolidated 2 days after 8 hours, restore normal, the state of an illness is without recurrence at present.
Case 5：
Zhang, man, 42, supermarket security personnel, the work hours fall in a swoon suddenly, and numbness of lower limbs is senseless, teeth clenched, and two hold admittedly；
The same day at once take this drug, can voluntarily get up after 10 hours, sustaining wall walking, take this drug after 3 days can with independent ambulation,
Restore normal, no sequel after 7 days.
Case 6：
Lee, female, peasant, 43 years old, peasant fell in a swoon suddenly when being in grandson, this facial paralysis, lower limb paralysis, and bed is not
It rises, the same day takes this drug, and can voluntarily leave the bed sanitary napkin after 8 hours, and medication is fully recovered after 5 days, no sequel, not multiple so far
Hair.
Case 7：
Mr. Wang, female 45 years old, supermarket is gone in getting up early, and dashing forward, one's ears rang and spots danced before one's eyes for sense, and right leg numbness cannot walk, and the same day takes this drug, and second
It restores walking, fully recovers after taking this drug 3 days, no sequel.
Four, specific implementation mode:
The present invention is made further explanation and description with reference to specific embodiment：
Embodiment 1, a kind of drug for treating apoplexy, as unit of parts by weight, the bulk pharmaceutical chemicals that its active ingredient is made are：Uncaria
20 parts, 15 parts of pyrrosia lingua, 25 parts of pueraria lobata is 15 parts parasitic, 10 parts of antelope's horn, 7 parts of stiff silkworm, 25 parts of the shell of seaear, 20 parts of chrysanthemum, Prunella vulgaris
25 parts, 15 parts of the root of bidentate achyranthes, 7 parts of bark of ash, 15 parts of Radix Salviae Miltiorrhizae.
The dosage form of the drug of the treatment apoplexy is Chinese medicinal soft capsule.
The drug and preparation method thereof of above-mentioned treatment treatment apoplexy, specific procedure of processing are as follows：
A, claim each raw material of its parts by weight to mix, add the water of 6 times of amounts to impregnate 40 minutes, it is small to decoct 2 for then heating
When, obtain decoction liquor A and dregs of a decoction A；
B, the water of 4 times of amounts is added into dregs of a decoction A, heating decocts 1.5 hours, obtains decoction liquor B and dregs of a decoction B；
C, the water of 2 times of amounts is added into dregs of a decoction B, heating decocts 50 minutes, obtains dregs of a decoction C and decoction liquor C；
D, merge 3 decoction liquors, after static 12 hours, supernatant is crossed into 200 mesh sieve, it is for use to obtain filtrate A；
E, filtrate A is concentrated by evaporation to paste, stops heating, 75% ethanol of 2 times of amounts is added into thick paste, it is quiet after uniform
It sets overnight, liquor B is obtained after supernatant liquid filtering；
F, edible vegetable oil dissolving is added in liquor B, and it is 80% or more expression amount containing traditional Chinese medicine ingredients to adjust concentration to every ball, is made
It is for use for liquid A；
G, another that qs glycerin is taken to be heated to 80 degrees Celsius, the gelatin of amounts of glycerol 20% is added, stirring call keeps the temperature 1.5h, filtering
Obtain liquor C；
H, liquid A and liquor C are added in pill and carry out dripping, the capsule and pill of condensation is collected after cooling, is removed photoresist with gauze
The coolant liquid adhered on ball, cold wind are dried after blowing 3 hours, with petroleum ether 3 times, remove the liquid stone of capsule and pill outer layer
Wax, screening, quality inspection, packaging.
Embodiment 2, a kind of drug for treating apoplexy, as unit of parts by weight, the bulk pharmaceutical chemicals that its active ingredient is made are：
15 parts of uncaria, 10 parts of pyrrosia lingua, 20 parts of pueraria lobata is 10 parts parasitic, 5 parts of antelope's horn, 5 parts of stiff silkworm, 20 parts of the shell of seaear, 15 parts of chrysanthemum, the summer
20 parts of withered grass, 10 parts of the root of bidentate achyranthes, 5 parts of bark of ash, 10 parts of Radix Salviae Miltiorrhizae.
Embodiment 3, a kind of drug for treating apoplexy, parts by weight are unit, and the bulk pharmaceutical chemicals that its active ingredient is made are：Hook
25 parts of rattan, 20 parts of pyrrosia lingua, 30 parts of pueraria lobata is 20 parts parasitic, 15 parts of antelope's horn, 10 parts of stiff silkworm, 30 parts of the shell of seaear, 25 parts of chrysanthemum, the summer
30 parts of withered grass, 20 parts of the root of bidentate achyranthes, 10 parts of bark of ash, 20 parts of Radix Salviae Miltiorrhizae.
Embodiment 4, a kind of drug for treating apoplexy, as unit of parts by weight, the bulk pharmaceutical chemicals that its active ingredient is made are：
17 parts of uncaria, 12 parts of pyrrosia lingua, 22 parts of pueraria lobata is 12 parts parasitic, 7 parts of antelope's horn, 6 parts of stiff silkworm, 22 parts of the shell of seaear, 17 parts of chrysanthemum, the summer
22 parts of withered grass, 12 parts of the root of bidentate achyranthes, 6 parts of bark of ash, 12 parts of Radix Salviae Miltiorrhizae.
Embodiment 5, a kind of drug for treating apoplexy, as unit of parts by weight, the bulk pharmaceutical chemicals that its active ingredient is made are：
23 parts of uncaria, 18 parts of pyrrosia lingua, 28 parts of pueraria lobata is 18 parts parasitic, 13 parts of antelope's horn, 9 parts of stiff silkworm, 28 parts of the shell of seaear, 23 parts of chrysanthemum, the summer
28 parts of withered grass, 18 parts of the root of bidentate achyranthes, 9 parts of bark of ash, 18 parts of Radix Salviae Miltiorrhizae.
Embodiment 6, a kind of drug for treating apoplexy, as unit of parts by weight, the bulk pharmaceutical chemicals that its active ingredient is made are：
21 parts of uncaria, 16 parts of pyrrosia lingua, 26 parts of pueraria lobata is 16 parts parasitic, 11 parts of antelope's horn, 8 parts of stiff silkworm, 26 parts of the shell of seaear, 21 parts of chrysanthemum, the summer
26 parts of withered grass, 16 parts of the root of bidentate achyranthes, 8 parts of bark of ash, 16 parts of Radix Salviae Miltiorrhizae.
Claims (4)
1. a kind of drug for treating apoplexy, it is characterised in that：As unit of parts by weight, the bulk pharmaceutical chemicals of its active ingredient are made
For：15~25 parts of uncaria, 10~20 parts of pyrrosia lingua, 20~30 parts of pueraria lobata is 10~20 parts parasitic, 5~15 parts of antelope's horn, and stiff silkworm 5~
10 parts, 20~30 parts of the shell of seaear, 15~25 parts of chrysanthemum, 20~30 parts of Prunella vulgaris, 10~20 parts of the root of bidentate achyranthes, 5 ~ 10 parts of bark of ash, Radix Salviae Miltiorrhizae
10~20 parts.
2. the drug for the treatment of apoplexy according to claim 1, it is characterised in that：As unit of parts by weight, it, which is made, has
Effect ingredient bulk pharmaceutical chemicals be：20 parts of uncaria, 15 parts of pyrrosia lingua, 25 parts of pueraria lobata is 15 parts parasitic, 10 parts of antelope's horn, 7 parts of stiff silkworm, Shi Jue
Bright 25 parts, 20 parts of chrysanthemum, 25 parts of Prunella vulgaris, 15 parts of the root of bidentate achyranthes, 7 parts of bark of ash, 15 parts of Radix Salviae Miltiorrhizae.
3. the drug for the treatment of apoplexy according to claim 1 or 2, it is characterised in that：The drug of the treatment apoplexy
Dosage form be Chinese medicinal soft capsule.
4. the drug and preparation method thereof of the treatment apoplexy described in claim 3, specific procedure of processing are as follows：
A, claim each raw material of its parts by weight to mix, add the water of 6 times of amounts to impregnate 40 minutes, it is small to decoct 2 for then heating
When, obtain decoction liquor A and dregs of a decoction A；
B, the water of 4 times of amounts is added into dregs of a decoction A, heating decocts 1.5 hours, obtains decoction liquor B and dregs of a decoction B；
C, the water of 2 times of amounts is added into dregs of a decoction B, heating decocts 50 minutes, obtains dregs of a decoction C and decoction liquor C；
D, merge 3 decoction liquors, after static 12 hours, supernatant is crossed into 200 mesh sieve, it is for use to obtain filtrate A；
E, filtrate A is concentrated by evaporation to paste, stops heating, 75% ethanol of 2 times of amounts is added into thick paste, it is quiet after uniform
It sets overnight, liquor B is obtained after supernatant liquid filtering；
F, edible vegetable oil dissolving is added in liquor B, and it is 80% or more expression amount containing traditional Chinese medicine ingredients to adjust concentration to every ball, is made
It is for use for liquid A；
G, another that qs glycerin is taken to be heated to 80 degrees Celsius, the gelatin of amounts of glycerol 20% is added, stirring call keeps the temperature 1.5h, filtering
Obtain liquor C；
H, liquid A and liquor C are added in pill and carry out dripping, the capsule and pill of condensation is collected after cooling, is removed photoresist with gauze
The coolant liquid adhered on ball, cold wind are dried after blowing 3 hours, with petroleum ether 3 times, remove the liquid stone of capsule and pill outer layer
Wax, screening, quality inspection, packaging.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810746855.7A CN108671050A (en) | 2018-07-09 | 2018-07-09 | Treat the drug and preparation method thereof of apoplexy |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102755474A (en) * | 2012-07-04 | 2012-10-31 | 陕西步长制药有限公司 | Chinese medicinal preparation for treating apoplexy and preparation method thereof |
| US20140369995A1 (en) * | 2008-11-10 | 2014-12-18 | Moleac Pte. Ltd. | Combination therapy for treatment of patients with neurological disorders and cerebral infarction |
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2018
- 2018-07-09 CN CN201810746855.7A patent/CN108671050A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140369995A1 (en) * | 2008-11-10 | 2014-12-18 | Moleac Pte. Ltd. | Combination therapy for treatment of patients with neurological disorders and cerebral infarction |
| CN102755474A (en) * | 2012-07-04 | 2012-10-31 | 陕西步长制药有限公司 | Chinese medicinal preparation for treating apoplexy and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 董淑艳等: "中西医结合治疗中风临床观察", 《牡丹江医学院学报》 * |
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Application publication date: 20181019 |