CN106266722A - A kind of Traditional Chinese medicine eye drop and preparation method thereof - Google Patents
A kind of Traditional Chinese medicine eye drop and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of Traditional Chinese medicine eye drop, it is made up of the raw material of following weight portion: Flos Eriocauli 30 40 parts, Margarita powder 30 40 parts, Fructus Viticis 30 40 parts, wild Folium Trematis Dielsianae 25 35 parts, Semen Cassiae 25 35 parts, Cortex Dictamni 25 35 parts, Fructus Lycii 20 30 parts, Herba Houttuyniae 20 30 parts, Herba Digitariae 15 25 parts, Flos Lonicerae 15 25 parts, Herba Sedi Linearis 10 20 parts, Folium Granati 5 15 parts, Herba Lysimachiae 10 25 parts, Folium Lycii 10 30 parts, 10 20 parts of Folium Mori, Herba Taraxaci 15 25 parts, luxuriant Folium Persicae 10 20 parts, calabash grass 10 20 parts and 1 20 parts of sodium chloride, also disclose its manufacture method.Product of the present invention directly acts on eye, gets through meridians through microcirculation in human body, is recycled to each position of health, there is effect of heat-clearing and toxic substances removing, nourishing blood for improving eyesight, dispelling wind and heat pathogens, can not only effectively alleviate that eye is dry and astringent and slight sense of discomfort, moreover it is possible to playing the effect of moistening improving eyesight, should be widely promoted application.
Description
Technical field
The invention belongs to processing technique of Chinese herbs field, be specifically related to a kind of Traditional Chinese medicine eye drop and preparation method thereof.
Background technology
Collyrium is one of the most frequently used pharmaceutical dosage form of ophthalmic diseases, and for many oculopathy, collyrium has direct, quick
Therapeutical effect.Traditional Chinese Medicine uses Chinese medicine based on decoction, separately has pill, powder, extract and pellet preparation, controls for people's civil defence disease for thousands of years
Sick.The external eye dripping medicine for the treatment of oculopathy mostly is western medicine component at present, and Western medicine collyrium is very big to the stimulation of eyes, treats eye
While disease, the bigger side effect that can bring.Traditional Chinese medicine eye drop on market mostly is again health-related collyrium, can alleviate
The various symptoms that eyestrain causes, not only cost is high, involves great expense, and does not possess therapeutic effect.
Summary of the invention
For the deficiency of above-mentioned existence, the invention provides a kind of Traditional Chinese medicine eye drop, product of the present invention directly acts on eye,
Get through collaterals of human through microcirculation in human body, be recycled to each position of health, not only have and dissolve thrombosis, get rid of toxin rubbish,
Supplement the nutrients function, also there is effect of heat-clearing and toxic substances removing, nourishing blood for improving eyesight, dispelling wind and heat pathogens, to treatment trachoma and eye is dry and astringent, pain
The symptoms such as pain have significant curative effect, can effectively alleviate that eye is dry and astringent and slight sense of discomfort, moreover it is possible to play the effect of moistening improving eyesight,
Should be widely promoted application.
To achieve these goals, the technical solution used in the present invention is as follows:
A kind of Traditional Chinese medicine eye drop, is prepared from by the raw material of following weight portion: Flos Eriocauli 30-40 part, Margarita powder 30-40 part, climing
Fructus Vitics Simplicifoliae 30-40 part, wild Folium Trematis Dielsianae 25-35 part, Semen Cassiae 25-35 part, Cortex Dictamni 25-35 part, Fructus Lycii 20-30 part, flake
Grass 20-30 part, Herba Digitariae 15-25 part, Flos Lonicerae 15-25 part, Herba Sedi Linearis 10-20 part, Folium Granati 5-15 part, Herba Lysimachiae 10-25 part,
Folium Lycii 10-30 part, Folium Mori 10-20 part, Herba Taraxaci 15-25 part, luxuriant Folium Persicae 10-20 part, calabash grass 10-20 part and sodium chloride 1-
20 parts.
Currently preferred technical scheme is, described a kind of Traditional Chinese medicine eye drop, by the raw material preparation of following weight portion
Become: Flos Eriocauli 33-37 part, Margarita powder 33-37 part, Fructus Viticis 33-37 part, wild Folium Trematis Dielsianae 27-33 part, Semen Cassiae 27-33 part,
Cortex Dictamni 27-33 part, Fructus Lycii 22-28 part, Herba Houttuyniae 22-28 part, Herba Digitariae 17-22 part, Flos Lonicerae 17-22 part, Herba Sedi Linearis 13-
17 parts, Folium Granati 7-13 part, Herba Lysimachiae 15-20 part, Folium Lycii 15-25 part, Folium Mori 13-17 part, Herba Taraxaci 18-22 part, luxuriant Fructus Persicae
Leaf 13-17 part, calabash grass 12-18 part and sodium chloride 5-15 part.
Further, described a kind of Traditional Chinese medicine eye drop, the raw material of following weight portion it is prepared from: Flos Eriocauli 35 parts,
Margarita powder 35 parts, Fructus Viticis 35 parts, wild Folium Trematis Dielsianae 30 parts, Semen Cassiae 30 parts, Cortex Dictamni 30 parts, Fructus Lycii 25 parts, Herba Houttuyniae
25 parts, Herba Digitariae 20 parts, Flos Lonicerae 20 parts, Herba Sedi Linearis 15 parts, Folium Granati 10 parts, Herba Lysimachiae 18 parts, Folium Lycii 20 parts, Folium Mori 15
Part, Herba Taraxaci 20 parts, luxuriant Folium Persicae 15 parts, calabash grass 15 parts and 10 parts of sodium chloride.
Further, the preparation method of described a kind of Traditional Chinese medicine eye drop, comprise the steps of:
(1) weigh Flos Eriocauli by weight, add the ethanol of 3 times of weight 95%, use supercritical-CO2 entrainer extracting process pair
Its effective ingredient carries out extracting, filters, reclaims ethanol, obtains Flos Eriocauli extract；Extraction calabash is careless, golden after the same method
Money grass, Herba Sedi Linearis, Herba Houttuyniae；By the extract mix homogeneously of each extracting substances gained, obtain mixed extracts；
(2) weigh by weight Margarita powder, Fructus Viticis, wild Folium Trematis Dielsianae, Semen Cassiae, Cortex Dictamni, Fructus Lycii, Herba Digitariae, Flos Lonicerae,
Folium Granati, Folium Lycii, Folium Mori, Herba Taraxaci, luxuriant Folium Persicae, roguing, clean after put into container, add 1-4 times of distilled water of Margarita powder,
Soak 10-15h, extract after boiling 4-6h；Add 1-3 times of distilled water of Margarita powder, boil 3-5h, extract, merge twice extraction
Liquid, is then collected by filtration filtrate, obtains pure medicinal liquid；
(3) the pure medicinal liquid mixing that mixed extracts sodium chloride, step (1) obtained and step (2) obtain, stirring makes
Its mix homogeneously, stands 8-12h, as without precipitation, being and prepare described Traditional Chinese medicine eye drop.
Further, the preparation method of described a kind of Traditional Chinese medicine eye drop, in step (1), described extraction parameters is: extraction
Pressure is 20-25MPa, and extraction temperature is 40-50 DEG C, and extraction time is 35-50min.
Further, the preparation method of described a kind of Traditional Chinese medicine eye drop, in step (1) and step (2), described filtration is
Using microporous membrane filtration, add water to enough, stirring makes its mix homogeneously, recycles microporous membrane fine straining.
Further, the preparation method of described a kind of Traditional Chinese medicine eye drop, in step (3), the stirring of described stirring technique
Speed is 200-300r/min.
Further, the preparation method of described a kind of Traditional Chinese medicine eye drop, in step (3), if left standing for after have precipitation, then
Need to use microporous membrane fine straining.
The acting as of each medicine in the present invention:
Flos Eriocauli, Chinese medicine name.Annual herb, fibrous root jewelry, expensive clothing and other valuables are dense, and phyllopodium is raw, and length drapes over one's shoulders needle-like bar shaped.Head inflorescence is hemisphere
Shape, bract close-packed arrays layer by layer, bract pistac, the close raw white undercoat of top edge, inflorescence top canescence are arranged at bottom.Flower
Stem is very thin, different in size, and pistac is glossy, slightly distorts, have crest line several.The most area of China is with this kind of plant herb
It is used as medicine as Flos Eriocauli, gathers when fall flowering beads up, dry.There is dispelling wind and heat pathogens, effect of improving acuity of vision and removing nebula.For Liver Channel wind
The diseases such as heat, conjunctival congestion and swelling pain, mesh raw cataracta, headache due to pathogenic wind-heat, nyctalopia.
Margarita powder: described in Compendium of Material Medica, Margarita salty in the mouth is sweet cold nontoxic, relieving palpitation point mesh；Margarita be coated with face, make us moist well
Color.It is coated with brothers, removes skin hangnail；Pendant expectorant, except speckle, antidiarrheal；Except children's's fever (of children) accompanied by fear, pacify soul；Only pass out semen nebulousurine, solve pox and treat
Poison.
Fructus Viticis, Chinese medicine name.Another name: wild pepper reality, Fructus Vitics Simplicifoliae, FRUCTUS VITICIS, turnip, wild pepper, Auricularia polytricha (Mout) Sacc., little Semen Canavaliae rattan,
Back of the body grass the most leeward, white.Source is Verbenaceae Vitex rotundifolia or the dry mature fruit of wild pepper.Acrid in the mouth, hardship, cold nature.
Return lung, bladder, Liver Channel.Its primary efficacy is dispelling wind and heat pathogens, the clear profit head, joint at dehumidifying.It is usually used in headache due to invasion of exogenous pathogens, polarization head
Wind, the mesh that swoons is dark, the many tear of acute conjunctivitis, pain, gingivitis, arthralgia chiefly caused by damp pathogen contracture in mesh eyeball.
Wild Folium Trematis Dielsianae: Classification system: Trema dielsiana Hand.-Mzt, hardship cold in nature, micro-, there is heat-clearing and toxic substances removing,
Pain relieving, effect of hemostasis.Cure mainly furuncle poison, and control traumatic hemorrhage." will planted by Tianmu Mountains of Zhejiang Province medicine ": " controlling furuncle poison, fresh leaf is mashed, and adds
White sugar external application affected part, changes once every day." " GUIHAIA register ": " root, leaf: refrigerant, pain relieving, hemostasis."
Semen Cassiae: Semen Cassiae, Chinese medicine name.It is leguminous plant Semen Cassiae or the dry mature seed of little Semen Cassiae, has the merit of improving eyesight with it
And name it.Gather autumn mature fruit, dry, lay seed, remove impurity.Luxuriant Folium Persicae bitter in the mouth, sweet, salty, cold nature, enter liver,
Kidney, large intestine channel；Loosening bowel to relieve constipation, blood fat reducing improving eyesight, treatment constipation and hyperlipidemia, hypertension.Liver heat removing and eyesight improving, diuretic relieving constipation, there is cathartic
Effect, reducing blood pressure and blood fat.
Cortex Dictamni, another name: Cortex Dictamni, stereotyped writing cattle, Cortex Argyreiae Seguinii Radicis, the fresh grass of sheep.For Rutaceae herbaceos perennial shaggy-fruited dittany and
The root bark of Dictamnus angustifolius.Main product in Liaoning, Hebei, Sichuan, the ground such as Jiangsu.Spring, excavate root season in autumn two, remove silt and thick
Skin, strips root bark, section, is dried.Raw use.There is heat clearing and damp drying, the effect of removing toxic substances of dispeling the wind.
Herba Houttuyniae: bitter in the mouth；Cold in nature.Heat-clearing and toxic substances removing, dispelling pathogenic wind for improving eyesight.Main pneumonia, hepatitis, dysentery, dyspepsia, malaria, night
Blind, leukorrhagia, skin infection." Yunnan Chinese herbal medicine " carries: " heat-clearing and toxic substances removing.Treating the liver is scorching, infantile dyspepsia, nyctalopia, skin infection.”
Herba Digitariae: sweet in the mouth, cold in nature.Improving eyesight, lung moistening.Cure mainly poor vision, cough due to lung-heat." not Lu " carries, " in homophony, bright knowledge.”
Flos Lonicerae is described as the good medicine of heat-clearing and toxic substances removing from ancient times.Its property sweet cold fragrance, clearing away heat with drugs sweet in flavor and cold in nature and do not injure one's stomach, fragrance thoroughly reach and
Can be eliminating evil.Flos Lonicerae can dispelling wind-heat, be also apt to removing summer-heat blood poison, for various febrile diseases, such as fever of the body, dermexanthesis, send out speckle, pyretic toxicity skin ulcer
The disease such as carbuncle, laryngopharynx swelling and pain, equal effect is notable.
Herba Sedi Linearis: there is heat clearing away, detumescence, function of detoxification.Can control laryngopharynx swelling and pain, carbuncle, furuncle, erysipelas, scald, Serpentis stings
Wound, jaundice, dysentery.
Folium Granati is Punicaceae Punica species, Classification system: Punic a granatum L, meridian distribution of property and flavor: sour, puckery,
Temperature.Summer, autumn gather, and clean, using fresh herb or dry.Folium Granati has astringing to arrest diarrhea, worm is killed at angle, master has loose bowels, variolar carbuncle, leprosy
Skin ulcer, effect of traumatic injury.
Herba Lysimachiae is Ofthe Primulaceae, another name: Lysimachia christinae Hance, Drymoglossum subcordatum, Cui Pingcao, lotus bud grass, Boiled small dumplings with pork grass, Jin Suo
Spoon, Herba Glechomae, to seat grass, leaf Herba Lysimachiae, Qian Yecao, Qian Qianjin etc..Latin literary fame is Lysimachia christinae
Hance, sweet in the mouth, micro-hardship, cool in nature.Return liver, gallbladder, kidney, bladder warp.Herb hyoscine, primary efficacy can prevent calculus and function of gallbladder promoting row
Stone, it may be said that calculus is had extraordinary treatment and prevention effect.There are clearing away heat and promoting diuresis, wind-expelling pain-stopping, hemostasia and promoting granulation, antiinflammatory solution
Poison, the merit of parasite killing.Can treating acute and chronic hepatitis, icterohepatitis, cholecystitis, nephritis, urinary system infection, tonsillitis, stomatitis
And carbuncle furuncle treatment poison, venom, acute mastitis, dysentery, malaria, pneumorrhagia etc..
Fructus Lycii: sweet in the mouth, property are flat.Tonifying liver, kidney tonifying.Compendium of Material Medica carries: " the hard muscles and bones of clothes for a long time, makes light of one's life by commiting suicide not old, resistance to cold and summer-heat.In "
Doctor conventional it treat hepatic and renal YIN deficiency, soreness of the waist and knees, dizziness, forgetful, dizzy, the many tear of blurred vision, quench one's thirst, the disease such as seminal emission.Modern
Pharmaceutical research confirms, Fructus Lycii scalable body's immunity, can effectively suppress growth of tumour cell and cell mutation, has
Slow down aging, anti-fatty liver, regulation blood fat and the effect of the aspect such as blood glucose, promotion hemopoietic function, and it is applied to clinic.
Folium Mori: nature and flavor: bitter in the mouth, sweet, cold in nature.Gui Jing: return lung, Liver Channel.Effect: dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, suppressing the hyperactive liver is bright
Mesh, cooling blood for hemostasis.Curing mainly: anemopyretic cold, epidemic febrile disease is from the beginning of, cough due to lung-heat, excessive rising of liver-YANG dizziness, and conjunctival congestion is dim-sighted, bleeding due to blood-heat it
Hemoptysis, haematemesis.
Herba Taraxaci plant becomes containing multiple health-nutritions such as taraxol, taraxacin, choline, organic acid, inulin
Point.Nature and flavor are sweet, micro-hardship, cold.Return liver, stomach warp.There are the effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting.Control pyretic toxicity, carbuncle, skin infection, interior
Carbuncle, conjunctival congestion and swelling pain, damp and hot, the puckery pain of jaundice, dribbling urination, furuncle swelling toxin, acute mastitis, scrofula, toothache, conjunctival congestion, pharyngalgia, lung abscess, intestinal
Carbuncle, jaundice due to damp-heat, the puckery pain of pyretic stranguria.Control acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever,
Acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection etc..
Luxuriant Folium Persicae: formal name used at school: Folium Psidii Guajavae Psidium guajava L., another name chicken vows tea, kind Fructus Persicae
Bar in leaf, fiber crops, sweet-puckery flavor, property is put down, nontoxic, " Nanning City's medicine will ": astringing to arrest diarrhea.There is heat-clearing and toxic substances removing, antidiarrheal, stop blooding, only
The effect itched.
Calabash grass, another name: dragon red tongue, dragon tongue tea, gold calabash, salmon Cordyceps, field handle of a knife, hundred labor tongues, cured fish grass, nontoxic, taste
Sweet puckery, cool in nature, enter lung spleen channel.Clearing away summer-heat for oral administration, diuresis dissipates gas, changes long-pending parasite killing.The cough due to common cold, cough due to lung-heat, Sunstroke is thirsty,
Prevention heatstroke, goes on a long journey thirsty, laryngalgia, rheumatism infections pain, lumbago, edema, infantile malnutrition.
Sodium chloride, English name: Sodium chloride, stability is relatively good, and its aqueous solution is neutrality.Institute in adult body
Total amount containing sodium ion is about 60g, and wherein 80% is present in extracellular fluid, and chloride ion is also primarily present in extracellular fluid.In blood
Na ion concentration be directly connected to the regulation of level of security of body fluid.The water of sodium chloride-containing 0.9% is referred to as normal saline, because
It has identical osmotic pressure with blood plasma.Normal saline is main humor substitute, is widely used in treatment and prevention dehydration, also uses
In intravenous medical treatment and prevention hypovolemic shock.
Supercritical fluid be a kind of between gas and liquid physical state, only at material (such as carbon dioxide
CO2) could exist during temperature and pressure postcritical.The density of supercritical fluid is relatively big, and similar to liquid, its viscosity is the most relatively
Close to gas, it therefore it is a kind of very good extractant.The supercritical CO 2 entrainer abstraction technique that the present invention uses is (i.e.
Supercritical liquid extraction technique) principle be utilize supercritical carbon dioxide some special natural product is had special dissolve make
With, utilize the solvability of supercritical carbon dioxide and the relation of its density, i.e. utilize pressure and temperature to supercritical titanium dioxide
The impact of carbon dissolution ability and carry out.In the supercritical state, supercritical carbon dioxide is contacted with material to be separated, makes
It extracts the composition of polarity size, boiling point height and molecular size range selectively successively.Corresponding different pressures model
Enclose obtained extract and be unlikely to be single, but the blending constituent of optimal proportion can be obtained by controlling extraction conditions,
Then the method by decompression, intensification makes supercritical fluid become common gases, is extracted material and the most wholly or substantially separates out, from
And reach the purpose of separating-purifying.So supercritical fluid carbon dioxide extraction process combines by extracting and separate.
The method has the advantage of its uniqueness relative to traditional steam distillation and liquid-liquid extraction method, and on the one hand supercritical fluid has
Higher solvability, on the other hand also has higher mass transfer rate, preferable mobile performance and quickly reaches the energy of balance
Power.
In sum, due to the fact that and have employed such scheme, the invention have the advantages that
(1) present invention uses supercritical-CO2 entrainer extracting process to extract, and this extracting process steams relative to traditional water
Steam distillation and liquid-liquid extraction method have the advantage of its uniqueness, and on the one hand supercritical fluid has higher solvability, the opposing party
Face also has higher mass transfer rate, preferable mobile performance and quickly reaches the ability of balance；
(2) product of the present invention directly acts on eye, gets through collaterals of human through microcirculation in human body, is recycled to each portion of health
Position, not only has and dissolves thrombosis, gets rid of toxin rubbish, the function of extra-nutrition；
(3) present invention product use safe and effective, non-stimulated, there is good stability, also have heat-clearing and toxic substances removing, nourish blood bright
Mesh, effect of dispelling wind and heat pathogens, have significant curative effect to the treatment symptom such as trachoma and eye is dry and astringent, pain, can effectively alleviate eye
Portion is dry and astringent and slight sense of discomfort, moreover it is possible to playing the effect of moistening improving eyesight, should be widely promoted application.
Detailed description of the invention
Below in conjunction with embodiment to one Traditional Chinese medicine eye drop of the present invention and preparation method thereof and preparation method thereof, make further
Explanation.
Embodiment 1
A kind of Traditional Chinese medicine eye drop, is prepared from by the raw material of following weight portion: Flos Eriocauli 30 parts, Margarita powder 30 parts, Fructus Viticis 30
Part, wild Folium Trematis Dielsianae 25 parts, Semen Cassiae 25 parts, Cortex Dictamni 25 parts, Fructus Lycii 20 parts, Herba Houttuyniae 20 parts, Herba Digitariae 15 parts, Flos Lonicerae
15 parts, Herba Sedi Linearis 10 parts, Folium Granati 5 parts, Herba Lysimachiae 10 parts, Folium Lycii 10 parts, 10 parts of Folium Mori, Herba Taraxaci 15 parts, luxuriant Folium Persicae 10
Part, calabash grass 10 parts and 1 part of sodium chloride.
The preparation method of a kind of Traditional Chinese medicine eye drop described above, comprises the steps of:
(1) weigh Flos Eriocauli by weight, add the ethanol of 3 times of weight 95%, use supercritical-CO2 entrainer extracting process pair
Its effective ingredient extracts, and extraction parameters is: pressure is 20MPa, temperature is 40 DEG C, the time is 35min, then uses micropore thin
Membrane filtration, adds water to enough, and stirring makes its mix homogeneously, recycles microporous membrane fine straining, reclaims ethanol, obtains Flos Eriocauli extraction
Thing；Extraction calabash grass, Herba Lysimachiae, Herba Sedi Linearis, Herba Houttuyniae after the same method；The extract of each extracting substances gained is mixed
Uniformly, mixed extracts is obtained；
(2) weigh by weight Margarita powder, Fructus Viticis, wild Folium Trematis Dielsianae, Semen Cassiae, Cortex Dictamni, Fructus Lycii, Herba Digitariae, Flos Lonicerae,
Folium Granati, Folium Lycii, Folium Mori, Herba Taraxaci, luxuriant Folium Persicae, roguing, clean after put into container, add 1 times of distilled water of Margarita powder, leaching
Bubble 10h, extracts after boiling 4h；Add Margarita powder 1 times amount distilled water, boil 3h, extract, merge twice extracting solution, then adopt
With microporous membrane filtration, adding water to enough, stirring makes its mix homogeneously, recycles microporous membrane fine straining, collects filtrate, obtains nothing
The medicinal liquid of impurity；
(3) the pure medicinal liquid mixing that mixed extracts sodium chloride, step (1) obtained and step (2) obtain, with
The speed stirring of 200r/min makes its mix homogeneously, stands 8h, if any precipitation, then needs to use microporous membrane fine straining；As without heavy
Form sediment, be and prepare described Traditional Chinese medicine eye drop.
Embodiment 2
A kind of Traditional Chinese medicine eye drop, is prepared from by the raw material of following weight portion: Flos Eriocauli 40 parts, Margarita powder 40 parts, Fructus Viticis 40
Part, wild Folium Trematis Dielsianae 35 parts, Semen Cassiae 35 parts, Cortex Dictamni 35 parts, Fructus Lycii 30 parts, Herba Houttuyniae 30 parts, Herba Digitariae 25 parts, Flos Lonicerae
25 parts, Herba Sedi Linearis 20 parts, Folium Granati 15 parts, Herba Lysimachiae 25 parts, Folium Lycii 30 parts, 20 parts of Folium Mori, Herba Taraxaci 25 parts, luxuriant Folium Persicae 20
Part, calabash grass 20 parts and 20 parts of sodium chloride.
The preparation method of a kind of Traditional Chinese medicine eye drop described above, comprises the steps of:
(1) weigh Flos Eriocauli by weight, add the ethanol of 3 times of weight 95%, use supercritical-CO2 entrainer extracting process pair
Its effective ingredient extracts, and extraction parameters is: pressure is 25MPa, temperature is 50 DEG C, the time is 50min, then uses micropore thin
Membrane filtration, adds water to enough, and stirring makes its mix homogeneously, recycles microporous membrane fine straining, reclaims ethanol, obtains Flos Eriocauli extraction
Thing；Extraction calabash grass, Herba Lysimachiae, Herba Sedi Linearis, Herba Houttuyniae after the same method；The extract of each extracting substances gained is mixed
Uniformly, mixed extracts is obtained；
(2) weigh by weight Margarita powder, Fructus Viticis, wild Folium Trematis Dielsianae, Semen Cassiae, Cortex Dictamni, Fructus Lycii, Herba Digitariae, Flos Lonicerae,
Folium Granati, Folium Lycii, Folium Mori, Herba Taraxaci, luxuriant Folium Persicae, roguing, clean after put into container, add 4 times of distilled water of Margarita powder, leaching
Bubble 15h, extracts after boiling 6h；Add Margarita powder 3 times amount distilled water, boil 5h, extract, merge twice extracting solution, then adopt
With microporous membrane filtration, adding water to enough, stirring makes its mix homogeneously, recycles microporous membrane fine straining, collects filtrate, obtains nothing
The medicinal liquid of impurity；
(3) the pure medicinal liquid mixing that mixed extracts sodium chloride, step (1) obtained and step (2) obtain, with
The speed stirring of 300r/min makes its mix homogeneously, stands 12h, if any precipitation, then needs to use microporous membrane fine straining；As without heavy
Form sediment, be and prepare described Traditional Chinese medicine eye drop.
Embodiment 3
A kind of Traditional Chinese medicine eye drop, is prepared from by the raw material of following weight portion: Flos Eriocauli 33 parts, Margarita powder 33 parts, Fructus Viticis 33
Part, wild Folium Trematis Dielsianae 27 parts, Semen Cassiae 27 parts, Cortex Dictamni 27 parts, Fructus Lycii 22 parts, Herba Houttuyniae 22 parts, Herba Digitariae 17 parts, Flos Lonicerae
17 parts, Herba Sedi Linearis 13 parts, Folium Granati 7 parts, Herba Lysimachiae 15 parts, Folium Lycii 15 parts, 13 parts of Folium Mori, Herba Taraxaci 18 parts, luxuriant Folium Persicae 13
Part, calabash grass 12 parts and 5 parts of sodium chloride.
The preparation method of a kind of Traditional Chinese medicine eye drop described above, comprises the steps of:
(1) weigh Flos Eriocauli by weight, add the ethanol of 3 times of weight 95%, use supercritical-CO2 entrainer extracting process pair
Its effective ingredient extracts, and extraction parameters is: pressure is 21MPa, temperature is 42 DEG C, the time is 40min, then uses micropore thin
Membrane filtration, adds water to enough, and stirring makes its mix homogeneously, recycles microporous membrane fine straining, reclaims ethanol, obtains Flos Eriocauli extraction
Thing；Extraction calabash grass, Herba Lysimachiae, Herba Sedi Linearis, Herba Houttuyniae after the same method；The extract of each extracting substances gained is mixed
Uniformly, mixed extracts is obtained；
(2) weigh by weight Margarita powder, Fructus Viticis, wild Folium Trematis Dielsianae, Semen Cassiae, Cortex Dictamni, Fructus Lycii, Herba Digitariae, Flos Lonicerae,
Folium Granati, Folium Lycii, Folium Mori, Herba Taraxaci, luxuriant Folium Persicae, roguing, clean after put into container, add 2 times of distilled water of Margarita powder, leaching
Bubble 11h, extracts after boiling 4.5h；Add Margarita powder 1.5 times amount distilled water, boil 3.5h, extract, merge twice extracting solution,
Then using microporous membrane filtration, add water to enough, stirring makes its mix homogeneously, recycles microporous membrane fine straining, collects filtrate,
Obtain pure medicinal liquid；
(3) the pure medicinal liquid mixing that mixed extracts sodium chloride, step (1) obtained and step (2) obtain, with
The speed stirring of 225r/min makes its mix homogeneously, stands 9h, if any precipitation, then needs to use microporous membrane fine straining；As without heavy
Form sediment, be and prepare described Traditional Chinese medicine eye drop.
Embodiment 4
A kind of Traditional Chinese medicine eye drop, is prepared from by the raw material of following weight portion: Flos Eriocauli 37 parts, Margarita powder 37 parts, Fructus Viticis 37
Part, wild Folium Trematis Dielsianae 33 parts, Semen Cassiae 33 parts, Cortex Dictamni 33 parts, Fructus Lycii 28 parts, Herba Houttuyniae 28 parts, Herba Digitariae 22 parts, Flos Lonicerae
22 parts, Herba Sedi Linearis 17 parts, Folium Granati 13 parts, Herba Lysimachiae 20 parts, Folium Lycii 25 parts, 17 parts of Folium Mori, Herba Taraxaci 22 parts, luxuriant Folium Persicae 17
Part, calabash grass 18 parts and 15 parts of sodium chloride.
The preparation method of a kind of Traditional Chinese medicine eye drop described above, comprises the steps of:
(1) weigh Flos Eriocauli by weight, add the ethanol of 3 times of weight 95%, use supercritical-CO2 entrainer extracting process pair
Its effective ingredient extracts, and extraction parameters is: pressure is 24MPa, temperature is 48 DEG C, the time is 45min, then uses micropore thin
Membrane filtration, adds water to enough, and stirring makes its mix homogeneously, recycles microporous membrane fine straining, reclaims ethanol, obtains Flos Eriocauli extraction
Thing；Extraction calabash grass, Herba Lysimachiae, Herba Sedi Linearis, Herba Houttuyniae after the same method；The extract of each extracting substances gained is mixed
Uniformly, mixed extracts is obtained；
(2) weigh by weight Margarita powder, Fructus Viticis, wild Folium Trematis Dielsianae, Semen Cassiae, Cortex Dictamni, Fructus Lycii, Herba Digitariae, Flos Lonicerae,
Folium Granati, Folium Lycii, Folium Mori, Herba Taraxaci, luxuriant Folium Persicae, roguing, clean after put into container, add 3 times of distilled water of Margarita powder, leaching
Bubble 14h, extracts after boiling 5.5h；Add Margarita powder 2.5 times amount distilled water, boil 4.5h, extract, merge twice extracting solution,
Then using microporous membrane filtration, add water to enough, stirring makes its mix homogeneously, recycles microporous membrane fine straining, collects filtrate,
Obtain pure medicinal liquid；
(3) the pure medicinal liquid mixing that mixed extracts sodium chloride, step (1) obtained and step (2) obtain, with
The speed stirring of 275r/min makes its mix homogeneously, stands 11h, if any precipitation, then needs to use microporous membrane fine straining；As without heavy
Form sediment, be and prepare described Traditional Chinese medicine eye drop.
Embodiment 5
A kind of Traditional Chinese medicine eye drop, is prepared from by the raw material of following weight portion: Flos Eriocauli 35 parts, Margarita powder 35 parts, Fructus Viticis 35
Part, wild Folium Trematis Dielsianae 30 parts, Semen Cassiae 30 parts, Cortex Dictamni 30 parts, Fructus Lycii 25 parts, Herba Houttuyniae 25 parts, Herba Digitariae 20 parts, Flos Lonicerae
20 parts, Herba Sedi Linearis 15 parts, Folium Granati 10 parts, Herba Lysimachiae 18 parts, Folium Lycii 20 parts, 15 parts of Folium Mori, Herba Taraxaci 20 parts, luxuriant Folium Persicae 15
Part, calabash grass 15 parts and 10 parts of sodium chloride.
The preparation method of a kind of Traditional Chinese medicine eye drop described above, comprises the steps of:
(1) weigh Flos Eriocauli by weight, add the ethanol of 3 times of weight 95%, use supercritical-CO2 entrainer extracting process pair
Its effective ingredient extracts, and extraction parameters is: pressure is 23MPa, temperature is 45 DEG C, the time is 42min, then uses micropore thin
Membrane filtration, adds water to enough, and stirring makes its mix homogeneously, recycles microporous membrane fine straining, reclaims ethanol, obtains Flos Eriocauli extraction
Thing；Extraction calabash grass, Herba Lysimachiae, Herba Sedi Linearis, Herba Houttuyniae after the same method；The extract of each extracting substances gained is mixed
Uniformly, mixed extracts is obtained；
(2) weigh by weight Margarita powder, Fructus Viticis, wild Folium Trematis Dielsianae, Semen Cassiae, Cortex Dictamni, Fructus Lycii, Herba Digitariae, Flos Lonicerae,
Folium Granati, Folium Lycii, Folium Mori, Herba Taraxaci, luxuriant Folium Persicae, roguing, clean after put into container, add 2.5 times of distilled water of Margarita powder,
Soak 13h, extract after boiling 5h；Add Margarita powder 2 times amount distilled water, boil 4h, extract, merge twice extracting solution, then
Using microporous membrane filtration, add water to enough, stirring makes its mix homogeneously, recycles microporous membrane fine straining, collects filtrate, obtains
Pure medicinal liquid；
(3) the pure medicinal liquid mixing that mixed extracts sodium chloride, step (1) obtained and step (2) obtain, with
The speed stirring of 250r/min makes its mix homogeneously, stands 10h, if any precipitation, then needs to use microporous membrane fine straining；As without heavy
Form sediment, be and prepare described Traditional Chinese medicine eye drop.
In sum, the present invention uses supercritical-CO2 entrainer extracting process to extract, this extracting process relative to
Traditional steam distillation and liquid-liquid extraction method have the advantage of its uniqueness, and on the one hand supercritical fluid has higher dissolving energy
Power, on the other hand also has higher mass transfer rate, preferable mobile performance and quickly reaches the ability of balance.The product of the present invention
Product directly act on eye, get through collaterals of human through microcirculation in human body, are recycled to each position of health, not only have and dissolve blood
Bolt, gets rid of toxin rubbish, the function of extra-nutrition, uses safe and effective, non-stimulated, have good stability, also has clear
Thermal detoxification, nourishing blood for improving eyesight, effect of dispelling wind and heat pathogens, have significant curative effect to the treatment symptom such as trachoma and eye is dry and astringent, pain,
Can effectively alleviate that eye is dry and astringent and slight sense of discomfort, moreover it is possible to playing the effect of moistening improving eyesight, preparation is simple, easy to operate, is worth
Wide popularization and application.
Above-described detailed description of the invention, has been carried out the purpose of the present invention, technical scheme and beneficial effect further
Describe in detail, be it should be understood that the detailed description of the invention that the foregoing is only the present invention, be not intended to limit the present invention
Protection domain, all within the spirit and principles in the present invention, any modification, equivalent substitution and improvement etc. done, all should comprise
Within protection scope of the present invention.
Claims (8)
1. a Traditional Chinese medicine eye drop, it is characterised in that be prepared from by the raw material of following weight portion: Flos Eriocauli 30-40 part, Margarita
Powder 30-40 part, Fructus Viticis 30-40 part, wild Folium Trematis Dielsianae 25-35 part, Semen Cassiae 25-35 part, Cortex Dictamni 25-35 part, Fructus Lycii
20-30 part, Herba Houttuyniae 20-30 part, Herba Digitariae 15-25 part, Flos Lonicerae 15-25 part, Herba Sedi Linearis 10-20 part, Folium Granati 5-15 part, gold
Money grass 10-25 part, Folium Lycii 10-30 part, Folium Mori 10-20 part, Herba Taraxaci 15-25 part, luxuriant Folium Persicae 10-20 part, calabash grass 10-20
Part and sodium chloride 1-20 part.
A kind of Traditional Chinese medicine eye drop the most according to claim 1, it is characterised in that by the raw material preparation of following weight portion
Become: Flos Eriocauli 33-37 part, Margarita powder 33-37 part, Fructus Viticis 33-37 part, wild Folium Trematis Dielsianae 27-33 part, Semen Cassiae 27-33 part,
Cortex Dictamni 27-33 part, Fructus Lycii 22-28 part, Herba Houttuyniae 22-28 part, Herba Digitariae 17-22 part, Flos Lonicerae 17-22 part, Herba Sedi Linearis 13-
17 parts, Folium Granati 7-13 part, Herba Lysimachiae 15-20 part, Folium Lycii 15-25 part, Folium Mori 13-17 part, Herba Taraxaci 18-22 part, luxuriant Fructus Persicae
Leaf 13-17 part, calabash grass 12-18 part and sodium chloride 5-15 part.
A kind of Traditional Chinese medicine eye drop the most according to claim 1, it is characterised in that by the raw material preparation of following weight portion
Become: Flos Eriocauli 35 parts, Margarita powder 35 parts, Fructus Viticis 35 parts, wild Folium Trematis Dielsianae 30 parts, Semen Cassiae 30 parts, Cortex Dictamni 30 parts, Fructus Lycii
Son 25 parts, Herba Houttuyniae 25 parts, Herba Digitariae 20 parts, Flos Lonicerae 20 parts, Herba Sedi Linearis 15 parts, Folium Granati 10 parts, Herba Lysimachiae 18 parts, Folium Lycii
20 parts, 15 parts of Folium Mori, Herba Taraxaci 20 parts, luxuriant Folium Persicae 15 parts, calabash grass 15 parts and 10 parts of sodium chloride.
4. according to the preparation method of a kind of Traditional Chinese medicine eye drop described in any one of claims 1 to 3, it is characterised in that by following
Step forms:
(1) weigh Flos Eriocauli by weight, add the ethanol of 3 times of weight 95%, use supercritical-CO2 entrainer extracting process pair
Its effective ingredient carries out extracting, filters, reclaims ethanol, obtains Flos Eriocauli extract；Extraction calabash is careless, golden after the same method
Money grass, Herba Sedi Linearis, Herba Houttuyniae；By the extract mix homogeneously of each extracting substances gained, obtain mixed extracts；
(2) weigh by weight Margarita powder, Fructus Viticis, wild Folium Trematis Dielsianae, Semen Cassiae, Cortex Dictamni, Fructus Lycii, Herba Digitariae, Flos Lonicerae,
Folium Granati, Folium Lycii, Folium Mori, Herba Taraxaci, luxuriant Folium Persicae, roguing, clean after put into container, add 1-4 times of distilled water of Margarita powder,
Soak 10-15h, extract after boiling 4-6h；Add 1-3 times of distilled water of Margarita powder, boil 3-5h, extract, merge twice extraction
Liquid, is then collected by filtration filtrate, obtains pure medicinal liquid；
(3) the pure medicinal liquid mixing that mixed extracts sodium chloride, step (1) obtained and step (2) obtain, stirring makes
Its mix homogeneously, stands 8-12h, as without precipitation, being and prepare described Traditional Chinese medicine eye drop.
The preparation method of a kind of Traditional Chinese medicine eye drop the most according to claim 4, it is characterised in that: in step (1), described extraction
Taking parameter is: extracting pressure is 20-25MPa, and extraction temperature is 40-50 DEG C, and extraction time is 35-50min.
The preparation method of a kind of Traditional Chinese medicine eye drop the most according to claim 4, it is characterised in that: in step (1) and step
(2), described filtration is to use microporous membrane filtration, adds water to enough, and stirring makes its mix homogeneously, recycling microporous membrane essence
Filter.
The preparation method of a kind of Traditional Chinese medicine eye drop the most according to claim 4, it is characterised in that: in step (3), described in stir
The mixing speed mixing technique is 200-300r/min.
The preparation method of a kind of Traditional Chinese medicine eye drop the most according to claim 4, it is characterised in that: in step (3), if quiet
Postpone precipitation, then needed to use microporous membrane fine straining.
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|---|---|---|---|---|
| CN105031486A (en) * | 2015-06-30 | 2015-11-11 | 孟庆牛 | Traditional Chinese medicinal eye drops for treating eye diseases and preparation method for traditional Chinese medicinal eye drops |
| CN105031324A (en) * | 2015-06-30 | 2015-11-11 | 孟庆牛 | Traditional Chinese medicinal eye drops and preparation method thereof |
| CN105327026A (en) * | 2015-12-09 | 2016-02-17 | 郑州郑先医药科技有限公司 | Traditional Chinese medicine eye drops and preparing method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105031486A (en) * | 2015-06-30 | 2015-11-11 | 孟庆牛 | Traditional Chinese medicinal eye drops for treating eye diseases and preparation method for traditional Chinese medicinal eye drops |
| CN105031324A (en) * | 2015-06-30 | 2015-11-11 | 孟庆牛 | Traditional Chinese medicinal eye drops and preparation method thereof |
| CN105327026A (en) * | 2015-12-09 | 2016-02-17 | 郑州郑先医药科技有限公司 | Traditional Chinese medicine eye drops and preparing method thereof |
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Application publication date: 20170104 |