CN103845628A - Medicine for treating cat tetanus and preparation method of medicine - Google Patents

Abstract

The invention discloses a medicine for treating cat tetanus and a preparation method of the medicine. The medicine comprises the following raw material medicines: divaricate saposhnikovia roots, lysimachia hui diels, schizonepeta spikes, rhizoma dioscoreae septemlobae, mint, periostracum cicada, fructus ulmi, radix angelicae, arisaema cum bile, gastrodia elata, rattletop, stiff silkworms, puerarin, notopterygium roots, scorpio, ligusticum wallichii, asarum, flos carthami, pinellia ternate, garter snakes, botrypus virginianus, nitella expansa allen, grubs, szechuan melandium roots, allium macrostemon, redpunjab sumac roots and nux prinsepiae. The medicine disclosed by the invention has the beneficial effects that the medicine for treating cat tetanus disclosed by the invention has the advantages of high cure rate, short curative effect and advantages that western medicines do not have; and through treatment based on syndrome differentiation, the medicine can enhance the immunity of cat, the death rate is reduced, and the cost price is low.

Description

One is used for the treatment of tetanic medicine of cat and preparation method thereof

Technical field

The present invention relates to technical field of traditional Chinese medicine pharmacy, particularly one is used for the treatment of tetanic medicine of cat and preparation method thereof.

Background technology

Cat tetanus is invaded wound growth and breeding and secreted clostridium tetani toxin and the acute infectious disease of the Zoonosis that causes by clostridium tetani, and with central nervous system's elevation of irritability, muscle and ankylosis are feature.

Clostridium tetani is Gram-positive escherichia coli, tool week flagellum, without pod membrane, can form brood cell.Clostridium tetani can produce two kinds of extracellular toxins, and one is sphaceltoxin, and Main Function is in nervous system, and another kind is hemotoxin.

After the brood cell of clostridium tetani enters the wound and deep wound of cat, because of the anaerobic environment in wound deep, be conducive to the growth and breeding of clostridium tetani, so breed in a large number, produce extracellular toxin, cause cat morbidity.In nature situation, cat, dog all can infect, and other many animals and people also can infect.

Ill cat muscle and joint are spasmodic rigdity, and mannequin's steps state is stiff, on tail, lifts, and are typical opisthotonus posture.Instant embrane is benumbed and is given prominence to, and pupil increases, and chews dysphagia, sialorrhea.To touching, light and sound reflexive strengthen.

The tetanic principle of western medical treatment cat is mainly guarantee respiratory tract, blood vessel, urethra unobstructed.Remove foreign body in wound and slough, pus once there is the in time cleaning of outer wound response, with 3% hydrogen peroxide irrigation and disinfection; To ill cat intensive care, reduce and stimulate.Sick cat should be placed in more quiet dark room, and note feeding, can not enter trencherman and answer fluid infusion; Injection tetanus antitoxin.Tetanus antiserum is the specific medicament for the treatment of primary disease, can intravenous injection 100-1000 units/kg body weight, be used in conjunction 2-3 times.

Chinese veterinarian thinks, tetanus refers to first broken wound, and the heresy of pathogenic wind toxic is invaded by wound and caused a kind of disease of infantile convulsion.Tetanus name of disease head sees Song dynasty Holy Benevolent Prescriptions, cloud: " orthotonus, locked mouth can not be opened, extremity tremble, diaphysis pain, appearance fish sticking its mouth out of the water tiltedly, this all damages in part in ailment said due to cold or exposure, therefore named tetanus." heresy of pathogenic wind toxic extensively exists, and not only betides the broken wound of skin and flesh, in operation sterilization not strict, or neonatal umbilical cord pollutes, or produces and miscarry mishandlingly, or decubital ulcer contamination, also can cause tetanus.Person due to wound, claims gold wound convulsion; Send out survivor puerperal, claim postpartum convulsion; Person due to the disconnected umbilicus of neonate, claims infantum tetanus to take the photograph mouth.

The cause of disease is the broken wound of skin and flesh, experiences again the heresy of pathogenic wind toxic.The heresy of pathogenic wind toxic takes advantage of that skin and flesh is broken hinders in part invasion and attack people, wind being YANG-pathogen, and benefaction and number becomes, exogenous wind priming liver-wind stirring up internally, with the passing of time pathogenic wind toxic people invades, and heat-transformation fire-transformation makes zang-fu disharmony, qi-blood disharmony, deficiency of YIN affecting YANG, even dissociation of YIN from YANG and death.Pathogenic wind toxic is being shown slight dysphagia, gnathospasma, and whole body contracture, twitches lighter, and spasm period is short, and the intermission is longer.Pathogenic wind toxic enters inner tic of the limbs, opisthotonus, and high heat shiver with cold, whole-body muscle spasm, the intermission is short, rapid breathing, accumulation and obstruction of sputum, constipation, urinary obstruction; It is numb that the deficiency of YIN is lost foster extremity, joint stuffiness.

Western modern medicine treatment cat tetanus, effect is undesirable, and the course for the treatment of is long, and PD is rapid, wayward.Chinese medicine not only has the advantage of Western medicine, and treatment cat tetanus cure rate is high, by determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, can strengthen cat immunity, reduces mortality rate.Therefore, Chinese medicine, aspect treatment cat tetanus disease, has the advantage that Western medicine does not have, and is also more and more subject to people's favor.

Summary of the invention

Technical problem to be solved by this invention is: provide one to be used for the treatment of tetanic medicine of cat and preparation method thereof, treatment cat tetanus cure rate is high, by determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, can strengthen cat immunity, and cost price is cheap.Medicine, aspect treatment cat tetanus disease, has the advantage that Western medicine does not have.

In order to realize foregoing invention object, the invention provides one and be used for the treatment of the tetanic medicine of cat, described medicine comprises following raw medicinal material: Radix Saposhnikoviae, crawl Pheretima, Herba Schizonepetae, Rhizoma Dioscoreae Septemlobae ,herba Menthae, Periostracum Cicadae, Fructus Ulmus preparatium, the Radix Angelicae Dahuricae, Arisaema Cum Bile, Rhizoma Gastrodiae, Rhizoma Cimicifugae, Bombyx Batryticatus, Radix Puerariae, Rhizoma Et Radix Notopterygii, Scorpio, Rhizoma Chuanxiong, Herba Asari, Flos Carthami, the Rhizoma Pinelliae, Zaocys, Herba pteridii latiusculi beanstalk, Herba Limnophilae rugosae algae, Holotrichia diomphalia Bates, blue or green bone rattan, Bulbus Allii Macrostemonis, Radix Rhois Sinicae and Nux Prinsepiae.

Wherein, in medicine, the parts by weight of each raw medicinal material are preferably: Radix Saposhnikoviae 20-30 weight portion, crawl Pheretima 10-20 weight portion, Herba Schizonepetae 10-25 weight portion, Rhizoma Dioscoreae Septemlobae 10-20 weight portion ,herba Menthae 10-25 weight portion, Periostracum Cicadae 20-30 weight portion, Fructus Ulmus preparatium 15-30 weight portion, Radix Angelicae Dahuricae 10-30 weight portion, Arisaema Cum Bile 15-30 weight portion, Rhizoma Gastrodiae 10-25 weight portion, Rhizoma Cimicifugae 10-30 weight portion, Bombyx Batryticatus 10-20 weight portion, Radix Puerariae 15-30 weight portion, Rhizoma Et Radix Notopterygii 10-30 weight portion, Scorpio 10-25 weight portion, Rhizoma Chuanxiong 10-25 weight portion, Herba Asari 10-25 weight portion, Flos Carthami 10-25 weight portion, Rhizoma Pinelliae 20-30 weight portion, Zaocys 20-30 weight portion, Herba pteridii latiusculi beanstalk 20-30 weight portion, Herba Limnophilae rugosae algae 10-30 weight portion, Holotrichia diomphalia Bates 15-30 weight portion, blue or green bone rattan 10-25 weight portion, Bulbus Allii Macrostemonis 10-30 weight portion, Radix Rhois Sinicae 15-30 weight portion and Nux Prinsepiae 20-30 weight portion.

Wherein, in described medicine, the parts by weight of each raw medicinal material can be again: Radix Saposhnikoviae 25-30 weight portion, crawl Pheretima 15-20 weight portion, Herba Schizonepetae 15-25 weight portion, Rhizoma Dioscoreae Septemlobae 15-20 weight portion ,herba Menthae 15-25 weight portion, Periostracum Cicadae 22-30 weight portion, Fructus Ulmus preparatium 17-30 weight portion, Radix Angelicae Dahuricae 15-30 weight portion, Arisaema Cum Bile 17-30 weight portion, Rhizoma Gastrodiae 15-25 weight portion, Rhizoma Cimicifugae 15-30 weight portion, Bombyx Batryticatus 15-20 weight portion, Radix Puerariae 17-30 weight portion, Rhizoma Et Radix Notopterygii 15-30 weight portion, Scorpio 15-25 weight portion, Rhizoma Chuanxiong 15-25 weight portion, Herba Asari 15-25 weight portion, Flos Carthami 16-25 weight portion, Rhizoma Pinelliae 25-30 weight portion, Zaocys 22-30 weight portion, Herba pteridii latiusculi beanstalk 25-30 weight portion, Herba Limnophilae rugosae algae 18-30 weight portion, Holotrichia diomphalia Bates 17-30 weight portion, blue or green bone rattan 15-25 weight portion, Bulbus Allii Macrostemonis 15-30 weight portion, Radix Rhois Sinicae 17-30 weight portion and Nux Prinsepiae 25-30 weight portion.

Wherein, in described medicine, the parts by weight of each raw medicinal material can also be: Radix Saposhnikoviae 27-30 weight portion, crawl Pheretima 18-20 weight portion, Herba Schizonepetae 18-25 weight portion, Rhizoma Dioscoreae Septemlobae 17-20 weight portion ,herba Menthae 18-25 weight portion, Periostracum Cicadae 27-30 weight portion, Fructus Ulmus preparatium 17-25 weight portion, Radix Angelicae Dahuricae 17-25 weight portion, Arisaema Cum Bile 18-28 weight portion, Rhizoma Gastrodiae 15-22 weight portion, Rhizoma Cimicifugae 17-25 weight portion, Bombyx Batryticatus 17-20 weight portion, Radix Puerariae 17-25 weight portion, Rhizoma Et Radix Notopterygii 17-25 weight portion, Scorpio 18-22 weight portion, Rhizoma Chuanxiong 15-20 weight portion, Herba Asari 18-22 weight portion, Flos Carthami 18-22 weight portion, Rhizoma Pinelliae 27-30 weight portion, Zaocys 22-28 weight portion, Herba pteridii latiusculi beanstalk 27-30 weight portion, Herba Limnophilae rugosae algae 20-30 weight portion, Holotrichia diomphalia Bates 17-28 weight portion, blue or green bone rattan 15-22 weight portion, Bulbus Allii Macrostemonis 18-25 weight portion, Radix Rhois Sinicae 18-30 weight portion and Nux Prinsepiae 25-28 weight portion.

Wherein, in medicine, the parts by weight of each raw medicinal material are: Radix Saposhnikoviae 28 weight portions, crawl Pheretima 19 weight portions, Herba Schizonepetae 19 weight portions, Rhizoma Dioscoreae Septemlobae 18 weight portions ,herba Menthae 20 weight portions, Periostracum Cicadae 28 weight portions, Fructus Ulmus preparatium 20 weight portions, the Radix Angelicae Dahuricae 22 weight portions, Arisaema Cum Bile 20 weight portions, Rhizoma Gastrodiae 18 weight portions, Rhizoma Cimicifugae 19 weight portions, Bombyx Batryticatus 18 weight portions, Radix Puerariae 19 weight portions, Rhizoma Et Radix Notopterygii 20 weight portions, Scorpio 20 weight portions, Rhizoma Chuanxiong 18 weight portions, Herba Asari 20 weight portions, Flos Carthami 19 weight portions, the Rhizoma Pinelliae 28 weight portions, Zaocys 25 weight portions, Herba pteridii latiusculi beanstalk 28 weight portions, Herba Limnophilae rugosae algae 25 weight portions, Holotrichia diomphalia Bates 18 weight portions, blue or green bone rattan 18 weight portions, Bulbus Allii Macrostemonis 19 weight portions, Radix Rhois Sinicae 20 weight portions and Nux Prinsepiae 26 weight portions.

Wherein, in described medicine, the parts by weight of each raw medicinal material can also be: Radix Saposhnikoviae 20 weight portions, crawl Pheretima 18 weight portions, Herba Schizonepetae 12 weight portions, Rhizoma Dioscoreae Septemlobae 17 weight portions ,herba Menthae 15 weight portions, Periostracum Cicadae 25 weight portions, Fructus Ulmus preparatium 17 weight portions, the Radix Angelicae Dahuricae 15 weight portions, Arisaema Cum Bile 25 weight portions, Rhizoma Gastrodiae 19 weight portions, Rhizoma Cimicifugae 17 weight portions, Bombyx Batryticatus 16 weight portions, Radix Puerariae 15 weight portions, Rhizoma Et Radix Notopterygii 17 weight portions, Scorpio 19 weight portions, Rhizoma Chuanxiong 15 weight portions, Herba Asari 20 weight portions, Flos Carthami 20 weight portions, the Rhizoma Pinelliae 25 weight portions, Zaocys 28 weight portions, Herba pteridii latiusculi beanstalk 25 weight portions, Herba Limnophilae rugosae algae 17 weight portions, Holotrichia diomphalia Bates 19 weight portions, blue or green bone rattan 22 weight portions, Bulbus Allii Macrostemonis 20 weight portions, Radix Rhois Sinicae 17 weight portions and Nux Prinsepiae 25 weight portions.

Wherein, in described medicine, the parts by weight of each raw medicinal material can be again: Radix Saposhnikoviae 22 weight portions, crawl Pheretima 19 weight portions, Herba Schizonepetae 15 weight portions, Rhizoma Dioscoreae Septemlobae 19 weight portions ,herba Menthae 17 weight portions, Periostracum Cicadae 20 weight portions, Fructus Ulmus preparatium 18 weight portions, the Radix Angelicae Dahuricae 17 weight portions, Arisaema Cum Bile 22 weight portions, Rhizoma Gastrodiae 20 weight portions, Rhizoma Cimicifugae 22 weight portions, Bombyx Batryticatus 18 weight portions, Radix Puerariae 17 weight portions, Rhizoma Et Radix Notopterygii 19 weight portions, Scorpio 20 weight portions, Rhizoma Chuanxiong 17 weight portions, Herba Asari 19 weight portions, Flos Carthami 18 weight portions, the Rhizoma Pinelliae 20 weight portions, Zaocys 25 weight portions, Herba pteridii latiusculi beanstalk 22 weight portions, Herba Limnophilae rugosae algae 18 weight portions, Holotrichia diomphalia Bates 20 weight portions, blue or green bone rattan 20 weight portions, Bulbus Allii Macrostemonis 22 weight portions, Radix Rhois Sinicae 18 weight portions and Nux Prinsepiae 20 weight portions.

For solving the problems of the technologies described above, the invention provides a kind of preparation method that is used for the treatment of the tetanic medicine of cat, described preparation method comprises the following steps: all raw medicinal materials are dropped in pulverizer and are ground into fine powder, put into acid and alkali-resistance infusion kettle, the ethanol that is 80%-90% by the determining alcohol doubly of the 3-5 with respect to fine powder quality is poured in pot, at normal temperatures and pressures, dipping 20-30 days, subsequently the liquid having flooded and dregs pressing are filtered, filtrate decompression concentrates to obtain paste, the medicinal residues that obtain will be filtered, put into oven for drying, the temperature of oven drying is 110-115 DEG C, drying time 10-20 minute, after oven dry, grind to form 150-250 order fine powder, make its fine powder amount reach the more than 95% of total material, obtain described medicine.

The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: medicine of the present invention has at treatment cat tetanus tool the advantage that cure rate is high, curative effect is short, by determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, can strengthen cat immunity, reduces mortality rate, and cost price is cheap.Medicine, aspect treatment cat tetanus disease, has the advantage that Western medicine does not have.

Detailed description of the invention

Chinese veterinarian thinks, the cause of disease is the broken wound of skin and flesh, experiences again the heresy of pathogenic wind toxic.The heresy of pathogenic wind toxic takes advantage of that skin and flesh is broken hinders in part attacks, wind being YANG-pathogen, and benefaction and number becomes, exogenous wind priming liver-wind stirring up internally, with the passing of time pathogenic wind toxic invades, and heat-transformation fire-transformation makes zang-fu disharmony, qi-blood disharmony, deficiency of YIN affecting YANG, even dissociation of YIN from YANG and death.Therefore with the spasmolytic that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., heat-clearing and toxic substances removing; The yin nourishing of enriching blood, dredging the meridian is total Therapeutic Principle.

Therefore, the invention provides a kind of preparation method that is used for the treatment of the tetanic medicine of cat, it comprises normal feedstuff composition saccharomyces cerevisiae, lactoenterococcus, manganese oxide, ferrous sulfate and medicine; Described medicine comprises following raw medicinal material: Radix Saposhnikoviae, crawl Pheretima, Herba Schizonepetae, Rhizoma Dioscoreae Septemlobae ,herba Menthae, Periostracum Cicadae, Fructus Ulmus preparatium, the Radix Angelicae Dahuricae, Arisaema Cum Bile, Rhizoma Gastrodiae, Bombyx Batryticatus, Radix Puerariae, Rhizoma Et Radix Notopterygii, Scorpio, Rhizoma Cimicifugae, Rhizoma Chuanxiong, Herba Asari, Flos Carthami, the Rhizoma Pinelliae, Zaocys, Herba pteridii latiusculi beanstalk, Herba Limnophilae rugosae algae, Holotrichia diomphalia Bates, blue or green bone rattan, Bulbus Allii Macrostemonis, Radix Rhois Sinicae, Nux Prinsepiae.

In described medicine, each component pharmacology is as follows:

Radix Saposhnikoviae: acrid in the mouth, sweet, slightly warm in nature; Enter urinary bladder channel, lung meridian, spleen channel, Liver Channel." Japan hanako materia medica ": " wind as controlling 36, all labor of man are bad, invigorating middle warmer benefit god, blepharitis marginalis, arresting lacrimation and paralysis are slow, tonneau the five internal organs GUAN-pulse, five kinds of strain and seven kinds of impairment, thin damage night sweat, vexed body weight, energy tranquilizing the mind, even gaseous pulse." " Changsha medicine solution ": " and the network of passing through, by wet excessive, gets round by bribery, the pain that relieves the pain, and relaxing muscles and tendons arteries and veins, stretches anxious twinly, and the podomere of living, plays paralysis, holds back spontaneous perspiration, night sweat, breaks, metrorrhagia." function expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic.For affection of exogenous wind-cold, headache general pain, rheumatic arthralgia, joint is ached, stomachache is had loose bowels, discharging fresh blood stool, tetanus, rubella pruritus, skin infection from the beginning of.Deficiency of YIN-blood, calentura wind symptom person should not use, and blood deficiency convulsion urgency or headache be not because ailment said due to cold or exposure person avoids clothes.

Herba Schizonepetae: acrid in the mouth, slightly warm in nature, enters lung, Liver Channel, has relieving the exterior syndrome by diaphoresis, declares malicious rash, and the effect of blood hemostasis, is mainly used in the fever and headache due to affection of exogenous wind-cold wind heat, no matter has antiperspirant lossless, all can apply; The headache of attacking in wind heat is dizzy, and rash goes out not saturating; Puerperal blood faints apoplexy, the cards such as discharging fresh blood stool.Herba Schizonepetae and Radix Saposhnikoviae all belong to relieving the exterior syndrome with drugs of pungent in flavor and warm in nature, the product of expelling wind and cold, and Radix Saposhnikoviae is the profit agent in wind medicine, can dredge wind prevailing over dampness, yang invigorating and inspire temper, but the power of diaphoresis is not as good as Herba Schizonepetae; Herba Schizonepetae property is also gentle, and makings lightly floats, and gets final product dispersing wind and cold, the wind heat of can faling apart again, and what use of two medicines, the power of inducing sweat strengthens, and is the obstruction-removing prescription of 4 o'clock affection of exogenous wind-cold.

Herba Menthae: nature and flavor are pungent is cool.Enter lung meridian, Liver Channel.For anemopyretic cold, epidemic febrile disease from the beginning of.These product are pungent to disperse, cool to heat clearing away, clear light cool loose, are the product that dispelling wind and heat pathogens is conventional, control anemopyretic cold or epidemic febrile disease from the beginning of, evil defending point therefore available, and headache, heating, the micro evil wind person that trembles with fear often joins Flos Lonicerae, Fructus Forsythiae, Fructus Arctii, Herba Schizonepetae and is equal to use.Be used for the conjunctival congestion of having a headache, laryngopharynx swelling and pain.These product lightly float and rise floating, awakening consciousness, kind part of the body cavity above the diaphragm housing the heart and lungs wind heat, refresh oneself, the throat evacuated of merit.Attack with controlling in wind heat, headache conjunctival congestion, polygamy closes Folium Mori, Flos Chrysanthemi, Fructus Viticis and is equal to use; Stop up and contain with controlling wind heat, laryngopharynx swelling and pain, often joins Radix Platycodonis, Radix Glycyrrhizae, Bombyx Batryticatus, Herba Schizonepetae, Radix Saposhnikoviae and is equal to use.Modern study shows, Herba Menthae has antivirus action; Analgesia, itching-relieving action; Irritation, antitussive action; Bactericidal action; Antibacterial action: Herba Menthae has extremely strong sterilization antibacterial action, often drinks its energy preventing viral flu, oral disease, makes breath freshening.Gargle with mint tea juice, can be anti-halitosis in advance.With mint tea mist steaming face, also has the effect of shrinking pore.Apply and on eyes, can feel refrigerant by the blade that steeped tea, can remove eyestrain.It is said that Herba Menthae also has the another name of " eyes grass ", can be used for treating ophthalmic.Skin effect: shrink blood capillary, get rid of vivotoxin, improve eczema, tinea, releive itch, inflammation and burning, soft skin, eliminates blackhead, is of value to oiliness hair quality and skin quality.Physiological function: Herba Menthae is the best quintessence oil for the treatment of flu, can suppress fever and mucosa inflammation, and promote perspire; Cleaning throat and moistening larynx, elimination halitosis have good effect; Effect of relieveing pain and refreshing, can alleviate headache, migraine and toothache; In addition for respiratory system, digestive system, hormonal system, there is good effect.

The Radix Angelicae Dahuricae: expelling wind and cold, understand things pain-stopping, the evacuation of pus of invigorating blood circulation, granulation promoting pain relieving, dampness leukorrhagia stopping.For mastalgia, swell and ache, have a headache, toothache, nasal sinusitis, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus.Modern pharmacological research proves that the Radix Angelicae Dahuricae also has antiinflammatory, antipyretic-antalgic, active eliminating stagnation, can be used for controlling the effects such as mammary gland caking with other Chinese Medicine and Clavicular.Radix Angelicae Dahuricae external is beauty treatment key medicine.The Compendium of Material Medica meaning Radix Angelicae Dahuricae " longue skin, moist color, can make face fat ", in ancient times beauty treatment sides multiplex it.

Arisaema Cum Bile: bitter cold, micro-pungent, cool.Return lung, liver, spleen channel.Clearing away fire and eliminating phlegm, relieving convulsion fixed chronic.Control middle wind-phlegm fan, infantile convulsion epilepsy, phlegm-fire is breathed heavily and is coughed, phlegm-accumulating vertigo." book on Chinese herbal medicine converges and says ": " control the frightened expectorant of infantile convulsion, tic of the limbs, adult's deficiency of vital energy interior-heat, the raw expectorant of heat stagnation."

Rhizoma Gastrodiae: sweet in the mouth, property are flat, enter Liver Channel, have suppressing the hyperactive liver to relieve the wind syndrome, spasmolytic, the effect of removing obstruction in the collateral to relieve pain, is mainly used in the dizzy headache of flaming up of liver-fire, the symptom such as strong wind tic, epilepsy due to excessive rising of liver-YANG, liver-wind stirring up internally.

Rhizoma Cimicifugae: acrid in the mouth, sweet, cold nature; Return lung meridian, spleen channel, large intestine channel, stomach warp." property of medicine opinion ": " control little eclampsia, infantile convulsion, the hot disease of seasonal epidemic pathogens.Can control the swollen pain of ability to speak wind NI, root of the tooth floats rotten stench, pyretic toxicity pus and blood.Remove cardiopulmonary pathogenic wind toxic heat obstructed and constipated, aphtha, unhappiness.Treat carbuncle, smallpox; Decocting silk floss is stained with and is wiped in skin ulcer." Compendium of Material Medica: " and speckle removing rash, clots absorbing blood are controlled sun and are fallen into dizzy fortune, and the empty pain of the breast side of body is heavy after chronic diarrhea dysentery, lose turbid, leukorrhagia, metrorrhagia, stranguria with blood, hematochezia, impotence cold foot." function heat-clearing and toxic substances removing, rash.Thoroughly send out smooth, maculopapulae due to toxic heat, diseases caused by exogenous pathogenic factor exterior syndrome, weight, women's leukorrhagia, metrorrhagia under epidemic disease fire-toxin, aphtha, pharyngalgia, headache cold and heat, carbuncle sore tumefacting virus, sinking of QI of middle-JIAO, diarrhea due to hypofunction of the spleen, chronic dysentery for measles.

Bombyx Batryticatus: salty, pungent, flat.Return liver, lung, stomach warp.Expelling wind for relieving convulsion, dissipating phlegm and resolving masses.(dissipating phlegm and resolving masses of relieving spasm by subduing liver-wind wind-expelling pain-stopping) for convulsion with spasms, laryngopharynx swelling and pain, submandibular lymph nodes inflammation, facial paralysis, skin pruritus.

Radix Puerariae: be again Radix Puerariae.Sweet in the mouth is pungent, and having induces sweat brings down a fever, and promotes the production of body fluid, the several functions such as rash, yang invigorating antidiarrheal, can control fever caused by exogenous pathogens headache, hypertension neck pain, thirsty, quench one's thirst, measles without adequate eruption, heat rash, the various diseases such as have loose bowels.General Pachyrhizua angulatus matter is tough, and fibroid is strong.

Rhizoma Et Radix Notopterygii: acrid in the mouth, hardship, warm in nature; Enter bladder, kidney channel." property of medicine opinion ": " control harmful wind, aphonia in silence, the blood leprosy of itching, hands and feet caused by paralysis, the askew heresy of actinal surface, insensitive impediment all over more." " product remittance essence is wanted ": " main all joints being painful all over, flesh table eight winds coming from eight orientations harmful climatic factors, except new and old rheumatism, arranges slough cellulitis skin ulcer." " Thunder God concoct the property of medicine solution ": " Rhizoma Et Radix Notopterygii gas belongs to clearly sun, and benefaction edema caused by disorder of QI relaxes and do not hold back, and rises and can sink, male and be apt to fall apart, and can deliver heresy, therefore the sun small intestinal of starting with.Foot sun bladder is with reason urticaria, though if its function is different from Radix Angelicae Pubescentis, reality is the exterior and the interior mutually." the loose exterior cold of function, wind-damp dispelling, sharp joint, pain relieving.Main affection of exogenous wind-cold, has a headache lossless, edema due to wind pathogen edema, sore swollen toxin.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, alopecia areata.The cold expelling that induces sweat, expelling wind and dampness, pain relieving.Rhizoma Et Radix Notopterygii volatile oil has antiinflammatory and anti-allergic effects. and after gastric infusion, xylol dropsy of ear, carrageenin and dextran foot swelling have inhibitory action.

Periostracum Cicadae: salty, sweet, cold, nontoxic, " detailed outline ": " salty sweet, cold, nontoxic." return lung, Liver Channel " book on Chinese herbal medicine is new again ": " enters liver, spleen, lung three warps." the effect having: loose wind heat extraction, rash, nebula removing." detailed outline ": " Cicadae, main treatment is all wind-heat syndromes all, ancients' body, descendant, with sloughing off, on the whole controls dirty mansion meridians, when using Cicadae body; Control sores ulceration of skin wind heat, when using Periostracum Cicadae ".For measles without adequate eruption, rubella pruritus, conjunctival congestion cataracta, convulsion with spasms.Periostracum Cicadae has dispelling wind and heat pathogens effect, often coordinates Herba Menthae to be equal to use for wind heat table disease, rubella pruritus is also had to the function of dispelling wind for relieving itching.Periostracum Cicadae thoroughly sends out and has a heat clearing away effect.

Scorpio: acrid in the mouth, property is flat, returns Liver Channel, has endogenous wind stopping spasmolytic, dispersing pathogen accumulation, effect of removing obstruction in the collateral to relieve pain, cures mainly infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, the cards such as scrofula.

Rhizoma Chuanxiong: acrid in the mouth, warm in nature.Return liver, gallbladder, pericardium channel." Japan hanako materia medica " records it: the in vitro testses such as " control a wind cutting, all gas, all strains; all blood, mend five kinds of over strain, strengthening bone and muscle; adjust many arteries and veins, broken crux stagnated blood, supports fresh blood; put on flesh, serious epistaxis is spitted blood and hematuria; hemorrhoid complicated by anal fistula, brain carbuncle carbuncle on the back, scrofula wart is superfluous; skin ulcer scabies, and evacuation of pus repercussive blood " modern pharmacology experiment antibacterial action: Rhizoma Chuanxiong has inhibitory action to large intestine, dysentery (Song Nei Shi), distortion, green pus, typhoid fever, Salmonella paratyphi and vibrio cholera etc.

Herba Asari: acrid in the mouth, warm in nature, return lung, kidney channel, " property of medicine opinion ": " control cough with dyspnea, aversion to wind, public attention, spasm of the extremities, settling five organs six internal organs, add courage, and peeling rheumatism ancient term for country school can stop under a lacrimation induced by wind pathogen, and improving eyesight is opened stagnantly in the heart, removes toothache, and main blood closes, married woman's blood drop lumbago." " Japan hanako materia medica ": " and control and cough, the dead flesh skin ulcer meat that disappears, knot is poly-in the heart." there is expelling wind and cold pain relieving; the effect that warming the lung to resolve fluid-retention is sensible, cure mainly affection of exogenous wind-cold, headache; toothache; wind and cold temperature numbness, affection of exogenous wind-cold, in stop lung cold cough with asthma due to cold fluid-retention, the nasal sinusitis of having a stuffy nose; wind-eye corneal nebula; deafness pharyngalgia, the cards such as aphtha halitosis, Herba Asari has obvious inhibitory action to cellular immunization and humoral immunization.

Flos Carthami: warm in nature, acrid in the mouth, enters, the heart, Liver Channel, has promoting blood circulation to restore menstrual flow, the effect of stasis-dispelling and pain-killing, for amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, injury from falling down, the skin infection disease such as swell and ache, " Bencao Jingshu ": red blue flower is the key medicine of promoting the circulation of blood.Its main puerperal blood faints locked mouth person, edge stagnant blood not under, the contrary upper centre of punch, therefore coma and dizzy and locked mouth enter the heart and enter liver makes stagnant blood descending, dizzy and locked mouth are from only.Angor in abdomen, due to stagnant blood not to the utmost, retention of dead fetus, non-activating blood circulation not under; Stasis of blood row blood is lived, therefore can stop angor, lower stillborn fetus also.Also, bruise solution, the row of being detained, stop the medicine of this promoting the circulation of blood of red blue flower, crosses with making blood incessantly get killed, and Flos Carthami has slight excited heart, reduces coronary resistance, increases the effect of coronary flow and myocardial nutritional flow amount.

The Rhizoma Pinelliae: acrid in the mouth, warm in nature, poisonous, enter spleen, stomach warp, there is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, effect of dissolving lump and resolving mass, the pungent loose warm-dryness syndrome of these product is poisonous, main enter taste double enter lung, the water of manageing it is wet, lowering the adverse flow of QI, and the kind taste damp-phlegm of dispelling, water is wet goes the strong and sputum of spleen from disappearing, contrary gas harmonization of the stomach falls and feeling of fullness vomiting from only, therefore be drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the good medicine of dissolving lump and resolving mass, for abundant expectoration cough, breast gastral cavity painful abdominal mass is vexed, the thoracic obstruction, blocked-up chest, goiter scrofula, skin infection swell and ache, globus hystericus, the cards such as adverse rising of stomach-QI, nausea and vomiting.

Zaocys: sweet, flat, return Liver Channel.Function cures mainly: dispels the wind, and dredging collateral, relieving convulsion.For leprosy scabies, scrofula malignant boil.

Herba pteridii latiusculi beanstalk: nature and flavor are bitter, puckery, cool.Cure mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For lung abscess, eye conjunctivitis; Traumatic injury is controlled in external, venom, lymphoid tuberculosis.

Herba Limnophilae rugosae algae: nature and flavor, pungent; Flat.Gui Jing: lung meridian.Cure mainly: wind and heat dispersing; Cough-relieving.Main anemopyretic cold; Cough; Scald.Holotrichia diomphalia Bates: nature and flavor: 1. " herbal classic ": " salty in the mouth, tepor." 2. " not Lu ": " is slightly cold, poisonous." return through: " book on Chinese herbal medicine converge with speech ": " enters liver channel of foot-Jueyin." cure mainly: removing blood stasis, clots absorbing, eliminating stagnation, lactogenesis.Control and lose stasis of blood pain, gout, tetanus, sore throat, corneal nebula, erysipelas, carbuncle, anal fistula.1. " herbal classic ": " main stagnant blood blood stasis stagnated QI, breaks the hard full pain of folding blood stagnating in the hypochondriac region, and the moon closes, excessive skin, blue or green nebula tunica albuginea in order." 2. " not Lu ": " treated to spit blood and do not gone and broken bone Wei folding blood agglomeration at breast abdomen, plug in incised wound, puerperal invasion by pathogenic cold, lower milk." 3. " property of medicine opinion ": " juice drips in order, removing nebula barrier, main blood, pain relieving." 4. supplement to the Herbal: " main red white trip rash, rash galling, broken Holotrichia diomphalia Bates extracting juice is coated with it." 5. " Japan hanako materia medica ": " can apply malignant boil."

Fructus Ulmus preparatium: nature and flavor: toil, temperature.1. " herbal classic ": " acrid in the mouth is flat." 2. " property of medicine opinion ": " bitter in the mouth is pungent." 3. " Haiyao Bencao, Oversea Materia Medica ": " acrid in the mouth, temperature, nontoxic." return through: enter spleen, stomach warp.1. " Thunder God is concocted property of medicine solution ": " enter lung, spleen two warps." 2. " beautiful Chinese catalpa medicine solution ": " cloudy Liver Channel enters to faint." 3. " key medicine is divided agent ": " enters spleen, stomach two warps." 4. " book on Chinese herbal medicine is new again ": " enters the heart, spleen two warps." cure mainly: parasite killing, removing food stagnancy.Control abdominal pain due to worm stagnation.Children's's infantile malnutrition with diarrhea, cold-dysentery, scabies, malignant boil.1. " herbal classic ": " main five interior pathogens, in loose skin joint, excessive temperature row poison, goes three worms, relieving dyspepsia." 2. " not Lu ": ", by very little white, in loose intestinal, Investigations-on Investigations-on pants.The main accumulation of pathogenic cold gas of " 3. " property of medicine opinion ": " energy, trusted subordinate's disease pain, removes skin joint apoplexy excessive in worm row." 4. the Meng numerous: " controls herpes simplex, pounds leaf fat and is coated with.Control exudative dermatitis with whitish honey again.Treat all skin ulcers with husky cattle cheese.Long dietetic therapy five hemorrhoid.Pain due to disorder of QI in " 5. " Treatise on Dietetic Therapy ": " loose abdomen.Can control tinea with horse cheese again.Kill again attacked by pestiferous factors insect poison." 6. " Haiyao Bencao, Oversea Materia Medica ": " controls the cold-dysentery motive, parasite killing pain relieving.Control again married woman uterus wind void, child's infantile malnutrition with diarrhea." 7. " Japan hanako materia medica ": " controls hemorrhoidal hamorrhage anal fistula, malignant boil scabies." 8. " medical center bun is wanted ": " eliminating the pathogens from the lung method rheumatism, dry diabetes involving middle-JIAO cold food, controls subcutaneous ulcer Huang, and parasite killing goes ascarid." 9. " middle traditional Chinese medicines are planted illustrated handbook ": " diuresis of eliminating the phlegm." blue or green bone rattan: nature and flavor, bitter, pungent, cool.Slightly poisonous.Cure mainly: analgesia, hemostasis, heat clearing away, diuresis.For traumatic injury, rheumatic ostalgia, stomach abdomen pain, bronchitis, urinary tract infection; Traumatic hemorrhage is controlled in external, furuncle toxic swelling.

Bulbus Allii Macrostemonis: nature and flavor: arduous, temperature.1. " wood warp ": " acrid in the mouth, temperature." 2. " not Lu ": " hardship, temperature, nontoxic." 3. " a thousand pieces of gold dietetic therapy ": " bitter in the mouth is pungent, and temperature is sliding, nontoxic." 4. " medical center bun is wanted ": " is sweet misery, temperature." return through: 1. Materia Medica of Decoction: " enters meridian of Hand-YANG MING." 2. " book on Chinese herbal medicine is through separating ": " enters liver channel of foot-Jueyin, lung meridian, heart channel of Hand-Shaoyin." cure mainly: regulate the flow of vital energy, the chest stuffiness relieving, activates yang, eliminating stagnation.Control the thorough back of the body of obstruction of qi in the chest and cardialgia, gastral cavity painful abdominal mass is not relaxed, and retches, heavy after dysentery, furuncle.1. " herbal classic ": " main incised wound skin ulcer loses." 2. " not Lu ": " is attributed to bone.Except cold and heat, the gas that anhydrates, warming middle-JIAO eliminating stagnation.Wind and cold edema in all skin ulcers, to be coated with it." 3. " a thousand pieces of gold dietetic therapy ": " energy granulation promoting meat, sharp puerpera.A fishbone or other bone caught in the throat is not swallowing person, and that eats goes." 4. Tang materia medica ": " white person mends and beautiful, the main incised wound of red person and phoenix." 5. " Treatise on Dietetic Therapy ": " controls married woman's leucorrhea with red and white discharge.During " 6. supplement to the Herbal: " adjusted, main chronic diarrhea is not recovered, normal evil person in large abdomen, but cook it more." 7. " Bencao Tujing ": " tonify deficiency, removing toxic substances." " main foot gas; Boil with straw mat woman and drink it, easily produce." 8. amplification on Canon of Materia Medica: " with smashing, is coated with burn with honey." 9. " medication heart method ": " controls dysentery with rectal heaviness, stagnation of QI in lower-JIAO." 10. " detailed outline ": " controlled SHAO YIN syndrome and fainted and contrary let out dysentery, and thoracic obstruction twinge, and the therapeutic method to keep the adverse QI flowing downwards blood that falls apart is antiabortive.The supporing yang road of " " temperature compensation." (11) essentials of Matea Medica: " sharp key.Control lung qi dyspnea with rapid respiration." (12) " herbal classic is met former ": " smash juice and drunk raw, and can tell expectorant carnivorism in stomach and amass." (13) " south of the Five Ridges gather medicinal herbs record ": " and Sal are mashed deposited skin ulcer; Hindered by ferrum pin, stay rust in muscle, that applies can sucking-off.Can disperse and induce sweat, stomach invigorating, opens diaphragm." (14) " Nanjing medicinal herbs among the people ": " batter down external application, control various furuncle.Getting in addition Flos Chrysanthemi Indici, to decoct water for oral administration."

Radix Rhois Sinicae: cure mainly: 1. " Hunan medicine will ": " control dysentery." 2. " Guizhou medicine is planted catalogue ": " astringing intestine to stop diarrhea.Control dysentery, diarrhoea."

Rhizoma Dioscoreae Septemlobae: nature and flavor: hardship, flat.Gui Jing: return kidney, stomach warp.Cure mainly: dampness removing goes turbid, blood stasis dispelling dispels the wind.For gonorrhea nebulousurine, leukorrhagia, damp and hot sore, waist knee joint arthralgia pain.

Crawl Pheretima: nature and flavor: micro-hardship, cool.Cure mainly: diuresis and expelling stone, heat-clearing and toxic substances removing, reason diabetes involving middle-JIAO is long-pending.For lithangiuria, Biliary Calculi, icteric infectious hepatitis, rabies, gill fungus neutron poisoning, infantile malnutrition, gingiva toxic swelling, carbuncle furuncle.

Nux Prinsepiae: nature and flavor: sweet, cold.1. not " not Lu ": " be slightly cold, nontoxic." 2. " medical center bun is wanted ": " is sweet salty, cold." return through: enter liver, heart channel.1. " Thunder God is concocted property of medicine solution ": " enter the heart, liver, spleen three warps." 2. " beautiful Chinese catalpa medicine solution ": " start with lunar lung, liver channel of foot-Jueyin." cure mainly: dispel the wind, heat radiation, nourishing the liver, improving eyesight.Control conjunctival congestion and swelling pain, dim photophobia, the rotten many tear of the corner of the eyes, epistaxis.1. " herbal classic ": " conjunctival congestion with ophthalmalgia is hindered lacrimation for main trusted subordinate's pathogens agglomerating gas, improving eyesight." 2. " WU Pu Bencao ": " strong will of invigorating middle warmer, improve visual and auditory acuity.The swollen corner of the eyes Lan ， Weng nose of " 3. " not Lu ": " order, ties fullness and oppression sensation in the epigastrium due to accumulation of phlegm gas under the broken heart." 4. " property of medicine opinion ": " controls epistaxis." 5. supplement to the Herbal: " raw foot of controlling is slept, the ripe sleeplessness of controlling." 6. " book on Chinese herbal medicine covers bamboo fish trap ": " specially controls ophthalmology, the rotten string of upper lower eyelid swelling due to wind that disappears, and except left and right corner of the eyes thermal boundary bulbar conjunctiva polyp, annealing arresting lacrimation, beneficial aquatic light."

Wherein, in medicine, the parts by weight of each raw medicinal material are preferably: Radix Saposhnikoviae 20-30 weight portion, crawl Pheretima 10-20 weight portion, Herba Schizonepetae 10-25 weight portion, Rhizoma Dioscoreae Septemlobae 10-20 weight portion ,herba Menthae 10-25 weight portion, Periostracum Cicadae 20-30 weight portion, Fructus Ulmus preparatium 15-30 weight portion, Radix Angelicae Dahuricae 10-30 weight portion, Arisaema Cum Bile 15-30 weight portion, Rhizoma Gastrodiae 10-25 weight portion, Rhizoma Cimicifugae 10-30 weight portion, Bombyx Batryticatus 10-20 weight portion, Radix Puerariae 15-30 weight portion, Rhizoma Et Radix Notopterygii 10-30 weight portion, Scorpio 10-25 weight portion, Rhizoma Chuanxiong 10-25 weight portion, Herba Asari 10-25 weight portion, Flos Carthami 10-25 weight portion, Rhizoma Pinelliae 20-30 weight portion, Zaocys 20-30 weight portion, Herba pteridii latiusculi beanstalk 20-30 weight portion, Herba Limnophilae rugosae algae 10-30 weight portion, Holotrichia diomphalia Bates 15-30 weight portion, blue or green bone rattan 10-25 weight portion, Bulbus Allii Macrostemonis 10-30 weight portion, Radix Rhois Sinicae 15-30 weight portion and Nux Prinsepiae 20-30 weight portion.

Wherein, in described medicine, the parts by weight of each raw medicinal material can be again: Radix Saposhnikoviae 25-30 weight portion, crawl Pheretima 15-20 weight portion, Herba Schizonepetae 15-25 weight portion, Rhizoma Dioscoreae Septemlobae 15-20 weight portion ,herba Menthae 15-25 weight portion, Periostracum Cicadae 22-30 weight portion, Fructus Ulmus preparatium 17-30 weight portion, Radix Angelicae Dahuricae 15-30 weight portion, Arisaema Cum Bile 17-30 weight portion, Rhizoma Gastrodiae 15-25 weight portion, Rhizoma Cimicifugae 15-30 weight portion, Bombyx Batryticatus 15-20 weight portion, Radix Puerariae 17-30 weight portion, Rhizoma Et Radix Notopterygii 15-30 weight portion, Scorpio 15-25 weight portion, Rhizoma Chuanxiong 15-25 weight portion, Herba Asari 15-25 weight portion, Flos Carthami 16-25 weight portion, Rhizoma Pinelliae 25-30 weight portion, Zaocys 22-30 weight portion, Herba pteridii latiusculi beanstalk 25-30 weight portion, Herba Limnophilae rugosae algae 18-30 weight portion, Holotrichia diomphalia Bates 17-30 weight portion, blue or green bone rattan 15-25 weight portion, Bulbus Allii Macrostemonis 15-30 weight portion, Radix Rhois Sinicae 17-30 weight portion and Nux Prinsepiae 25-30 weight portion.

Wherein, in described medicine, the parts by weight of each raw medicinal material can also be: Radix Saposhnikoviae 27-30 weight portion, crawl Pheretima 18-20 weight portion, Herba Schizonepetae 18-25 weight portion, Rhizoma Dioscoreae Septemlobae 17-20 weight portion ,herba Menthae 18-25 weight portion, Periostracum Cicadae 27-30 weight portion, Fructus Ulmus preparatium 17-25 weight portion, Radix Angelicae Dahuricae 17-25 weight portion, Arisaema Cum Bile 18-28 weight portion, Rhizoma Gastrodiae 15-22 weight portion, Rhizoma Cimicifugae 17-25 weight portion, Bombyx Batryticatus 17-20 weight portion, Radix Puerariae 17-25 weight portion, Rhizoma Et Radix Notopterygii 17-25 weight portion, Scorpio 18-22 weight portion, Rhizoma Chuanxiong 15-20 weight portion, Herba Asari 18-22 weight portion, Flos Carthami 18-22 weight portion, Rhizoma Pinelliae 27-30 weight portion, Zaocys 22-28 weight portion, Herba pteridii latiusculi beanstalk 27-30 weight portion, Herba Limnophilae rugosae algae 20-30 weight portion, Holotrichia diomphalia Bates 17-28 weight portion, blue or green bone rattan 15-22 weight portion, Bulbus Allii Macrostemonis 18-25 weight portion, Radix Rhois Sinicae 18-30 weight portion and Nux Prinsepiae 25-28 weight portion.

Wherein, in medicine, the parts by weight of each raw medicinal material are: Radix Saposhnikoviae 28 weight portions, crawl Pheretima 19 weight portions, Herba Schizonepetae 19 weight portions, Rhizoma Dioscoreae Septemlobae 18 weight portions ,herba Menthae 20 weight portions, Periostracum Cicadae 28 weight portions, Fructus Ulmus preparatium 20 weight portions, the Radix Angelicae Dahuricae 22 weight portions, Arisaema Cum Bile 20 weight portions, Rhizoma Gastrodiae 18 weight portions, Rhizoma Cimicifugae 19 weight portions, Bombyx Batryticatus 18 weight portions, Radix Puerariae 19 weight portions, Rhizoma Et Radix Notopterygii 20 weight portions, Scorpio 20 weight portions, Rhizoma Chuanxiong 18 weight portions, Herba Asari 20 weight portions, Flos Carthami 19 weight portions, the Rhizoma Pinelliae 28 weight portions, Zaocys 25 weight portions, Herba pteridii latiusculi beanstalk 28 weight portions, Herba Limnophilae rugosae algae 25 weight portions, Holotrichia diomphalia Bates 18 weight portions, blue or green bone rattan 18 weight portions, Bulbus Allii Macrostemonis 19 weight portions, Radix Rhois Sinicae 20 weight portions and Nux Prinsepiae 26 weight portions.

Wherein, in described medicine, the parts by weight of each raw medicinal material can also be: Radix Saposhnikoviae 20 weight portions, crawl Pheretima 18 weight portions, Herba Schizonepetae 12 weight portions, Rhizoma Dioscoreae Septemlobae 17 weight portions ,herba Menthae 15 weight portions, Periostracum Cicadae 25 weight portions, Fructus Ulmus preparatium 17 weight portions, the Radix Angelicae Dahuricae 15 weight portions, Arisaema Cum Bile 25 weight portions, Rhizoma Gastrodiae 19 weight portions, Rhizoma Cimicifugae 17 weight portions, Bombyx Batryticatus 16 weight portions, Radix Puerariae 15 weight portions, Rhizoma Et Radix Notopterygii 17 weight portions, Scorpio 19 weight portions, Rhizoma Chuanxiong 15 weight portions, Herba Asari 20 weight portions, Flos Carthami 20 weight portions, the Rhizoma Pinelliae 25 weight portions, Zaocys 28 weight portions, Herba pteridii latiusculi beanstalk 25 weight portions, Herba Limnophilae rugosae algae 17 weight portions, Holotrichia diomphalia Bates 19 weight portions, blue or green bone rattan 22 weight portions, Bulbus Allii Macrostemonis 20 weight portions, Radix Rhois Sinicae 17 weight portions and Nux Prinsepiae 25 weight portions.

Wherein, in described medicine, the parts by weight of each raw medicinal material can be again: Radix Saposhnikoviae 22 weight portions, crawl Pheretima 19 weight portions, Herba Schizonepetae 15 weight portions, Rhizoma Dioscoreae Septemlobae 19 weight portions ,herba Menthae 17 weight portions, Periostracum Cicadae 20 weight portions, Fructus Ulmus preparatium 18 weight portions, the Radix Angelicae Dahuricae 17 weight portions, Arisaema Cum Bile 22 weight portions, Rhizoma Gastrodiae 20 weight portions, Rhizoma Cimicifugae 22 weight portions, Bombyx Batryticatus 18 weight portions, Radix Puerariae 17 weight portions, Rhizoma Et Radix Notopterygii 19 weight portions, Scorpio 20 weight portions, Rhizoma Chuanxiong 17 weight portions, Herba Asari 19 weight portions, Flos Carthami 18 weight portions, the Rhizoma Pinelliae 20 weight portions, Zaocys 25 weight portions, Herba pteridii latiusculi beanstalk 22 weight portions, Herba Limnophilae rugosae algae 18 weight portions, Holotrichia diomphalia Bates 20 weight portions, blue or green bone rattan 20 weight portions, Bulbus Allii Macrostemonis 22 weight portions, Radix Rhois Sinicae 18 weight portions and Nux Prinsepiae 20 weight portions.

For solving the problems of the technologies described above, the invention provides a kind of preparation method that is used for the treatment of the tetanic medicine of cat, described preparation method comprises the following steps: all raw medicinal materials are dropped in pulverizer and are ground into fine powder, put into acid and alkali-resistance infusion kettle, the ethanol that is 80%-90% by the determining alcohol doubly of the 3-5 with respect to fine powder quality is poured in pot, at normal temperatures and pressures, dipping 20-30 days, subsequently the liquid having flooded and dregs pressing are filtered, filtrate decompression concentrates to obtain paste, the medicinal residues that obtain will be filtered, put into oven for drying, the temperature of oven drying is 110-115 DEG C, drying time 10-20 minute, after oven dry, grind to form 150-250 order fine powder, make its fine powder amount reach the more than 95% of total material, obtain described medicine.

Embodiment 1 medicine 1

The embodiment of the present invention provides one to be used for the treatment of the tetanic medicine of cat, is made up of the raw medicinal material of following parts by weight: Radix Saposhnikoviae 28 weight portions, crawl Pheretima 19 weight portions, Herba Schizonepetae 19 weight portions, Rhizoma Dioscoreae Septemlobae 18 weight portions ,herba Menthae 20 weight portions, Periostracum Cicadae 28 weight portions, Fructus Ulmus preparatium 20 weight portions, the Radix Angelicae Dahuricae 22 weight portions, Arisaema Cum Bile 20 weight portions, Rhizoma Gastrodiae 18 weight portions, Rhizoma Cimicifugae 19 weight portions, Bombyx Batryticatus 18 weight portions, Radix Puerariae 19 weight portions, Rhizoma Et Radix Notopterygii 20 weight portions, Scorpio 20 weight portions, Rhizoma Chuanxiong 18 weight portions, Herba Asari 20 weight portions, Flos Carthami 19 weight portions, the Rhizoma Pinelliae 28 weight portions, Zaocys 25 weight portions, Herba pteridii latiusculi beanstalk 28 weight portions, Herba Limnophilae rugosae algae 25 weight portions, Holotrichia diomphalia Bates 18 weight portions, blue or green bone rattan 18 weight portions, Bulbus Allii Macrostemonis 19 weight portions, Radix Rhois Sinicae 20 weight portions, Nux Prinsepiae 26 weight portions.

Said medicine makes by following preparation method: according to above-mentioned parts by weight, all raw medicinal materials are dropped in pulverizer and are ground into fine powder, put into acid and alkali-resistance infusion kettle, the ethanol that is 85% with respect to the determining alcohol of 4 times of fine powder quality is poured in pot, at normal temperatures and pressures, flood 25 days, subsequently the liquid having flooded and dregs pressing are filtered, filtrate decompression concentrates to obtain paste, the medicinal residues that obtain will be filtered, put into oven for drying, the temperature of oven drying is 110 DEG C, 15 minutes drying times, after oven dry, grind to form 200 order fine powders, make its fine powder amount reach the more than 95% of total material, obtain described medicine.

Embodiment 2 medicines 2

The embodiment of the present invention provides one to be used for the treatment of the tetanic medicine of cat, can also be made up of the raw medicinal material of following parts by weight: Radix Saposhnikoviae 20 weight portions, crawl Pheretima 18 weight portions, Herba Schizonepetae 12 weight portions, Rhizoma Dioscoreae Septemlobae 17 weight portions ,herba Menthae 15 weight portions, Periostracum Cicadae 25 weight portions, Fructus Ulmus preparatium 17 weight portions, the Radix Angelicae Dahuricae 15 weight portions, Arisaema Cum Bile 25 weight portions, Rhizoma Gastrodiae 19 weight portions, Rhizoma Cimicifugae 17 weight portions, Bombyx Batryticatus 16 weight portions, Radix Puerariae 15 weight portions, Rhizoma Et Radix Notopterygii 17 weight portions, Scorpio 19 weight portions, Rhizoma Chuanxiong 15 weight portions, Herba Asari 20 weight portions, Flos Carthami 20 weight portions, the Rhizoma Pinelliae 25 weight portions, Zaocys 28 weight portions, Herba pteridii latiusculi beanstalk 25 weight portions, Herba Limnophilae rugosae algae 17 weight portions, Holotrichia diomphalia Bates 19 weight portions, blue or green bone rattan 22 weight portions, Bulbus Allii Macrostemonis 20 weight portions, Radix Rhois Sinicae 17 weight portions, Nux Prinsepiae 25 weight portions.

Said medicine makes by following preparation method: according to above-mentioned parts by weight, all raw medicinal materials are dropped in pulverizer and are ground into fine powder, put into acid and alkali-resistance infusion kettle, the ethanol that is 90% with respect to the determining alcohol of 5 times of fine powder quality is poured in pot, at normal temperatures and pressures, flood 20 days, subsequently the liquid having flooded and dregs pressing are filtered, filtrate decompression concentrates to obtain paste, the medicinal residues that obtain will be filtered, put into oven for drying, the temperature of oven drying is 110 DEG C, 10 minutes drying times, after oven dry, grind to form 150 order fine powders, make its fine powder amount reach the more than 95% of total material, obtain described medicine.

Embodiment 3 medicines 3

The embodiment of the present invention provides one to be used for the treatment of the tetanic medicine of cat, can be made up of the raw medicinal material of following parts by weight again: Radix Saposhnikoviae 22 weight portions, crawl Pheretima 19 weight portions, Herba Schizonepetae 15 weight portions, Rhizoma Dioscoreae Septemlobae 19 weight portions ,herba Menthae 17 weight portions, Periostracum Cicadae 20 weight portions, Fructus Ulmus preparatium 18 weight portions, the Radix Angelicae Dahuricae 17 weight portions, Arisaema Cum Bile 22 weight portions, Rhizoma Gastrodiae 20 weight portions, Rhizoma Cimicifugae 22 weight portions, Bombyx Batryticatus 18 weight portions, Radix Puerariae 17 weight portions, Rhizoma Et Radix Notopterygii 19 weight portions, Scorpio 20 weight portions, Rhizoma Chuanxiong 17 weight portions, Herba Asari 19 weight portions, Flos Carthami 18 weight portions, the Rhizoma Pinelliae 20 weight portions, Zaocys 25 weight portions, Herba pteridii latiusculi beanstalk 22 weight portions, Herba Limnophilae rugosae algae 18 weight portions, Holotrichia diomphalia Bates 20 weight portions, blue or green bone rattan 20 weight portions, Bulbus Allii Macrostemonis 22 weight portions, Radix Rhois Sinicae 18 weight portions, Nux Prinsepiae 20 weight portions.

Said medicine makes by following preparation method: according to above-mentioned parts by weight, all raw medicinal materials are dropped in pulverizer and are ground into fine powder, put into acid and alkali-resistance infusion kettle, the ethanol that is 80% with respect to the determining alcohol of 3 times of fine powder quality is poured in pot, at normal temperatures and pressures, flood 30 days, subsequently the liquid having flooded and dregs pressing are filtered, filtrate decompression concentrates to obtain paste, the medicinal residues that obtain will be filtered, put into oven for drying, the temperature of oven drying is 115 DEG C, 20 minutes drying times, after oven dry, grind to form 250 order fine powders, make its fine powder amount reach the more than 95% of total material, obtain described medicine.

Toxicity test

1, cumulative toxicity test report

Select 30 healthy mices, female, male each 10, taking the medicine of the embodiment of the present invention 1 as object, it is first phase that dosage designs every 7 days, each issue dosage is respectively 0.10LD50,0.20LD50,0.25LD50,0.30LD 50,0.40LD50, and the LD 50 female, male mice of this sample is 4000m part/k part BW (five dosage be 500,750,1100,1800,2400m part/k part BW).Within every 7 days, weigh once, adjust dosage, by 0.05ml/10 part BW per os gavage.After 28 days, animal occurs without death condition, off-test, and by ascending-dose, to tested material after 28 days, female, buck all occurs without death condition.Taking the medicine of embodiment 2, embodiment 3 as object, carry out according to the method described above toxicity test, result is as identical in embodiment 1.

2, acute toxicity test

40 of application NIH mices, SPF level, male and female half and half, body weight 15～20g, carries out acute toxicity test.Mice is divided into two groups at random, and 20 every group, i.e. matched group and administration group, fasting 12 hours before experiment; Medicine dissolution prepared by embodiments of the invention 1 is in water, (concentration is 6.75g crude drug/ml, maximum concentration) gavage, gavage volume is that 7ml/kg(is that single-dose dosage is 28.7 crude drugs/kg), matched group gives equivalent normal saline, administration in a day 3 times, delivery time 8 hours, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mice.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 21 days, and mice overall health of patients, diet, drinking-water, body weight gain are all normal.Therefore the acute toxicity of the medicine of the embodiment of the present invention 1 is low, clinical drug safety.Taking the medicine of embodiment 2 and embodiment 3 as object, carry out according to the method described above toxicity test respectively, result is as identical in embodiment 1.

Clinical trial

Animal experiment adopts single factor contrast test design, gets 100 45 week ages, body weight 2 ㎏ left and right, healthy domestic cat, and male and female half and half, test is managed and is prevented routinely in cat field, compiles overbit, anthelmintic and protective inoculation in preliminary trial period.

The phase of just trying is divided into test group (test group is respectively embodiment group 1, embodiment group 2 and embodiment group 3) and matched group, 25 every group at random.Test period is 60 days, and free choice feeding during this time, freely drinks water, and carries out routinely immunity and anthelmintic.

Feed as follows:

Matched group: basal diet;

Test group:

Embodiment group 1: basal diet+1.5% medicine; Said medicine is the medicine 1 that the embodiment of the present invention 1 makes;

Embodiment group 2: basal diet+1.0% medicine; Said medicine is the medicine 2 that the embodiment of the present invention 2 makes;

Embodiment group 3: basal diet+1.8% medicine; Said medicine is the medicine 3 that the embodiment of the present invention 3 makes.

Test period is 60 days, prepares to record feeding capacity and the clout amount of duration of test, calculates every cat average daily ingestion amount and complete average daily ingestion amount of phase weekly; On-test and 7:30 weighs on an empty stomach morning while finishing, calculate the average daily gain of every cat; Carry out the health status record of routine work record and cat.All data adopt SPSS13.0 software kit to carry out variance analysis and Duncan ' S multiple comparisons.Result represents with mean+SD.

To the cat of embodiment group 1, embodiment group 2, embodiment group 3 and matched group, gather the empty venous blood of 10mL, get the mensuration of 2mL heparin anti-coagulating for t lymphocyte subset group (CD3, CD4, CD8) quantity, lymphocyte positive rate.The serum separating is used for measuring interleukin (IL-2), gamma interferon content.Lymphocyte positive rate adopts acid α-naphthyl acetate esterase Determination Staining.IL-2, gamma interferon content are detected by ELISA method, and IL-2, gamma interferon test kit provide by content MARKET company of the U.S..Adopt the U.S. EPICS-XL of Coulter company flow cytometer to detect the quantity of T lymphocyte subsets.

The impact of table 1 medicine on cat tetanus immunological function

As can be seen from Table 1, the cat of drug treating group is compared with matched group, and the IL-2 in serum, gamma interferon, lymphocyte positive rate, CD4, CD4/CD8 value all increase.As can be seen here, medicine of the present invention has improved CD4(T accessory cell in cat immunocyte) and CD4(T accessory cell) with CD8(T suppress cell) ratio, increase the composition such as complement, IL-2, gamma interferon of serum, improve to a certain extent innate immune activity in cat body, strengthen the immunity of cat body.

Treatment contrast test:

In May, 2010-2012 year May, there are 400 domestic cats to suffer from tetanus, 400 cats are divided into 4 groups at random, be respectively embodiment group 1, embodiment group 2, embodiment group 3 and western medicine group, use respectively medicine 1 that embodiment 1 makes, medicine 2 that embodiment 2 makes, medicine 3 that embodiment 3 makes to treat and conventional medicament is treated, wherein, the dose of embodiment group 1-3 be every every day 0.3g, during treatment, be 10-20 days; The conventional medicament of western medicine group selects tetanus antitoxin 10mg/mL, tetanus immune globulin 15mg/mL to carry out neck injection, every day 1 time, treatment 15-28 days; Blank group is not carried out any treatment.Treatment finishes rear observation three months, records cure rate and the mortality rate of each group of cat, and result is as shown in table 2.

The each experimental group therapeutic effect of table 2 synopsis

Data from table 2: medicine of the present invention is obviously better than western medicine group to the tetanic therapeutic effect of cat, reduce mortality rate, improve cure rate.

The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.

Claims (8)

1. be used for the treatment of the tetanic medicine of cat, it is characterized in that, described medicine comprises following raw medicinal material: Radix Saposhnikoviae, crawl Pheretima, Herba Schizonepetae, Rhizoma Dioscoreae Septemlobae ,herba Menthae, Periostracum Cicadae, Fructus Ulmus preparatium, the Radix Angelicae Dahuricae, Arisaema Cum Bile, Rhizoma Gastrodiae, Rhizoma Cimicifugae, Bombyx Batryticatus, Radix Puerariae, Rhizoma Et Radix Notopterygii, Scorpio, Rhizoma Chuanxiong, Herba Asari, Flos Carthami, the Rhizoma Pinelliae, Zaocys, Herba pteridii latiusculi beanstalk, Herba Limnophilae rugosae algae, Holotrichia diomphalia Bates, blue or green bone rattan, Bulbus Allii Macrostemonis, Radix Rhois Sinicae and Nux Prinsepiae.

2. the tetanic medicine for the treatment of cat according to claim 1, is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Radix Saposhnikoviae 20-30 weight portion, crawl Pheretima 10-20 weight portion, Herba Schizonepetae 10-25 weight portion, Rhizoma Dioscoreae Septemlobae 10-20 weight portion ,herba Menthae 10-25 weight portion, Periostracum Cicadae 20-30 weight portion, Fructus Ulmus preparatium 15-30 weight portion, Radix Angelicae Dahuricae 10-30 weight portion, Arisaema Cum Bile 15-30 weight portion, Rhizoma Gastrodiae 10-25 weight portion, Rhizoma Cimicifugae 10-30 weight portion, Bombyx Batryticatus 10-20 weight portion, Radix Puerariae 15-30 weight portion, Rhizoma Et Radix Notopterygii 10-30 weight portion, Scorpio 10-25 weight portion, Rhizoma Chuanxiong 10-25 weight portion, Herba Asari 10-25 weight portion, Flos Carthami 10-25 weight portion, Rhizoma Pinelliae 20-30 weight portion, Zaocys 20-30 weight portion, Herba pteridii latiusculi beanstalk 20-30 weight portion, Herba Limnophilae rugosae algae 10-30 weight portion, Holotrichia diomphalia Bates 15-30 weight portion, blue or green bone rattan 10-25 weight portion, Bulbus Allii Macrostemonis 10-30 weight portion, Radix Rhois Sinicae 15-30 weight portion and Nux Prinsepiae 20-30 weight portion.

3. the tetanic medicine of cat that is used for the treatment of according to claim 1 and 2, it is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Radix Saposhnikoviae 25-30 weight portion, crawl Pheretima 15-20 weight portion, Herba Schizonepetae 15-25 weight portion, Rhizoma Dioscoreae Septemlobae 15-20 weight portion ,herba Menthae 15-25 weight portion, Periostracum Cicadae 22-30 weight portion, Fructus Ulmus preparatium 17-30 weight portion, Radix Angelicae Dahuricae 15-30 weight portion, Arisaema Cum Bile 17-30 weight portion, Rhizoma Gastrodiae 15-25 weight portion, Rhizoma Cimicifugae 15-30 weight portion, Bombyx Batryticatus 15-20 weight portion, Radix Puerariae 17-30 weight portion, Rhizoma Et Radix Notopterygii 15-30 weight portion, Scorpio 15-25 weight portion, Rhizoma Chuanxiong 15-25 weight portion, Herba Asari 15-25 weight portion, Flos Carthami 16-25 weight portion, Rhizoma Pinelliae 25-30 weight portion, Zaocys 22-30 weight portion, Herba pteridii latiusculi beanstalk 25-30 weight portion, Herba Limnophilae rugosae algae 18-30 weight portion, Holotrichia diomphalia Bates 17-30 weight portion, blue or green bone rattan 15-25 weight portion, Bulbus Allii Macrostemonis 15-30 weight portion, Radix Rhois Sinicae 17-30 weight portion and Nux Prinsepiae 25-30 weight portion.

4. according to being used for the treatment of the tetanic medicine of cat described in claim 1-3 any one, it is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Radix Saposhnikoviae 27-30 weight portion, crawl Pheretima 18-20 weight portion, Herba Schizonepetae 18-25 weight portion, Rhizoma Dioscoreae Septemlobae 17-20 weight portion ,herba Menthae 18-25 weight portion, Periostracum Cicadae 27-30 weight portion, Fructus Ulmus preparatium 17-25 weight portion, Radix Angelicae Dahuricae 17-25 weight portion, Arisaema Cum Bile 18-28 weight portion, Rhizoma Gastrodiae 15-22 weight portion, Rhizoma Cimicifugae 17-25 weight portion, Bombyx Batryticatus 17-20 weight portion, Radix Puerariae 17-25 weight portion, Rhizoma Et Radix Notopterygii 17-25 weight portion, Scorpio 18-22 weight portion, Rhizoma Chuanxiong 15-20 weight portion, Herba Asari 18-22 weight portion, Flos Carthami 18-22 weight portion, Rhizoma Pinelliae 27-30 weight portion, Zaocys 22-28 weight portion, Herba pteridii latiusculi beanstalk 27-30 weight portion, Herba Limnophilae rugosae algae 20-30 weight portion, Holotrichia diomphalia Bates 17-28 weight portion, blue or green bone rattan 15-22 weight portion, Bulbus Allii Macrostemonis 18-25 weight portion, Radix Rhois Sinicae 18-30 weight portion and Nux Prinsepiae 25-28 weight portion.

5. according to the arbitrary described tetanic medicine of cat that is used for the treatment of of claim 1-4, it is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Radix Saposhnikoviae 28 weight portions, crawl Pheretima 19 weight portions, Herba Schizonepetae 19 weight portions, Rhizoma Dioscoreae Septemlobae 18 weight portions ,herba Menthae 20 weight portions, Periostracum Cicadae 28 weight portions, Fructus Ulmus preparatium 20 weight portions, the Radix Angelicae Dahuricae 22 weight portions, Arisaema Cum Bile 20 weight portions, Rhizoma Gastrodiae 18 weight portions, Rhizoma Cimicifugae 19 weight portions, Bombyx Batryticatus 18 weight portions, Radix Puerariae 19 weight portions, Rhizoma Et Radix Notopterygii 20 weight portions, Scorpio 20 weight portions, Rhizoma Chuanxiong 18 weight portions, Herba Asari 20 weight portions, Flos Carthami 19 weight portions, the Rhizoma Pinelliae 28 weight portions, Zaocys 25 weight portions, Herba pteridii latiusculi beanstalk 28 weight portions, Herba Limnophilae rugosae algae 25 weight portions, Holotrichia diomphalia Bates 18 weight portions, blue or green bone rattan 18 weight portions, Bulbus Allii Macrostemonis 19 weight portions, Radix Rhois Sinicae 20 weight portions and Nux Prinsepiae 26 weight portions.

6. according to the arbitrary described tetanic medicine of cat that is used for the treatment of of claim 1-5, it is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Radix Saposhnikoviae 20 weight portions, crawl Pheretima 18 weight portions, Herba Schizonepetae 12 weight portions, Rhizoma Dioscoreae Septemlobae 17 weight portions ,herba Menthae 15 weight portions, Periostracum Cicadae 25 weight portions, Fructus Ulmus preparatium 17 weight portions, the Radix Angelicae Dahuricae 15 weight portions, Arisaema Cum Bile 25 weight portions, Rhizoma Gastrodiae 19 weight portions, Rhizoma Cimicifugae 17 weight portions, Bombyx Batryticatus 16 weight portions, Radix Puerariae 15 weight portions, Rhizoma Et Radix Notopterygii 17 weight portions, Scorpio 19 weight portions, Rhizoma Chuanxiong 15 weight portions, Herba Asari 20 weight portions, Flos Carthami 20 weight portions, the Rhizoma Pinelliae 25 weight portions, Zaocys 28 weight portions, Herba pteridii latiusculi beanstalk 25 weight portions, Herba Limnophilae rugosae algae 17 weight portions, Holotrichia diomphalia Bates 19 weight portions, blue or green bone rattan 22 weight portions, Bulbus Allii Macrostemonis 20 weight portions, Radix Rhois Sinicae 17 weight portions and Nux Prinsepiae 25 weight portions.

7. according to the arbitrary described tetanic medicine of cat that is used for the treatment of of claim 1-6, it is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Radix Saposhnikoviae 22 weight portions, crawl Pheretima 19 weight portions, Herba Schizonepetae 15 weight portions, Rhizoma Dioscoreae Septemlobae 19 weight portions ,herba Menthae 17 weight portions, Periostracum Cicadae 20 weight portions, Fructus Ulmus preparatium 18 weight portions, the Radix Angelicae Dahuricae 17 weight portions, Arisaema Cum Bile 22 weight portions, Rhizoma Gastrodiae 20 weight portions, Rhizoma Cimicifugae 22 weight portions, Bombyx Batryticatus 18 weight portions, Radix Puerariae 17 weight portions, Rhizoma Et Radix Notopterygii 19 weight portions, Scorpio 20 weight portions, Rhizoma Chuanxiong 17 weight portions, Herba Asari 19 weight portions, Flos Carthami 18 weight portions, the Rhizoma Pinelliae 20 weight portions, Zaocys 25 weight portions, Herba pteridii latiusculi beanstalk 22 weight portions, Herba Limnophilae rugosae algae 18 weight portions, Holotrichia diomphalia Bates 20 weight portions, blue or green bone rattan 20 weight portions, Bulbus Allii Macrostemonis 22 weight portions, Radix Rhois Sinicae 18 weight portions and Nux Prinsepiae 20 weight portions.

8. according to the preparation method that is used for the treatment of the tetanic medicine of cat described in claim 1-7, described preparation method comprises the following steps: all raw medicinal materials are dropped in pulverizer and are ground into fine powder, put into acid and alkali-resistance infusion kettle, the ethanol that is 80%-90% by the determining alcohol doubly of the 3-5 with respect to fine powder quality is poured in pot, at normal temperatures and pressures, dipping 20-30 days, subsequently the liquid having flooded and dregs pressing are filtered, filtrate decompression concentrates to obtain paste, the medicinal residues that obtain will be filtered, put into oven for drying, the temperature of oven drying is 110-115 DEG C, drying time 10-20 minute, after oven dry, grind to form 150-250 order fine powder, make its fine powder amount reach the more than 95% of total material, obtain described medicine.